ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2023
·
IF 11.4
Xiangrui Wang,Wen-Xiong Wang
Cu-based nanoparticles (NPs) have been increasingly fabricated, and different Cu species (i.e., Cu+ and Cu2+) of these NPs are tuned to achieve differential physicochemical properties. Although ion release is one of the major toxic mechanisms of Cu-based NPs, differences in cytotoxicity between released Cu(I) and Cu(II) ions are largely unknown. In this study, the A549 cells exhibited a lower tolerance to Cu(I) compared with Cu(II) accumulation. Bioimaging of labile Cu(I) indicated that the change of the Cu(I) level upon CuO and Cu2O exposure displayed different trends. We then developed a novel method to selectively release Cu(I) and Cu(II) ions within the cells by designing CuxS shells for Cu2O and CuO NPs, respectively. This method confirmed that Cu(I) and Cu(II) exhibited different cytotoxicity mechanisms. Specifically, excess Cu(I) induced cell death through mitochondrial fragmentation, which further led to apoptosis, whereas Cu(II) resulted in cell cycle arrest at the S phase and induced reactive oxygen species generation. Cu(II) also led to mitochondrial fusion, which was likely due to the influence of the cell cycle. Our study first uncovered the difference between the cytotoxicity mechanisms of Cu(I) and Cu(II), which could be greatly beneficial for the green fabrication of engineered Cu-based NPs.
研究领域:
毒理学
·
细胞生物学
·
纳米医学
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DOI
PubMed
高影响因子
CHEMOSPHERE
·
2019
·
IF 5.108
Jiajun Long,Longqian Xu,Linghui Zhao,Huaqiang Chu,Yunfeng Mao,Deli Wu
In this study, Cu(0) was synthesized with NaBH 4 as a reducing agent for Cu(II) and used to activate dissolved molecular oxygen (O 2 ) under acidic conditions. The Cu(0) synthesized had much higher activity than the purchased. The roles of Cu was clarified and the formation of reactive oxygen species was discussed through direct detection for the first time. By detecting the valence change of Cu in a CuO system, Bisphenol A (BPA) was found to accelerate the transformation of Cu(II) to Cu(I). Besides, the evidence from electron spin resonance (ESR) studies and scavenging tests revealed the new roles of Cu(0) that Cu(0) could not only convert O 2 to produce ·O 2 − , but also catalyze H 2 O 2 to ·OH. The results from this study offer evidence of new reaction pathways in Cu-activated O 2 systems and deepen understanding of the reaction between Cu species and O 2 .
研究领域:
环境科学
·
化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
ChemSusChem
·
2023
·Vol. 16
·期 14
·e202300180
·
IF 8.4
Yinjian Zheng,Zhiyuan Wang,Peng Chen,Wenbiao Zhang,Qingsheng Gao
Graphical Roughness-dependence of Cu electrodes is for the first time identified in the electro-reductive coupling of nitro and carbonyl compounds. With increased roughness, the selectivity of nitrones decreases, while that of imines increases, thanks to the feasible control over the reduction of nitroarenes to hydroxylamines or amines on Cu I /Cu 0 interfaces. The electro-reductive coupling of nitro and carbonyl compounds enables a facile, environmentally friendly and energy benign transformation toward value-added nitrones or imines, but the selectivity is still challenging. Here, the surface roughness of Cu electrodes is introduced for the first time as the determinant to switch products from nitrones to imines owing to the controllable reduction of nitroarenes to hydroxylamines or amines on tailored Cu I /Cu 0 interfaces. The roughness-dependent selectivity, that is the decrease of nitrones and the increase of imines with enhanced roughness, is visible in the electro-reductive coupling of nitrobenzene and furfural. Thus, the high selectivity of nitrone (98 %) and imine (80 %) can be achieved on a surface smooth Cu foil and the one electrochemically roughened in the presence of I − , respectively. Such roughness-dependence of nitrone/imine selectivity on Cu electrodes is further verified in a wide substrate scope, highlighting the promise of surface/interfacial engineering for electrochemical synthesis.
研究领域:
电化学
·
有机合成
·
材料科学
·
表面科学
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产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2020
·Vol. 12
·期 36
·4473-4478
·
IF 2.596
Shuihua Wu,Weiqing Cheng,Zhixin Li,Fang Luo,Longhua Guo,Bin Qiu,Zhenyu Lin
The amount of copper affects the quality of herbal medicine greatly, it is necessary to develop some simple and sensitive methods to detect copper for the remote or resource-limited area. An electronic balance is one of the most familiar equipment that can be found nearly in all laboratories. The presence of Cu(I) can catalyze azide–alkyne cycloaddition reaction (called as click chemistry) with high efficiency. In this study, a simple method had been developed to detect copper ions in herbal medicine using an electronic balance as a readout device based on click chemistry. Cu(II) is reduced to Cu(I) by sodium ascorbate in situ, which induces the “click” reaction between azido–DNA modified magnetic beads (MB–DNA) and alkynyl–DNA modified platinum nanoparticles (Pt NP–DNA) and results in the fixing of the platinum nanoparticles on the beads (called as MB–Pt NPs). MB–Pt NPs can be separated by a magnetic frame easily and transferred into a drainage reaction device containing hydrogen peroxide. Then, hydrogen peroxide can be decomposed by Pt NPs modified on MB to generate oxygen, which increases the pressure in the drainage reaction device and forces the water in the system to be discharged. The weight of the discharged water can be easily and accurately measured by an electronic balance. The weight of the water has a linear relationship with Cu(II) in the range of 2.0–200 μM and a detection limit of 0.83 μM under 30 min of collected time. This method does not need complicated and expensive instruments, skilled technicians, and a complex data processing process. The proposed method had been applied to detect copper ions in herbal medicine with satisfactory results.
研究领域:
分析化学
·
药学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 33
·16183-16191
·
IF 3.925
Ping Ouyang,Rui Zhang,Jian Zhou,Haiyan Liu,Zhichang Liu,Chunming Xu,Shaojuan Zeng,Qian Su,Xiangping Zhang,Xianghai Meng
The effective electrochemical recovery of metal for bimetallic composite ionic liquid (IL) is related to the ion species and even the reaction mechanism under different Cu(I) contents. Thus, bimetallic composite ILs (Et3NHCl–1.54AlCl3–xCuCl, x = 0–0.23) were synthesized to investigate the Cu(I) speciation, voltammetric behavior and electrodeposition mechanism under different Cu(I) contents. For the cyclic voltammogram, three cathodic peaks of Et3NHCl–1.54AlCl3–0.010CuCl were related to the reduction of Cu(II) to Cu(I), Cu(I) to Cu(0), and Al(III) to Al(0), respectively. Meanwhile, for Et3NHCl–1.54AlCl3–0.23CuCl, the cathodic and anodic peaks were related to the redox reaction of copper. The whole offline detection of bimetallic composite ILs showed that the anodic reaction under low content of Cu(I) (≤ 0.60 wt%) was dominated by the generation of chlorine gas, while the cathodic reaction was related to the potential. However, when the Cu(I) content was higher than 2.23 wt%, only the disproportionation reaction of Cu(I) occurred and CuCl2 was obtained on the anode. Long-term electrodeposition showed that the effective recovery of copper from industrial bimetallic composite IL was realized. This study lays a good foundation for the clear understanding and comprehensive implementation of the resource utilization.
研究领域:
电化学
·
材料科学
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DOI
高影响因子
CHEMISTRY LETTERS
·
2016
·Vol. 45
·期 9
·1051-1053
·
IF 1.55
Wang Luanjiao,Rao Pinhua,Yao Wei,Zhang Wenqi
CuSn-codoped CdS (CdS:CuSn) quantum dots (QDs) with different Cu(I) and Sn(IV) doping levels have been successfully synthesized by a simple one-pot procedure. It was found that the doping ratio of Cu(I) and Sn(IV) in CdS QDs significantly affected the photoluminescence (PL) quantum yields (QYs), Stokes shifts, and emission window of as-prepared QDs. Compared to single Cu doping, CuSn codoping further significantly improved the PL QYs of as-prepared QDs (up to 24.6%). The CdS:CuSn QDs may be used as potential emitters in the PL industry.
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DOI
高影响因子
JOURNAL OF CATALYSIS
·
2025
·
IF 6.5
Juan Chen,Linmeng Wang,Hongyi Gao,Rushuo Li,Zhiyuan Liu,Tao Ban,Shunzheng Zhao,Jichao Yang,Ge Wang
Single-atom catalysts (SACs) catalysts have unique electronic properties and geometric structures, offering maximum atom-utilization efficiency. Noble metal-free SACs anchored within metal–organic frameworks (MOFs) enable precise tuning of electronic structures and significantly enhance catalytic activity beyond conventional porous materials. Herein, we synthesized the synthesis of Cu(I)/Ce-MOF-808-EA by anchoring atomically dispersed Cu(II) species onto the open Ce 6 nodes of the Ce-MOF-808 framework, followed by in situ reduction to Cu(I) via ethanol treatment and thermal activation processes. The atomic dispersion and valence transformation of Cu sites on Ce-MOF-808 were confirmed by X-ray Absorption Spectroscopy (XAS), high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), and X-ray photoelectron spectroscopy (XPS). The resulting Cu(I)/Ce-MOF-808-EA exhibited outstanding catalytic performance for the hydrogenation of Dicyclopentadiene (DCPD), achieving 100 % conversion, 91.54 % selectivity toward Dihydrodicyclopentadiene (DHDCPD), and 8.45 % selectivity toward Tetrahydrodicyclopentadiene (THDCPD) at 100 °C, 2 MPa. Notably, Cu(I)/Ce-MOF-808-EA outperformed other transition metal catalysts (Co/Ce-MOF-808-EA, Ni/Ce-MOF-808-EA and Zn/Ce-MOF-808-EA). For the first time, Density Functional Theory (DFT) calculations, combined with experimental investigations, revealed a low-energy reaction pathway for DCPD hydrogenation, wherein Cu(I) sites, in cooperation with adjacent oxygen atoms, act as bi-active centers to heterolytically cleave H 2 into proton and hydride species (*H δ+ -H δ- ) for subsequent hydrogenation. This study underscores the potential of MOFs as versatile platforms for engineering single-atom catalysts with enhanced catalytic properties.
研究领域:
化学
·
材料科学
·
催化
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产品关联
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Tianrui Li,Baoling Tang,Jiance Jin,Kai Han,Haoran Zhang,Hailian Zhao,Xuejie Zhang,Maxim Molokeev,Yuzhen Wang,Zhiguo Xia,Bingfu Lei
Cu(I)-based halide scintillators are promising candidates for X-ray detection due to excellent scintillation and low-cost solution processability. However, the rational design of Cu(I)-based halide scintillators remains challenging due to insufficient theoretical frameworks elucidating their structure-property correlations. In this work, two Cu(I)-based hybrid metal halides, Cu 2 I 4 -IC (Ionic compound) are designed and Cu 4 I 4 -CC (Coordination compound) via bonding mode control engineering. The Cu 2 I 4 -IC exhibits blue emission, and the Cu 4 I 4 -CC exhibits yellow emission, and the photoluminescence quantum yield (PLQY) of Cu 2 I 4 -IC and Cu 2 I 4 -IC are 91% and 100% respectively. The non-radiative transitions are reduced due to the high rigidity of Cu 4 I 4 , resulting in a light yield up to 67 500 photons MeV −1 and a detection limit as low as 47.3 nGy s −1 of Cu 4 I 4 -CC. Additionally, a high-performance scintillator hydrogel based on Cu 4 I 4 -CC with polyvinyl alcohol (PVA),H 2 O and dimethyl sulfoxide (DMSO) is innovatively developed. Owing to the high transmittance, the large-area scintillator hydrogel film (10 × 10 cm 2 ) achieves an X-ray imaging resolution of 14 lp mm −1 . Furthermore, the synergistic effects of hydrogen bonding and coordination bonding endow the hydrogel scintillator with excellent plasticity and flexible stretchability. The Cu 4 I 4 -CC@PVA hydrogel proves promising for X-ray imaging with excellent stability in harsh environments, matching state-of-the-art scintillators.
研究领域:
材料科学
·
核医学
·
生物医学工程
·
放射影像学
·
无机化学
·
高分子材料
·
功能材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science China-Materials
·
2026
·
IF 7.7
He Jiaman,Kang Liwen,Zeng Weigang,Shi Wanxin,Ling Qidan,Lin Zhenghuan
Organic-inorganic hybrid metal halides (OIMHs) based on Cu(I) ions show broad application prospects in the field of stimulus-responsive luminescent materials based on their rich structural diversity and highly adjustable electronic state. However, achieving sensitive and broad-temperature-range thermal responses for OIMHs remains a significant challenge, despite the growing interest in smart luminescence materials. In this study, 4-morpholinopiperidine (4-MP) and CuI are used to synthesize a zero-dimensional warm white-light emitting OIMH, namely MPC-W ((C 9 H 20 N 2 O) 4 (Cu 2 I 4 )(Cu 2 I 6 )(H 2 PO 2 ) 2 ), which features hybrid structures of [Cu 2 I 4 ] 2− and [Cu 2 I 6 ] 4− . Owing to the coexistence of three luminescent mechanisms-organic cluster luminescence (CL), self-trapped exciton (STE) emission of [Cu 2 I 6 ] 4− , and cluster-centered (CC) state luminescence of [Cu 2 I 4 ] 2− , MPC-W exhibits temperature and excitation wavelength-dependent dynamic luminescence. When the temperature is increased from 77 to 297 K, the luminescence color of MPC-W can be continuously tuned from blue to cyan, green, yellow-green, and white. In the range of 217–463 K, MPC-W displays an abnormal luminescence enhancement phenomenon with increasing temperature. Additionally, upon chemical stimulus, MPC-W can reversibly transform into a blue-light emitting crystal named MPC-B ((C 9 H 20 N 2 O)Cu 2 I 4 ), and a yellow-light emitting crystal named MPC-Y ((C 9 H 18 N 2 O) 7 Cu 8 I 8 ). These unique dynamic luminescent properties endow MPC-W with great application potential in temperature sensing, optical anti-counterfeiting, and password locks. The work provides a new insight for the development of novel wide temperature-responsive multifunctional intelligent luminescent materials.
The alternative text for this image may have been generated using AI.
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Fei Yu,Xueting Bai,Mingxing Liang,Jie Ma
Considering the increasingly serious levels of antibiotic pollution, it is necessary to find new and efficient adsorbents. In this study, the adsorptive removal of a model quinolone antibiotic, ciprofloxacin (CIP), from wastewater is presented using a metal–organic framework (MOF)-derived carbon. HKUST-1-derived carbon (HDC-1100) was obtained by high-temperature carbonization of the HKUST-1 precursor at 1100 °C. HDC-1100 has a regular octahedron shape decorated with Cu/Cu 2 O particles and has a microporous and mesoporous structure with abundant oxygen-containing functional groups on the surface. Within 48 h, HDC-1100 could reach adsorption equilibrium for 30 mg·L -1 CIP, and the kinetic data were fitted with a pseudo-first-order model and a pseudo-second-order model. In this study, the maximum adsorption capacity of HDC-1100 for CIP was as high as 592 mg·g −1 . The high adsorption capacity is attributed mainly to metal–organic complexation, electrostatic interactions, and hydrogen bonding. Also, the effects of environmental factors, such as pH, ionic strength, and humic acid, on the adsorption capacity were considered. This study is significant for the treatment of high-concentration antibiotic-polluted wastewater.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2023
·
IF 2.9
Qinhong Yin,Xiaolan Yang,Lihua Yang,Dezhi Yang,Yaling Yang,Yanqin Zhu
As newly developed synthetic enzymes with exceptional catalytic capabilities and outstanding stability, nanozymes have drawn considerable interest in the realm of sensing. Using a simple hydrothermal process, iodine and copper-doped carbon dots (Cu,I-CDs) with simulated enzymes were fabricated in the current investigation. Cu,I-CDs demonstrate peroxidase-mimicking function together with high catalytic effectiveness due to aforementioned features. This led to generation of a colorimetric sensor for quick and accurate quantitative assessment of morphine (MOR). The outcomes showed the method's usefulness for the colorimetric detection of MOR. The linear range for MOR detection is 0.25–25 μg/mL having a reduced detection limit of 64 ng/mL. This sensor's successful use in the analysis of MOR in biological material is more noteworthy.
研究领域:
生物传感
·
纳米酶研究
·
医学检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF INORGANIC BIOCHEMISTRY
·
2021
·
IF 4.155
Rui-Xue Liu,Ru-Yi Luo,Meng-Ting Tang,Yan-Cheng Liu,Zhen-Feng Chen,Hong Liang
Based on the anticancer pharmacophore of anthrahydrazone and quinoline, a new quinolylanthrahydrazone ligand, 9-AQH (anthracene-9-quinolylhydrazone), was synthesized to further afford four metal complexes, [Co II (9-AQH)(NO 3 ) 2 (H 2 O)] ( 1 ), [Ni II (9-AQH) 2 (H 2 O) 2 ]·2NO 3 ( 2 ), [Cu I (9-AQH) 2 ]·NO 3 ( 3 ), [Zn II (9-AQH) 2 (NO 3 )]·NO 3 ( 4 ), determined by X-ray single crystal diffraction analysis. The reaction of Cu(NO 3 ) 2 with 9-AQH formed the stable and repeatable copper(I) complex 3 . In vitro screening demonstrated only 3 showed significant and broad-spectrum anticancer activity , indicating that Cu(I) played a key role in exerting the anticancer activity. In solution, Cu(I) was not naturally oxidized to Cu(II) suggested by 1 H-NMR (Nuclear Magnetic Resonance) and EPR (Electron Paramagnetic Resonance) analysis. The presence of 3 could also catalyze the H 2 O 2 system to give hydroxyl free radicals , suggested by further EPR and electrophoresis assay. At the cellular level, although no obvious Cu(II) signals were detected and the total ROS (Reactive Oxygen Species) scavenging in the tumor cells treated with 3 , the potential redox property between Cu(I)/Cu(II), as a key role, should not be denied for the significant anticancer activity of 3 , considering the much complicated circumstance and other reductive substances in cells. The anticancer mechanism of 3 on the most sensitive MGC-803 cells pointed to significant cell apoptosis through mitochondrial pathway, rather than cell cycle arrest . While the autophagy observed in tumor cells treated by 3 suggested its complicated anticancer mechanism, and whether there was an intrinsic correlation still needed to be further investigated.
研究领域:
无机化学
·
药物化学
·
癌症研究
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
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