ENVIRONMENTAL POLLUTION
·
2023
·
IF 8.9
Tao Pei,Feng Shi,Can Liu,Yi Lu,Xu Lin,Defa Hou,Shunxiong Yang,Jirong Li,Zhifeng Zheng,Yunwu Zheng
In this study, a novel nitrogen-doped magnetic Fe–Ca codoped biochar for phenol removal was successfully fabricated via a hydrothermal and coactivation pyrolysis method. A series of adsorption process parameters (K 2 FeO 4 to CaCO 3 ratio, initial phenol concentration, pH value, adsorption time, adsorbent dosage and ion strength) and adsorption models (kinetic models, isotherms and thermodynamic models) were determined using batch experiments and various analysis techniques (XRD, BET, SEM-EDX, Raman spectroscopy , VSM, FTIR and XPS) to investigate the adsorption mechanism and metal-nitrogen-carbon interaction. The biochar with a ratio of Biochar: K 2 FeO 4 : CaCO 3 = 3:1:1 exhibited superior properties for adsorption of phenol and had a maximum adsorption capacity of 211.73 mg/g at 298 K, C 0 = 200 mg/L, pH = 6.0 and t = 480 min. These excellent adsorption properties were due to superior physicomechanical properties (a large specific surface area (610.53 m 2 /g) and pore volume (0.3950 cm 3 /g), a well-developed pore structure (hierarchical), a high graphitization degree (I D /I G = 2.02), the presence of O/N-rich functional groups and Fe-Ox,Ca-Ox, N-doping, as well as synergistic activation by K 2 FeO 4 and CaCO 3 ). The Freundlich and pseudo-second-order models effectively fit the adsorption data, indicating multilayer physicochemical adsorption. Pore filling and π-π interactions were the predominant mechanisms for phenol removal, and H-bonding interactions, Lewis-acid-base interactions, and metal complexation played an important role in enhancing phenol removal. A simple, feasible approach with application potential to organic contaminant/pollutant removal was developed in this study.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS SCIENCE FORUM
·
2014
·
IF 0
Fang Wei Qi,Xue Gang Luo,Xiao Yan Lin
In present study, two kinds of CaCO3 with micro-sized and nanometer-sized particles were treated by pimelic acid (PA) with different proportion. Then the treated particles (the total content of micro-sized and nanometer-sized CaCO3 particles was 10 wt%) were mixed with polypropylene (PP) to prepare CaCO3/PP composites by melting blending. The crystallization behavior and morphology of composites were studied by wide-angle-X-ray diffraction (WAXD), differential scanning calorimetry (DSC) and polarized microscope (PLM), respectively. Compared with PP and other samples, the content of β-crystal in the composite NCP2 where the ratio of nanoand micro particles was 2:8 (NCP2), reached the highest values. The growth speed of crystals in PP matrix was much quicker, leading to the larger spherulites than the NCP2 and NCP8. The time of complete nucleation for NCP8 was lower than PP, but higher than NCP2.
研究领域:
材料科学
·
高分子科学
·
复合材料
✓ 已验证
DOI
VACUUM
·
2023
·
IF 4
Zhihua Liu,Qiaoling Liu,Xiaoyu He,Yihai Zhu,Qunlong Pan,Rongmou Zhang,Haiming Yu
Failure of surgical treatment is usually the result of bacterial colonization around the implant. This subsequently brings about various diseases such as peri-implantitis and sepsis. The purpose of this study was to develop and evaluate the antimicrobial properties of polydopamine adhered eggshell powder-loaded copper sulfide antimicrobial coatings. Here, we used eggshell powder-loaded copper sulfide as an antimicrobial agent to form an antimicrobial coating on the surface of titanium alloy screws using the chelating action of polydopamine. The coating showed good antibacterial effects against both Gram-positive and Gram-negative bacteria represented by Staphylococcus aureus and Escherichia coli . A series of subsequent characterizations confirmed the perfect loading of the material on the screws, and subsequent friction experiments on porcine femurs also demonstrated the good adhesion of the antimicrobial coating. Meanwhile, cytotoxicity assessment was performed by the CCK-8 method, confirming cellular biosafety. This work explores the value of eggshell-loaded CuS nanomaterial coatings in the prevention and treatment of orthopedic endothelial infections, which contributes to the translational application of novel antimicrobial materials in the clinical setting and has important social and economic value.
研究领域:
材料科学
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生物材料
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生物医学工程
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抗菌技术
·
骨科
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Jian Shi,Xuesong Jiang,Jifei Sun,Boyuan Ban,Jingwei Li,Jian Chen
Silicon/carbon composite anodes with void space are widely touted as a promising candidate for lithium-ion batteries (LIBs), providing a good volume change tolerance to maintain the integrity of the electrodes. However, the void space is usually created by complicated and environmentally-unfriendly methods with corrosive HF. Herein, a 3D hierarchical porous carbon framework supported silicon-based composite with void space (Si@Voids@PC) is synthesized by diluted HCl-assisted etching a self-assembly CaCO 3 template method coupled with pyrolysis of citric acid as the carbon source. The Si@Voids@PC electrode exhibits reversible capacity retention of 1527 mAhg −1 at 200 mAg −1 after 200 cycles with an initial discharge specific capacity of 3060.6 mAhg −1 and an initial Coulomb efficiency of 74.4%, which is superior to most of that in the reported literatures. This unique structure can not only provide more pathways for lithium ion diffusion and electron transfer but also maintain the integrity of the electrodes. Besides, the effect of lithiation behavior on the solid electrolyte interphase (SEI)-related problems is observed and discussed. This work might provide a facile and green method to synthesize silicon-based anodes with excellent electrochemical performance, and it also can be applied to the design of other materials with porous architecture.
研究领域:
材料科学
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能源科学
✓ 已验证
DOI
高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Yuan Liu,Yingxin Li,Guilan Xue,Wenxiong Cao,Zhanlin Zhang,Chaomin Wang,Xiaohong Li
Geometry and mechanical property have emerged as important parameters in designing nanocarriers, in addition to their size, surface charge, and hydrophilicity . However, inconsistent and even contradictory demands regarding the shape and stiffness of nanoparticles have been noted in blood circulation, tumor accumulation, and tumor cell internalization . Herein, CaCO 3 nanorods (NRs) with an aspect ratio of around 2.4 are assembled with hyaluronic acid (HA) hydrogel layers to prepare CaCO 3 @HA NRs. The rod geometry enables lower recognition by macrophages and higher extravasation into tumor tissues than the spherical counterpart. In response to the slightly acidic tumor matrix, the acid-labile removal of CaCO 3 templates achieves shape switching into spherical HA nanocapsules (NCs). The shape switchable CaCO 3 @HA NRs show significantly higher uptake and cytotoxicities to 4T1 cells than CaCO 3 [email protected] NRs with silica layers on CaCO 3 cores to inhibit shape switching. In addition, HA NCs with 2 − 8 layers of HA hydrogels exhibit stiffness from 1.85 to 12.3 N/m, and the assembly of 4 layers shows 2- to 3-fold higher cellular uptake than those of other NCs. The shape shift satisfies long-term blood circulation of NRs, and the resulting stiffness-adjustable NCs promote tissue infiltration and intracellular accommodation, resulting in a 4-fold higher drug accumulation in tumors. The CaCO 3 @HA NR treatment significantly suppresses tumor growth; prolongs animal survival; inhibits lung metastasis; and eliminates systemic toxicities to blood, liver, kidney, and heart tissues. This study achieves a comprehensive understanding of the shape and stiffness effects and demonstrates a hierarchical targeting strategy to address the multiple delivery barriers for chemotherapeutic agents. Statement of significance The different barriers involved in the drug delivery pathway have inconsistent and even contradictory demands on the shape and stiffness of nanoparticles. In the current study, in situ switching of nanorods (NRs) into spherical nanocapsules (NCs) in tumor tissues is proposed to address these dilemmas. The NR shape ensures long-term blood circulation and high tumor tissue accumulation , while the in situ switching into NCs promotes tissue infiltration and cellular internalization. NCs with different numbers of hydrogel layers also provide a robust system wherein NC stiffness is controlled as a single variable to study stiffness-dependent cellular behaviors. Thus, this straightforward design offers a comprehensive understanding of how the shape and stiffness of nanocarriers affect their biological pathways.
研究领域:
纳米技术
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药学
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生物医学工程
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癌症研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2013
·Vol. 1
·期 9
·1326-1332
·
IF 0
Wei Cui,Yue Cui,Jie Zhao,Junbai Li
Layer-by-layer assembled TRAIL/ALG shells have been successfully coated on the surface of highly loaded doxorubicin (DOX) calcium carbonate (CaCO3) nanoparticles as drug carriers. The assembled core/shell structure was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). They show that the assembled TRAIL/ALG coated DOX@CaCO3 nanocomposites can be internalized by cancer cells. The outer layer of the system is TRAIL which can be specifically recognized by tumors and leads to the apoptosis of tumors. The release of DOX can directly kill the cancer cells. This demonstrates that the core/shell nanocomposites of TRAIL/ALG-CaCO3 loaded with DOX have good potential applications in the treatment of cancer.
研究领域:
生物医学工程
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纳米医学
·
肿瘤学
✓ 已验证
DOI
PubMed
Biomaterials Science
·
2019
·Vol. 7
·期 9
·3614-3626
·
IF 5.251
Yihong Gong,Yiling Zhang,Zhinan Cao,Feng Ye,Zefeng Lin,Yan Li
Injectable scaffolds have attracted much attention because of their minimum surgical invasiveness. However, limited osteogenic induction property and low mechanical properties hampered their application in bone tissue engineering. CaCO3 microspheres, which possess osteoinductivity, rough surfaces and specific binding sites for BMP-2, were first fabricated; after BMP-2 uploading, microspheres were further entrapped in fibrin-glue hydrogel. CaCO3 microspheres were co-functionalized with casein and heparin. To obtain a high encapsulation of heparin and thus BMP-2 uploading, along with controlled release and simultaneous maintenance of the presence of vaterite which had osteogenic induction property, fabrication parameters were optimized and microspheres were characterized using XRD, FITR and SEM. The formed CaCO3 had a microsphere morphology of ∼1 μm. Both vaterite and calcite phases were present and the relative amount of calcite phase increased with the amount of heparin. Sample 25 mM_4-1Hep with the highest loading amount of heparin was selected as carrier for BMP-2 and BMP-2 loaded CaCO3 microspheres were further entrapped in fibrin-glue hydrogel (FC-B). For the as-prepared composite hydrogel, mechanical properties were characterized and the presence of CaCO3 significantly elevated the tensile strength; controlled release of BMP-2 was sustained until day 21. Based on ALP activity, alizarin red staining and RT-PCR, in vitro osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) was found to be significantly enhanced under induction of FC-B. Rabbit tibia bone defect model was applied to evaluate its in vivo performance. After implantation for 4 weeks, presence of composite hydrogel was observed in defects. After 8 weeks, bone defects of FC-B group were nearly completely healed. Using the fact that autologous scaffolds can be derived based on fibrin-glue hydrogel, the well-designed BMP-2 loaded fibrin-glue composite hydrogel demonstrated good potential in bone tissue engineering.
研究领域:
组织工程
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生物材料
·
骨再生
·
药物递送系统
✓ 已验证
DOI
PubMed
高影响因子
Energy Technology
·
2022
·Vol. 10
·期 9
·2200163
·
IF 4.149
Yan Cui,Jiahui Chen,Jingyang Zhao,Zhen Ma,Yuming Tan,Jianjun Xue,Hanliang Xu,Junmin Nan
Based on a strategy of stabilizing the LiMn 2 O 4 (LMO) cathode interface, the high-temperature cycling and storage performance of 18 650-type LMO/graphite lithium-ion batteries (LIBs) is effectively improved. The LMO cathode is prepared using lithium carboxymethyl cellulose (CMCLi)–polyacrylic acid/acrylate copolymer composite binder and nanoscale CaCO 3 functional component (marked as binder C). Compared with the traditional oily binder, the dissolution of Mn 2+ from LMO cathode into the electrolyte can effectively decrease, and the structure stability of LMO cathode can increase. The batteries exhibit retention capacity of 80.3% at 1 C after 600 cycles at room temperature and 76.7% at 1 C after 200 cycles at temperature of 45 °C. The high-temperature storage performance is also improved and there are 81.1% and 73.5% residual capacities when the fully charged batteries are stored in 60 °C for 14 and 28 days. The enhanced performance is mainly attributed to the interfacial stability of LMO cathode due to the bonding ability of composite binders and the elimination of HF by CaCO 3 . These results reveal the application prospect of as-developed aqueous binders and provide a way to improve the performance of LMO-based LIBs through stable interface strategy.
研究领域:
材料科学
·
电化学
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电池技术
✓ 已验证
产品关联
DOI
高影响因子
BIOCHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 3.9
Peng-Cheng Chen,Yao-Dan Zhang,Pu Zheng,Ruo-Xi Sun,Dan Wu
The efficiency of multi-enzyme immobilization is often influenced by the carrier and immobilization techniques employed. In this work, we proposed a ternary enzyme cascade reaction system composed of β-glucosidase (β-G), glucose oxidase (GOD) and horseradish peroxidase (HRP). CaCO 3 microspheres served as a template for in situ immobilization, while poly (allylamine hydrochloride) (PAH) and sodium poly (4-styrene sulfonate) (PSS) were utilized to create PAH-CaCO 3 and PSS-CaCO 3 templates for layer-by-layer multi-enzyme immobilization. The effects of template structure, glutaraldehyde (GA) addition, ethylenediaminetetraacetic acid (EDTA) concentration, and the structure of layer-by-layer assembly were systematically investigated. Our results indicated that an assembly of PSS-CaCO 3 --PAH--β-G--HRP--GOD presented simultaneous high enzyme loading and relative activity. The loadings of β-G, GOD and HRP were 75.2 ± 2.0%, 87.7 ± 4.4% and 85.5 ± 3.2%, respectively, while the relative activities were 81.8 ± 2.7%, 93.6 ± 4.7% and 90.6 ± 3.1%, respectively. Kinetic parameters confirmed that the reaction rate of the immobilized ternary enzymes in this assembly was close to that of the free enzymes. This work provides insights for constructing other multi-enzyme cascade reaction systems using immobilization techniques.
研究领域:
生物技术
·
酶工程
·
材料科学
✓ 已验证
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2023
·
IF 12.6
Huanhuan Li,Wenhui Geng,Zhixiong Qi,Waqas Ahmad,Suleiman A. Haruna,Quansheng Chen
In this work, a stimuli-responsive SERS biosensor was fabricated for tetracycline (TTC) by “signal-on” strategy using (EDTA)-driven polyethyleneimine grafted calcium carbonate ( [email protected] 3 ) microcapsule and chitosan-Fe magnetic microbeads ( [email protected] ). Initially, aptamer conjugated magnetic-bead [email protected] @Apt with superparamagnetism and excellent biocompatibility was employed as capture probe, which facilitated the rapid and easy magnetic separation. Subsequently, the PEI cross-linked layer and aptamer network layer were constructed onto the outer layer of CaCO 3 @4-ATP microcapsule to form sensing probes ( [email protected] 3 @ [email protected] ) via the layer-by-layer assembly method. In the presence of TTC, a sandwich SERS-assay was exploited by aptamer recognition induced target-bridged strategy. When the solution of EDTA was added, the core layer of CaCO 3 would be dissolved quickly, destroying the microcapsule to release 4-ATP. The released 4-ATP could be quantitatively monitored by dripping the supernatant onto the [email protected] SERS platform, resulting in a strong Raman “signal-on”. Under the optimal conditions, a good linear relationship was established with a correlation coefficient ( R 2 ) of 0.9938 and a LOD of 0.03 ng/mL. Additionally, the application capacity of the biosensor to detect TTC was also affirmed in food matrixes, and the results were consistent with the standard ELISA method ( P > 0.05). Hence, this SERS biosensor affords extensive application prospects for TTC detection with multiple merits such as high sensitivity, environment friendliness, and high stability.
研究领域:
分析化学
·
环境科学
·
食品安全
·
生物传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Mashiti Sha,Huansong Li,Yangsui Liu,Cong Tang,Xue Bai,Yun Wang,Bo Yuan,Kairui Liu,Xiaoning Gao,Jun Yan,Silong Wei,Jin Chang,Jun Kang
Cancer immunotherapy has improved the survival rate of patients with malignant tumors. However, the response of solid tumors to immunotherapy is quite limited. Here, we report a pH-responsive nanocomposite for augmented sonodynamic-chemodynamic immunotherapy. This Mn-CaCO 3 -2,2′-azobis[2-(2-imidazolin-2-yl) propane]-dihydrochloride (AIPH) nanosystem, Lipo@MCA, was prepared through a simple two-step reaction. It released sonosensitizer AIPH and Ca 2+ within the acidic tumor microenvironment. AIPH generated alkyl free radicals under ultrasound irradiation, and Mn 2+ produces ·OH through Fenton-like reaction. The Ca 2+ induced calcium overload in tumor cells. This induced mitochondrial dysfunction and promoted tumor cell apoptosis. Lipo@MCA also inhibited the phosphorylation of Akt and PI3K. In vitro experiments indicated that the nanoparticle inhibited tumor cell invasion and migration, and induced tumor cell apoptosis. In vivo experiments demonstrated that Lipo@MCA inhibited tumor growth by promoting cytokine secretion, stimulating dendritic cell maturation, and enhancing T-cell differentiation. In summary, this study paves the way for synergistic inhibition of tumor cell metastasis and immunotherapy in solid tumors through PI3K signaling pathway inhibition.
研究领域:
癌症治疗
·
纳米技术
·
免疫学
·
细胞生物学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
Translational Oncology
·
2023
·
IF 5
Jiale Cai,Guiping Hu,Lihua Hu,Junge Chen,Dan Chen,Dan Liu,Xiaolei Wang,Boxian Hu,Cheng Li
Introduction Sonodynamic therapy (SDT) has potential clinical applications for cancer therapy, and is yet restricted by complex tumor microenvironmental (TME) factors. Thus, the research problem of TME modulation as well as efficient tumor treatment still needs to be clarified. Method In this study, a calcium carbonate (CaCO 3 ) nanoplatform was designed for ultrasound (US) and TME response-triggered, which encapsulated Ag 2 S and loaded with l -Arg, and further wrapped with RBC/Platelet membrane, named as QD@Ca/M L-Arg . Results Non-invasive US-triggered SDT by Ag 2 S and acidic environment-responsive drug release were achieved. In vitro experiments validated the efficacy of SDT, Ca-ion interference and nitric oxide (NO) gas therapy as combined therapy for cancer treatment. By means of RNA sequencing, the cancer therapeutic mechanism of SDT in redox-related pathways was elucidated. The immunosuppressive TME was simulated with a M2-macrophage/cancer cell co-culture system to confirm the immune activating effect of immunogenic cell death (ICD). Conclusion Accordingly, the potential of QD@Ca/M L- Arg- was demonstrated for in vitro TME modulation, cancer therapeutic efficacy and clinical translation.
研究领域:
癌症治疗
·
纳米技术
·
生物医学工程
·
分子生物学
·
免疫学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）