RSC Advances
·
2016
·Vol. 6
·期 108
·106201-106210
·
IF 3.289
Rong-Zhong Wang,Dan-Lian Huang,Yun-Guo Liu,Zhi-Wei Peng,Guang-Ming Zeng,Cui Lai,Piao Xu,Chao Huang,Chen Zhang,Xiao-Min Gong
Bisphenol A (BPA) is a chemical with the potential to cause estrogenic and genotoxic effects on humans and wildlife. In this study, a novel and quick method was employed for selective removal of BPA from aqueous solutions, which used magnetic graphene oxide-based molecularly imprinted polymers as the adsorbent. Adsorption experiments were carried out to examine the effect of pH, initial concentration of BPA, isotherms and sorption kinetics on the adsorption of BPA by magnetic molecularly imprinted polymers (MMIPs). Results revealed the maximum adsorption capacity of BPA by MMIPs was 106.38 mg g−1 at 298 K and the equilibrium data of MMIPs were described well by a Langmuir isotherm model. Furthermore, the sorption kinetics followed the pseudo-second-order equation, which indicated that the chemical process might be the rate limiting step in the adsorption process for BPA. In addition, selective binding experiments were performed using 2,4-dichlorophenol and phenol as competitive compounds, and the resulting selectivity coefficients for the experiment were 2.505 and 2.440, respectively. All these results revealed that the prepared MMIPs had good selectivity and effective adsorption for BPA.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Wenmin Yin,Long Wu,Fan Ding,Qin Li,Pan Wang,Jinjie Li,Zhicheng Lu,Heyou Han
To circumvent the limitations of natural antibodies, receptor, or enzyme, molecular imprinting technique has received intensive attention in analytical methods Herein, based on surface enhanced Raman scattering (SERS) molecularly imprinted polymer (SERS-MIP), a SERS-MIP sensor has been developed for the sensitive and selective detection of bisphenol A (BPA). To construct the BPA sensor, raspberry-type SiO 2 @Ag nanoparticles (SiO 2 @Ag NPs) were prepared to act as supporting substrate, and BPA was adopted as template molecule, tetraethyl orthosilicate (TEOS) as functional monomer and 3-aminopropyltriethoxysilane (APTES) as cross-linker. Due to the strong plasma resonance character of Ag NPs, the SERS-MIP sensor showed good sensitivity in the detection of BPA. The core-shell and satellite-like structure of the SiO 2 @Ag composites could provide a large surface area for BPA recognition by molecular binding domains. In addition, the sensor could prevent interferences such as 4,4′-(Hexafluoroisopropylidene) diphenol (BPAF) and 4,4′-Dihydroxybiphenyl (DOD). Moreover, the real water samples were tested to verify the reliability and feasibility of the method. Under the optimal conditions, the proposed method behaved good analytical performance to BPA with a wide linear range from 1.75 × 10 −11 to 1.75 × 10 −6 M and a detection limit of 1.46 × 10 −11 M.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
PLoS One
·
2013
·Vol. 8
·期 1
·e54198
·
IF 3.73
Hao Gong,Xin Zhang,Biao Cheng,Yue Sun,Chuanzhou Li,Ting Li,Ling Zheng,Kun Huang
Bisphenol A (BPA) is a chemical compound widely used in manufacturing plastic products. Recent epidemiological studies suggest BPA exposure is positively associated with the incidence of type 2 diabetes mellitus (T2DM), however the mechanisms underlying this link remain unclear. Human islet amyloid polypeptide (hIAPP) is a hormone synthesized and secreted by the pancreatic β-cells. Misfolding of hIAPP into toxic oligomers and mature fibrils can disrupt cell membrane and lead to β-cell death, which is regarded as one of the causative factors of T2DM. To test whether there are any connections between BPA exposure and hIAPP misfolding, we investigated the effects of BPA on hIAPP aggregation using thioflavin-T based fluorescence, transmission electronic microscopy, circular dichroism, dynamic light scattering, size-exclusion chromatography,fluorescence-dye leakage assay in an artificial micelle system and the generation of reactive oxygen species in INS-1 cells. We demonstrated that BPA not only dose-dependently promotes the aggregation of hIAPP and enhances the membrane disruption effects of hIAPP, but also promotes the extent of hIAPP aggregation related oxidative stress. Taken together, our results suggest that BPA exposure increased T2DM risk may involve the exacerbated toxic aggregation of hIAPP.
研究领域:
毒理学
·
内分泌学
·
分子生物学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Zarfashan Shahid,Bairong Fu,Saima Rehman,Zia Ahmad,Jiping Chen,Xianbo Lu
Bisphenol compounds, including BPA and BPS, are significant pollutants found in the environment, food, and daily necessities. They pose various adverse effects, including estrogenic, immunotoxic, metabolic, and reproductive toxicity, which severely threaten human health and ecological safety. Achieving simultaneous rapid detection of BPA and BPS is still very challenging due to their similar structures and co-existence in actual samples at ultratrace level. This study addresses the problem of developing an effective method for the rapid detection of BPA and BPS simultaneously. A new electrochemical nanosensor based on ionic liquid (IL) coupled Zr-MOF@GO was developed for ultrasensitive real-time detection of BPA and BPS. The Zr-MOF@GO/IL nanocomposite features a custom-built structure with an ordered framework, abundant pores, and highly coupled interfaces. The experimental findings demonstrate that the introduction of IL enhances the conductivity and dispersibility of the nanocomposite, improves the absorption capability for target bisphenols, and significantly improves the detection limit and linear range of the Zr-MOF@GO based electrochemical sensor. The sensor demonstrated wide linear ranges with detection limits of 5.5 nmol/L for BPA and 7.1 nmol/L for BPS (S/N = 3), respectively. Comparative studies revealed that the detection limits of the Zr-MOF@GO/IL-based sensor improved by an order of magnitude compared to the Zr-MOF@GO-based sensor. Additionally, the sensor exhibited superior analytical performance regarding reproducibility, stability, and selectivity. This study investigated the capability and synergy of IL coupled high-valent stable transition metal Zr IV -based MOFs in electrochemical sensing for the first time. This development sets a new benchmark in non-enzymatic electrochemical sensing, establishing the Zr-MOF@GO/IL-based sensor as a promising platform for the individual or simultaneous rapid detection of bisphenols in actual samples.
研究领域:
环境科学
·
分析化学
·
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
POLYMER
·
2025
·
IF 4.5
Tao Deng,Lin Cui,Mengen Zhang,Ziang Mu,Zhenhuan Li,Bowen Cheng,Maliang Zhang
To meet the demanding performance criteria of packaging materials for high-power electronic devices, this study designed a thermosetting film material with enhanced toughness, mechanical strength, and thermal resistance by synergistically modifying Diglycidyl Ether of Bisphenol A (DGEBA) epoxy resin through bisphenol A (BPA) chain extension and carboxylic acid-terminated butadiene-acrylonitrile copolymer (CTBN) toughening. Initially, the liquid epoxy resin was structurally optimized by varying the BPA content (8–30 parts per hundred resins, phr), which extended the molecular chains and reduced crosslink density. The 30 phr BPA-modified formulation demonstrated optimal performance, achieving a tensile strength of 98.69 MPa. Subsequently, CTBN (0–40 phr) was incorporated to enhance toughness further. The sample containing 30 phr CTBN (DT-30) exhibited superior mechanical properties, with a tensile strength of 99.86 MPa (a 25 % increase) and an 80 % improvement in elongation at break compared to the BPA-extended resin without CTBN. Additionally, the Al–Al lap shear strength reached 27.85 MPa, while the high-temperature char yield increased to 8.94 %, indicating enhanced thermal stability. Dynamic mechanical analysis (DMA) showed that CTBN significantly enhances toughness through nanoparticle voiding and shear yielding mechanisms, but slightly reduces the glass transition temperature (Tg). Molecular simulations revealed crack deflection in the epoxy resin and the toughening mechanism of the voiding effect. Scanning electron microscopy (SEM) confirmed that CTBN is uniformly dispersed and induces tough fracture. Rheological testing determines 133.8 °C as the optimal processing temperature. This work establishes a structure-property relationship and provides a practical strategy for designing high-performance composites through balanced BPA-CTBN modification.
研究领域:
材料科学
·
高分子化学
·
胶粘剂技术
·
复合材料
·
热固性聚合物
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2026
·
IF 6.7
Qian Xie,Jinxin Chi,Zhixin Li,Limei Xu,Yujuan Xiao,Xucong Lin,Guihua Huang
The environmental risks of microplastics are exacerbated by the leaching of endocrine-disrupting additives such as bisphenol A (BPA). Effective monitoring requires analytical methods that are ultrasensitive, specific, and suitable for on-site application, requirements that remain challenging for conventional techniques. Herein, we develop an integrated capillary-based SERS aptasensor for the rapid and specific detection of BPA leached from microplastics. The sensor core is a three-dimensional hierarchical porous silica monolith (3D-PSM) anchored inside a quartz capillary. A DNA-programmed nanogap SERS hotspot matrix is constructed on the 3D-PSM by immobilizing cDNA-modified Au nanoparticles, followed by hybridization with aptamer-conjugated Au@4-MBN@Ag nanotags. This design utilizes the cDNA-aptamer duplex as a programmable molecular spacer to create a uniform sub-10-nm gap, generating an intense initial SERS signal (“signal-on”). Competitive binding of BPA triggers nanotag release and quantifiable signal attenuation (“signal-off”). Benefiting from convective mass transport within the 3D architecture, the platform achieves a limit of detection (LOD) of 1.24 pM for BPA, exhibiting a linear range spanning five orders of magnitude (1.0 pM to 0.1 μM), with a recognition time of 10 min. Practical utility was demonstrated by analyzing BPA thermally liberated (70 °C) from polycarbonate microplastics (PC-MPs, 100 and 1000 mesh) in environmental water matrices. The method exhibited high specificity and satisfactory recoveries (93.7 ± 3.6% to 102.0 ± 7.6%) in spiked river water samples, demonstrating a positive correlation between leached BPA amounts and MP contamination levels. This work provides a reliable tool for the direct assessment of hazardous chemical leaching from microplastics.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2025
·
IF 6.1
Jie Tang,Bairu Chen,Fang Yu,Long Xu,Muxin Yu,Chunji Wang,Fang Zhang,Li Zhang,Yujia Yang,Jiani Hou,Xingfei Li,Weihao Xu,Nenghua Zhang
Increasing evidence links hearing loss to environmental pollutant exposure, with cochlear hair cell being a key target. Bisphenol A (BPA) has been suggested to cause ototoxicity, but its mechanism is not fully understood. In this study, cell viability was assessed by varying concentrations of BPA (0–150 μM) exposed to mouse cochlear hair cells (HEI-OC1), followed by RNA transcriptome sequencing to identify the possible molecular mechanisms. Results showed that BPA above 50 μM reduced cell viability in a dose-dependent manner. RNA sequencing identified 1764 differentially-expressed genes, comprised of 1152 up-regulated and 612 down-regulated genes. Notably, estrogen receptor-related genes were enriched, with a marked up-regulation of estrogen receptor α (ER-α) at both mRNA and protein levels. GO and KEGG analyses revealed the main pathway involvement for oxidative damage, lipid metabolism, protein phosphorylation, and DNA damage. STRING analyses constructed gene networks to identify functionally interacting genes correlated with pyroptotic pathways. BPA exposure induced pyroptosis-like morphological changes characterized by cell swelling, rounding, and membrane blebbing. Increased intracellular ROS and mitochondrial superoxide (MitoSOX) levels, reduced mitochondrial membrane potential ( ΔΨm ), and elevated intracellular calcium (Ca²⁺) levels were observed. Flow cytometry showed an increased proportion of apoptotic and necrotic cells. Pyroptosis-related genes, including caspase-3, caspase-8, caspase-9, and GSDME, were down-regulated, while IL-1β and IL-18 were up-regulated. Protein expressions of caspase-3, caspase-8, caspase-9, and GSDME were decreased, while cleaved caspase-3 and N-terminal GSDME (GSDME-NT) were increased. Furthermore, ROS inhibitor N-acetylcysteine (NAC) and the ER-α antagonist fulvestrant alleviated BPA-induced cell death, and suppressed the protein expressions of the pyroptotic pathway. These results demonstrate that BPA exposure induces ototoxicity possibly through activating ER-α and triggering mitochondrial ROS that contributes to pyroptosis.
研究领域:
毒理学
·
耳科学
·
分子生物学
·
环境健康
·
细胞死亡机制
·
内分泌干扰物
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Xinyang Liu,Jiarui Chen,Wenbo Ji,Longyi Lv,Duoying Zhang
Bisphenol A (BPA) severely inhibits anaerobic digestion (AD), reducing treatment efficiency and methanogenesis. Critically, this work establishes the first evidence of Fe₃O₄ NPs conferring BPA resilience via synergistic adsorption-bioaugmentation—an unreported mechanism in AD systems. This study demonstrates that Fe₃O₄ nanoparticles (NPs) mitigate BPA inhibition in anaerobic granular sludge (AnGS) systems. Electrochemical characterization confirmed enhanced capacitance and redox reversibility in Fe₃O₄-doped AnGS. The modified system achieved significant performance improvements: 24.4 % higher chemical oxygen demand removal, 31.8 % increased methane production, and enhanced extracellular polymeric substance stability versus control. Microbial analysis revealed enriched hydrolytic bacteria and methanogens, alongside elevated metabolite production. Mechanistically, Fe₃O₄ NPs function through: (1) adsorbing BPA, reducing its bioavailability, and (2) enhancing direct interspecies electron transfer (DIET) by serving as electron conduits, accelerating BPA degradation. This dual-action model—combining adsorption and DIET enhancement—effectively strengthens system resilience against BPA shock loads, providing a validated strategy for maintaining AD performance under toxicant stress.
研究领域:
环境科学
·
环境工程
·
微生物学
·
水处理技术
·
纳米材料应用
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Enliang Zhang,Guogang Xu,Huiyong Wang,Shaowei Jin,XinZhen Wang,Lulu Liu,Jian Tian
High efficiency sewage purification is of great significant to environmental protection and water resources utilization. The integration of ozone into conventional water treatment processes is considered as a potential way to enhance water purification efficiency. However, this method is still hindered by low utilization efficiency, poor dispersion, and slow mass transfer rates. In this study, a catalytic ozone functional microporous aeration ceramic membrane (COMA) with nozzle structure was prepared by a hydrothermal method. The results showed that the as-prepared COMA displayed ultra-high efficient catalytic degradation of BPA. The degradation efficiency reached 90 % after 60 min, which is much higher than that of pure ceramic membrane (CM) (75 %), titanium alloy (70 %), and previous reported results. The catalytic degradation mechanism was investigated based on the analysis of COMA surface condition. The high degradation efficiency may be ascribed to unique pore structure of ceramic membranes, increased efficiency of ozone use and microbubble. This paper provide a high efficiency water purification membrane and ozone aeration method, which have wide potential application in the field of sewage treatment.
研究领域:
环境科学
·
材料科学
·
污水处理
✓ 已验证
产品关联
DOI
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2018
·
IF 4.61
Limin Hu,Guangshan Zhang,Meng Liu,Qiao Wang,Shuying Dong,Peng Wang
Nickel foam (NF)-functionalized Co 3 O 4 -Bi 2 O 3 nanoparticles (CBO@NF) synthesized using a facile one-step microwave-assistant method were employed as catalysts to activate peroxymonosulfate (PMS) with bisphenol A (BPA) as the target pollutant. The crystallinity , morphology, and chemical valence state of the synthesized CBO@NF were analyzed using XRD, SEM , and XPS, respectively. Moreover, effects of the preparation parameters, including the calcination temperature and calcination time as well as the loading dosage, were evaluated in detail. A degradation efficiency of 95.6% was achieved within 30 min with the optimal degradation system. The CBO@NF/PMS system shows great catalytic activity in a pH range from 3.0 to 11.0. The stability and reusability of the CBO@NF supported catalyst was evaluated through a recycling experiment. In addition, the possible degradation mechanism was also explored using a quenching experiment and electron paramagnetic resonance (EPR) detection. The result shows that both the surface-bound SO 4 − and OH play significant roles during the degradation process, where the electron transfer of Co 2+ /Co 3+ , Bi 3+ /Bi 5+ , and Ni 2+ /Ni 3+ realizes the sustained regeneration of the active radicals. This work provides new insight for the practical applications of sulfate radical-based advanced oxidation processes (SR-AOPs) in wastewater treatment .
研究领域:
环境科学
·
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2014
·
IF 4.058
Jianguo Zhao,Xiurong Chen,Fengkai Lin,Na Yang,Hua Huang,Jun Zhao
Organic sludge toxicity is a critical issue for sludge land applications. To investigate sludge organic toxicity formation and spatial distribution properties, sludge was acclimated using synthetic effluent containing various bisphenol A (BPA) concentrations in sequential aerobic activated sludge reactors (SBRs). Acute sludge toxicity, which was characterized by the inhibition rate of the luminescent bacterium Photobacterium phosphoreum , was the focus of this study. The original influent COD of the SBR was approximately 300 mg/L; the sludge retention time (SRT) and hydraulic retention time (HRT) were controlled at 20 d and 12 h, respectively. The results indicated that a positive correlation existed between sludge toxicity and the influent BPA concentration. Furthermore, the toxicity was centralized in the intracellular and inner sections of extracellular polymeric substance (EPS) in sludge flocs. BPA concentrations were controlled at 2.5 mg/L, 5.0 mg/L, 7.5 mg/L and 20 mg/L; the sludge toxicities, measured by comparing the control SBR with the blank, were 2.99%, 4.05%, 6.99% and 10.64%, respectively, at the end of 28-day operation. In the 12-h SBR treatment process, aqueous and sludge phase BPA was completely removed within 2 h. However, the maximum sludge toxicity appeared in the 8th hour. The DGGE analysis suggested that the existence of BPA in wastewater increased bacterial diversity in activated sludge. However, the bacterial similarity between sludge in SBRs decreased with increasing BPA concentration. Lastly, the bacterial similarity between blank sludge and control sludge of 20 mg/L BPA was 0.47.
研究领域:
环境科学
·
毒理学
✓ 已验证
产品关联
DOI
高影响因子
CHEMOSPHERE
·
2021
·
IF 7.086
Ran Ma,Sai Zhang,Xuewei Liu,Mingtai Sun,Jianzhong Cao,Jian Wang,Suhua Wang,Tao Wen,Xiangke Wang
Two-dimensional (2D) bismuth-based semiconductors have aroused intensive concern owing to their prominent photocatalytic activity for organic pollutants removal . In this work, a facile strategy for introducing oxygen vacancy in Bi-based oxyiodides (Bi x O y I z ) sheet-like architectures to activate molecular oxygen was proposed. The structure, photoelectric properties and visible light (λ > 420 nm) induced photocatalytic activities of these samples for decomposition of bisphenol A (BPA) were systematically characterized and evaluated. The as-prepared Bi 7 O 9 I 3 with a feeding Bi/I molar ratio of 1:1 exhibited the best photocatalytic activity comparable to those of similarly synthesized Bi 7 O 9 I 3 with other molar ratios and BiOIO 3 catalysts. The optimal Bi 7 O 9 I 3 achieved excellent photocatalytic activity with 99.6 % degradation efficiency of BPA within 20 min and superior structural stability with 95.1 % degradation retention over 5 cycling tests. In addition, the resulting Bi 7 O 9 I 3 sample displayed a high mineralization efficiency of BPA. Importantly, the plenty of oxygen vacancies (V o s) exsiting in Bi 7 O 9 I 3 played the dominant role in both accelerating electron transfer and activating molecular oxygen to facilitate the generation of superoxide radical (O 2 ·- ) and singlet oxygen ( 1 O 2 ), thereby proceeding oxidative degradation of BPA molecules during photoreactions. The efforts and attempts are also extendable to synthesis other 2D photocatalysts, providing potential for effective charge-carrier separation and molecular oxygen activation.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）