RSC Advances
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2017
·Vol. 7
·期 67
·42541-42548
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IF 3.108
Haibo Zhang,Xin Huang,Jianxin Jiang,Shibin Shang,Zhanqian Song
In recent years, double-network (DN) hydrogels with high mechanical strength and toughness have been developed as promising materials, such as absorbents, tissue scaffolds and wastewater treatment agents. Herein, we present a novel DN hydrogels, which were prepared by micellar copolymerization of acrylamide (AM) and a rosin-based crosslinking agent (FPA–PEG200–AC) in a micellar solution of sodium dodecyl sulfate (SDS). The hydrogels using a rosin-based crosslinking agent (RPAM hydrogels) could form both chemical crosslinks and crosslinked centers for hydrophobic association to enhance mechanical strength. The formulated hydrogels exhibited high elongation ratios at break (500–1500%) and excellent compressive strain (>95%). Also, with an increase in the amount of crosslinking agent, the elongation at break and swelling ratio decreased. The surface morphology of the hydrogels was observed by scanning electron microscopy (SEM), while the thermal properties were characterized by thermogravimetric analysis. The results indicate a successful synthesis of the double-network (DN) hydrogels with high mechanical strength. The RPAM DN hydrogel synthesis can open fresh avenues for the design and construction of DN systems, broadening the scope of the current research and applications of hydrogels with excellent mechanical properties.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2016
·
IF 2.857
Jing-Bo Liu,Yu-Xin Li,Xiu-Lan Zhang,Xue-Wen Hua,Chang-Chun Wu,Wei Wei,Ying-Ying Wan,Dan-Dan Cheng,Li-Xia Xiong,Na Yang,Hai-Bin Song,Zheng-Ming Li
To discover potent insecticides targeting ryanodine receptors (RyRs), a series of novel anthranilic diamides analogues (12a–12u) containing N-substituted phenylpyrazole were designed and synthesized. These compounds were characterized by 1H NMR, 13C NMR, and HRMS, and the structure of compound 12u was confirmed by X-ray diffraction. Their insecticidal activities indicated that these compounds displayed moderate to excellent activities. In particular, 12i showed 100 and 37% larvicidal activities against oriental armyworm (Mythimna separata) at 0.25 and 0.05 mg L–1, equivalent to that of chlorantraniliprole (100%, 0.25 mg L–1; and 33%, 0.05 mg L–1). The activity of 12i against diamondback moth (Plutella xylostella) was 95% at 0.05 mg L–1, whereas the control was 100% at 0.05 mg L–1. The calcium-imaging technique experiment results showed that the effects of 12i on the intracellular calcium ion concentration ([Ca2+]i) in neurons were concentration-dependent. After the central neurons of Helicoverpa armigera were dyed by loading with fluo-5N and treated with 12i, the free calcium released in endoplasmic reticulum indicated the target of compound 12i is RyRs or IP3Rs. The activation of RyRs by natural ryanodine completely blocked the calcium release induced by 12i, which indicated that RyRs in the central neurons of H. armigera third-instar larvae is the possible target of compound 12i.
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FIBERS AND POLYMERS
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2017
·Vol. 18
·期 10
·1848-1857
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IF 1.113
Bai Shengjie,Zheng Wenyu,Yang Guifang,Fu Fujin,Liu Yifan,Xu Pingfan,Lv Yuancai,Liu Minghua
Core-shell fluorinated acrylate copolymers emulsion was thus synthesized via the core-shell emulsion polymerization with the fluorinated monomers and acrylic monomers as the main raw materials and its properties were studied. PFMA, the fluorinated acrylate monomers, was synthesized by the esterification of perfluorooctanoyl chloride (PFOC) and hydroxypropyl methacrylate (HPMA). Then the core-shell fluorinated acrylate copolymers emulsion with a poly(MMA/BA/St) core and a poly(PFMA/MMA/BA) shell was synthesized via a starved semi-continuous core-shell emulsion polymerization method by using KPS and sodium bicarbonate as the initiator/buffer system and SDS/Twain 80 as the commixture emulsifier. Lastly, the synthesized copolymers was applied as textile finishing agent for cotton textile. The results of FT-IR and NMR indicated that PFMA had been synthesized as expected and effectively combined in the emulsion copolymerization. The GPC, zeta potential, TEM and DSC showed that the particles had uniform spherical core-shell structure with a diameter of 65-150 nm, and the distribution and emulsion stability was satisfactory. As XPS, FESEM and AFM shown, a hydrophobic structure which was similar to the structure of the lotus leaf were formed and the surface hydrophobicity of the films can be improved. Based on the analysis of DSC, thermal stabilities of the films were enhanced with the increase of fluorine content. Besides, FESEM of textiles showed that the surface of treated textiles were smooth and the edges were clear and visible, indicating significant improvement of the performance on water and oil repellent.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2017
·
IF 2.843
Xiaobin Shen,Xiaoqing Liu,Jinggang Wang,Jinyue Dai,Jin Zhu
A bio-based epoxy 2,5-bis[(2-oxiranylmethoxy)methyl]-furan (BOF) has been synthesized from 2,5-furandimethanol and toughened by its Diels–Alder (DA) reaction adduct DA-BOF, which contained a flexible pendant chain. The chemical structures of the synthesized monomers were identified by nuclear magnetic resonance (1H NMR and 13C NMR). The thermal reversibility of DA-BOF was investigated by differential scanning calorimetry and ultraviolet–visible (UV–vis) spectroscopy. On the basis of the UV–vis results, the degree of retro Diels–Alder reaction was determined to be 25–27% in different cured systems. The study of the mechanical properties indicated that when the content of DA-BOF reached 50%, an 85% increase in impact strength could be obtained without seriously sacrificing its tensile strength or modulus. The strategy described in this work could help us to achieve a bio-based epoxy resin with increased impact strength and nearly unaffected tensile properties.
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DYES AND PIGMENTS
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2016
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IF 4.055
Yingliang Liu,Zhenru Zhang,Xuemei Chen,Shengang Xu,Shaokui Cao
Soluble dithiolene nickel complexes are designed and synthesized as near-infrared (NIR) absorbing dyes through the introduction of strong electron-donating groups at the molecular periphery. The resulting complexes are characterized by 1 H/ 13 C NMR, IR, ESI-MS, UV–vis–NIR, TG , DSC , XPS and elemental analysis . The identification results are in accord with the chemical structure of designed dithiolene nickel complexes. The XPS results suggested that the dithiolene ligands in carbazole-containing nickel complex take a radical monoanion, which depends on the substituent electron-donating ability to a large extent. The TG and DSC measurements indicated that the resulting complexes have an excellent thermal stability and take on a glassy state at low temperature. The laser transmittance measurement suggested that the optical filters fabricated through static solution-casting approach with dithiolene nickel complexes as NIR absorbing dyes could be well applied to the NIR laser protection at 1064 nm.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2017
·
IF 3.582
Xiaoliang Li,Jie Cheng,Yanxiang Liu,Shoutao Gong,Gaohong He,Lingdong Li,Shanshan Li,Fengxiang Zhang
This work reports the design, fabrication and properties of 4,4′-oxydiphenylguanidinium-bridged-silsesquioxane (ODGBS) modified polysulfone anion exchange membrane (AEM). It was prepared by sol-gel polymerization of ODGBS in the network of cross-linked, quaternized polysulfone. With hydrophilic biphenylguanidinium and Si O Si moieties working synergistically, the ODGBS derived gel functions as a water “reservoir” in the membrane and thus gives rise to high water uptake, which facilitates hydroxide ion transport via a vehicular mechanism. High water uptake may also “dilute” hydroxide ion at the vicinity of cations and lessen the hydroxide attack on cations. Moreover, ODGBS does not contain β hydrogen atoms , thus reducing the likelihood of Hofmann elimination under hydroxide attack. Due to the above benefits, ODGBS modified AEM could exhibit an improved conductivity from 19 to 25 mS/cm 2 at 30 °C, and a conductivity retention of 85% when treated in 1 M NaOH at 60 °C for 120 h, higher than that of the un-modified AEM (72%). This work provides a new strategy for enhancing stability and conductivity of AEM.
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Journal of Materials Chemistry B
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2017
·Vol. 5
·期 42
·8330-8336
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IF 4.543
Jing Han,Mengfei Zhang,Guojun Chen,Yongqing Zhang,Qing Wei,Ying Zhuo,Gang Xie,Ruo Yuan,Sanping Chen
Here a new type of ferrocene confined in a metal–organic framework (Fc-Zn-MOF) as an electrochemical signal tag has been synthesized and applied in an immunosensor for highly sensitive amyloid-β (Aβ, as a model protein) detection. In the present work, an electrochemically active molecule of Fc was covalently bonded in a Zn-MOF via postsynthetic modification to obtain a flower-like Fc-Zn-MOF, in which the high-content Fc signal units were periodically arranged in a well-defined porous structure, showing enhanced electrochemical activity. As noticed, Fc molecules are chemically anchored on the Zn-MOF, which avoids leakage of signal molecules, protects those electrochemical activities from potential damage and exhibits good stability. The Fc-Zn-MOF signal tag was further explored in constructing an electrochemical immunosensor for Aβ detection, with a linear range from 0.0001 to 100 ng mL−1 and a detection limit of 0.03 pg mL−1, showing improved analytical performance. This work presents an example of an Fc-MOF as a signal tag for Aβ detection, which would encourage atypical research lines for MOFs in bioassays where the introduction of ordered structures promises new opportunities.
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BIOSENSORS & BIOELECTRONICS
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2017
·
IF 7.78
Jin Peng,Xianfeng Hou,Fang Zeng,Shuizhu Wu
Drug-induced organ damages have been considered as a grave problem regarding public health; hence effective method for in vivo detection of drug-induced organ damages is of great significance. Herein we developed a ratiometric fluorescent nanoprobe (NPs-A), which was prepared by loading the probe molecules into phospholipid bilayer, for assaying hydrogen peroxide (H 2 O 2 , an organ damage biomarker) level in vivo. The photophysical behavior of the probe molecule depends on the electron-withdrawing ability of the group at the 6- position of anthracene ring, on which the recognition moiety for hydrogen peroxide (dicarbonyl coupled with nitrophenyl, referred to as nitrophenyl-dicarbonyl) was introduced. Upon the reaction of the probe with H 2 O 2 , nitrophenyl-dicarbonyl group transforms into carboxyl group, and due to the variation of the electron-withdrawing ability of the 6th substituent , the fluorescent properties of the probe molecule alters accordingly, thus ensuring the ratiometric detection for H 2 O 2 with high selectivity with the detection limit of 0.49 μM. In addition, the nanoprobe (NPs-A) was applied for cell and in vivo imaging applications; and the results indicate that it can detect and track the level of H 2 O 2 in living cells and to monitor and spatially map endogenous H 2 O 2 levels in a drug-induced organ damage model of zebrafish.
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Molecular Medicine Reports
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2017
·Vol. 15
·期 6
·3761-3766
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IF 1.692
Juewei Ning,Baozhan Huang,Zeliang Wei,Wen'en Li,Huajie Zheng,Limei Ma,Zhihua Xing,Hai Niu,Wen Huang
The future of personalized cancer treatments relies on the development of functional agents that have tumor-targeted anticancer activities and can be detected in tumors using imaging. However, application of these functional agents in the clinic has been limited due to inefficient drug delivery, low specificity for tumor imaging, development of drug resistance, low signal-to-noise ratio and safety concerns regarding potential toxicity. Currently, the most common strategy to develop these functional agents is to conjugate therapeutic agents with the appropriate fluorescent probe. The present study synthesized a novel mitochondria-targeted heptamethine cyanine (Cy) derivative Cy‑triphenylphosphonium. The newly developed compound exhibited stronger near infrared (NIR) fluorescence and reacted with bovine serum albumin. In addition, it preferentially accumulated in the mitochondria of cancer cells, as observed using confocal microscopy, and efficiently reduced cancer cell viability (IC50=3.04 µM). This novel multifunctional heptamethine Cy derivative, with cancer mitochondria targeting and NIR fluorescence imaging, may be promising as an alternative anticancer agent.
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RSC Advances
·
2017
·Vol. 7
·期 24
·14631-14639
·
IF 3.108
Na Li,Sijing Yi,Zhaohong Qian,Jiao Wang,Nana Lei,Xiao Chen
The unique and interesting aggregation behaviors of a novel surfactant-encapsulated complex (SEC), composed of a Keggin-type polyoxometalate (POM), phosphotungstic acid and a redox-responsive ferrocene-containing cationic surfactant, dimethyldioctadecylammonium bromide (BFDMA), have been investigated in N,N-dimethylformamide (DMF)/butanol mixed solvent. By carefully tuning the composition of the solvent, hollow spherical aggregates with multilayered shells were initially observed with a diameter of 55 ± 9 nm using transmission or scanning electron microscopes. Owing to the solvophobic effect and π–π stacking interaction between alkyl chains or ferrocene groups, these spherical aggregates were found to gradually fuse together into aggregates with flower-like and finally compartment-like morphologies with an average size of 120–150 nm. Based on X-ray diffraction measurements and the molecular configuration data of SEC, the multilayers in aggregates were composed of bilayers of SEC with the POM inside and three rearranged BFDMA molecules outside. The morphology of such aggregates was partially reversible under electrochemical modulation. Applying an anodic oxidation potential would induce the disassembling of compartment-like aggregates into irregular spheres with a size of about 200 nm, which could be turned back after applying a cathodic reduction potential. The obtained results here should shed light on the design of novel nanostructures from such inorganic/organic hybrid clusters.
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Alexandria Engineering Journal
·
2024
·
IF 6.2
Wenya Zhu,Bangsen Li,Jinrui Liu,Shishu Sun,Yan Zhang,Dashuai Zhang,Tianyi Sun,Sumin Zhang,Chen Li,Jianjun Shi,Zaifeng Shi
The modification of stereoregulated functionalized polymers on the surface of natural rubber (NR) is a challenging task. This work provided a practicable grafting method to design photochromic polymer brushes on the NR surfaces using surface-initiated ring-opening metathesis polymerization (SI-ROMP). The designed photochromic polymer brushes were based on norbornenes with spiropyrin (SP) pendents, and grew from the surface of NR films in the presence of Grubbs 2nd catalyst. The results showed that the grafting rate of polymer brushes with photoisomerization structure reached up to 44.91 %. The modified natural rubber (NR-SP) films exhibited rapid coloring/decolorization property under UV irradiation and visible light. This photochromic property initiated by the light-induced isomerisation of the spiropyran structure and the increased surface energy under light stimuli. NR-SP films exhibited stable photochromic characteristics and outstanding anti-fatigue properties after exposing to over six cycles of consecutive UV/Vis irradiation. A simple and practical strategy for the preparation of highly sensitive photochromic natural rubber materials is proposed and provides a potential application in the fields of information storage and anti-counterfeiting.
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ChemistrySelect
·
2024
·Vol. 9
·期 42
·e202401655
·
IF 1.9
Yang Lin,Ju Liang,Wenlan Wu,Yunyun Zhang,Fuqing Yan
Graphical In this study, the reduction responsive prodrug folic acid-polyethylene glycol-disulfide bond-curcumin (FA-PEG-SS-CUR) was synthesized. The prodrug could self-assemble into micelles in an aqueous solution. The chemical structure of the prodrug was determined using FTIR and NMR. Subsequently, the properties of the micelles were evaluated through TEM, particle size analysis, cell experiments, and in vitro drug release assessment. In order to improve the delivery performance of curcumin (CUR) in liver cancer cells, we prepared a targeted and reduction-sensitive prodrug, folic acid-polyethylene glycol-disulfide bond-curcumin (FA-PEG-SS-CUR). The synthesis involved the conjugation of CUR with NH 2 -PEG-NH 2 through a disulfide bond, followed by the connection of CUR-SS-PEG-NH 2 to FA-COOH via acylation. The resultant FA-PEG-SS-CUR prodrug self-assembled into nano micelles in aqueous solutions, displaying excellent dispersibility with an approximate particle size of 119 nm. In vitro drug release studies demonstrated the sensitivity of FA-PEG-SS-CUR to glutathione (GSH), displaying sustained release performance. After 72 h, FA-PEG-SS-CUR exhibited a drug release rate of 38% at low GSH concentration and 59% at high GSH concentration. Notably, FA-PEG-SS-CUR micelles exhibited favorable biocompatibility. The hemolysis rate resulting from co-incubation with red blood cells remained below 3%. Furthermore, cytotoxicity experiments unveiled the substantial cytotoxicity of FA-PEG-SS-CUR micelles against HepG2 tumor cells. Cellular uptake studies confirmed the greater internalization of FA-PEG-SS-CUR by HepG2 cells compared to the non-targeted PEG-SS-CUR. The findings highlight the potential of FA-PEG-SS-CUR as an ideal drug delivery system for CUR due to its facile synthesis and strong self-assembly performance.
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