RSC Advances
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2017
·Vol. 7
·期 10
·5621-5627
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IF 3.108
Shan Huang,Kai-Li Yang,Xiao-Fang Liu,Hu Pan,Heng Zhang,Song Yang
MIL-100(Fe) was used for the first time in the catalytic transformation of hexose sugars into lactic acid (LA). The as-synthesized MIL-100(Fe) was systematically characterized, and its superior morphological and textural properties were demonstrated to contribute greatly to the pronounced catalytic performance in fructose-to-LA conversion (up to 32% yield), as compared with other catalysts like Cu-BTC and MIL-100(Cr). The effects of reaction conditions including temperature, reaction time, and substrate loading were explored. In addition, MIL-100(Fe) could be easily reused for 4 cycles with no evident decrease in catalytic activity.
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CATALYSIS COMMUNICATIONS
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2017
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IF 3.33
Yanxiu Liu,Hu Li,Jian He,Wenfeng Zhao,Tingting Yang,Song Yang
A series of niobium-containing catalysts were prepared by hydrothermal synthesis method, and characterized by NH 3 -TPD, TEM, XRD, N 2 adsorption-desorption and pyridine-adsorption FT-IR techniques. Fe-NbP (Fe-doped niobium phosphate) with higher total acid density (3.59 mmol/g) and appropriate Brønsted/Lewis acid ratio (1.32) was found to show superior activity in production of levulinic acid (LA) from glucose, and a high LA yield of 64.2% was achieved at 180 °C in 3.0 h. The effect of various reaction parameters such as temperature, time, catalyst dosage, and substrate concentration on LA production has been investigated. The catalyst can be recycled for several times without significant loss of activity.
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BIOCONJUGATE CHEMISTRY
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2024
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IF 4
Yexi Peng,Yuming Qi,Mingze Xu,Yiqiao Chen,Xiaoxian Wang,Xingya Jiang,Bujie Du
Noninvasive fluorescence imaging of renal function is a valuable technique for understanding kidney disease progression and the development of renal medicine. This technique requires sensitive imaging probes for reporting renal dysfunction accurately at early stage. Herein, a molecularly engineered imaging probe (800CW–PEG45–COOH) was synthesized by simply PEGylating conventional near-infrared fluorophore IRDye800CW with NH2–PEG45–COOH (molecular weight ∼2100 Da) for early detection and staging of renal dysfunction through noninvasive real-time kidney imaging. 800CW–PEG45–COOH not only cleared through the kidney efficiently (>90% injection dosage at 24 h postinjection) but was also found to be freely filtered by glomeruli without renal tubular reabsorption and secretion. Despite this simple construction strategy, the transport of 800CW–PEG45–COOH within the kidneys was extremely sensitive to the alteration of the glomerular filtration rate (GFR), which enabled it to detect renal dysfunction much earlier than commonly used serum biomarkers and stage kidney function impairments (mild vs severe dysfunction) via imaging-based kidney clearance kinetics. This work not only provides a promising optical imaging probe for the noninvasive evaluation of kidney function but also highlights the utility of PEGylation in enhancing the performance of conventional organic dyes in biomedical applications.
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Asia-Pacific Journal of Chemical Engineering
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2017
·Vol. 12
·期 4
·527-535
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IF 0.836
Guizhuan Xu,Binglin Chen,Zhangbin Zheng,Kai Li,Hongge Tao
5-Ethoxymethylfurfural (EMF) and ethyl levulinate (EL) have been considered as the new promising biofuels. A comparative study was conducted for the direct conversion of carbohydrates into EMF and EL in different medium containing ethanol. The distribution and formation kinetics of EL, EMF, 5-hydroxymethylfurfural (HMF) and levulinic acid (LA) in pure ethanol and ethanol/organic solvent medium were compared, and the results showed that the addition of n-hexane can improve the accumulation of EMF. When the volume ratio of ethanol to n-hexane was 6:4, 66.29% of EMF yield can be obtained from fructose at 120°C and 180 min. The total yield of the EMF and EL can reach to 83.71%, increased by 5.73% compared with that in pure ethanol medium. Moreover, water addition can suppress the etherification of HMF to EMF and promote the rehydration of HMF to LA in the process. On the basis, a putative reaction pathway for the conversion of carbohydrates in ethanol/n-hexane medium was proposed. © 2017 Curtin University of Technology and John Wiley & Sons, Ltd.
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CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Pengrong Zhu,Lingtong Meng,Yue Shu,Yuqiao Xu,Weiming Liu,Yong Bi,Jian Xu,Lijuan Meng,Yanan Li
The abundance of Fusobacterium nucleatum ( F. nucleatum ) is highly associated with the development and poor prognosis of colorectal cancer (CRC), which is regarded as a promising target for CRC. However, until now, the novel strategy to clear F. nucleatum in the colon and CRC has not been well proposed. Herein, a probiotic strain Enterococcus faecium ( E. faecium , EF47) is verified to secrete various organic acids and bacteriocins to exert superior antimicrobial activity towards F. nucleatum . However, the oral delivery of EF47 is affected by the complex digestive tract environment, so we design the hyaluronic acid-inulin (HA-IN) coated EF47 for colon-targeted delivery to fight F. nucleatum . IN can protect EF47 from the harsh gastrointestinal tract environment and is degraded specifically in the colon, acting as prebiotics to further promote the proliferation of EF47. The exposed HA can also enhance the targeting effect to the tumor area via the interaction with the CD44 receptor on the tumor cells, which is confirmed to increase the adhesive ability in tumor tissues and inhibit the growth of F. nucleatum . Therefore, this colon-targeted delivery system provides a novel platform to realize high-activity and adhesive delivery of probiotics to assist the therapeutic efficiency of CRC.
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FOOD RESEARCH INTERNATIONAL
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2025
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IF 8
Xiliang Yu,Chen Li,Mengdi Zhou,Sangeeta Prakash,Xiuping Dong
Many countries have aging populations, which continue to grow. Compound diets based on the nutritional needs of older adults were prepared using mixed grain rice and cooked surimi. The textural, rheological, and 3D-printing properties were regulated through the synergy between carrageenan (CG) and inulin (IN) (The total addition of CG and IN is 1.5% (w/w) and the ratio between CG and IN was 3/1, 1/1, 1/3(w/w)). The results show that all compound diets have shear thinning behavior, and the apparent viscosity, support properties, and recovery rate increased with increased CG/IN. The compound diets with a 3/1 CG/IN ratio had the best shear recovery rate (80.95%). Compared with the control group, adding CG/IN increased the yield stress and extrusion force of the compound diets, which decreased with the increased IN ratio. The combination of CG and IN in compound diets could facilitate easier chewing and safer swallowing. When the CG/IN ratio was 3/1or 1/1, the compound diets had the best 3D-printing properties, those which have the highest degree of similarity to the example design graphic and the most pronounced line texture. When the CG and IN were added, the hardness, springiness, and chewiness of the compound diets were enhanced, and the microstructure became denser and more regular. The compound diets are suitable for people with dysphagia and can be classified into levels 5–6 in the International Dysphagia Diet Standardization Initiative framework.
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ACS Nano
·
2025
·
IF 16
Zan Cui,Chenyu Shi,Ran An,Yan Tang,Yinping Li,Xueting Cao,Xukai Jiang,Chang-Cheng Liu,Min Xiao,Li Xu
Cancer vaccines utilizing nanoparticle (NP) structures that integrate antigens and adjuvants to enhance delivery and stimulate immune responses are emerging as a promising avenue in cancer immunotherapy. However, the development of cancer vaccines has been significantly hindered by the low immunogenicity of tumor antigens. To address this challenge, substantial efforts have been made in developing innovative adjuvants to elicit effective immune responses. In this study, we develop a NP cancer vaccine assisted by a polysaccharide derivative adjuvant, designed through a computational strategy, to evoke effective antigen-specific antitumor immunity. Using TLR4 as the putative receptor, we conducted a comprehensive evaluation of a prescreening library consisting of 34 inulin derivatives through docking and molecular dynamics simulation. Consequently, a new derivative, benzoylated inulin (InBz), is selected as the most promising TLR4 agonist. The adjuvant effect of InBz is evaluated by fabricating InBz NPs encapsulating the model antigen ovalbumin (OVA). In vitro, InBz-OVA NPs effectively activate the TLR4 signaling pathways and facilitate dendritic cell maturation, thereby enhancing the antigen delivery and presentation. In vivo, InBz-OVA NPs outperform a commercial aluminum-based adjuvant, elicit robust antibody titers, induce antigen-specific cytotoxic T lymphocytes, and achieve significant tumor suppression in murine models. Besides, the adjuvant effects of other representative derivatives, namely, acetylated and chloroacetylated inulin, with moderate and low potential from the library, are also chemically synthesized and experimentally evaluated and found to be in agreement with computational predictions, confirming the credibility of the strategy. This study provides an effective platform for the pursuit of efficient polysaccharide-based vaccine adjuvants.
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Current Research in Food Science
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2024
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IF 6.2
Jinjiao Dong,Wenjun Wang,Guodong Zheng,Nansheng Wu,Jingjing Xie,Shiyi Xiong,Panting Tian,Jingen Li
Choerospondias axillaris fruit has attracted more and more attention due to its various pharmacological activities, which are rich in polysaccharides. This study investigated the in vitro saliva-gastrointestinal digestion and fecal fermentation behaviors of polysaccharides from Choerospondias axillaris fruit (CAP), as well as its impact on human gut microbiota. The results showed that CAP could be partially degraded during the gastrointestinal digestion. The FT-IR spectra of the digested CAP didn't change significantly, however, the morphological feature of SEM changed to disordered flocculent and rod-like structures. 16S rRNA sequencing analysis found that after in vitro fermentation, CAP could increase the relative abundances of beneficial bacteria including Megasphaera , Megamonas and Bifidobacterium to produce short-chain fatty acids (SCFAs), while it can also reduce the abundances of harmful bacteria of Collinsella , Gemmiger , Klebsiella and Citrobacter , suggesting that CAP could modulate the composition and abundance of gut microbiota. These results implied that CAP can be developed as a potential prebiotic in the future.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Qing Ge,Chen-long Hou,Xiu-hua Rao,An-qiang Zhang,Guo-ming Xiao,Lu-yao Wang,Kai-ning Jin,Pei-long Sun,Li-Chun Chen
Coix seed polysaccharides had received increasing attention due to their diverse biological activities. In this study, a homogeneous polysaccharide (CSPW) was extracted and purified from coix seed. Furthermore, the saliva-gastrointestinal digestion and fecal fermentation behavior of CSPW were simulated in vitro. The results showed that CSPW was mainly composed of glucose. It cannot be degraded by the simulated salivary and intestinal digestive system, but can be degraded by the simulated gastric digestive system. After fermentation for 24 h, CSPW promoted the production of short-chain fatty acids (SCFAs), with acetic acid, propionic acid and n-butyric acid being the main metabolites. In addition, CSPW could significantly regulate the composition and microbial diversity of gut microbiota by increasing the relative abundance of beneficial bacteria, such as Limosilicactobacillus, Bifidobacterium and Collinsella . Finally, further analysis of functional prediction revealed that amino acid metabolism, nucleotide metabolism and carbohydrate metabolism were the most important pathways for CSPW to promote health. In summary, our findings suggested that CSPW could potentially be used as a good source of prebiotics because it can be used by gut microbiota to produce SCFAs and regulate the gut microbiota.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Lin Wang,Zhikun Zeng,Yaqing Lin,Baodong Zheng,Yi Zhang,Lei Pan
The in vitro dynamic digestive model more realistically simulates the human digestive system compared to static digestive model. In this study, the dynamic in vitro stomach-intestine digestive system and fecal fermentation was used to investigate the dynamic digestion properties and fermentation properties of Dictyophora indusiata polysaccharide. The results showed that there were no significant changes in molecular weight, functional groups and surface morphology after the in vitro dynamic simulated digestion, indicating that D. indusiata polysaccharide maintained a relatively stable structure during the dynamic in vitro salivary-gastrointestinal digestion. In addition, D. indusiata polysaccharide improved the abundance of beneficial bacteria, including Blautia , Coprobacter and Fusicatenibacter . It is remarkable that D. indusiata polysaccharide significantly increased the level of acetic acid and propionic acid. In conclusion, these results suggested that D. indusiata polysaccharide was a potential source of prebiotics, which provides a basis for the development of D. indusiata polysaccharide in the food or medical field.
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FOOD HYDROCOLLOIDS
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2024
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IF 11
Fang Fang,Yu-Xin He,Hao-Qiang Wang,Yan-Li Zhang,Ya-dong Zhong,Xiao-Tian Hu,Shao-Ping Nie,Ming-Yong Xie,Jie-Lun Hu
We selected an array of whole grains (WGs), including highland barley, buckwheat, coix seed, foxtail millet, barley, oats, proso millet and sorghum to determine their carbohydrates profile before and after extrusion-expansion, estimated glycemic index (GI) and fermentation characteristics. Our findings reveal that the extrusion processing can significantly influence the structural properties and digestibility of starch. A notable rise in the total dietary fiber (TDF) content was found in foxtail millet, barley and sorghum ( p < 0.05) after extrusion. Digestion results of extruded whole grains (EWGs) suggested that coix seeds, oats, and sorghum after extrusion can better manage glycemic index (GI) values due to low starch hydrolysis degree and higher resistant starch (RS) and slowly digestible starch (SDS) content. EWGs with higher TDF content (HE, FE, SE, OE and BE) demonstrated greater SCFA yield, with extruded highland barley exhibiting a superior capacity for generating propionic acid and butyric acid. Extruded barley, buckwheat, oats, and proso millet significantly boosted microbial diversity. All eight EWGs notably curtailed Bilophila growth and fostered beneficial bacteria such as Prevotella , Megamonas , Megasphaera , Bifidobacterium , Parabacteroides and Phascolarctobacterium . This study provides a robust scientific foundation for the application of extrusion technology in functional WGs products.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Shiwen Zhao,Danyang Wang,Qiong Zhou,Beibei Wang,Zhao Tong,Honglei Tian,Jianke Li,Yuhuan Zhang
Nanozymes with oxidase or peroxidase-mimicking activity have emerged as a promising alternative for disinfecting resistant pathogens. However, further research and clinical applications of nanozymes are hampered by their low in vivo biosafety and biocompatibility. In this study, inulin-confined gold nanoparticles (IN@AuNP) are synthesized as an antibacterial agent via a straightforward in situ reduction of Au 3+ ions by the hydroxyl groups in inulin. The IN@AuNP exhibits both peroxidase-mimicking and oxidase-mimicking catalytic activities, of which the maximum reaction velocity ( V max ) for H 2 O 2 is 2.66 times higher than that of horseradish peroxidase. IN@AuNP can catalyze the production of reactive oxygen species (ROS), resulting in effective antibacterial behavior against both Gram-negative ( Escherichia coli ) and Gram-positive ( Staphylococcus aureus ) bacteria. Abundant hydroxyl groups retained in inulin endow the nanozyme with high adhesion to bacteria, reducing the distance between the captured bacteria and ROS, achieving an antibacterial ratio of 100 % within 1 h. Importantly, due to the natural biosafety and non-absorption of the dietary fiber inulin, as well as the inability of inulin-trapped AuNP to diffuse, the IN@AuNP exhibits high biosafety and biocompatibility under physiological conditions. This work is expected to open a new avenue for nanozymes with great clinical application value.
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