FOOD CHEMISTRY
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2020
·
IF 6.306
Jing-jing Zhang,Zong-cai Tu,Hui Wang,Yue-ming Hu,Peng-cheng Du,Yi-peng Yang
In this work, the mechanism of the effect of lipid oxidation on the IgG/IgE binding ability of ovalbumin (OVA) was investigated via the peroxyl radicals produced by 2, 2′-azobis (2-amidinopropane) dihydrochloride to simulate lipid oxidation. Results showed that the structure of OVA unfolded partially with an increase in oxidation degree, leading to the exposure of the allergenic epitopes and increasing the IgG/IgE binding ability of OVA. Nine oxidation sites were found on the α-helix, and these sites may unwind the α-helix and expose the allergenic epitopes on the OVA surface, leading to antibody recognition and combination. Consequently, the IgG/IgE binding ability of OVA was increased. In conclusion, the allergenic capacity of OVA can be promoted by modifying peroxyl radical oxidation in processing egg products.
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PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Zhongde Wang,Juan Du,Wenjun Yan,Wei Zhang,Junjian Niu,Ailian Wu,Xiaogang Hao,Guoqing Guan
A potential-responsive 2-2′-dithiodibenzoic acid (DTSA)/Polyaniline (PANI) hybrid film with high ion-exchange capability and selectivity to cadmium ions was successfully fabricated on electrode by a one-step cyclic voltammetry (CV) method. S–S bonds in the DTSA serve as a gate that can be controllably opened and closed to let cadmium ions get in and out of the hybrid film when changing its redox state , and the PANI mainly enhanced the conductivity of the hybrid film. The working mechanism of the film is proposed and identified via the electrochemical quartz crystal microbalance (EQCM) technique, X-ray photoelectron spectroscopy (XPS), Raman and density functional theory (DFT) computations. As a result, the obtained hybrid film exhibited high selectivity towards cadmium ions even in the presences of other cations. More interestingly, over 240% of its initial capacity was retained after 25 consecutive cycles and maintained in the following cycles. Furthermore, the regeneration rate of the hybrid film retains 99% of its initial value even after 30 cycles. It is expected that such a potential-responsive film can be applied for the removal and recovery of cadmium ions from wastewater in various industrial processes.
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ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Jun Zhang,Xiu-tian-feng E,Bo Yang,Xiumei Ma,Xueping Wang,Ninghui Chang,Qiuyu Zhang,Ji-Jun Zou,Junjian Xie
High-energy-density cyclobutane fuels were directly synthesized via room-temperature-integrated one-pot two-step oxidation/self-photosensitized [2 + 2] cycloaddition using lignocellulose-derived cyclic ketones and cyclic alcohols for the first time, which endow much higher density, lower freezing point, and higher neat heat of combustion than other biofuels achieved from the same feedstocks and hence denote a new kind of sustainable high-density fuels appealing for practical applications.
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高影响因子
KEY ENGINEERING MATERIALS
·
2021
·
IF 0
Yang Yi Chen,Wen Jing Wen,Zhi Qin Su,Qi Huan,Chu Yang Zhang
Thermo-responsive random copolymer poly (2-(2-methoxyethoxy) ethoxyethyl methacrylate-co-poly (ethylene glycol) methyl ether methacrylate), abbreviated as P(MEO2MA-co-OEGMA300) was synthesized by 2-(2-methoxyethoxy) ethoxyethyl methacrylate (MEO2MA) and poly (ethylene glycol) methyl ether methacrylate (OEGMA300) with a molar ratio of 1:1 via atom transfer radical polymerization (ATRP). The structure of P(MEO2MA-co-OEGMA300) was confirmed by 1H NMR and GPC. The transition behaviors of P(MEO2MA-co-OEGMA300) in aqueous solution were investigated by UV-Vis and DLS. While the transition behaviors of P(MEO2MA-co-OEGMA300) thin films were probed by white light interferometry. Compared to the P(MEO2MA-co-OEGMA300) in solution, it shows a much broader transition region, which is a promising candidate for the slow release of drug in the field of medicine.
研究领域:
材料科学
·
生物医学工程
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INORGANICA CHIMICA ACTA
·
2024
·
IF 2.7
Hou Cong Li,Ye Fan Zheng,Ming Zhu Wang,Chen Chen Geng,Min Hou,Chang Qing Liu,Wen Ge Li
Two new ligands, 2-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)phenol (H 2 L1′) and 2-(5,6-dihydrobenzo[4,5]imidazo[1,2-c]quinazolin-6-yl)-4-fluorophenol (H 2 L2′) were synthesized by 2-(2-aminophenyl)benzimidazole with salicylaldehyde and 5-fluorosalicylaldehyde, respectively. While the two ligands (H 2 L1′ and H 2 L2′) were coordinated with nickel (II) and cobalt (II) ions and represented open-chain Schiff base structures (H 2 L1 and H 2 L2). Their metal complexes: [Ni 2 (HL1) 2 (C 2 H 5 OH) 2 Cl 2 ]‧2C 2 H 5 OH (complex 1), [Co (HL1) (L1)] (complex 2), [Ni 2 (HL2) 2 (C 2 H 5 OH) 2 Cl 2 ]‧2C 2 H 5 OH (complex 3) and [Co (HL2) (L2)] (complex 4) were obtained by solvothermal reaction. The four Schiff base complexes were characterized by infrared spectroscopy, elemental analysis, thermal stability analysis, X-ray powder diffraction, single-crystal X-ray diffraction, and lipophilicity assay. Single crystal X-ray analysis reveals that complexes 1 and 3 crystallize in a monoclinic system with space group P 21/n, while complexes 2 and 4 crystallize in a trigonal system with space group R -3. The lipophilicity assay (Log P) showed that the introduction of fluorine atoms enhanced the lipophilicity of ligands and complexes. The MTT method was used to determine the IC 50 values of complexes, ligands, and cisplatin against four different tumor cells (A-549, SMMC-7721, MDA-MB-231, and CNE-2Z) and one normal cell (IOSE 80). The results indicated that the four complexes exhibited stronger anticancer efficacy than ligands, among which the fluorine-substituted Co (III) complex (complex 4) displayed greater cytotoxicity compared with cisplatin in inhibiting SMMC-7721, MDA-MB-231 cells and A-549 cells, respectively. In addition, complex 4 can increase intracellular reactive oxygen species levels, arrest cells in the G0/G1 phase, upregulate Bax levels, and downregulate Bcl-2 levels, inducing MDA-MB-231 cell apoptosis in a dose-dependent manner.
研究领域:
化学
·
医学
·
肿瘤学
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高影响因子
ENVIRONMENTAL POLLUTION
·
2020
·
IF 6.793
Cui Ma,Shengyong Jia,Pengfei Yuan,Zhengguang He
Composite magnetic oxide at cow dung ash, nano-Fe 3 O 4 @cow dung ash (nano-Fe 3 O 4 @CDA), was used as catalytic material for the degradation of 2, 2′-methylenebis (4-methyl-6-tert-butylphenol) (AO 2246) in real biologically pretreated landfill leachate . The Fe 3 O 4 @CDA composite exhibited catalytic ozonation activity and allowed material separation and magnetic recovery. The effects of several operating parameters including O 3 concentration, catalyst dosage, temperature and scavengers were evaluated in parallel. Over 70% of AO 2246 were removed by the nano-Fe 3 O 4 @CDA/O 3 system under optimum conditions within 120min reaction time. The EPR, GC–MS and free-radical quenching experiments expatiated the mechanism of this degradation process. It was confirmed that the AO 2246 was degraded efficiently in this catalytic micro-ozonation process, Additionally, GC–MS analysis state clearly that the 3,5-bis(1,1-dimethylethyl)phenol, 4-(1,5-dihydroxy-2,6,6-trimethylcyclohex-2-enyl)but-3-en-2-one, ethanone, 1-(1,4-dimethyl-3-cyclohexen-1-yl)-, 5-tert-butyl-6-3, 5-diene-2-one, 2-hydroxyhexanoic acid, 2-propenoic acid 1,1-dimethylethyl ester, butanoic acid, 2-methyl-, methyl ester and propanoic acid, 2, 2-dimethyl- were the dominant oxidation products (OPs) during the degradation of the AO 2246. The EPR results showed that the catalytic ozonation over Fe 3 O 4 @CDA led to produce more hydroxyl radicals , which were in favor of AO 2246 degradation. The toxicity evolution was also performed through a QSAR analysis calculated by the ECOSAR program which further demonstrated the different responses toward the AO 2246 and its OPs.
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PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2014
·
IF 2.129
Zhijian Che,Shaoxiang Wang,Shenggui Liu,Guobi Li,Qiting Wu,Chunyu Lin,Linglang Kong,Sheng Wang
A new complex [Zn(bbb)Cl 2 ]·DMF, where bbb is 2-(2-(1H-benzo[ d ]imidazol-2-yl)benzyl)-1H-benzo[ d ]imidazole, was synthesized and characterized by element analysis, 1 H NMR and X-ray single crystal structure analyses. For complex: crystal system, triclinic, space group, P – 1 , a = 9.4661(13), b = 10.3534(14), c = 13.0025(18) Å, α = 73.477(2), β = 80.743(2), γ = 88.658(2)°, V = 1205.5(3) Å 3 , Z = 2. In this complex, the Zn 2+ distorted tetrahedron geometry is coordinated by two nitrogen atoms from 2-(2-(1H-benzo[ d ]imidazol-2-yl)benzyl)-1H-benzo[ d ]imidazole and two Cl − . The complex emits yellow green luminescence with the maximal emission peak at 550 nm in DMF solution. The complex exhibits inhibition on the growth of Eca109 cancer cell with IC 50 value of 8.9 ± 1.1 μM, which was lower than that of cisplatin (14.3 ± 1.4 μM). This complex has potential application in treatment of esophageal cancer.
研究领域:
无机化学
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药物化学
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材料科学
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生物无机化学
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药物研究
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高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2022
·
IF 3.841
Lina Guo,Xiaochao Chen,Ruijun Xie,Limin Han,Ning Zhu
4-Phenyl-2-(2′-pyridyl) quinoline ( L1 ) was synthesized by a three-component reaction of aniline, phenylacetylene and pyridine-2-aldehyde catalyzed by trifluoromethanesulfonic acid (TfOH). Its structure was confirmed by FT-IR, MS, NMR and X-ray single crystal diffraction analysis. L1 was investigated as a probe for the detection of Fe 3+ and Fe 2+ ions, which displayed fluorescence enhancement by Fe 3+ and fluorescence quenching by Fe 2+ . This unique fluorescence switching property of L1 was used to identify Fe 2+ and Fe 3+ with high selectivity and sensitivity. The detection limit of Fe 2+ was 8.772 × 10 −9 mol/L and that of Fe 3+ was 1.912 × 10 −9 mol/L. Mechanism investigation revealed that the fluorescence quenching of probe L1 was caused by ferrous-induced PET process and the fluorescence enhancement was due to the combinational effect of ferric-induced PCT enhancement and PET inhibition. In addition, the cyclic voltammetry curves demonstrated that both the Fe 2+ complexes and the Fe 3+ complexes displayed reversible redox process, indicating that the Fe 2+ and Fe 3+ complexes can be reversibly converted into each other upon electrical stimulation. The reversible “On” and “Off” of the fluorescence emission of iron complexes upon electrochemical stimulation could potentially be used in information recording and erasing.
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高影响因子
CRYSTENGCOMM
·
2021
·Vol. 23
·期 30
·5200-5207
·
IF 3.545
Qi-Ming Qiu,Guo-Yu Yang
Three new metal borates, namely K0.5[B6O10]·H2O·1.5H3O (1), [GaB5O10]·H2en (2) and NaCs[Ga{B5O9(OH)}{BO(OH)2}] (3), have been synthesized under solvothermal conditions. Compound 1 features an intricate 3D framework composed of [B6O13]8− clusters, resulting in a 6-connected achiral pcu net. After introducing the organic gallium, one of the BO4 groups of the [B6O13]8− cluster is substituted by a GaO4 polyhedron to form the acentric [GaB5O13]8− cluster in 2. It also displays a high second-harmonic generation (SHG) response about approximately 2.6 times that of KH2PO4 (KDP), which is higher than those of alumino-borates (ABOs) containing the acentric [AlB5O13]8− cluster (0.3–2.1 times that of KDP). Dipole moment calculations have been carried out to confirm these results. In the process of trying to synthesize a new compound with a denser structure than 2, we have unexpectedly obtained 3 crystallized in the centrosymmetric (CS) space group, which shows a 1D structure constructed from the [Ga{B5O9(OH)}{BO(OH)2}]2− cluster. This kind of low-dimensional structure is rare in gallo-borates (GBOs) as well as ABOs.
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高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2018
·
IF 4.805
Jin-Yan Liang,Shou-Jie Shen,Xiao-Qian Chai,Ting Lv
The first Lewis-base-catalyzed unexpected [1 + 2 + 2] annulation reaction between Morita–Baylis–Hillman carbonates and unsaturated pyrazolones was developed. The multicyclic cyclopentane-fused dispiropyrazolone constructions containing five contiguous stereogenic centers, including two spiro quaternary centers, were prepared with excellent yields (81–98%) and moderate to good diastereoselectivities (1:1 to 13:1). Further transformation and gram-scale operations were also achieved efficiently.
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PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2013
·
IF 2.004
Chao Guo,Shaoyun Chen,Yongchun Zhang
Solubility measurements of carbon dioxide (CO2) in aqueous 2-(2-aminoethylamino)ethanol (AEEA, 15 wt %), AEEA + N-methyldiethanolamine (MDEA, 5, 10 wt %), and AEEA + 2-amino-2-methyl-1-propanol (AMP, 5, 10 wt %) solutions as CO2 absorbents were performed at CO2 partial pressure from (0.8 to 800) kPa and temperatures of (303, 313, and 323) K. With increasing the MDEA/AMP amount to AEEA, CO2 loading of the absorbents decreased, while the absorption rate increased. At low CO2 partial pressure (< 30 kPa), the loading of AEEA + AMP was higher than that of AEEA + MDEA, while at high CO2 partial pressure (> 100 kPa), the loading of AEEA + AMP was lower than that of AEEA + MDEA at the same concentration. Furthermore, the absorption rate was in the order AEEA + AMP > AEEA + MDEA > AEEA.
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高影响因子
Arabian Journal of Chemistry
·
2023
·
IF 6
Min Hou,Hou Cong Li,Ning An,Wen Ge Li,Jing Tong
Three metal complexes [Cu(HL)Cl](C 2 H 5 OH) 2 ] (complex 1), [Ni 4 L 2 (CH 3 COO) 4 (C 2 H 5 OH) 4 ] (complex 2) and [CoHL 2 ] (complex 3) based on 2,3-dihydroxybenzaldehyde-2-(2-aminophenyl)benzimidazole Schiff base (H 2 L) were synthesized by solvothermal reaction. The three complexes were characterized by FT-IR spectrometer, elemental analysis, thermogravimetric analysis, and X-ray single-crystal diffraction. X-ray single-crystal diffraction analysis confirmed that complex 1 belongs to monoclinic crystal system with P 2 1 /c space group, and complex 3 crystallizes in trigonal crystal system with R-3 space group. However, complex 2 crystallized in triclinic crystal system with P-1 space group and exhibits centrosymmetric tetranuclear crystallographic structure. Besides, MTT assay was studied antitumor activities against different tumor cells. The results show that the three complexes all have fine anticancer activities. Among them, complex 2 has significantly better anticancer properties against CNE-2Z cells than that of cisplatin. Finally, apoptosis and cell migration were studied to prove that complex 2 could inhibit tumor cells from proliferating in the manner of apoptosis and migration.
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高影响因子
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