COLLOID AND POLYMER SCIENCE
·
2015
·Vol. 293
·期 7
·2129-2135
·
IF 1.865
Du Xiangxiang,Jiang Guohua,Li Lei,Liu Yongkun,Chen Hua,Huang Qin
The glucose-responsive amphiphilic poly(PEGMA- co -AAPBA) copolymer micelles as drug carriers have been developed using 3-phenylpyruvic acid (3-PPA) as photoinitiator. Under the light irradiation, 3-PPA could be self-polymerized into the trimer structure to execute the emulsifier and initiator functions that confirmed by gas chromatography-mass spectrum (GC-MS) analysis. The structure and morphology of resultant poly(PEGMA- co -AAPBA) micelles were characterized by 1 H NMR and TEM. Insulin, as the model drug of diabetes, was loaded into micelles during the photopolymerization process. The as-prepared polymeric micelles exhibited the excellent glucose sensitivity. The loaded insulin could be released from micelles triggered by regulation of temperature and glucose concentration in the environment. The new drug carriers provided a potential application for the therapy of diabetes based on glucose-sensitive controlled drug delivery systems.
研究领域:
生物材料学
·
药物递送系统
·
糖尿病治疗
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Qingyan Zhang,Yuanyuan Liu,Zeyan Wang,Peng Wang,Zhaoke Zheng,Hefeng Cheng,Xiaoyan Qin,Xiaoyang Zhang,Ying Dai,Baibiao Huang
The low toxicity and good photo active property endow bismuth based metal–organic frameworks (MOFs) potential candidates for efficient light-sensitive drug carrier. In this work, SU-101, composed of Bi and ellagic acid (EA), is found to display high ciprofloxacin (CIP) loading ratio (85.8%) and controlled CIP release under light illumination (the maximum CIP release ratio is 95.56%). Further investigations suggest that hydrogen bond between the C O group in EA and the –OH group in CIP is responsible for above behavior. Light irradiation decreases the electron density around the C O group in EA, which consequently leads to the broken of the hydrogen bond and therefore the release of CIP. Further investigations suggest that SU-101 is universal for other drugs, such as norfloxacin (NOR), amoxicillin (AMO), tetracycline (TET) and doxorubicin hydrochloride (DOX), since all of them can form hydrogen bond with SU-101. This work suggests that SU-101 holds great potential as efficient light-sensitive drug carrier, and the investigation of other Bi based MOFs as drug carrier is under investigation.
研究领域:
生物医学工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Xing-Qun Pu,Xiao-Jie Ju,Lei Zhang,Quan-Wei Cai,Yu-Qiong Liu,Han-Yu Peng,Rui Xie,Wei Wang,Zhuang Liu,Liang-Yin Chu
In this study, a novel class of multifunctional responsive nanoparticles is designed and fabricated as drug nanocarriers for synergetic chemo–photothermal therapy of tumors. The proposed nanoparticles are composed of a thermo-/pH-responsive poly(N-isopropylacrylamide-co-acrylic acid) (PNA) nanogel core, a polydopamine (PDA) layer for photothermal conversion, and an outer folic acid (FA) layer as a targeting agent for the folate receptors on tumor cells. The fabricated nanoparticles show good biocompatibility and outstanding photothermal conversion efficiency. The proposed nanoparticles loaded with doxorubicin (DOX) drug molecules are stable under physiological conditions with low leakage of drugs, while rapidly release drugs in environments with low pH conditions and at high temperature. The experimental results show that the drug release process is mainly governed by Fickian diffusion. In vitro cell experimental results demonstrate that the PNA–DOX@PDA–FA nanoparticles can be phagocytized by 4T1 tumor cells and release drugs in tumor cell acidic environments, and confirm that the combined chemo and photothermal therapeutic efficacy of PNA–DOX@PDA–FA nanoparticles is higher than the photothermal therapeutic efficacy or the chemotherapeutic efficacy alone. The proposed multifunctional responsive nanoparticles in this study provide a novel class of drug nanocarriers as a promising tool for synergetic chemo–photothermal therapy of tumors.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2014
·Vol. 16
·期 5
·1-12
·
IF 2.278
Lv Shaonan,Zhao Meiqin,Cheng Changjing,Zhao Zhigang
β-Cyclodextrin (β-CD) polymer
brushes decorated magnetic Fe 3 O 4 colloidal nanocrystal clusters (Fe 3 O 4 @PG-CD) were fabricated by a combination of surface-initiated atom transfer radical polymerization on the surface of Br-anchored Fe 3 O 4 colloidal nanocrystal clusters (Fe 3 O 4 –Br) and ring-opening reaction of epoxy groups. The resulted Fe 3 O 4 @PG-CD hybrid nanoparticles were characterized by several methods including Fourier transform infrared, transmission electron microscope, dynamic light scattering instrument, X-ray diffraction, thermogravimetric analysis, and vibrating sample magnetometer. Moreover, the potential of as-synthesized Fe 3 O 4 @PG-CD as a carrier of hydrophobic anticancer drug 5-fluorouracil (5-FU) was also investigated. The results showed that the prepared Fe 3 O 4 @PG-CD have core/shell structure and high saturated magnetism. 5-FU could be loaded into the Fe 3 O 4 @PG-CD via the formation of β-CD/5-FU inclusion complex. Furthermore, the Fe 3 O 4 @PG-CD displayed a high loading capacity and pH-dependent release behavior for 5-FU. The release behavior demonstrated a simple Fickian diffusion in the acidic environment (pH 2.0 and 4.0) but neither non-Fickian nor anomalous when neutral. The results reveal that this nanosystem seems to be a very promising vehicle for the hydrophobic drugs for pH-dependent controlled release.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2014
·
IF 4.287
Mengtan Cai,Mengtian Leng,Aijing Lu,Liu He,Xiaoxiong Xie,Lei Huang,Yuhao Ma,Jun Cao,Yuanwei Chen,Xianglin Luo
Amphiphilic poly(ɛ-caprolactone)-SS-poly(N,N-diethylaminoethyl methacrylate)-r-poly(N-(3-sulfopropyl)-N-methacrylate-N,N-diethylammonium-betaine) (PCL-SS-PDEASB) was designed and synthesized successfully. pH and redox dually responsive micelles were prepared based on the obtained copolymers, with zwitterionic sulfobetaines as hydrophilic shell, DEA as pH sensitive content and disulfide as redox responsive linkage. The micelle diameters were all less than 200 nm and the micelle diameter distributions were narrow. These micelles could be triggered by pH and redox condition. The drug release from the drug-loaded micelles displayed fastest under simultaneously acidic and reductive conditions. Results of in vitro cell toxicity evaluation showed that introduction of sulfobetaines could greatly decrease the toxicity of poly(ɛ-caprolactone)-SS-poly(N,N-diethylaminoethyl methacrylate) (PCL-SS-PDEA) micelles. DOX-loaded PCL-SS-PDEASB micelles showed higher efficiency to kill HeLa cells than DOX-loaded PCL-PDEASB micelles. Half inhibitory concentration (IC 50 ) of DOX-loaded PCL-SS-PDEASB micelles decreased with the content of sulfobetaines increasing and was even closer to that of DOX·HCl. Thus, the pH and redox dually responsive biodegradable micelles generated by PCL-SS-PDEASB may be potential smart drug carriers for tumor targeted delivery.
研究领域:
高分子化学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Zongliang Kou,Detian Dou,Lihong Lan,Jinyan Zhang,Ping Lan,Qiumei Yu,Yanhua Zhang
A novel amphiphilic starch-based polymer carrier (R-St-PEG; R = hexadecyl, St = starch, PEG = polyethylene glycol) was prepared using tapioca starch. It was then applied as an effective carrier for encapsulated drug, and used for sustained drug release . First, tapioca starch was made to react with hexadecane bromide (R 16 ) for hydrophobic modification, and then the hydrophobically-modified tapioca starch molecules were grafted onto hydrophilic carboxyl-terminated PEG (mPEG-COOH). The drug-loading capacity and drug release behavior of R-St-PEG were systematically evaluated using curcumin as drug. The results show that the polymer has good drug-loading capacity and sustained-release properties, and it can act as an effective drug carrier. Thus, this study provides a suitable platform for preparing stable amphiphilic polymer carriers and broadens the application range of tapioca starch.
研究领域:
材料科学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Zuobing Xiao,Ke Song,Xin Huang,Yunwei Niu,Qinfei Ke,Xingran Kou
Metal–phenolic networks (MPNs), which are formed by phenolic molecules and metal ions via coordination bonds, are emerging as highly templated functional metal–organic materials. These networks are mostly used in the form of particles for short-term in vivo drug delivery; however, there is a lack of research on durable and stable MPN hollow particles as delivery carriers for in vitro applications. In this study, hollow and yolk-like hybrid cubic MPNs were prepared by etching zeolitic imidazolate framework-8 (ZIF-8) with proanthocyanidins (PCs). Polydopamine (PDA) resulting from the oxidative self-polymerisation of dopamine was deposited on the surface of the fabricated MPN to obtain a PDA coating, which enhanced the mechanical properties of the MPN. The prepared Zn II –PC/PDA capsules consisted of two layers: a Zn II –PC layer and a PDA–PDA layer. It showed stability at 25 ℃ for at least 280 days after freeze–drying. Moreover, when loaded with carvacrol , this MPN exhibited an enhanced antibacterial performance. Therefore, this study lays the foundation for the use of MPNs as long-lasting functional carriers.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
International Journal of Polymeric Materials and Polymeric Biomaterials
·
2023
·
IF 3.2
Sahid Mehmood,Md Alim Uddin,Haojie Yu,Li Wang,Bilal Ul Amin,Fazal Haq,Shah Fahad,Muhammad Haroon
In this research, hexachlorocyclotriphosphazene (HCCP) was cross-linked with epigallocatechin (EGC) via one-pot precipitation polymerization. The synthesis was confirmed using FT-IR spectroscopy. The cross-linking density of the nanospheres was investigated by EPR spectroscopy. The mole ratio of HCCP:EGC had a major effect on the nanospheres’ formation, growth, particle size, and shape. The thermal properties of the nanospheres were improved due to their cross-linked polymeric structures. The PCTPEC-3 nanospheres were used as anti-cancer drug carriers and the in vitro drug release profile was studied. The findings revealed that the cumulative release of drugs was dependent on the pH environment.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Xin Yu,Jinlan Li,Jianing Zhang,Jing Jin,Yanxiong Pan,Xiangling Ji,Wei Jiang
Shape transformation of polymer particles is generally a nonequilibrium dynamics process. Controlling the shape transformation of polymers is increasingly attractive and challenging for scientists due to their extensive use in drug delivery and cancer therapy. Herein, we investigated the UV-triggered shape transformation pathway of polymeric vesicles assembled from Polystyrene-block-poly(4-vinylpyridine) and 4-hydroxyazobenzene (PS-b-P4VP(Azo–OH)) and the direct assembly pathway of UV-irradiated PS-b-P4VP(Azo–OH) homogeneous solution. In the shape transformation process, well-assembled vesicles can be transformed into toroid, cylindrical, rod-like, and spherical micelles. In the direct assembly pathway, rod-like and spherical micelles can be obtained. Interestingly, the toroid micelles can be obtained only from the UV-triggered shape transformation pathway. Contrasting the two pathways reveals the pathway dependence of PS-b-P4VP(Azo–OH) assembly, suggesting that the final assembly morphology is determined by the initial state and dynamic process. The speed of UV-triggered shape transformation and the final morphology of assemblies can be tuned easily by adjusting the UV illuminance, time, and content of Azo–OH addition. Moreover, the light-responsive polymeric vesicles can be used as drug carriers and have the potential to release drugs precisely.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomed Research International
·
2018
·
IF 2.583
Huiling Lv,Chao Wu,Xuan Liu,Andi Bai,Yue Cao,Wenjing Shang,Lili Hu,Ying Liu
In this study, we prepared PTX-loaded mesoporous hollow SnO2 nanofibers conjugated with folic acid (SFNFP) for liver cancer therapy. According to SEM and TEM characterization, SFNF showed a mesoporous hollow structure. The average outer diameter was 200 nm, and the wall thickness was 50 nm. The DSC and XRD study showed that PTX in the channels of nanofibers was present in an amorphous state. The in vitro release experiments demonstrated that SFNF could efficiently improve the dissolution rate of PTX. Both in vitro cell experiments and in vivo antitumor experiments showed that SFNFP could efficiently inhibit the growth of liver cancer cells. Therefore, SFNF is a promising targeting antitumor drug delivery carrier.
研究领域:
纳米技术
·
药学
·
癌症研究
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Yongsan Li,Xing Wang,Ya-nan Fu,Yen Wei,Lingyun Zhao,Lei Tao
Smart materials that can respond to multistimuli have been broadly studied. However, the smart materials that can spontaneously answer the ever-changing inner environment of living bodies have not been reported. Here, we report a strategy based on the dynamic chemistry to develop possible self-adapting solid materials that can automatically change shape without external stimuli, as organisms do. The self-adapting property of a chitosan-based self-healing hydrogel has been rediscovered since its dynamic Schiff-base network confers the unique mobility to that solid gel. As a result, the hydrogel can move slowly, like an octopus climbing through a narrow channel, only following the natural forces of surface tension and gravity. The fascinating self-adapting feature enables this hydrogel as an excellent drug carrier for the in vivo wound treatment. In a healing process of the rat-liver laceration, this self-adapting hydrogel demonstrated remarkable superiority over traditional drug delivery methods, suggesting the great potential of this self-adapting hydrogel as a promising new material for biomedical applications. We believe the current research revealed a possible strategy to achieve self-adapting materials and may pave the way toward the further development, study, and application of new-generation smart materials.
研究领域:
生物医学工程
·
材料科学
·
组织工程
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2013
·Vol. 130
·期 6
·4137-4146
·
IF 1.395
Yan-Ling Luo,Xiao-Li Yang,Feng Xu,Ya-Shao Chen,Zhuo-Ma Ren-Ting
A novel A 2 BA 2 -type thermosensitive four-armed star block copolymer, poly( N -isopropyl acrylamide) 2 - b -poly(lactic acid)- b -poly( N -isopropyl acrylamide) 2 , was synthesized by atom transfer radical polymerization and characterized by 1 H-NMR, Fourier transform infrared spectroscopy, and size exclusion chromatography. The copolymers can self-assemble into nanoscale spherical core–shell micelles. Dynamic light scattering, surface tension, and ultraviolet–visible determination revealed that the micelles had hydrodynamic diameters ( D h ) below 200 nm, critical micelle concentrations from 50 to 55 mg/L, ζ potentials from −7 to −19 mV, and cloud points (CPs) of 34–36°C, depending on the [Monomer]/[Macroinitiator] ratios. The CPs and ζ potential absolute values were slightly decreased in simulated physiological media, whereas D h increased somewhat. The hydrophobic camptothecin (CPT) was entrapped in polymer micelles to investigate the thermo-induced drug release. The stability of the CPT-loaded micelles was evaluated by changes in the CPT contents loaded in the micelles and micellar sizes. The MTT cell viability was used to validate the biocompatibility of the developed copolymer micelle aggregates. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 130: 4137–4146, 2013
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）