Foods
·
2022
·Vol. 11
·期 3
·386
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IF 5.561
Ying Xu,Xuan Yu,Jiaqi Gui,Yiqun Wan,Jinping Chen,Ting Tan,Fan Liu,Lan Guo
A rapid and effective ultra-high performance liquid chromatography (UHPLC) method was developed for the determination of five anthraquinones (emodin, physcion, aloe-emodin, rhein, and chrysophanol) inPolygonum multiflorum. The target compounds were ultrasonically extracted with 70% methanol, followed by dispersive solid-phase extraction (d-SPE) with HC-C18 and desorption with acetonitrile. The five anthraquinones were separated on an ACQUITY UPLC®HSS T3 column (2.1 × 100 mm, 1.8 μm) and detected by a photodiode array detector (PDA) at 254 nm. Under the optimized conditions, linear relationships were achieved in the range of 0.3~100 mg/L for emodin, 0.3~40 mg/L for physcion, 0.1~20 mg/L for aloe-emodin, and 0.05~20 mg/L for rhein and chrysophanol. The limits of detection of the five analytes ranged from 0.01 to 0.08 mg/L, and the recoveries were within the range of 82.8~118.4% with an RSD (n= 6) of 1.0~10.3%. The intra-day and inter-day precision (n= 5) of the five targets were in the range of 1.0~1.8% and 3.0~3.1%, respectively. Furthermore, this method was applied to analyses ofPolygonum multiflorumsamples collected from different regions in China with satisfactory results. All the results indicated that this method is suitable for the detection of five anthraquinones inPolygonum multiflorum.Keywords:anthraquinones;Polygonum multiflorum;d-SPE;UHPLC
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Natural Product Communications
·
2022
·
IF 1.496
Qing Liu,Ying Wei,Yongjia Hao,Jian Yang,Bowen Pan,Xiaosheng Yang,Ying Zhou,Xia Wang
Viral infection imposes a major threat to human health. To develop new potent antiviral agents, Hederagenin (HE), a known inhibitor of HIV-1 and HCV NS3/4A proteases, was used as a starting material to synthesize 4 types of HE derivatives, HE-3,23-diacyl, HES-3,23-diacyl, HES-3-acyl, and HES-3-oxo-23-acyl. We evaluated the in vitro inhibitory activities of the derivatives against HIV-1 and HCV NS3/4A proteases. (3β,23)-Di-O-diglutaryl-hederagenin (1b) and (3β,23)-di-O-(3′,3′-dimethylsuccinyl-hederagenin ethyl ester (2b) exhibited potent inhibitory activities against the HIV-1 and/or HCV NS3/4A proteases with IC50 values < 10 μM, but did not appreciably inhibit general human proteases renin and trypsin. The SARs showed that dicarboxylic acid hemiesters of HE significantly enhance the antiviral activities when C3 or C23 are linked with 6 carbon acyl chains.
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Foods
·
2022
·Vol. 11
·期 3
·302
·
IF 5.561
Xuan Yu,Yuan Gao,Ying Xu,Xian Guo,Lan Guo,Ting Tan,Fan Liu,Yiqun Wan
In this study, a new and simple method was established for the simultaneous determination of analogues of aristolochic acids (aristolochic acid I, aristolochic acid II, aristolactam I and aristolactam AII) inHouttuynia cordataby ultra-high performance liquid chromatography–quadrupole/time-of-flight mass spectrometry (UHPLC–Q/TOF-MS). The samples were ultrasonically extracted with methanol, purified with HC-C18, and then separated on a C18 column (75 × 2.1 mm, 2.0 μm) at 35 °C. Under the optimized conditions, aristolochic acid I (AA-I), aristolochic acid II (AA-II), aristolactam I (AL-I) and aristolactam AII (AL-AII) all showed good linear regression (not less than 0.9987). The average recoveries of the four analytes were within the range of 72.3–105.5%, with the relative standard deviations (RSDs) being ≤7.6%. The proposed method was then applied to the determination ofHouttuynia cordatasamples collected from different regions in China. The results showed that none of the three carcinogenic substances (aristolochic acid I, aristolochic acid II and aristolactam I) were detected in any of the 22 samples collected from 22 different regions of China, while aristolactam AII, which has not been reported to have genotoxicity, was detected in all samples. This study provides a valuable reference for the further safety assessment ofHouttuynia cordata.Keywords:Houttuynia cordata;aristolochic acid analogues;detection;UHPLC-Q/TOF-MS
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2022
·
IF 5.876
Yongkui Liu,Fumin Wang,Xubin Zhang,Qing Zhang,Yi Zhai,Guojun Lv,Mengyao Li,Mengyue Li
Development of economic routes for synthesis of hollow titanium silicalite-1 (TS-1) zeolite is of great importance in industry. However, there are still challenges to synthesize hollow TS-1 zeolite without anatase TiO 2 . In this work, a one-step strategy without mesoporogen by the solid-phase conversion method was successfully developed to synthesize anatase-free hollow TS-1. The appropriate low amount of TPAOH (TPA/SiO 2 = 0.13) and the suitable crystallization temperature (170 °C) can not merely induce the formation of hollow structures, but also enable more titanium to enter the framework. Moreover, the transformation mechanism based on crystallization rate and dissolution rate was proposed according to the investigation of the transformation process. The hollow TS-1 with large cavities exhibits high catalytic activity and recycle stability in 1-hexene epoxidation. The efficient strategy reported in this paper will provide new opportunities for further promoting the industrial application of hollow TS-1.
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CHEMOSPHERE
·
2023
·
IF 8.8
Juan Sun,Xiaoyang Wang,Quanwei Song,Ran Li,Jiacai Xie,Xiaoqing Yang,Liuping Cai,Zihao Wang,Chaocheng Zhao,Xiuxia Zhang
Chemical fingerprinting is essential for identifying the presence and responding to oil spills that frequently contaminate the groundwater environment of refineries. In this study, crude oil and oil products from the atmospheric and vacuum distillation units of a refinery were analyzed by gas chromatography-mass spectrometry (GC-MS) to evaluate their chemical variability before and after refinery. A series of experiments involving evaporation and soil column penetration were conducted to simulate refined oil spilling into groundwater and determine appropriate characteristic ratios (CRs) for principal component analysis (PCA) for oil source identification. The simulated study demonstrated that all products had bell-shaped n -alkane distributions, with dominant peaks that remained unchanged or shifted towards longer chain lengths compared to the source oil. Similarly, naphthalene and dibenzothiophene series remained the main PAH components like the source oil. Ten relatively stable CRs were selected for PCA to identify different oil products through the simulated experiments. The chosen CRs were then utilized to identify the sources for two groundwater oil spills recently occurred, one that occurred in an oil depot area, and another near a continuous catalytic reforming unit in a refinery. This study showed that the components with long-chain n -alkanes (n ≥ C 18 ), pristane, phytane, and phenanthrene and dibenzothiophene series PAHs played an important role in the identification of refined oil products spilling into the groundwater environment. The selected CRs provide an effective tool for rapid and accurate identification of oil spills, especially for newly occurring spills in the groundwater environment, which can aid in developing appropriate response strategies.
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Molecular Catalysis
·
2023
·
IF 4.6
Tianyun Cui,Yu Ling,Jipeng Meng,Ke Li,Changhai Liang,Chuang Li
Nowadays, the rational design of high-performance catalysts with desirable resistance to metal leaching has become the principal challenge in the hydrogenation of nitrile butadiene rubber. In the present work, the Pd-Pt bimetallic alloy nanocatalyst exhibits an outstanding hydrogenation degree of 99.0%, obviously higher than that of the conventional monometallic Pd/SiO 2 catalyst with the same Pd content (92.9%), accompanied by approximately 100% selectivity to C=C bonds. The results reveal that electron transfer from Pt to Pd confirms that the Pd species are in a rich-electron state, which boosts hydrogen activation and improves catalytic activity. Additionally, the incorporation of inactive Pt species promotes the formation of uniformly dispersed Pd-Pt alloy nanoparticles. The incorporation of inactive Pt species can enhance the metal-support interaction, reducing the residual metal content in hydrogenated nitrile butadiene rubber. The current research demonstrates a simple procedure for designing efficient bimetallic catalysts for the hydrogenation of unsaturated elastomer.
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Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 14
·3252-3261
·
IF 7
Yuhui Zhang,Xiaohong Pan,Haixing Shi,Yaqi Wang,Wenzhen Liu,Liangzhi Cai,Le Wang,Huanhuan Wang,Zhuo Chen
Photodynamic therapy (PDT) with aggregation-induced emission photosensitizers (AIE-PSs) has attracted increasing attention for their enhanced fluorescence and reactive oxygen species (ROS) generation abilities upon aggregation. However, it is difficult for AIE-PSs to simultaneously achieve long-wavelength excitation (>600 nm) and high singlet oxygen quantum yield, which restricts their application in deep-tissue PDT. In this study, four novel AIE-PSs were developed by appropriate molecular engineering, and their absorption peaks shifted from 478 to 540 nm with a tail extending to 700 nm. Meanwhile, their emission peaks were also moved from 697 nm to 779 nm with a tail extending over 950 nm. Importantly, their singlet oxygen quantum yields successfully increased from 0.61 to 0.89. Moreover, TBQ, the best photosensitizer developed by us, has been successfully applied to image-guided PDT in BALB/C mice bearing 4T1 breast cancer under red light (605 ± 5 nm) irradiation, with IC50 less than 2.5 μM at a low light dose (10.8 J cm−2). The success of this molecular engineering indicates that increasing the number of acceptors is more effective at red-shifting the absorption band of AIE-PSs than increasing the number of donors, and extending the π-conjugation of acceptors will red-shift the absorption–emission band, increase the maximum molar extinction coefficient, and improve the ROS generation ability of AIE-PSs, thus providing a new strategy for the design of advanced AIE-PSs for deep-tissue PDT.
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JOURNAL OF ASIAN EARTH SCIENCES
·
2023
·
IF 3
Peng Fang,Zhibin Hong,Jia Wu,Yuan Wang,Keyu Liu,Minghui Zhou
The thermal evolution of components trapped in matrix of asphaltenes is supposed to be retarded, as compared to the free ones. Studying the geochemical evolution of trapped polycyclic aromatic hydrocarbons (PAHs) may provide insight for the characterization of high-maturity organic matter. The discrepancies in the thermal evolution between free and trapped (asphaltene-adsorbed/occluded) PAHs (phenanthrene, chrysene, pyrene, and their methylated isomers) were studied by thermal maturation (gold tubes, 300 ∼ 400 °C) experiments on a low-maturity solid bitumen from the Sichuan Basin, southwestern China. The results show that the thermal evolution of asphaltene-adsorbed PAHs is retarded compared to that of free ones. This is attributed to slight differences in reaction kinetics due to steric hindrance by the asphaltene structure. The asphaltene matrix appears to act as a reaction inhibitor leading to a retardation of the thermal evolution of the methylphenanthrene index (MPI) in asphaltene-adsorbed hydrocarbons. This could provide a possibility for maturity assessment of high-maturity organic matter. The thermal evolution of asphaltene-occluded PAHs in the experiments resulted in thermodynamically controlled isomer distributions of occluded methylphenanthrenes and methylchrysenes. However, the occluded methylpyrene isomers were hardly affected by thermal stress. They probably retained their original distributions and may serve as source indicators.
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ADVANCED FUNCTIONAL MATERIALS
·
2023
·
IF 19
Yuwei Duan,Jungang Wang,Dongfang Xu,Peigen Ji,Hui Zhou,Yong Li,Shaoming Yang,Zhuang Xie,Xiaohu Hai,Xuruo Lei,Rui Sun,Zihao Fan,Ke Zhang,Shengzhong Liu,Zhike Liu
To simultaneously stabilize cesium lead triiodide (CsPbI 3 ) precursor solution and passivate the defects in CsPbI 3 film is greatly significant for achieving highly stable and efficient CsPbI 3 perovskite solar cells (PSCs). Herein, an effective redox 4-fluorobenzothiohydrazide (FBTH) is developed to stabilize the precursor solution and passivate iodine/lead-related defects for high-quality CsPbI 3 film. The comprehensive research confirms that 1) a new compound FBTH-I is obtained from an effective redox interaction between FBTH and molecular iodine (I 2 ) in perovskite precursor solution, which can effectively impede the formation of I 2 molecule and restrain I − migration in perovskite film by forming N–H···I bond; 2) FBTH-I can also passivate Pb-related defects via forming S···Pb interaction. Consequently, the CsPbI 3 PSC based on FBTH-treated precursor solution exhibits a fascinating power conversion efficiency (PCE) of 21.41%, which is one of the highest PCE values among the reported pure CsPbI 3 PSCs so far, and an outstanding stability against the harsh conditions, such as thermal annealing and continuous light-illumination.
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FUEL
·
2023
·
IF 7.4
Yujun Ma,Wenliang Wang,Yishuai Fu,Hui Miao,Jiale Huang,Sizhe Han,Yutong Chen
Improving the yield of the target product of monocyclic aromatic hydrocarbons plays an important role in increasing the economic competitiveness of biomass and waste plastics. In this study, a 3D SiC@HZSM-5@CoFe 2 O 4 multifunctional catalyst with high microwave absorptivity and excellent catalysis was successfully fabricated by a “coating-coating” method. Results showed that the obtained SiC@HZSM-5@CoFe 2 O 4 catalyst had a stable porous structure, abundant oxygen vacancy defects, high specific surface area, good dielectric loss performance, and magnetic loss performance. Encouragingly, co-pyrolysis of corncob (CC) and polystyrene (PS) revealed that the catalyst significantly promoted the synergistic effect and improved the selectivity of renewable gasoline-range aromatics (47.2 area %). In addition, finite element simulations indicated that the prepared catalyst with high microwave absorptivity could effectively accelerate the mass and heat transfer, thereby facilitating the cracking and conversion of pyrolysis vapors. This work provides an efficient method for the production of renewable gasoline-range aromatics from the mixture of biomass and waste plastics by microwave-assisted co-pyrolysis (MACP).
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BIOORGANIC & MEDICINAL CHEMISTRY
·
2013
·
IF 2.903
Jianzhang Wu,Yali Zhang,Yuepiao Cai,Jian Wang,Bixia Weng,Qinqin Tang,Xiangjian Chen,Zheer Pan,Guang Liang,Shulin Yang
We previously reported the design and discovery of three series of 5-carbon linker-containing mono-carbonyl analogs of curcumin (MCACs) as excellent anti-inflammatory agents. In continuation of our ongoing research, we designed and synthesized the fourth series of MCACs, whose central linker is a piperid-4-one. Their inhibitory effects against IL-6 production were evaluated in lipopolysaccharide (LPS)-stimulated macrophages. Among them, compounds F8 , F29 , F33 , F35 , and F36 exhibited the IC 50 values under 5 μM. The structure–activity relationship was discussed. Mechanistically, F35 and F36 dose-dependently prevented LPS-induced NF-κB and ERK activation. Finally, pretreatment with F35 and F36 significantly protected the C57B/L6 mice from LPS-induced septic death. Together, these data present a series of new analogs of curcumin as promising anti-inflammatory agents.
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JOURNAL OF NATURAL PRODUCTS
·
2020
·
IF 3.782
Peng Zhu,Jianqiang Qian,Zhongyuan Xu,Chi Meng,Ji Liu,Wenpei Shan,Weizhong Zhu,Yongjun Wang,Yumin Yang,Wei Zhang,Yanan Zhang,Yong Ling
The natural products piperlongumine and piperine have been shown to inhibit cancer cell proliferation through elevation of reactive oxidative species (ROS) and eventually cell death, but only have modest cytotoxic potencies. A series of 14 novel phenylallylidenecyclohexenone analogues based on piperlongumine and piperine therefore were designed and synthesized, and their pharmacological properties were evaluated. Most of the compounds produced antiproliferative activities against five human cancer cells with IC50 values lower than those of piperlongumine and piperine. Among these, compound 9m exerted the most potent antiproliferative activity against drug-resistant Bel-7402/5-FU human liver cancer 5-FU resistant cells (IC50 = 0.8 μM), which was approximately 10-fold lower than piperlongumine (IC50 = 8.4 μM). Further, 9m showed considerably lower cytotoxicity against LO2 human normal liver epithelial cells compared to Bel-7402/5-FU. Mechanistically, compound 9m inhibited thioredoxin reductase (TrxR) activity, increased ROS levels, reduced mitochondrial transmembrane potential (MTP), and induced autophagy in Bel-7402/5-FU cells via regulation of autophagy-related proteins LC3, p62, and beclin-1. Finally, 9m activated significantly the p38 signaling pathways and suppressed the Akt/mTOR signaling pathways. In conclusion, 9m could be a promising candidate for the treatment of drug-resistant cancer cells and, as such, warrants further investigation.
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