Applied Materials Today
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2025
·
IF 6.9
Xin Zhang,Wenqing Hai,Junjie Pan,Ye Zhang,Xiang Chen,Zhihao Li,Wenlong Huang,Jinhua Jiang,Siyi Bi,Huiqi Shao,Nanliang Chen,Guangwei Shao
Multifunctional flexible wearable electronic devices will become an important trend in the future development of intelligent electronics. Concurrently, researchers have also turned their attention to reducing the energy consumption of devices during system operation. Here, a flexible, stretchable plush fabric is first knitted by using core-spun yarn similar to the structure of polar bear fur as the raw material, with full rib stitch and weft inlay stitch as the fabric structure. Furthermore, the e-textiles are developed by direct in situ polymerization of polydopamine (PDA) and polypyrrole (PPy) to endow plush fabrics with electrical conductivity. Thanks to the increased contact area of yarn-to-yarn due to the fluff-like appearance and tight fabric construction, our e-textile has high electrical conductivity (1559 S/cm). On the one hand, the test power consumption is reduced, and on the other hand, the e-textile has excellent sensitivity (GF max = -1.75) and a broad sensing range (30%), making it ideal for monitoring the state of human motion and facilitating communication. Moreover, the e-textile excels in electrothermal conversion capabilities (up to 89.5 °C at 13 V), photothermal conversion efficiency (achieving 109 °C at 200 mW/cm 2 ), and scalable electromagnetic interference (EMI) shielding characteristics within the X-band (22 dB). Consequently, biomimetic design provides a viable pathway for the development of adaptable multifunctional wearable devices.
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MICROBIOLOGICAL RESEARCH
·
2024
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IF 6.1
Ruixiang Yang,Thiruselvam Viswanatham,Shuangqin Huang,Yuanping Li,Yanshuang Yu,Jinlin Zhang,Jian Chen,Martin Herzberg,Renwei Feng,Barry P. Rosen,Christopher Rensing
Antimony is pervasive environmental toxic substance, and numerous genes encoding mechanisms to resist, transform and extrude the toxic metalloid antimony have been discovered in various microorganisms. Here we identified a major facilitator superfamily (MFS) transporter, AntB, on the chromosome of the arsenite-oxidizing bacterium Ensifer adhaerens E-60 that confers resistance to Sb(III) and Sb(V). The antB gene is adjacent to gene encoding a LysR family transcriptional regulator termed LysR ars , which is an As(III)/Sb(III)-responsive transcriptional repressor that is predicted to control expression of antB . Similar antB and lysR ars genes are found in related arsenic-resistant bacteria, especially strains of Ensifer adhaerens , and the lysR ars gene adjacent to antB encodes a member of a divergent subgroup of putative LysR-type regulators. Closely related AntB and LysR ars orthologs contain three conserved cysteine residues, which are Cys17, Cys99, and Cys350 in AntB and Cys81, Cys289 and Cys294 in LysR ars , respectively. Expression of antB is induced by As(III), Sb(III), Sb(V) and Rox(III) (4-hydroxy-3-nitrophenyl arsenite). Heterologous expression of antB in E. coli AW3110 (Δ ars ) conferred resistance to Sb(III) and Sb(V) and reduced the intracellular concentration of Sb(III). The discovery of the Sb(III) efflux transporter AntB enriches our knowledge of the role of the efflux transporter in the antimony biogeochemical cycle .
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
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IF 6.2
Wenjing Li,Ling Xiao,Juan Qi,Yuanyuan Zhang,Zhu Huang,Liangliang Zhu
Inhibition of gut β-glucuronidase (GUS) protects the gastrointestinal tract by reducing local exposure to toxic aglycones from inactive glucuronides. Development of highly safe GUS inhibitors has attracted extensive attentions. The current study demonstrates that natural and synthetic vitamin E (VE) analogues all display potent inhibition toward GUS. dl-α-tocopherol acts as the most potent inhibitor with the Ki value of 0.14 μM, while the other analogues have Ki values below 15.1 μM. Docking analysis indicates that the amino residues in the active pocket of GUS form various hydrophobic interactions with both the chromanol ring and side chain of VE, as well as hydrogen bonds with the hydroxyl group. It is predicted that GUS inhibition readily occurs owing to the daily intake of common plant foods. The current study offers highly safe inhibitors for GUS, as well demonstrates a novel nonantioxidant target for VE providing new insights into the vitamin’s gastrointestinal protection.
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PubMed
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ADVANCED ENGINEERING MATERIALS
·
2025
·
IF 3.3
Yue Zhu,Liya Dai,Mingshuang Hu,Fei Wang,Haoran Guo,XiaoYun Zhao,Hui Yang
Electronic tattoos (e-tattoos), which can be conformally attached to the human skin for real-time, continuous, and noninvasive sensing of physiological signals, hold great promise for personalized healthcare applications. However, e-tattoos based on these water-soluble materials are easily degraded by sweat in the course of daily exercise, leading to the inaccuracy of human signal sensing for long-term monitoring. Herein, enhanced waterproof breathable e-tattoos via spray deposition of a water-soluble composite ink containing poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS), single-walled carbon nanotubes, waterborne polyurethane, and maltitol (as a plasticizer) is developed. The sprayed e-tattoos exhibit a distinctive 3D network structure. This unique architecture endows them with exceptional waterproof properties, excellent conformal adhesion, breathability, and biocompatibility, thereby ensuring their long-term wearability. As epidermal electronic devices, the highly conformal e-tattoos serve as ion-selective interdigital electrodes and seamlessly integrated with a flexible printed circuit board. Such integration enabled wireless, continuous, and real-time monitoring of potassium ion (K + ) concentrations in human sweat during daily activities. Therefore, the waterproof and breathable e-tattoos with excellent comprehensive performance could provide a promising platform for next-generation wearable epidermal electronics.
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SENSORS AND ACTUATORS A-PHYSICAL
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2025
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IF 4.9
Yue Zhang,Ziting Deng,Peng Hong,Zhenchen Bao,Xiangyu Yin,Pengli Zhu
Conformal e-tattoos have recently received widespread attention because of their great potential for precise and immediate monitoring of physiological signals. However, expensive materials or complex fabrication processes are often required to obtain e-tattoos that meet the above application requirements. Here, we propose a facile strategy for the preparation of e-tattoos via screen printing while achieving versatile parameters collection capabilities. The screen printing inks can be obtained only by mixing and stirring carboxylated MWCNTs water slurry, elastomer transparent glue, glycerin and commercial ink according to the needs of target signal detection. Furthermore, a layer of ultra-thin medical pressure-sensitive adhesive layer was subtly involved in the temperature and humidity sensitive e-tattoos, successfully avoiding the mutual interference between the physical signals and the electrophysiological signals. The continuous monitoring of sEMG signals, ECG signals, local humidity conditions, and skin temperature changes can be achieved by applying the multifunctional e-tattoo platform onto the human skin surface. This technology shows promise as a potential avenue for the advancement of electronic tattoo sensing in the future.
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Journal of Ocean University of China
·
2025
·Vol. 24
·期 6
·1827-1833
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IF 1.2
Xin Wenyuan,Zhou Yunbing,Liu Daixi,Wang Cong,Sherwin K. B. Sy
Astaxanthin (AX) and vitamin E (VE) are widely consumed nutritional supplements in China, with its beneficial effects predominantly attributed to all-trans AX and VE. The aim of this study is to develop and validate a rapid and accurate method for quantifying the content of AX and VE in nutritional supplement products using highly sensitive 1 H NMR method. Coumarin was chosen as the internal standard. Specific signals from AX was optimal at H-7,7′ in the chemical shift range of δ 6.17–6.24 ppm, whereas the signals of VE at δ 2.59 ppm. To demonstrate the reliability of this analytical approach the proposed method underwent rigorous validation, specificity, limit of detection (LOD), limit of quantitation (LOQ), linearity, accuracy, precision, and recovery. The accuracy of the validation method was 3.10% for AX and 1.99% for VE. The results indicated that the method was precise and reliable. The method has been successfully applied to simultaneous quantification of AX and VE in nutritional supplements products.
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ACS Applied Materials & Interfaces
·
2021
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IF 9.229
Xue-Feng Zhao,Xiao-Hong Wen,Shu-Lin Zhong,Meng-Yang Liu,Yu-Hang Liu,Xue-Bin Yu,Ru-Guang Ma,David Wei Zhang,Jia-Cheng Wang,Hong-Liang Lu
Skin-like electronics that can provide comprehensively tactile sensing is required for applications such as soft robotics, health monitoring, medical treatment, and human–machine interfaces. In particular, the capacity to monitor the contact parameters such as the magnitude, direction, and contact location of external forces is crucial for skin-like tactile sensing devices. Herein, a flexible electronic skin which can measure and discriminate the contact parameters in real time is designed. It is fabricated by integrating the three-dimensional (3D) hollow MXene spheres/Ag NW hybrid nanocomposite-based embedded stretchable electrodes and T-ZnOw/PDMS film-based capacitive pressure sensors. To the best of our knowledge, it is the first stretchable electrode to utilize the 3D hollow MXene spheres with the essential characteristic, which can effectively avoid the drawbacks of stress concentration and shedding of the conductive layer. The strain-resistance module and the pressure-capacitance module show the excellent sensing performance in stability and response time, respectively. Moreover, a 6 × 6 sensor array is used as a demonstration to prove that it can realize the multiplex detection of random external force stimuli without mutual interference, illustrating its potential applications in biomimetic soft wearable devices, object recognition, and robotic manipulation.
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IEEE SENSORS JOURNAL
·
2024
·Vol. 24
·期 11
·18327-18335
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IF 4.3
Zihan Wang,Kai-Chong Lei,Huaze Tang,Yang Luo,Hongfa Zhao,Peisheng He,Wenbo Ding,Liwei Lin
Vibration perception can help robots recognize their dynamic states to explore the surrounding environment. However, the intrinsic stretchability of soft robots poses challenges to integrating vibration sensors. This study introduces an innovative stretchable electronic skin (e-skin) that facilitates vibration proprioception in soft robots. Constructed with a thickness of approximately 0.1 mm, this ultrathin e-skin is produced using a screen-printing technique with liquid metal particles (LMPs), incorporating a kirigami design for seamless integration. The e-skin works by the triboelectric nanogenerator-based sensing mechanism, which transduces mechanical vibration into an electrical signal without an external power source. By analyzing the vibration signals generated by the dynamic motions of soft robots, the e-skin shows a wide range of applications. From the vibration signal of the soft robotic finger’s sliding motion, 17 different textures can be distinguished with 99% accuracy. Furthermore, analysis of the vibration signal from a soft robotic gripper’s swinging motion enables the estimation of both the type and weight of grains inside the container it grips, achieving accuracies of 97.7% and 95.3%, respectively. As such, this work presents a new approach to realizing the vibration proprioception of soft robots, thereby broadening the applications of dynamic proprioception in soft robotics.
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Device
·
2025
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IF 8
Xinyi Ke,Yifan Duan,Yifei Duan,Zhe Zhao,Chunyu You,Tingting Sun,Xingyu Gao,Ziyu Zhang,Wen Xue,Xuanyong Liu,Yongfeng Mei,Gaoshan Huang,Junhao Chu
Electronic skin (e-skin) mimics the sensing abilities of human skin and offers sensitivity and flexibility, which has garnered attention for medical health monitoring. Nonetheless, limitations in the properties of active materials and signal-to-noise ratio hinder the implementation of multi-functional detection such as integrating biomolecular sensing, motion detection, and electrocardiography in a single device. Here, we introduce a strategy of preparing a multi-functional e-skin that utilizes a composite material combining self-locking chitosan and conductive metal-organic framework film, achieving high-performance motion detection and biomolecular sensing. The integration of deep learning, specifically transformer neural networks, aids in recognizing subtle facial micro-expressions. A sensing array is crafted by utilizing a rapid assembly method that supports discerning more attributes with heightened precision.
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FOOD CONTROL
·
2021
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IF 5.548
Weibin Ma,Eric T. Johnson
Strategies for preventing the growth of mycotoxigenic fungi in agricultural commodities need to be identified. In this study, sorbaldehyde and ( E , E )-2,4-heptadienal, two natural aldehydes as derivatives of the common food preservative sorbic acid, were investigated for their antifungal efficacy as fumigants against Aspergillus flavus in stored peanut seeds. In vitro assays demonstrated that both sorbaldehyde and ( E , E )-2,4-heptadienal exhibited stronger inhibitory effects on A. flavus than sorbic acid. Moreover, the vapor phase of these two aldehydes were much more effective than direct contact on A. flavus growth. ( E , E )-2,4-Heptadienal showed higher fumigant activity than sorbaldehyde, with 50% effective concentration (EC 50 ) values of 1.5 and 2.6 mg/l air, and minimum inhibitory concentration (MIC) values of 16 and 8 mg/l air, respectively. Furthermore, fumigation with sorbaldehyde or ( E , E )-2,4-heptadienal could significantly reduce and delay A. flavus growth in stored peanut seeds, and the infection was completely inhibited by 100 mg/l air sorbaldehyde or 75 mg/l air ( E , E )-2,4-heptadienal. These results revealed that ( E , E )-2,4-heptadienal, a natural food flavour with better safety than sorbaldehyde, has high potential as an antifungal fumigant for protecting peanut seeds from contamination of A. flavus during storage.
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Food Bioscience
·
2025
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IF 5.9
Zi-Xuan Ding,Yue-Hua Chen,Jia-Nuo Zhang,Wen-Yu Wang,Xin-Ru Zhang,Rui-Bo Sun,Hui Zhang,Ming Xie,Hui-Peng Song
Processed Buddha's hand fruit (PBHF) is a widely consumed food, but its flavor profile and functional mechanisms remain understudied. In this study, human sensory evaluation (n = 120), E-tongue, E-nose, microbiomics, and metabolomics were integrated to comprehensively analyze PBHF's flavor characteristics and elucidate its dietary improvement mechanisms. Human sensory evaluation identified PBHF as predominantly sweet and sour with a soft texture, accompanied by subtle notes of saltiness, pomelo peel, liquorice, refreshment, hawthorn, fragrant aroma, and cinnamon. These findings were corroborated by E-tongue analysis, which confirmed sweetness and sourness as the primary tastes. E-nose detection revealed 36 aroma components, including limonene as the key contributor to the pomelo peel flavor. In animal studies, PBHF regulated dietary patterns in mice, significantly reducing weight gain and enhancing gastrointestinal motility. Importantly, it showed no adverse effects on organ indices (spleen, kidney, liver, or thymus). Microbiomics analysis indicated that PBHF increased the abundance of digestive bacteria such as Limosilactobacillus reuteri , Lacticaseibacillus johnsonii , and Ligilactobacillus murinus . Metabolomics profiling further demonstrated that PBHF mitigated weight gain by upregulating metabolic pathways such as lipolysis in adipocytes, fatty acid degradation, and glycerolipid metabolism. By synergizing large-scale human sensory evaluation, electronic sensory evaluation, microbiomics, and metabolomics, this study systematically deciphered PBHF's flavor attributes and mechanistic roles in promoting digestion and metabolic health. These findings provide robust scientific evidence for PBHF's potential applications in functional food development.
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RESPIRATORY RESEARCH
·
2025
·
IF 5
Xuanrong Bao,Hanbing Hu,Yu Dun,Yuedong Tang,Fuli Liu,Jian Zhou,Weichun Mo,Jie Shen
Background E-cigarette or vaping product use-associated Lung Injury (EVALI) has become a public health concern since 2019, with vitamin E acetate (VEA) identified as a potential causative agent. While previous studies have used whole-body VEA aerosol exposure or intratracheal instillation models, these approaches may introduce confounding exposure routes or do not fully reflect real-world vaping conditions. To better understand VEA-induced EVALI, there remains a need for an animal model that isolates airway exposure and closely mimics human vaping behaviour. Methods We utilized a nose-only exposure system to develop a mouse model of EVALI, with VEA aerosol generated by a commercially available vaping device. Puffs were generated at a volume of 55 mL over 3 s, delivered every 30 s for 1 h per day, up to 6 consecutive days. Lung injury was assessed through histopathological analysis, and airway function was measured via invasive airway function test. Ultrastructural changes in mouse alveoli were analyzed with transmission electron microscopy. Alveolar macrophages were assessed for pro-inflammatory polarization and functional impairment. Potential pathogenic mechanisms were explored with RNA-seq analysis. Results Our findings revealed acute lung injuries, characterized by pulmonary edema and typical histopathological findings. Additionally, we observed changes in airway functions with altered respiratory patterns and decreased lung dynamic compliance. Transmission electron microscopy further revealed type II pneumocyte hypertrophy, type I pneumocyte swelling, and prolonged activation of alveolar macrophages with electron-dense phagocytic contents. We also demonstrated macrophage dysfunction with sustained pro-inflammatory polarization and impaired efferocytosis function. The persistent inflammation of the lung was also characterized by the increased level of pro-inflammatory cytokines in the bronchoalveolar lavage fluid, especially IL-6. RNA-seq analysis highlighted pathways related to T cell activation, cytokine signaling, and leukocyte migration. Conclusion This study established a mouse model using a nose-only VEA aerosol exposure system to examine the respiratory effects of VEA in EVALI. Our results revealed that VEA inhalation triggered acute lung injury, accompanied by early signs of airway dysfunction. The findings support the hypothesis that VEA drives EVALI pathogenesis through both direct cytotoxic effects and macrophage-mediated inflammation. Our findings offer new insights into the mechanisms of EVALI and present a valuable model for future research. Supplementary Information The online version contains supplementary material available at 10.1186/s12931-025-03343-1.
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