AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
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2026
·Vol. 96
·期 2
·e70272
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IF 2.5
Di Wang,Yu Xie,Hongyuan Zhang,Tingting Dong,Xiaoyu Liu,Yilei Li,Yan Zhang,Xietong Wang,Qian Zhou
Objective Recurrent miscarriage (RM) is a complex pregnancy-related disorder closely associated with impaired extravillous trophoblast (EVT). Antiphospholipid antibody syndrome (APS) is an autoimmune condition that contributes to adverse pregnancy outcomes, including RM. However, the mechanism by which APS induces RM remains largely unclear. Migrasomes, a newly identified type of extracellular vesicle generated during cell migration, may regulate cellular functions through the transfer of microRNAs (miRNAs). Increasing evidence has suggested that migrasomes play important roles in the female reproductive system, particularly in pregnancy-related disorders such as RM. This study aimed to explore the potential role and underlying mechanism of EVT-derived migrasomes in the pathogenesis of RM associated with APS. Methods First, EVT-derived migrasomes (EVTDMs) were isolated from an in vitro RM/APS model established in HTR-8/SVneo cells. Differentially expressed miRNAs in EVTDMs were identified by small RNA sequencing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The predicted target gene of hsa-miR-206 was further validated using a dual-luciferase reporter assay. Results The results showed that migrasome markers were readily detected in EVTDMs derived from HTR-8/SVneo cells. An in vitro RM/APS model was established by co-incubation with anti-β2-glycoprotein I antibody (anti-β2-GPI Ab). Migrasome-like vesicles were identified by confocal microscopy and transmission electron microscopy. MiRNA profiling revealed that hsa-miR-206 was significantly upregulated in EVTDMs from the RM/APS group. Based on bioinformatic prediction and dual-luciferase reporter assays, IKBKB was identified as a direct binding target of hsa-miR-206. Conclusion In conclusion, HTR-8/SVneo cells were capable of generating migrasome-like vesicles, and anti-β2-GPI Ab treatment altered the miRNA cargo of EVTDMs. Among the differentially expressed miRNAs, hsa-miR-206 was markedly upregulated and was validated to bind directly to the 3′UTR of IKBKB, suggesting a potential role in posttranscriptional regulation. However, the downstream functional consequences of this interaction remain to be further elucidated.
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CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Xin Shi,Qiuyan Bi,Zizhen Peng,Zhicheng Wang,Fangbo Zhu,Yakai Lin,Wenzhong Ma,Chuanjie Fang,Shiai Xu
RIP microenvironment regulation and amino acid functionalization synergize NF design. • BDM scavenges H + to suppress PEI protonation and preserve reactivity. • L-Arginine functionalization enhances membrane hydration and positive charge. • P-B-0.8/A-0.1 membrane achieves 99.5% Mg 2+ rejection and an SF of 131.7. • After 80 h, MgCl 2 rejection >98%, showing stable and antifouling performance. Thin-film composite (TFC) nanofiltration (NF) membranes show great potential for Mg 2+ /Li + separation. However, during conventional interfacial polymerization, excessively rapid amine diffusion and local acidification at the reaction interface can lead to nonuniform interfacial reactions. This study proposes a synergistic construction strategy of membrane forming microenvironment regulation and amino acid interface empowerment. Bis (2-dimethylaminoethyl) ether moderated the apparent migration and protonation behavior of polyethylenimine and alleviated local acidification at the reaction front. Subsequent L-arginine post modification enhanced surface hydration and modified the acid–base/charge characteristics of the polyamide layer interface. P-B-0.8/A-0.1 membrane with high positive surface charge (IEP pH = 8.5), excellent antifouling properties, and a uniform pore-size distribution were constructed for Mg 2+ /Li + separation. In the MgCl 2 /LiCl mixed salt system, the membrane achieved an Mg 2+ rejection rate of 99.5% and a separation factor of 131.7. During 80 h of continuous operation, the Mg 2+ rejection rate remained above 98%. Moreover, the P-B-0.8/A-0.1 membrane exhibited excellent flux recovery and anti-scaling stability during BSA and lysozyme fouling cycles, as well as in CaSO 4 and CaCO 3 inorganic scaling systems.
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JOURNAL OF MEMBRANE SCIENCE
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2026
·
IF 8.8
Zhang-Fu Shi,Peng Cheng,Yi-Fan Li,Jie Yang,Yan Chen,Xiao-Jing Guo,Xi Yan,Wan-Zhong Lang
Polyethylene glycol (PEG), a versatile non-ionic surfactant with excellent biocompatibility and robust chemical stability, offers significant potential for the precise regulation of interfacial polymerization (IP). In this study, PEG was introduced into the aqueous phase as an additive to modulate the interfacial diffusion behavior of piperazine (PIP). By systematically optimizing its molecular weight, concentration, and terminal group parameters, a polyamide (PA) active layer with a smaller and more uniformly distributed pore structure was successfully constructed. This optimized architecture effectively strengthened both the size exclusion and charge repulsion mechanisms of the nanofiltration (NF) membrane. Consequently, the optimal MP 1000 -10 membrane exhibited highly competitive NF performance, achieving an impressive Na 2 SO 4 rejection of 98.0% and a high water permeance of 11.5 L m −2 h −1 bar −1 . More importantly, tailoring the PEG terminal groups facilitated targeted control over the pore size and surface charge properties, significantly enhancing the removal of structurally and physicochemically diverse emerging organic contaminants (EOCs). Across a broad set of experimental parameters, PEG modification consistently delivers improved separation performance for membranes. With excellent stability, high efficiency and economic feasibility, this strategy provides solid technical and theoretical support for developing advanced separation membranes targeting high-efficiency EOCs removal.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Xiaoqing Song,Xiaoye Wen,Yongfei Huang,Zhefeng Fan
Carbon dots nanozymes were synthesized from fresh garlic and ethylenediamine. • N-CDs showed excellent photo-responsive oxidase-like activity and blue fluorescence. • N-CDs with ethylenediamine doping show higher oxidase activity than undoped CDs. • A smartphone-assisted dual-mode sensing platform was used to detect TBHQ rapidly. Synthesis of highly active carbon dots nanozymes remains challenging. Using fresh garlic and ethylenediamine as precursors, nitrogen-doped carbon dots nanozymes (N-CDs) were fabricated in this study. The N-CDs exhibited light-responsive oxidase-like activity and blue fluorescence. For comparison, the carbon dots (CDs) without ethylenediamine doping demonstrated remarkable catalytic activity. Following doping with ethylenediamine, the maximum reaction rate and specific activity of N-CDs were approximately 1.4 times and 2 times those of CDs, respectively, indicating that nitrogen doping significantly enhanced the catalytic activity. Based on the catalytic performance and fluorescence properties of N-CDs, a dual-mode sensor was constructed for the detection of tert-butylhydroquinone (TBHQ), achieving detection limits of 0.19 μM and 0.05 μM for the colorimetric and fluorescence methods, respectively. Portable on-site detection of TBHQ in real samples was realized by integrating the sensing platform with a smartphone, providing a new strategy for the preparation of high-performance nanozymes. Download: Download high-res image (140KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Chenxia Zhen,Yinghua Che,Enqi Chen,Jian Zhao,Yanlong Luo,Xiujuan Wang
Dual heat-conduction pathways significantly enhance thermal transport. • In situ MOF growth is achieved on surface-modified BN fillers. • Interfacial functionalization improves filler-matrix compatibility. The heat transfer of electronic devices requires the use of thermal interface materials (TIM) with high heat dissipation capabilities and excellent thermal management performance to prevent overheating. However, in polymer-based thermal conductive phase-change composite systems, simple blending of functional nanofillers will lead to interface incompatibility, which cannot fully utilize the unique advantages of the fillers. Herein, a flexible polyurethane (PU)-based boron nitride/metal-organic framework/polyethylene glycol (BN/MOF/PEG) composite film (named BMP) is fabricated which integrates high latent heat and excellent thermal management capabilities via functional modification and the construction of dual heat conduction pathways. After sucrose treatment of BN, hydroxyl-functionalized BN (BN-OH) was obtained. Subsequently, MOF was in situ grown on the BN-OH surface to form BM, which was further deposited onto BN-OH/PU (TB) fibers for PEG adsorption, thereby yielding the BMP composite film. Among them, the thermal conductivity of the BMP-3 film reach 2.2 W·m −1 ·K −1 , and the latent heat retention rate reach 70%. Compared with commercial silicone grease, the developed BMP film can significantly reduce the full-load CPU temperature by 19 °C when with a heat sink, demonstrating excellent thermal management capabilities. Additionally, combining molecular dynamic and quantum chemistry simulations, the influence of functionalized modified nanofillers on the interface regulation was characterized from a microscopic perspective. This work provides a theoretical basis for designing advanced TIM materials with high latent heat and excellent thermal management capabilities, and is expected to promote the iterative update of the thermal management part of electronic devices. Download: Download high-res image (271KB) Download: Download full-size image
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Ziyan Niu,Qian Yin,Chunxia Liu,Mengke Song,Shunyao Li,Jialin Yu,Zhao Ma,Kai Sun
Endocrine disruptors bioaccumulate along food chains, impairing reproductive function in wildlife and elevating chronic disease risk in humans. Natural humification-inspired bioenzymatic catalysis (NH-IBC) can interrupt pollutant transfer from crops to higher trophic levels, but its efficacy in hydroponic root-zone decontamination and carbon sequestration remains poorly characterized. Here, we demonstrated that NH-IBC enhanced the polymerization and humification of dissolved organic carbon in the hydroponic root-zones of ryegrass ( Lolium perenne L.), resulting in a 17.3-fold increase in the dissipation kinetic constant of bisphenol A (BPA, a model endocrine disruptor) relative to the bioenzyme-deficient control. Mechanistically, NH-IBC generated reactive radical intermediates that boosted the copolymerization of root exudates (phenolic acids, amino acids) with BPA, forming water-insoluble, high-molar-mass polymers through stable covalent cross-coupling. This efficient polymerization, coupled with carbon sequestration, reduced BPA phytotoxicity and promoted ryegrass root cell proliferation and elongation. Mass balance and 14 C-ring-labeled BPA analyses confirmed that NH-IBC diminished BPA uptake and subcellular distribution in ryegrass. Hydrophobic BPA oligomers and polymers accumulated primarily in root epidermal and cortical tissues, limiting translocation to the endodermis and edible aerial parts. Our findings present a natural humification-inspired biocatalytic framework to remediate contaminant pollution and sequester carbon, advancing agroecosystem sustainability and improving crop- and animal-derived food safety.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2026
·
IF 5.3
Simeng Shao,Yi Wu,Peng Yu,Xilin Wan,Hongmei Yang
Panax ginseng is widely utilized as a functional food ingredient. The steaming process is a critical treatment that profoundly alters the metabolic profiles and enhances the therapeutic properties of Panax ginseng . This study characterized ginsenosides, saccharides, and amino acids in eight ginseng samples using ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) and multivariate data analysis. A total of 224 ginsenosides were identified, with 128 compounds exclusively detected in black ginseng (BG). Quantitative analysis of 49 metabolites showed that BG was enriched in rare ginsenosides (e.g., Rg3, Rg5, and Rk1) and monosaccharides (glucose and fructose) but had lower levels of basic amino acids, particularly arginine. Partial least-squares discriminant analysis (PLS-DA) identified 10 key discriminative markers distinguishing BG from other varieties. Furthermore, desorption electrospray ionization mass spectrometry imaging (DESI-MSI) visualized the spatial distribution of these markers, revealing their preferential accumulation in the cambium and phloem tissues. These findings provide comprehensive insights into the phytochemical transformation of ginseng during mild thermal processing, facilitating the development of BG as a functional food ingredient and supporting quality control in the food industry.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Zhang Xiangxiang,Zhao Jingjing,Li Chao,Li Shubin,Tang Xuefeng,Zhao Wan,Liu Fukai,Han Xiaojun
A large population suffers from diabetes worldwide. Type I diabetes mellitus results in insulin-deficient hyperglycemia, causing serious health issues. Pancreatic islet transplantation is a promising way to treat type I diabetes. It remains a challenge to obtain the islet spheroid with a core–mantle architecture similar to that of rodent pancreatic islets in vivo. We demonstrate a methodology to produce islet spheroids composed of β and α cells with a core–mantle architecture based on the magneto-Archimedes effect in a high-throughput manner. The core–mantle islet spheroid (CMIS) shows a more sensitive glucose stimulation response and better insulin secretion performance than the mixed islet spheroid at high-glucose conditions, as indicated by the relative mRNA expression levels. The high-throughput toxicity tests on immunosuppressive drugs using CMIS (β:α = 7:3) indicate that mycophenolate mofetil exhibits a less negative effect on cell viability and insulin secretion than rapamycin and tacrolimus. The CMIS (β:α = 7:3) exhibits a better therapeutic effect in treating diabetic mice after transplantation than the other types of islet spheroids, which holds great potential in the clinical treatment of diabetes. The proposed versatile methodology for core–mantle islet spheroids paves the path for fabricating spatially coded tissues with a complicated architecture in the organoid field.
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FOOD HYDROCOLLOIDS
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2026
·
IF 13.8
Zhongcan Peng,Jifei Feng,Chaoqing Yang,Hong-Bin Wang,Hong-Lei Jin
Fingered citron is a pectin-rich citrus resource, but extraction of fingered citron pectin (FCP) using natural deep eutectic solvents (NADES) remains limited. This study combined conductor-like screening model for real solvents (COSMO-RS) prediction with experimental validation to screen NADES for FCP extraction. Thirty-five NADES systems were evaluated using monosaccharides and pectin fragments as molecular models, and five candidates were selected for ultrasound-assisted extraction. Betaine-maltose (Bet-Mal) achieved the highest yield (11.86%), followed by choline chloride-maltose (ChCl-Mal) (9.57%), both higher than water extraction (4.88%). Structural analyses showed that NADES changed the domain composition, molecular size, methyl esterification, surface charge, conformation, and aggregation behavior of FCPs. L-proline-maltose (LP-Mal), Bet-Mal, and choline chloride-fructose (ChCl-Fru) extracted galacturonic acid-rich pectins with high homogalacturonan proportions, whereas glucose-maltose (Glc-Mal) yielded a highly branched rhamnogalacturonan-I-rich fraction with the highest molecular weight (945.2 kDa), largest particle size, and strongest nanoscale aggregation. ChCl-Mal-extracted pectin showed the highest DPPH scavenging activity, while the water-soluble pectin (WSP) had the strongest superoxide anion scavenging activity. The κ-carrageenan composite gels prepared from pectins extracted with different solvents exhibited distinct textural, rheological, thermal, and microstructural characteristics. The LP-Mal-extracted pectin formed the strongest water-retentive gel, with hardness of 1.54 N and water holding capacity of 92.34%, whereas ChCl-Mal and ChCl-Fru showed higher small-deformation viscoelastic moduli. These results provide insight into the solvent-dependent structure–function relationships of FCP and offer a COSMO-RS-guided NADES extraction strategy for obtaining fingered citron pectins with distinct food-related functionalities.
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Nature Communications
·
2026
·
IF 18.1
Han Zilong,Lu Yuchen,Yang Hua,Mu Yan,Li Siming,Wang Jiahao,Yang Wei,Qu Shaoxing
Water in hydrogels has often been overlooked or deemed detrimental to the mechanical properties of hydrogels due to the plasticizing effect of water, which weakens interchain interactions and accelerates crack propagation. Here, we propose a slow-water strategy that imparts enhanced fracture resistance to hydrogels. By converting free water into slowly migrating intermediate water, we suppress excess chain mobility by reducing the free volume around polymer chains, thereby enhancing interchain interactions and substantially extending the load-transfer length. Notably, even with only 13% polymer content and without additional network design, the hydrogels achieve orders-of-magnitude improvements in fracture toughness and fatigue threshold solely through medium design, and these enhancements are demonstrated to be dominated by the intermediate water. The strategy demonstrates versatility, providing insights into the role of intermediate water in biological systems and enabling innovative approaches to reinforcing biomimetic materials under complex stress conditions.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
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2026
·
IF 2.2
Yaohui Ni,Shicheng Tang,Haiyang Wu,Yufei Zhang,Saijiao Tang,Lexin Chen,Tianjian Lu,Defeng Xu,Hang Hu
Dimethylcurcumin (DMC) is a derivative of curcumin. Studies have shown that DMC can enhance the degradation of androgen receptors (AR), thereby inhibiting AR-related diseases. However, the extremely poor water solubility and fast metabolism in vivo of DMC greatly limit its clinical applications. In the present study, poly(ethylene glycol)-modified liposomes loaded with DMC (DMC@PEG-Liposomes) were prepared by an improved membrane hydration method. The prescription of the liposomes was optimized to obtain DMC@PEG-Liposomes with a particle size between 110 and 150 nm, moderate encapsulation efficiency and good freeze-drying stability. In vitro release studies showed that DMC@PEG-Liposomes displayed Fickian release at pH 7.4 and non-Fickian release at pH 5.0. Compared with free DMC, DMC@PEG-Liposomes were more toxic to 22Rv1 and HepG2 cells in vitro. DMC@PEG-Liposomes also exhibited enhanced AUC0-t as compared to free DMC in in vivo pharmacokinetic studies. These results suggest that DMC@PEG-Liposomes are a promising DMC formulation for anticancer DMC delivery.
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ELECTROCHIMICA ACTA
·
2025
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IF 5.6
Chao Ye,Wenqin Ling,Xiaowei Huang,Yao Wu,Naigen Zhou,Xuerui Yang
Olivine-structured LiMn x Fe 1-x PO 4 (LMFP) has garnered significant attention as a cathode material for lithium-ion batteries (LIBs) due to its high energy density and low cost. However, its widespread application is limited by its inherently low electronic and ionic conductivities, as well as structural instability arising from the Jahn-Teller distortion of Mn 3+ ions and interfacial side reactions. To address these challenges, this study developed an innovative synergistic modification strategy combining Nb 5+ doping with second-time carbon coating to prepare high-performance LiMn 0.6 Fe 0.4 PO 4 /C cathode materials. Nb 5+ doping stabilizes the crystal structure during cycling by strengthening M-O bonding interactions, thus effectively alleviating the Jahn-Teller distortion of Mn 3+ . Meanwhile, uniform carbon coating layer effectively suppresses electrolyte attack on the material and mitigates Mn dissolution. Furthermore, the synergistic effects of Nb 5+ doping and second-time carbon coating significantly enhance the Li + /e − transport efficiency of the material by narrowing the band gap and constructing a continuous conductive network. As a result, the dual-modified LMFP/DC-2Nb electrode exhibits significantly enhanced cycling stability and rate capability, delivering an initial discharge capacity of 158.3 mAh g −1 at 0.1 C and achieving 93.2 % capacity retention at 1 C after 700 cycles. Moreover, a high specific capacity of 156.2 mAh g −1 is delivered after 200 cycles at 1 C and 50 °C with negligible capacity fading, and a discharge capacity of 119.8 mAh g −1 is maintained even at a high rate of 5 C. The synergistic modification strategy holds great potential for application and offers broad prospects for the design and development of high-energy-density, low-cost, and high-performance lithium-ion batteries.
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