CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Zehao Chen,Qing Tan,Xuekai Jin,Xiufang Wen,Jihao Zuo,Pihui Pi
Three-dimensional superhydrophilic materials hardly achieve continuous high-flux demulsification and separation for oil-in-water emulsions due to intrinsic oleophilicity leading to potential penetration of oil droplets through hydration layer and contamination on the surface over long-term separation processes. Constructing intrinsic oleophobic micro-regions on superhydrophilic surface can intensify anti-oil-fouling capacity for three-dimensional superhydrophilic materials. Herein, a composite superhydrophilic-oleophobic copper foam was prepared through co-deposition of aminated and fluorinated carbon nanotubes, skillfully introducing inherent oleophobic micro-regions on superhydrophilic interface to intensify anti-oil-adhesion capacity. Through a column technique, the modified copper foams achieved continuous demulsification of surfactant-stabilized and free oil-in-water emulsions without interruption for cleaning with high fluxes over 6000 and 10,000 L·m −2 ·h −1 , and separation efficiencies over 95.1 % and 97.4 %, respectively. Various emulsions after demulsification transformed into immiscible oil–water mixtures, which can be quickly separated into pure oil and water at the aid of a second-step separation procedure by a superhydrophilic copper mesh. Importantly, the amount of recycled oil was consistent with that in feed emulsion during separation, indicating the accumulated oil in the copper foam could maintain dynamic equilibrium and a continuous and steady-state demulsification was achieved. The high-flux and continuous demulsification represents a significant breakthrough for superhydrophilic materials in the industrial application of oil–water separation.
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高影响因子
ACS Applied Bio Materials
·
2024
·
IF 4.6
Jianbo Wu,Minggang Yang,Yibo Huang,Yuan Zhang,Ben Wu,Shi Qiu,Feiyang Hong,Ye Gao,Zhuo Wang,Guocheng Wang
The poor clinical performance of titanium and its alloy implants is mainly attributed to their lack of antibacterial ability and poor osseointegration. The key and challenge lie in how to enhance their osteoinductivity while imparting antibacterial capability. In this study, a titanium oxide metasurface with light-responsive behavior was constructed on the surface of titanium alloy using an alkaline–acid bidirectional hydrothermal method. The effects of the acid type, acid concentration, hydrothermal time, hydrothermal temperature, and subsequent heat treatments on the optical behavior of the metasurface were systematically investigated with a focus on exploring the influence of the metasurface and photodynamic reaction on the osteogenic activity of osteoblasts. Results show that the type of acid and heat treatment significantly affect the light absorption of the titanium alloy surface, with HCl and post-heat-treatment favoring redshift in the light absorption. Under 808 nm near-infrared (NIR) irradiation for 10 min, in vitro antibacterial experiments demonstrate that the antibacterial rate of the metasurface titanium alloy against Staphylococcus aureus and Escherichia coli were 96.87% and 99.27%, respectively. In vitro cell experiments demonstrate that the nanostructure facilitates cell adhesion, proliferation, differentiation, and expression of osteogenic-related genes. Surprisingly, the nanostructure promoted the expression of relevant osteogenic genes of MC3T3-E1 under 808 nm NIR irradiation. This study provides a method for the surface modification of titanium alloy implants.
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高影响因子
ENVIRONMENTAL RESEARCH
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2024
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IF 7.7
Jisuan Tan,Lingzhen Kong,Qiaoxian Huang,Yulin Gan,Shaorong Lu
In this investigation, synthesis of a surface-functionalized chitosan known as amino-rich chitosan (ARCH) was achieved by successful modification of chitosan by polyethyleneimine (PEI). The synthesized ARCH was characterized by a specific surface area of 8.35 m 2 g −1 and a microporous structure, with pore sizes predominantly under 25 nm. The Zeta potential of ARCH maintained a strong positive charge across a wide pH range of 3–11. These characteristics contribute to its high adsorption efficiency in aqueous solutions, demonstrated by its application in removing various anionic dyes, including erioglaucine disodium salt (EDS), methyl orange (MO), amaranth (ART), tartrazine (TTZ), and hexavalent chromium ions (Cr(VI)). The adsorption capacities ( Q e ) for these contaminants were measured at 1301.15 mg g −1 for EDS, 1025.45 mg g −1 for MO, 940.72 mg g −1 for ART, 732.96 mg g −1 for TTZ, and 350.15 mg g −1 for Cr(VI). A significant observation was the rapid attainment of adsorption equilibrium, occurring within 10 min for ARCH. The adsorption behavior was well-described by the Pseudo-second-order and Langmuir models. Thermodynamic studies indicated that the adsorption process is spontaneous and endothermic in nature. Additionally, an increase in temperature was found to enhance the adsorption capacity of ARCH. The material demonstrated robust stability and selective adsorption capabilities in varied conditions, including different organic compounds, pH environments, sodium salt presence, and in the face of interfering ions. After five cycles of adsorption, ARCH maintained about 60% of its initial adsorption capacity. Due to its efficient adsorption performance, simple synthesis process, low biological toxicity, and cost-effectiveness, ARCH is a promising candidate for future water treatment technologies.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
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IF 7.7
Yuning Wang,Wenrui Yao,Zehuai Li,Haiyan Tan,Ce Sun,Dingyuan Zheng,Yanhua Zhang
The extensive use of organic dyes has led to significant water pollution. Using lignocellulosic waste as a precursor for catalysts preparation for sewage remediation presents an effective alternative with numerous advantages in sustainability, cost-effectiveness, and environmental compatibility. In this work, wood fiber waste collected from wood processing plants was decorated with Prussian blue (PB) and then annealed to produce carbonized wood fiber catalyst (Fe 3 C@Fe-CB). In the presence of peroxymonosulfate (PMS), the prepared catalyst could achieve over 98.69 % efficiency in degrading methylene blue (MB) solutions (20 mg/L) in 60 min across a pH range of 3 to 11. Electrochemical test and electron paramagnetic resonance (EPR) analysis respectively verified that electron transfer pathway and radical pathway were the key factors for the degradation of MB. Cyclic degradation tests demonstrated that the degradation efficiency remained above 93.67 % after five recycling experiments. Moreover, the used magnetic catalyst can be easily recycled by magnet. This study proposed a facile and sustainable carbonized wood fiber catalyst decorated by Fe 3 C@Fe-CB, which could realize efficient elimination of organic dyes. Moreover, we offered a novel choice for dyes-polluted water treatment and paving a new route for converting low-value lignocellulosic waste to high-value utilizations.
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高影响因子
BIOMACROMOLECULES
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2025
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IF 5.4
Fengyi Du,Lixia Xu,Haoran Wang,Mengke Lu,Qinxin Wang,Xiaonan Qiu,Baoding Chen,Miaomiao Zhang
Photothermal therapy-triggered whole-tumor cell antigens release has revolutionized in situ cancer vaccine, but insufficient anticancer immunity cycle activation greatly limits its curative effect. Herein, we designed an NIR-triggered cascading in situ vaccine (FCDs-A/C@HGs) by incorporating the Fe-doped carbon dots (FCDs), azo-initiator (AIPH), and immune adjuvant (cyclophosphamide) into the thermosensitive hydrogel. Due to iron doping, the as-prepared FCDs exhibited high photothermal conversion performance and favorable MR imaging capability. Upon intratumoral injection, local hyperthermia mediated by FCDs-A/C@HGs and the subsequent generation of alkyl radicals from AIPH synergistically induced immunogenic cell death in tumor cells. Remarkably, the FCDs-A/C@HGs elicited strong anticancer immune activation by inhibiting regulatory T cells and promoting dendritic cell maturation, thereby enhancing differentiation of cytotoxic CD8+ T cells and memory T cells. This study presents an effective therapeutic platform for in situ tumor suppression and sustained activation of the anticancer immunity cycle.
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Petroleum Science
·
2025
·
IF 6.1
Han-Yi Zhong,Shu-Sen Li,Da-Qi Li,Jun-Bin Jin,Chang-Zhi Chen,Zheng-Song Qiu,Wei-An Huang
In this study, hydrothermal carbon nanospheres (HCNs) were prepared by hydrothermal carbonization using glucose as the precursor, and introduced to improve the properties of water-based drilling fluid for the first time. The variation in rheological and filtration characteristics of water-based drilling fluid with varying concentrations of HCNs were compared between the cases before and after thermal aging. The results demonstrated that HCNs had little influence on the rheological properties of bentonite base mud, but could effectively reduce its filtration loss after thermal aging at 220 °C. For polymer-based drilling fluid, HCNs also exhibited minor influence on the rheology. The H-B model was the best fitting model for the rheological curves before thermal aging. After hot rolling at 220 °C, the viscosity retention rate increased from 29% to 63%–90% with addition of HCNs, and the filtration loss decreased by 78% with 1.0 w/v% HCNs. Meanwhile, the polymer-based drilling fluid with 0.5 w/v% HCNs maintained relatively stable rheology and low filtration loss after statically thermal aging at 200 °C for 96 h. For a bentonite-free water-based drilling fluid prepared mainly with modified natural polymers, the viscosity retention increased from 21% to 74% after hot rolling at 150 °C with 0.5 w/v% HCNs, and was further improved when HCNs and potassium formate were used in combination. The mechanism study revealed that, HCNs could trap dissolved oxygen, scavenge the free radicals and cross link with polymers, which prevented thermal oxidative degradation of polymers and improved the thermal stability of water-based drilling fluid. Meanwhile, HCNs could inhibit clay hydration and swelling in synergy with partially hydrolyzed polyacrylamide by physically sealing the micropores, contributing to shale formation stability. Furthermore, HCNs could effectively improve the lubrication and anti-wear performance of drilling fluid. This study indicated that HCNs could act as green, sustainable, and versatile additives in water-based drilling fluid.
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Journal of Environmental Sciences
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2024
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IF 5.9
Yunjin Yao,Zhongming Tao,Hongwei Hu,Lijie Zhang,Ziwei Ma,Yaoyao Wang,Shiyang Lin,Shaobin Wang
Catalytic oxidation of organic pollutants is a well-known and effective technique for pollutant abatement. Unfortunately, this method is significantly hindered in practical applications by the low efficiency and difficult recovery of the catalysts in a powdery form. Herein, a three-dimensional (3D) framework of Fe-incorporated Ni 3 S 2 nanosheets in-situ grown on Ni foam (Fe-Ni 3 S 2 @NF) was fabricated by a facile two-step hydrothermal process and applied to trigger peroxymonosulfate (PMS) oxidation of organic compounds in water. A homogeneous growth environment enabled the uniform and scalable growth of Fe-Ni 3 S 2 nanosheets on the Ni foam. Fe-Ni 3 S 2 @NF possessed outstanding activity and durability in activating PMS, as it effectively facilitated electron transfer from organic pollutants to PMS. Fe-Ni 3 S 2 @NF initially supplied electrons to PMS, causing the catalyst to undergo oxidation, and subsequently accepted electrons from organic compounds, returning to its initial state. The introduction of Fe into the Ni 3 S 2 lattice enhanced electrical conductivity, promoting mediated electron transfer between PMS and organic compounds. The 3D conductive Ni foam provided an ideal platform for the nucleation and growth of Fe-Ni 3 S 2 , accelerating pollutant abatement due to its porous structure and high conductivity. Furthermore, its monolithic nature simplified the catalyst recycling process. A continuous flow packed-bed reactor by encapsulating Fe-Ni 3 S 2 @NF catalyst achieved complete pollutant abatement with continuous operation for 240 h, highlighting its immense potential for practical environmental remediation. This study presents a facile synthesis method for creating a novel type of monolithic catalyst with high activity and durability for decontamination through Fenton-like processes.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Yunhui Yan,Na Xu,Xian Wang,Li Shi,Qianqian Huang,Jia Wang,Xiangrong Li,Tianjun Ni,Zhijun Yang,Wei Guo
Polydopamine has gained considerable attention in the biomaterial domain owing to its excellent biocompatibility, antioxidant activity, photothermal effect and adhesion property. Herein, copper sulfide (Cu 2-x S) wrapped in mesoporous polydopamine (MPDA) was synthesized through in-situ polymerization, followed by the surface modification with cationic polyethyleneimine (PEI). The mussel-inspired MPDA matrix successfully prevented the oxidation and agglomeration of Cu 2-x S nanoparticles, and regulated the release of copper ions and reactive oxygen species (ROS) levels. Surface-modified PEI endow MPDA@Cu 2-x S with positive charges, facilitating their rapid contact with negatively charged bacteria through electrostatic interactions. The pH-dependent Cu + /Cu 2+ release and NIR-responsive ROS generation were confirmed using molecular probes and electron spin resonance (ESR). The MPDA@Cu 2-x S/PEI showed significantly enhanced antibacterial activity and reduced cytotoxicity for NIH3T3 cells. Under NIR irradiation (1.0 W/cm 2 , 10 min), germicidal efficiency against Escherichia coli ( E. coli ) and Staphyloccocus aureus ( S. aureus ) could reach 100 % and 99.94 %, respectively. The exceptional antibacterial activities of MPDA@Cu 2-x S/PEI was mainly attributed to the synergistic photothermal effect, controlled release of copper ions and ROS generation, as well as electrostatic interaction. More importantly, the MPDA@Cu 2-x S/PEI composite exhibited excellent biocompatibility and biosafety. Overall, this organic/inorganic hybrid holds great potential as a promising candidate for wound treatment.
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高影响因子
MACROMOLECULES
·
2024
·
IF 5.1
Zhiye Yuan,Yijie Jin,Yu Wu,Xinjun Wu,Nan Hai,Jianlei Lu,Chuanzhuang Zhao,Jiawei Zhang
The properties of intelligent polymeric materials are essentially determined by their chemical structures. Shape memory hydrogels that utilize hydrophobic aggregation at elevated temperatures to stabilize temporary shapes, the association of polymer networks is similar to that of thermoresponsive polymers. To realize a precise control on the shape memory function of these materials and broaden their practical applications, it is essential to build up a structure–property relationship on a molecular level. In this study, we fabricated a series of poly(acrylic acid–methacrylic acid)/Ca(CH3COO)2 shape memory hydrogels with cooling-induced shape transformation behavior. The results showed that the incorporation of α-methyl groups would restrict the hydrophobic aggregation of hydrogel networks, and the soft-to-stiff transition temperature of the hydrogels would shift to elevated temperatures with the increasing density of α-methyl groups. Therefore, the shape recovery process could be regulated by adjusting the association degree of the polymer networks. Finally, the hydrogels were explored as smart capsules with sequential drug delivery capacity and as dredging devices capable of removing thrombus. This study reveals the influence of α-methyl groups on the association dynamics of the poly(acrylic acid–methacrylic acid)/Ca(CH3COO)2 hydrogels, which would promote the design of novel shape memory polymers guided by the relationship between chemical structure and properties.
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高影响因子
MOLECULAR MEDICINE
·
2025
·Vol. 31
·期 1
·1-14
·
IF 6.4
Jin Shengkai,Zhou Yuhua,Lv Jing,Lu Yichen,Zhang Yuwei,Li Menglu,Feng Ninghan
Background A close relationship exists between castration-resistant prostate cancer (CRPC) and histidine metabolism by gut microbes. However, the effects of the histidine metabolite imidazole propionate (IMP) on prostate cancer (PCa) and its underlying mechanisms are not well understood.Methods We first assessed the effects of IMP on cell proliferation and migration at the cellular level. Subsequently, we investigated the mechanism of action of IMP using transcriptome sequencing, qPCR, and Western blot analysis. Finally, we validated our findings in vivo using a mouse model.Results Histidine had no effect on PCa cell proliferation; however, IMP significantly inhibited the proliferation and migration of PC3 and DU145 cells. Mechanistic studies indicate that IMP exerts its effects by upregulating PDZK1 expression, which subsequently inhibits the phosphorylation of the PI3K-AKT pathway.Conclusion sIn conclusion, IMP significantly inhibits the progression of PCa, offering new insights into potential treatments for CRPC.
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CHEMICAL ENGINEERING JOURNAL
·
2024
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IF 13.3
Jicheng Jiang,Yan Peng,Liyan Qiu
Ferroptosis is an emerging form of cell death resulting from iron-dependent massive accumulation of lipid peroxides (LPOs). Efficient iron delivery and powerful iron homeostasis disruption remain quite challenging. Herein, we designed a nanovesicle-templated nanogel PCG-Fe/DHA facilitated by the self-assembly of amphiphilic polyphosphazene and the in situ coordination of gallic acid-modified chito-oligosaccharide with Fe 3+ to co-deliver iron and dihydroartemisinin (DHA) for ferroptosis cancer therapy. PCG-Fe/DHA exhibited excellent capability of dual drug loading as well as pH-responsive Fe 3+ release and esterase-responsive DHA release. The concurrent delivery of Fe 3+ and DHA synergistically disrupted intracellular iron homeostasis via the supplementation of exogenous Fe 3+ and DHA-induced ferritin degradation, resulting in a surge in the intracellular labile iron pool to initiate the Fenton reaction. Meanwhile, the intracellular redox homeostasis was disrupted due to the decline of glutathione peroxidase 4 (GPX4) abundance by Fe 3+ -depleting glutathione (GSH). As a result, the intracellular ROS and LPOs were distinctly accumulated, which consequently enhanced ferroptosis of tumor cells. After intravenous injection of PCG-Fe/DHA, the tumor inhibition ratio in 4 T1 breast tumor-bearing mice achieved 76.8 %. In addition the nanogel could target tumor and produce 3.1 times higher magnetic resonance imaging (MRI) signal intensity than free Fe. These evidences indicated that PCG-Fe/DHA platform could provide a dual-modal strategy for ferroptosis cancer therapy and MRI-guided tumor diagnosis.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Hao Cheng,Yongqiang Yang,Yueyue Wang,Jiqiang Guo,Xiong Jiao,Di Huang,Meiwen An,Xiaohong Yao,Paul K. Chu,Xiangyu Zhang
The hypoxic environment of deep tissue and the weak energy of microwave (MW) are still the major limitations of MW catalytic therapy. In this work, an MW-responsive nano-platform consisting of an Mn-doped porphyrin metal–organic framework loaded with calcium peroxide (Mn 0.1 PCC) is designed to regulate the microenvironment of the injection site and enhance the generation of reactive oxygen species. The excellent MW absorbing properties of Mn 0.1 PCC improve the Fenton reaction between hydrogen peroxide formed by the hydrolysis of calcium peroxide and released Mn 2+ generating more hydroxyl radicals under MW. This process does not consume the oxygen substrate and even produces oxygen to improve the hypoxic environment. Therefore, at a low and safe concentration (125 µg mL −1 ), the antibacterial rate of Mn 0.1 PCC against 4 × 10 8 CFU mL −1 of methicillin-resistant Staphylococcus aureus (MRSA) after MW irradiation for 15 min is 99.71% ± 0.18%. Mn 0.1 PCC, upon exposure to MW, prevents the recurrence of bacterial infections and overcomes drug resistance by inhibiting quorum sensing and the two-component system of MRSA. It can also induce macrophage M1 polarization, up-regulate the pro-inflammatory factor tumor necrosis factor-α, and enhance the phagocytosis of macrophage to bacteria. This strategy provides insights into the development of high-performance MW-responsive nanocomposites for the treatment of infections in deep tissues.
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危险品化学品经营许可证（带存储）