Nano Research
·
2015
·Vol. 8
·期 5
·1637-1647
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IF 7.01
Hu Feng,Li Chunyan,Zhang Yejun,Wang Mao,Wu Dongming,Wang Qiangbin
Real-time and objective feedback of therapeutic efficacies would be of great value for tumor treatment. Here, we report a smart Ag 2 S QD-based theranostic nanoplatform (DOX@PEG-Ag 2 S) obtained by loading the anti-cancer drug doxorubicin (DOX) into polyethylene glycol-coated silver sulfide quantum dots (PEG-Ag 2 S QDs) through hydrophobic-hydrophobic interactions, which exhibited high drug loading capability (93 wt.% of DOX to Ag 2 S QDs), long circulation in blood ( t
1/2 = 10.3 h), and high passive tumor-targeting efficiency (8.9% ID/gram) in living mice where % ID/gram reflects the probe concentration in terms of the percentage of the injected dose (ID) per gram of tissue. After targeting the tumor tissue, DOX from PEG-Ag 2 S cargoes was selectively and rapidly released into cancer cells, giving rise to a significant tumor inhibition. Owing to the deep tissue penetration and high spatio-temporal resolution of Ag 2 S QDs fluorescence in the second near-infrared window (NIR-II), the DOX@PEG-Ag 2 S enabled real-time in vivo reading of the drug targeting process and therapeutic efficacy. We expect that such a novel theranostic nanoplatform, DOX@PEG-Ag 2 S, with integrated drug delivery, therapy and assessment functionalities, will be highly useful for personalized treatments of tumors.
研究领域:
生物医学工程
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纳米医学
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肿瘤学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Ruofei Ma,Hanfei Gao,Yue Wang,Zhangrun Xu,Yuchen Wu
Efficient visible-light photocatalysts are essential for energy and environmental sustainability. Many efforts have been devoted to designing diverse heterostructures in the pursuit of high-performance photocatalysts. However, the effect of morphology of the heterostructures on the photocatalytic performance still needs to be further explored. Here, tunable Au-Ag 2 S heterostructures were synthesized to investigate the morphology-induced photocatalytic performance by surface-enhanced Raman scattering (SERS) spectroscopy. All the Au-Ag 2 S heterostructures possess remarkable visible-light photocatalytic and SERS activity compared with Au or Ag 2 S. Moreover, with increasing exposure of the Au component, the Janus heterostructures display better photocatalytic performance than the heterostructures with other morphologies. The possible mechanism is that the axially separated structure enhances the plasmon-induced electron-hole separation and facilitates interfacial charge transfer in the anisotropic heterostructures, owing to a stronger plasmon-enhanced near field. The photocatalytic degradation efficiency of methylene blue by the Au-Ag 2 S Janus heterostructures reached 93.9% within only 60 s. The photocatalytic degradation rate is 2.38, 1.53 and 1.48 times higher than that of the core–shell, eccentric core–shell-I and eccentric core–shell-II heterostructures. Our work demonstrates that the morphology of the Au-Ag 2 S heterostructures exhibits a significant effect on the visible-light photocatalytic performance, which opens a new pathway toward the design of heterostructures for high-performance photocatalysis.
研究领域:
材料科学
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光催化
·
纳米技术
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DOI
高影响因子
TALANTA
·
2016
·
IF 4.035
Yuhong Liu,Linlin Zhao,Jin Zhang,Jinzha Zhang,Wenbo Zhao,Chun Mao
The work investigates a new fluorescence resonance energy transfer (FRET) system using NaEuF 4 nanoparticles (NPs) and [email protected] 2 S NPs as the energy donor–acceptor pair for the first time. The NaEuF 4 / [email protected] 2 S NPs-based FRET DNA sensor was constructed with NaEuF 4 NPs as the fluorescence (FL) donor and [email protected] 2 S core−shell NPs as FL acceptor. In order to find the matching energy acceptor, the amount of AgNO 3 and Na 2 S were controlled in the synthesis process to overlap the absorption spectrum of energy acceptor with the emission spectrum of energy donors. The sensitivity of FRET-based DNA sensor can be enhanced and the self-absorption of ligand as well as the background of signals can be decreased because of Eu 3+ which owns large Stokes shifts and narrow emission bands due to f–f electronic transitions of 4f shell. We obtained the efficient FRET system by studying suitable distance between the donor and acceptor. Then the FRET-based DNA sensor was used for the design of specific and sensitive detection of target DNA and the quenching efficiency (ΔFL/F 0 , ΔFL=F−F 0 ) of FL was logarithmically related to the concentration of the target DNA, ranging from 100 aM to 100 pM. We can realize an ultrasensitive detection of target DNA with a detection limit of 32 aM. This proposed method was feasible to analyse target DNA in real samples with satisfactory results.
研究领域:
生物化学
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分子生物学
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纳米技术
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DOI
PubMed
高影响因子
Molecular Catalysis
·
2024
·
IF 3.9
Fangfang Huang,Xinyin Zhang,Yuhong Chang,Wenwen Chen,Haishun Wu,Lei Li,Jianfeng Jia
Semiconductor photocatalytic organic reactions have garnered extensive interest owing to their environmentally friendly and sustainable advantages. Herein, the preparation of Ag 2 S@CdS p-n heterojunction through in-situ ion exchange reaction for photocatalytic benzylamine coupling is reported. Compared with pure CdS, Ag 2 S@CdS exhibited significantly enhanced photocatalytic activity for the oxidative coupling reaction of benzylamine. In particular, Ag 2 S@CdS showed high photocatalytic benzylamine conversion (>99 %) after 90 min under sunlight irradiation. The photocatalytic performance test at different wavelengths shows that the broadening of the light absorption range of Ag 2 S@CdS effectively improves the utilization of visible light. The photoelectric performance test demonstrates that the internal electric field of the p-n heterojunction effectively enhances the efficiency of separating photogenerated carriers. Moreover, Ag 2 S@CdS exhibited excellent compatibility with various benzylamine derivatives. The mechanism of photocatalytic benzylamine oxidation by Ag 2 S@CdS was investigated. This work provides some insights into the design of visible-light photocatalysts for selective organic synthesis.
研究领域:
材料科学
·
有机合成
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光催化
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DOI
高影响因子
Small
·
2020
·Vol. 16
·期 14
·2001003
·
IF 11.459
Yejun Zhang,Hongchao Yang,Xinyi An,Zan Wang,Xiaohu Yang,Mengxuan Yu,Rong Zhang,Ziqiang Sun,Qiangbin Wang
Fluorescence in the second near-infrared window (NIR-II, 900–1700 nm) has drawn great interest for bioimaging, owing to its high tissue penetration depth and high spatiotemporal resolution. NIR-II fluorophores with high photoluminescence quantum yield (PLQY) and stability along with high biocompatibility are urgently pursued. In this work, a Ag-rich Ag 2 Te quantum dots (QDs) surface with sulfur source is successfully engineered to prepare a larger bandgap of Ag 2 S shell to passivate the Ag 2 Te core via a facile colloidal route, which greatly enhances the PLQY of Ag 2 Te QDs and significantly improves the stability of Ag 2 Te QDs. This strategy works well with different sized core Ag 2 Te QDs so that the NIR-II PL can be tuned in a wide range. In vivo imaging using the as-prepared Ag 2 Te@Ag 2 S QDs presents much higher spatial resolution images of organs and vascular structures as compared with the same dose of Ag 2 Te nanoprobes administrated, suggesting the success of the core–shell synthetic strategy and the potential biomedical applications of core–shell NIR-II nanoprobes.
研究领域:
材料科学
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生物医学工程
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纳米技术
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DOI
PubMed
高影响因子
Scientific African
·
2025
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IF 3.3
Abdulwahid Abamecha,Ahmed Awol Yimer,Guta Gonfa Muleta,Shimeles Addisu Kitte
In this work, a novel ternary nanocomposite electrochemical sensor based on Ag 2 S-CuO-ZnO was developed and put to use for ascorbic acid (AA) electrochemical detection. By combining CuO-ZnO and AgNO 3 precursors, an easy-to-use and inexpensive homogeneous precipitation procedure was used to produce the Ag 2 S-CuO-ZnO nanocomposite. X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), and ultraviolet-visible (UV–VIS) spectroscopy were used to analyze the produced ternary nanocomposite. AA displayed an irreversible oxidation peak on the cyclic voltammograms (CVs) at Ag 2 S-CuO-ZnO nanocomposite modified glassy carbon electrode (Ag 2 S-CuO-ZnO/GCE). The enhanced sensitivity of AA detection at Ag 2 S-CuO-ZnO/GCE was attributed to the ternary nanocomposite's synergistic effects and improved electron transfer efficiency. Using linear sweep voltammetry (LSV), the proposed electrochemical sensor demonstrated a linear range of 1 - 150 μM with a limit of detection (LOD) of 0.73 μM. The demonstrated sensor's practical applicability was successfully used to determine the amount of AA in an orange sample.
研究领域:
分析化学
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电化学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Qi Zhao,Wenxin Gou,Xueting Zhang,Mengyuan Zhang,Yanru Bu,Lijun Wang,Lei Hu,Wenli Yao,Zhengquan Yan
To improve the selectivity and sensitivity for naked-eye detection of toxic Hg 2+ , water-soluble Ag 2 S nanoparticle stabilized by graphene oxide (Ag 2 S@GO) was identified by virtue of the high catalytic activity of nano Ag 2 S and the excellent physicochemical property of graphene oxide. After its structure and spectral performance were characterized and investigated, it was noted that the proposed Ag 2 S@GO possesses outstanding Hg 2+ -activated oxidase-like activity to oxidize the chromogenic substrate of 3,3′,5,5′,-tramethylbenzidine (TMB) with an obvious hyperchromic effect from colorless to blue in the presence of Hg 2+ exclusively. Under the optimized conditions, the Ag 2 S@GO+TMB system was successfully applied for naked-eye detection of heavy metal Hg 2+ in real environmental samples, with a nmol·L −1 -level detection limit of 9.8 × 10 –9 mol/L, an accurate recovery among 97.0–101.8% and a low standard deviation less than 3.3%. The Hg 2+ -activated oxidase-like activity of Ag 2 S@GO and its exclusive recognition mechanism to toxic Hg 2+ were also proposed.
研究领域:
环境科学
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纳米生物学
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分析化学
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产品关联
DOI
高影响因子
TALANTA
·
2023
·
IF 6.1
Huiqin Chang,Qiying Zhu,Yuyin Wu,Anqi Liu,Meng Jiang,Chuang Li,Huiting Li,Ling Kong,Zhiwei Chen,Feng Sang
Prostate cancer is one of the most common cancers in the world, and its early diagnosis can effectively reduce mortality. A new label-free photoelectrochemical (PEC) immunosensor on the basis of Bi 2 WO 6 /BiOBr nanocomposite materials has been successfully prepared for the test of prostate-specific antigen (PSA) in human serum in this work. The Ag 2 S-sensitized Bi 2 WO 6 /BiOBr heterojunction was used as a photosensitive material, which effectively improved the photocurrent response. On Bi 2 WO 6 /BiOBr surface, dopamine immobilized PSA antibody by self-polymerizing to form polydopamine membrane. Antigen and antibody are specifically combined to achieve quantitative detection of PSA according to the current changes at different concentrations of antigen. Under the optimal experimental conditions, the PEC immunosensor has an ideal linear relationship between 1 pg/mL - 50 ng/mL, and the detection limit is 0.084 pg/mL. In addition, the prepared immunosensor has good stability, reproducibility and selectivity, providing a new method for the detection of PSA in actual sample analysis.
研究领域:
医学诊断
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生物传感
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癌症研究
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DOI
PubMed
高影响因子
Biomaterials Science
·
2024
·
IF 5.8
Jia-Hua Zou,Li-Li Chen,Yong-Guo Hu,Dong Zhou,Yong Li,Bin Zhang,Xin-Yue Xu,Bo Liu,Jin-Xuan Fan,Yuan-Di Zhao
Accurate tumor detection is crucial for the early discovery and subsequent treatment of small neoplastic foci. Molecular imaging, which combines non-invasiveness, high specificity, and strong sensitivity, excels in diagnosing early tumors and stands out among tumor diagnosis methods. Here, we introduced a dual-modal imaging probe capable of actively targeting tumor cells, suitable for both near-infrared (NIR) fluorescence and magnetic resonance imaging (MRI). Dendritic mesoporous silica was used as a carrier for the probe, encapsulating Ag2S quantum dots (QDs) for NIR fluorescence imaging. Additionally, the probe conjugated the MRI contrast agent Gd-DOTA and cetuximab, which targeted EGFR on the tumor cell membrane surface, to achieve dual-modal imaging in the tumor area. This strategy provided a methodology for the accurate diagnosis of early-stage tumor lesions and guides precise lesion resection during surgery, offering significant potential for clinical application.
研究领域:
生物医学工程
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分子成像
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癌症诊断
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纳米技术
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Qianqian Chen,Xiaobing Yang,Xingping Fu,Junjie Pan,Junmei Zhou,Gengwu Zhou,Kejun Cheng
Currently, antibiotics are extensively utilized in the pharmaceutical industry to assist humans and animals in combating various infectious diseases. The extensive use of various antibiotics enhances the quality of life. However, it can also have negative effects on the environment and human health, including water pollution and the rise of antibiotic-resistant microorganisms. To date, antibiotics have been detected in rivers, groundwater, and even drinking water. There is an urgent need to design and develop advanced materials for the remediation of antibiotics present in our environment. In this paper, we successfully synthesized a novel Ag 2 S-ZnS/ZIF-8 hollow heterojunction via facile sulphuration and solvothermal methods. This heterojunction was employed as a catalyst for the degradation of tetracycline (TC) in water under UV and visible light irradiation. The physicochemical properties of the as-synthesized catalysts were thoroughly analyzed using XRD, EDS, SEM, BET, XPS, TEM, ESR, UV–vis techniques. The results demonstrate that Ag 2 S-ZnS/ZIF-8 displays enhanced photocatalytic activity for TC degradation no matter under visible or UV light irradiation. After 10 min of UV light irradiation, its photocatalytic degradation efficiency was achieved 92.74 %. Additionally, Ag 2 S-ZnS/ZIF-8 was able to degrade 92.14 % of TC (visible light, with 35 min). The corresponding kinetic rate constant of Ag 2 S-ZnS/ZIF-8 is 0.145 min −1 (UV light) and 0.043 min −1 (visible light), respectively. Furthermore, Ag 2 S-ZnS/ZIF-8 also shown excellent stability for the degradation of TC in the presence of visible light. This is a result of its high specific surface area, superior photocurrent and efficient separation of photo-generated electrons-hole pairs. Apart from this, the photocatalytic degradation mechanism of TC over Ag 2 S-ZnS/ZIF-8 is discussed in detail.
研究领域:
环境科学
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材料科学
·
化学
·
纳米技术
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产品关联
DOI
高影响因子
ACS Applied Electronic Materials
·
2025
·
IF 4.7
Junyao Jiang,Zheng Ye,Nianling Kuang
The pursuit of high-performance flexible thermoelectric generators (FTEGs) for wearable electronics is facing a great challenge, and thermoelectric semiconductors should show both high thermoelectric efficiency and robust mechanical flexibility. Recently, ductile inorganic thermoelectric materials have shown promising plasticity, which provides good processability and moderate thermoelectric properties in both n- and p-type solid solutions. In this work, we first improved the thermoelectric performance of n-type Ag2Te0.2S0.8 by alloying Se at the S site, resulting in a high zT value of 0.62 at room temperature for the Ag2Te0.2S0.1Se0.7 sample. The transition from the cubic phase to the monoclinic phase when alloying Se at the S site should be responsible for the improved thermoelectric performance and the well-maintained plasticity, which has been proven by the calculated lattice spacing. Then, the thermoelectric properties of p-type AgCuX (X = S, Se, Te) solid solutions were also improved by alloying S at the Se site and introducing tiny vacancies, showing a high zT value of 0.42 at room temperature for the (AgCu)0.996Se0.18S0.08Te0.74 sample. Finally, based on the warm rolling forming thick films with the optimized n- and p-type compositions, we fabricated an 18-couple FTEG with an exceptional thickness of 0.7 mm. The open circuit voltage and output power of the flexible device reached 2.32 mV and 8.81 μW at ΔT = 32.1 K, showing a high normalized power density. Crucially, due to the robust mechanical flexibility of these ductile thermoelectric materials and the flexible polyimide substrates, the variation of the internal resistance for the flexible device is within 1% after 1000 bending cycles. This work provides an effective strategy of simultaneously improving the thermoelectric performance and mechanical flexibility by tuning the crystal structures and also shows the possible applications of ductile inorganic semiconductors for wearable electronics.
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DOI
高影响因子
Biomaterials Science
·
2022
·Vol. 10
·期 14
·3972-3980
·
IF 7.59
Yao Huang,Hongchao Geng,Zeming Wu,Leilei Sun,Chenhui Ji,Craig A. Grimes,Xinxin Feng,Qingyun Cai
Bacterial diseases pose a serious threat to human health. Continued development of precise diagnostic methods and synergistic therapy techniques for combating bacteria are needed. Herein a hybrid nanosystem (Ag2S@ZIF-Van NS) was constructed by one-step self-assembly of Zn2+, vancomycin (Van) and Ag2S quantum dots (QDs). The nanosystem possesses excellent second near-infrared transparency window (NIR-II) fluorescence properties (∼1200 nm emission wavelength), good photothermal conversion properties, and biocompatibility. The material system enables precise, targeted NIR-II fluorescent imaging of bacterial inflammation in vivo as well as promoting anti-bacterial and wound healing effects.
研究领域:
生物医学工程
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材料科学
·
微生物学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）