Communications Biology
·
2023
·Vol. 6
·期 1
·1-14
·
IF 5.9
Zhu Haixia,Wen Zongzhuang,Zhang Aizhen,Liu Dongyue,Wang Hongxiang,Cheng Yin,Yang Xing,Xiao Yu,Li Jianyuan,Sun Daqing,Wu Bin,Gao Jiangang
Spermatogenesis is an extremely complex process, and any obstruction can cause male infertility. RhoGDIα has been identified as a risk of male sterility. In this study, we generate RhoGDIα knockout mice, and find that the males have severely low fertility. The testes from RhoGDIα −/− mice are smaller than that in WT mice. The numbers of spermatogonia and spermatocytes are decreased in RhoGDIα −/− testis. Spermatogenesis is compromised, and spermatocyte meiosis is arrested at zygotene stage in RhoGDIα −/− mice. Acrosome dysplasia is also observed in sperms of the mutant mice. At the molecular level, RhoGDIα deficiency activate the LIMK/cofilin signaling pathway, inhibiting F-actin depolymerization, impairing testis and inducing low fertility in mouse. In addition, the treatment of RhoGDIα −/− mice with Rac1 inhibitor NSC23766 alleviate testis injury and improve sperm quality by inhibiting the LIMK/cofilin/F-actin pathway during spermatogenesis. Together, these findings reveal a previously unrecognized RhoGDIα/Rac1/F-actin-dependent mechanism involved in spermatogenesis and male fertility.
研究领域:
生殖生物学
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细胞生物学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Decheng Li,Guyue Li,Yifan Yu,Chilin Li
Fluoride ion batteries (FIBs) have garnered significant attention due to their ultrahigh theoretical energy density, dendrite-free safety, and resource abundance. Although some anion acceptors have been proposed to address the insolubility of inorganic fluoride salts, the difficulty in dissociating fluoride ions from acceptors results in short lifespan and extremely low specific capacity of FIBs. Here, a fluoride ion battery is demonstrated with unprecedented long life and ultrahigh specific capacity through the design of an acceptor-multi-F state electrolyte. The high Lewis acidity of triphenylantimony chloride (TSbCl) as a novel anion acceptor in electrolyte facilitates the complete dissociation of CsF, and the resulting TSbCl-F complex can further interact with fluoride ions to form the acceptor-multi-F states. This strategy combines the high dissociation capability for fluoride salts with the minimal thermodynamic barriers for releasing fluoride ions at electrode-electrolyte interface. This electrolyte design endows FIBs with durable reversible fluorination/defluorination reaction (3700 cycles with high coulombic efficiency of 99.5% and small voltage polarization of 30 mV) and ultrahigh reversible capacity (580 mAh g −1 after 40 cycles at 100 mA g −1 ). The high-output voltage FIBs of CuF 2 //Li configuration (with discharge plateau of 2.9 V) and larger-sized pouch-type FIBs of CuF 2 //Sn+SnF 2 configuration (with reversible capacity of 530 mAh g −1 ) are demonstrated.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Kaifeng Yang,Fangming Han,Yafeng Jin,Xiaobo Li
Herein, a stable and ultra-sensitive rutin electrochemical sensor was successfully developed. This sensor based on glassy carbon electrode (GCE) modified with C-GCS@ZIF-F/PL nanocomposite, which was made of thermally carbonized glucose (GCS) doped with flower-like ZIF (ZIF-F) and pencil lead (PL). The electrochemical response of rutin was considerably significant at C-GCS@ZIF-F/PL/GCE, demonstrating favorable conductivity and electrocatalytic properties for detection of rutin. Under optimal conditions, the linear range is 0.1–100 μM, with a low detection limit (LOD) of 0.0054 μM. It also exhibits excellent stability, reproducibility, as well as selectivity over common interfering ions such as Na + , uric acid, quercetin and riboflavin, etc. Meanwhile, the practical utility of developed sensor was evaluated in food samples including honey, orange, and buckwheat tea, achieving satisfactory recovery rates ranging from 98.2% to 101.7%. This paper introduces a novel technique for the detection of rutin in foods.
研究领域:
分析化学
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食品科学
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电化学传感器
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产品关联
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 10
·2298-2304
·
IF 7.779
Jiongquan Chen,Wenqi Jin,Yanhui Zhang,Yun Yang,Zhihua Yang,Shilie Pan
A new alkaline-earth and rare-earth borate fluoride, Ba10LuB18O32F13, the first example of borate in the Lu–B–O–F system, has been successfully synthesized in a high-temperature vacuum system. It crystallizes in the orthorhombic system, with the Fmm2 space group and the parameters a = 16.5749(6) Å, b = 16.7644(9) Å, c = 13.6222(6) Å, and Z = 4. It represents a new fundamental building block (FBB), [B9O22], with the notation 9:[2(4:2Δ + 2T) + T], in which two [BO3] triangles and two [BO4] tetrahedra are enclosed into a [B4O10] ring and every two [B4O10] rings are bridged by a [BO4] tetrahedron. The [B9O22] FBBs are further condensed into a 3D network with two types of channels that accommodate Ba2+ and Lu2+ cations. The UV cut-off edge is below 190 nm, indicating the application potential of Ba10LuB18O32F13 in the DUV region. Additionally, to further explore the structural novelty of Ba10LuB18O32F13, a comparison with all anhydrous borates with 18 boron atoms in their chemical formula was carried out. The fascinating results indicate that [B9O22] has been discovered for the first time, enriching borate fluoride structure chemistry.
研究领域:
材料科学
·
晶体学
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产品关联
DOI
高影响因子
ACS Omega
·
2020
·
IF 2.87
Ming Hu,Xue-Qiong Yang,Cui-Fang Wang,Tong-De Zhao,Dai-Li Wang,Ya-Bin Yang,Zhong-Tao Ding
Six new polyketides named paraverrucsins A–F (1–6) with oxabicyclic and dioxatricyclic skeletons, together with eight known metabolites (7–14), were discovered and isolated from the fermentation medium of Paraphaeosphaeria verruculosa. Paraverrucsin A–C possessed a novel decarboxylated skeleton compared with that of trichocladinols. Their structures were elucidated by extensive spectral analysis and DP4+ calculations. Paraverrucsins B/C and D/E were isolated as a mixture for the mutarotation occurred at C-2. Paraverrucsins B/C, D/E, F/trichocladinol B, 8, and 9 displayed antifeedant activities against silkworm larvae, with antifeedant index percentages ranging from 62.5 to 93.0%, at a concentration of 50 μg/cm2. Among them, Paraverrucsins B/C and 9 had EC50 values at 13.9 and 18.2 μg/cm2. Most compounds showed antifungal activities against phytopathogenic fungi with minimum inhibitory concentration (MIC) values of 16–64 μg/mL. Coculture of P. verruculosa and host plant Dendrobium officinale leads to the enhancement of antifeedant and antiphytopathogenic activities. Compounds 1, 2/3, 4/5, 6/14 were tested for cytotoxicity against five human carcinoma cell lines, HL-60, A549, MCF-7, SW480, and SMMC-7721, while they exhibited selected cytotoxicity against SW480 with inhibition ratios of 32–38% at a concentration of 40 μM.
研究领域:
天然产物化学
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植物病理学
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药理学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Gangan Wang,Chaoyi Chen,Junqi Li,Fan Yang,Linzhu Wang,Xin Lin,Hao Wu,Jun Zhang
Brown corundum fly ash (BCFA) is a solid waste from the brown corundum smelting process that contains abundant Ga, K, Si, and Al, but effectively extracting Ga can be challenging since most of it is located inside the particles. This study proposes a comprehensive utilization method of BCFA that combines hydrothermal leaching and alkali regeneration to extract Ga efficiently while producing silica-potassium compound fertilizer (SPCF) and zeolite F. By utilizing the transformation of phase and structure in the hydrothermal leaching process, Ga extraction is efficiently achieved. The results showed that under the conditions of 210 g/L KOH concentration, a liquid solid ratio of 25 mL/g, and 160 °C hydrothermal leaching for 60 min, the extraction efficiencies of Ga, K, and Si were 95.91 %, 51.78 %, and 69.57 %, respectively. The solid product’s effective SiO 2 and K 2 O contents increased to 24.72 wt% and 17.74 wt%, respectively, which can be further used as SPCF for agricultural production. The hydrothermal leaching solution was regenerated by adjusting the Al/Si molar ratio and crystalizing at 160 °C for 24 h. The Si was recovered in the form of high value-added zeolite F, with only a 3.60 % loss of Ga.
研究领域:
环境科学
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材料科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
De Zhao,Zhihua Wu,Wei Zhang,Jian Yu,He Li,Wen Di,Yourong Duan
To date, ZnO array-based microfluidic fluorescence assays have been widely investigated and have exhibited excellent performance in the detection of cancer biomarkers. However, the requirements of highly sensitive detection necessitate further improvement of current Zn-based fluorescence detection devices. Here, a rhombus-like Zn(OH)F array-based microfluidic fluorescence detection device is proposed. Construction of Zn(OH)F arrays on the inner wall of a microchannel is carried out via a microfluidic chemical method. A substrate-induced growth strategy for Zn(OH)F arrays is proposed, and various micro/nanostructured Zn(OH)F arrays are successfully obtained. Zn(OH)F nanorod arrays with a high aspect ratio can be constructed on the columnar ZnO nanorod arrays, and the results indicate that the fluorescence enhancement factor (EF) of the Zn(OH)F arrays toward Cy3 is approximately 4-fold that of the ZnO nanorod arrays, which can be attributed to the higher excitation light absorption and evanescent electric field. In human epididymis-specific protein 4 (HE4) detection, the limit of detection (LOD) reaches 9.3 fM, and the dynamic linear range is 10 fM to 100 pM. It has been demonstrated that Zn(OH)F nanorod array-based microfluidic devices are excellent fluorescence assay platforms that also provide a new design and construction strategy for fluorescence enhancement substrates for the detection of biomarkers.
研究领域:
材料科学
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生物医学工程
·
分析化学
✓ 已验证
DOI
高影响因子
Analytical Methods
·
2015
·Vol. 7
·期 18
·7625-7630
·
IF 1.821
Yi Li,Jinhui Zhou,Xiaofeng Xue,Liming Wu,Lanzhen Chen,Jinzhen Zhang,Shuming Yang
An optimization method of NBD-F derivatization has been developed for the determination of proline in honey using high performance liquid chromatography (HPLC) with fluorescence detection. To determine the free proline in different samples of honey, ultrasound extraction was performed using 0.1 M borate buffer solution as the extraction solvent. Chromatographic separation was performed on a XDB C18 column (150 × 4.6 mm i.d.) using 0.1 M sodium acetate buffer solution (pH 7.2) : methanol : tetrahydrofuran (900 : 95 : 5, respectively, v/v/v) as mobile phase A and methanol as mobile phase B at a flow rate of 1.0 mL min−1 with a run time of 10 min. The assay was linear over a range of 0.15 μg mL−1 to 100.00 μg mL−1 with a lower limit of detection of 3.00 mg kg−1, and recoveries were greater than 90%. The intra-day and inter-day precision was less than 4%. This method was successful in determining free proline in honey, ranging from 80.5 mg kg−1 to 426.4 mg kg−1 in different honey samples.
研究领域:
分析化学
·
食品科学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Zihan Yang,Jingkai Yang,Lixia Li,Wanning Cao,Jiao Zhang,Hongli Zhao,Liqin Wang
The challenge of creating effective S-scheme visible-light photocatalysts persists due to the inactive visible-light-driven component and the low band-gap characteristics of semiconductors. In this work, we developed a novel F-BiVO 4 /g-C 3 N 4 /CdS dual S-scheme photocatalyst using a sonochemical method. The removal efficiency of Cr(VI) and ciprofloxacin (CIP) can reach 98 % and 90 % in 5 min and 30 min, respectively, under simulated solar illumination. The excellent photocatalytic activity can be attributed to the efficient carrier separation and transport with the help of internal electric field at the interface. This work also reveals the reduction process of Cr(VI), as well as the intermediates and pathways involved in the CIP degradation, taking into account practical situations and expanding its potential applications. This research presents promising prospects for the design of bismuth-based dual S-scheme heterojunctions in the field of environmental remediation.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 55
·期 26
·12103-12113
·
IF 3.553
Jin Tianxiang,Chen Jianfa,Wang Chunyan,Qian Yong,Lu Limin
A three-dimensional (3D) fluorine-doped graphene aerogel (FGA) with rich semi-ionic C–F bonds was synthesized via a facile hydrothermal method and applied as the electrode material in supercapacitor. A porous 3D network structure with a high specific surface area of the FGA has been confirmed by the combination of scanning electron microscopy, transmission electron microscopy and N 2 adsorption method. X-ray photoelectron spectroscopy spectra indicated that the FGA was doped predominantly with semi-ionic C–F bonds, which ensured the high electronic conductivity and sufficient electrochemistry active sites of FGA. As a result, the FGA electrode showed a high specific capacity of 279.8 F g −1 at a current density of 0.5 A g −1 , which is much better than that of undoped graphene aerogel (UGA, 141.6 F g −1 ). Even though the current density increased to 10 A g −1 , 90.6% of its specific capacitance was retained. The FGA also maintained about 94.3% of the initial capacitance after 5000 cycles at a current density of 0.5 A g −1 . Furthermore, the assembled FGA//FGA symmetric supercapacitor presented a high energy density of 26.2 W h kg −1 at a power density of 899 W kg −1 . Accordingly, this work offers a facile and efficient approach to produce fluorine-doped graphene materials for high-performance supercapacitor applications.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Yanan Liu,Guangyan Wang,Shuaishuai Lu,Siqi Wang,Peijuan Jiang,Huan Chen,Fang Jiang
Pollution caused by per - and polyfluoroalkyl substances (PFASs) has raised global health concerns and there is an urgent need for researchers to find effective treatment methods. The covalent triazine framework (CTF) adsorbent materials with different structures based on various precursors using the ionothermal method were prepared and characterized in this study. Among them, F-doped CTF (F-CTF) is favorable for effective mass transfer in the adsorption process due to its rich microporous structure and large specific surface area. The maximum adsorption capacity (q max ) for PFOA reached 769.2 mg/g under the synergistic effect of electrostatic force and the interaction of F F. After six cycles of adsorption-desorption experiments, the adsorption and desorption rates of the F-CTF 400°C were stable at >90 %. This result indicates that F-CTF 400°C possesses high stability and recyclability. Furthermore, the desorption solution containing a high concentration of PFOA was treated directly by a UV/Na 2 SO 3 system, utilizing the e aq − within the system to decompose PFOA. The reduction and defluorination efficiencies for the desorption solution with high concentrations of PFOA reached 90 % and 40 %, respectively. The study results indicate that by leveraging the high adsorption selectivity and stable recoverability of F-CTF 400°C , the UV/Na 2 SO 3 system can completely remove PFOA. This approach offers a novel solution for the elimination of PFOA pollution in the environment.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 2
·213
·
IF 5.719
Hongli Ye,Lukai Zhao,Xinghui Ren,Youqiong Cai,Hai Chi
An approach to the detection of F−ions in food samples was developed based on a “switch-off-on” fluorescence probe of silicon nanoparticles (SiNPs). The fluorescence of the synthetic SiNPs was gradually quenched in the presence of Fe3+ion and slightly recovered with the addition of F−ion owing to the formation of a stable and colorless ferric fluoride. The fluorescence recovery exhibited a good linear relationship (R2= 0.9992) as the concentration of F−ion increased from 0 to 100 μmol·L−1. The detection limit of the established method of F−ion was 0.05 μmol·L−1. The recovery experiments confirmed the accuracy and reliability of the proposed method. The ultraviolet–visible spectra, fluorescence decays, and zeta potentials evidenced the fluorescence quenching mechanism involving the electron transfer between the SiNPs and Fe3+ion, while the fluorescence recovery resulted from the formation of ferric fluoride. Finally, SiNPs were successfully applied to detect F−ions in tap water, Antarctic krill, and Antarctic krill powder.Keywords:determination;Fe3+ion;F−ion;fluorescence switch-off-on;silicon nanoparticles;Antarctic krill
研究领域:
分析化学
·
食品科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）