Nanoscale
·
2015
·Vol. 8
·期 2
·1140-1146
·
IF 7.394
Chunmei Gao,Shaoyu Lü,Mingzhu Liu,Can Wu,Yun Xiong
The synthesis and properties of CO2 responsive and fluorescent dendritic polymers, poly(amido amine)/Pluronic F127 (PAMAM/F127), are reported in this paper. The morphologies and sizes of PAMAM/F127 dendritic polymers were investigated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). PAMAM/F127 dendritic polymers showed unimolecular micelle morphologies at low concentrations, and changed to multimolecular micelles at higher concentrations. Additionally, fluorescence spectra and confocal laser scanning microscopy images showed that PAMAM/F127 dendritic polymers exhibited a fluorescent enhancement response to the presence of CO2. Apart from that, the release behavior of PAMAM/F127 gels under simulated body fluids was investigated by choosing curcumin as the hydrophobic drug. The results indicated that PAMAM/F127 dendritic polymers can be used to improve the solubility of curcumin, and the drug released faster in the presence of CO2. Such CO2 responsive fluorescent dendritic polymers are potentially applicable in cellular imaging or drug controlled release.
研究领域:
材料科学
·
生物医学工程
·
药学
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 30
·期 36
·2002488
·
IF 16.836
Xuanyu Yang,Penghao Lu,Lei Yu,Panpan Pan,Ahmed A. Elzatahry,Abdulaziz Alghamdi,Wei Luo,Xiaowei Cheng,Yonghui Deng
Mesoporous carbon matrix with open pore structure, short diffusion length, and large pore size can favor the in-pore immobilization of active species and facilitate mass diffusion during catalytic reactions. However, a great difficulty still remains on controllable synthesis of uniform mesoporous carbon spheres with these structural characteristics. Herein, using amphiphilic Pluronic F127 as the surfactant, 1,3,5-trimethyl benzene (TMB) as the pore swelling and interface-adjusting agent, and dopamine as the carbon source, a robust emulsion-induced interface assembly approach for rational synthesis of mesoporous carbon spheres is demonstrated. The interface assembly process, including dopamine polymerization and fusion of TMB/F127/dopamine emulsions, can be regulated by tuning the dosage of dopamine and ammonia water, resulting in mesoporous carbon spheres with tunable pore sizes and versatile architectures, such as vesicles, walnut shapes, spheres with dendritic-like 3D radially aligned mesochannels (RA-MC), and isolated spherical mesopores. Moreover, the derived RA-MC is used as a promising matrix to immobilize ultra-small Au nanoparticles (≈3 nm). The Au/RA-MC exhibits no mass diffusion limitations in reduction of 4-nitrophenol, showing high conversion efficiency and good recyclability. This work paves a new avenue for controllable synthesis of mesoporous carbon spheres with well-developed mesoporosity and architectures and their application as novel heterogeneous catalysts.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
Science of Advanced Materials
·
2017
·
IF 1.671
Zhang Xiong,Li Yuebin,Cai Yaxuan,Zhang Yi,Tian Yiqun,Wang Lin,Gu Haoshuang,Chen Wei
Fluorescent dye-doped silica nanoparticles (FDSNPs) have exhibited great potential in applications including solid-state lighting, chemical sensing, and biological theranostics. However, the wide application of FDSNPs is still a big challenge due to the lack of efficient synthesis strategy.
Herein, red fluorescent hybrid silica nanocapsules (FHSNCPs) were assembled by a green, convenient, and benign method based on Pluronic®F127 micelles as a soft template. Morphologies, structures, sizes, and fluorescence properties of the as-prepared silica nanocapsules were
characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier Transform Infrared Spectroscopy (FTIR) and fluorescence spectroscopy. The size of the silica nanocapsules was well controlled from 20.5 nm to 23.6 nm by varying the concentration of F127 and tetramethylorthosilicate
(TMOS). Further investigations reveal that these nanocapsules exhibit monodisperse size, stable aqueous dispersibility, and novel optical properties, which show great potential for fluorescence imaging and temperature monitoring in biological tissues.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
光学
✓ 已验证
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2016
·
IF 3.782
Tingting Zhao,Xin Liu,Yuebin Li,Mingguang Zhang,Jian He,Xuewen Zhang,Hui Liu,Xingguo Wang,Haoshuang Gu
Hydrophobic ZnSe:Mn/ZnS core-shell fluorescence quantum dots (QDs) and anticancer drug paclitaxel (PTX) have been co-loaded into folate conjugated hybrid silica nanocapsules via F127 micelles based soft-template method in a mild aqueous environment at room temperature . The encapsulation of QDs shows a F127: QDs mass ratio dependent behavior, which impact much on the morphology and optical properties of composite nanocapsules . These as prepared composite nanocapsules also exhibit good photoluminescence stability under the temperature ranges from 19 °C to 49 °C. In addition, the aqueous solubility of PTX (0.1 μg/mL) can be efficiently enhanced about 630 times to 62.99 μg/mL, and the loaded PTX could be released during 12 h sustainably. These tunable fluorescence, enhanced drug loading efficiency and sustained release behavior manifest that the hybrid nanocapsule is a promising theranostic nanoplatform for future combined fluorescence imaging and chemotherapy.
研究领域:
生物医学工程
·
纳米医学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER ENGINEERING
·
2017
·Vol. 38
·期 4
·371-379
·
IF 0.658
Wanli Ye,Lidan Zhu,Shan Xia,Xiumei Zhang
The purpose of this investigation is to develop a dual pH-/temperature-responsive and fluorescent hydrogel based on piperazine and Pluronic F127 (PF127). Firstly, polyurethane was synthesized using 1,6-hexamethylene diisocyanate, 1,4-bis(hydroxyethyl) piperazine, and PF127 by a step polymerization process. Erythrosine B (EB) is then incorporated into copolymers to offer a fluorescence property. The polyurethane-PF127-EB copolymer can spontaneously self-assemble into hydrogels with a great number of closely packed micelles, and the hydrogels also have the ability to undergo thermo-sensitive sol-gel phase transition above the critical gelation concentration. The gelation temperature can be adjusted near the physiological condition by modulating the concentration of the copolymer in an aqueous medium. The acid-titration curves indicate a good pH-responsive property, and the UV-vis and fluorescence spectra exhibit strong self-fluorescence signals for hydrogels. As a result, the hydrogels not only can serve as drug carriers but can also be utilized as fluorescence imaging probes in biomedical applications.
研究领域:
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2014
·Vol. 140
·期 3
·797-802
·
IF 3.906
Chong Sun,Daoying Wang,Muhan Zhang,Yanxiu Ni,Xiaohui Shen,Youchao Song,Zhiming Geng,Weimin Xu,Fang Liu,Chun Mao
The development of advanced nanomaterials for the highly efficient electrical detection of biological species has attracted great attention. Here, novel polypyrrole-Pluronic F127 nanoparticles (PPy-F127 NPs) with conducting and biocompatibility properties were synthesized and used to construct a L-lactic acid biosensor that could be applied in biochemical assays. The PPy-F127 NPs were characterized by transmission electron microscopy (TEM), elemental analysis and UV-vis spectroscopy. Lactate oxidase (LOx) structure variation on the PPy-F127 NPs was investigated by circular dichroism (CD). The cyclic voltammetric results indicated that LOx immobilized on the PPy-F127 NPs exhibited direct electron transfer reaction with a formal potential value (E0′) of 0.154 V vs. SCE. Moreover, the biosensor had good electrocatalytic activity toward L-lactic acid with a wide linear range (0.015–37.5 mM) and a low detection limit of 0.0088 mM. The regression equation was I (μA) = 0.02353c (mM) + 1.4135 (R2 = 0.9939). The L-lactic acid biosensor had a good anti-interference property towards uric acid (UA), ascorbic acid (AA), glucose and cysteine. The idea and method provide a promising platform for the rapid development of biosensors that can be used in the detection of biological species.
研究领域:
生物化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qianyi Lin,Xin Liu,Xiangji Li,Junlong Yu,Wangdu Luo,Yujie Rao,Lin Xie
Glaucoma is an irreversible blinding eye disease characterized by the loss of retinal ganglion cells (RGCs), posing a significant threat to human visual health. Currently available, clinical treatments for glaucoma cannot completely suppress the progression of RGC death in glaucoma. Eriodictyol (Eri) has been shown to possess various biological activities, including anti-inflammatory, antioxidant, and neuroprotective effects. However, its low water solubility and bioavailability hinder its clinical application. To address these challenges, we developed a ROS-responsive liposome (Lip@Eri) embedded within an F127-CHO/Gel-NH₂ hydrogel (FG/Lip@Eri) for intraocular delivery of Eri, and further evaluated its ability to suppress ferroptosis and mitigate RGC loss. This drug delivery system enhanced the bioavailability of Eri and demonstrated excellent biocompatibility. In vitro, Lip@Eri inhibited glutamate-induced ferroptosis in R28 cells by reducing iron accumulation and lipid peroxidation, associated with PI3K–AKT pathway activation. Further in vivo experiments demonstrated that FG/Lip@Eri effectively suppresses ferroptosis, protects RGCs, and preserves visual function. Therefore, FG/Lip@Eri may represent a novel strategy for neuroprotection in glaucoma.
研究领域:
眼科学
·
神经科学
·
药物递送系统
·
生物材料
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2022
·
IF 5.195
Bin Du,Mengmeng Zhao,Yuehua Wang,Lili Yu,Qingqing Jiao,Yimeng Bai,Genyang Cheng
The oxidative stress and activation of the fibrosis pathway are essential pathological mechanisms of acute kidney injury (AKI). In this article, we designed a drug delivery system that could effectively improve oxidative stress and relieve fibrosis by the combination of precise targeting, solubilization, and reducing the toxicity of nano-transport system to strengthen the efficacy of AKI. Folic acid (FA) was used as the targeting molecule, and curcumin (Cur) and resveratrol (Res), which are Chinese medicine monomers with anti-inflammatory and antioxidant effects, were used as model drugs. Here, the targeting nanosystem (Cur/ [email protected] /TPGS) co-loaded with Cur and Res was successfully synthesized. Finally, the comprehensive therapeutic effect of the nanosystem was evaluated through the targeted and pharmacodynamic researches on the AKI models induced by cisplatin (CDDP) in vitro and in vivo . The studies in vitro proved that the nanosystem could not only specifically target HK-2 cells and promote the effective accumulation of Cur and Res in the kidney, but also effectively improve oxidative stress by eliminating reactive oxygen species (ROS), stabilizing mitochondrial membrane potential (MMP), and reducing the expression of apoptosis-related proteins. The studies in vivo showed that the nanosystem could effectively play the role of anti-oxidation, anti-inflammatory and alleviate fibrosis to reduce the apoptosis and necrosis of renal tubular cells. The nanosystem could coordinately repair damaged HK-2 cells by improving oxidative stress, inhibiting inflammation and tissue fibrosis, which provided a new idea for the treatment of AKI.
研究领域:
药学
·
纳米技术
·
药理学
·
肾脏生理学
·
治疗学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
·
IF 5.268
Baohuan Wu,Sixiang Sai,Keke Li,Xingchen Sun,Jingtian Han,Baocheng Tian
Drugs that are topically applied on the eyes have low bioavailability, which has always been an important problem. In this study, maleimide functionalized, voriconazole (VCZ) loaded mixed micelles (Mal-VCZ-MM) were designed. Pluronic F127 and phospholipid were used as materials, and maleimide was used as an adhesive. The prepared Mal-VCZ-MM was nearly spherical with a particle size of 84.45 ± 1.39 nm and a zeta potential of − 20.3 ± 0.29 mV. The encapsulation efficiency of Mal-VCZ-MM was 95.33 ± 0.06%, and it had high stability with a critical micelle concentration value of 1.28 × 10 -4 mg/mL. CCK-8 assay showed that its cytotoxicity was lower than that of free VCZ solution (VCZ-Sol). Both quantitative and qualitative analyses of the HCE-T cellular uptake showed that the cellular internalization of Mal-C6-MM was significantly stronger than that of C6-MM. The endocytosis pathway was macropinocytosis-mediated, cavernous-mediated, and energy-dependent. In vitro results against Candida albicans showed that the diameters of the antifungal inhibition zones of VCZ-Sol, VCZ-MM, and Mal-VCZ-MM were 15.5 ± 0.50 mm, 24.0 ± 0.71 mm, and 31.5 ± 1.12 mm, respectively. The antifungal effect of Mal-VCZ-MM was significantly higher than that of VCZ-Sol and VCZ-MM ( P < 0.001). This study shows that Mal-VCZ-MM is a highly effective hydrophobic ophthalmic drug-delivery carrier that can improve the therapeutic effect of the drug.
研究领域:
药剂学
·
药物递送
·
眼科学
·
微生物学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2018
·
IF 0
Xiang-Qian Zhang,An-Hui Lu,Qiang Sun,Xiao-Fei Yu,Jun-Yue Chen,Wen-Cui Li
Ordered carbon spheres with enlarged mesopores have been considered to be desirable carbon electrodes for ionic liquid-based supercapacitors. New synthesis of these materials to use commercially available soft templates is yet to be developed. In this study, we demonstrate that by silica encapsulation of self-assembled polymer nanospheres prepared using commercially available Pluronic F127, mesopore sizes of obtained carbon nanospheres can be enlarged from micropores to large mesopores up to 10.7 nm in size. A linear relationship between the mesopore size and the thicknesses of silica nanocages has been established, which enables us to alter the mesopore sizes in a controlled manner. The two-electrode test in EMI-BF4 electrolyte demonstrates that mesoporous carbon nanospheres show a capacitance of up to 113 F g–1 at 10 A g–1. They also exhibit an excellent energy density (E) of 56 W h kg–1 (working voltage of 4.0 V). Such high capacitance, outstanding rate capability, and excellent power density (P) are owing to enlarged mesoporous channels and large specific surface area allowing rapid mass transportation and full use of the surface area.
研究领域:
材料科学
·
能源存储
✓ 已验证
产品关联
DOI
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2019
·
IF 1.163
Huayao Chen,Junlong Hu,Hongjun Zhou,Xinhua Zhou,Hua Xu
The triblock copolymer F127 (molecular formula (EO)106(PO)70(EO)106) was adopted as template with TMOS as the silica source. They were hydrolyzed by acidic aqueous solution in which chlorpyrifos (CH) and metal ions (Mn+) were introduced to the products to construct "F127-Mn+-CH" coordination structure in one step. Different sustained release systems were prepared through changing the composition of acidic aqueous solution added during the preparation. The characterization results confirmed the coordination interaction existing among metal ions, mesoporous silica and chlorpyrifos. It was also proved that the chlorpyrifos loaded in the sustained release system existed as amorphous state. According to SEM and TEM observation, the pore of the material presented as face-centered cage-type cubic structure with IM-3M symmetry similar to SBA-16 which is in accordance with N2 adsorption isotherms. The as-synthesized system showed significant pH sensitivity in the sustained release process indicating that the sustained release system can be well stored in neutral environment and activated while sprayed into earth in acid or basic environment. Their sustained release curves can be described by Korsmeyer-Peppas equation in neutral while accords with Higuchi under acid or basic environment.
研究领域:
材料科学
·
纳米技术
·
药物递送系统
·
环境化学
·
农药制剂
✓ 已验证
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9
Ying Wang,Linlin Geng,Xiaoya Wang,Jianwen Wei,Xuecong Ma,Lei Liao
Amine-modified adsorbents exhibit remarkable potential for efficient CO 2 capture. In this study, a series of amine-based bifunctional solid adsorbents for CO 2 capture was synthesized via an impregnation method. Fe Zr cyanide frameworks were first functionalized with Pluronic F127, followed by the immobilization of diethanolamine (DEA) and tetraethylenepentamine (TEPA) at different loadings (20–40 wt%). Among the resulting materials, FZ(F)-D35% (DEA) and FZ(F)-T35% (TEPA), exhibited the maximum CO 2 adsorption capacity at 45 °C, reaching 1.846 and 2.377 mmol·g −1 . Compared with the unmodified material (FZ), which exhibits an adsorption capacity of 0.989 mmol/g, they increased by 47% and 59%, respectively. After 6 adsorption-desorption cycles, FZ(F)-D35% and FZ(F)-T35% still retained 93.4% and 95.2% of their original capacities, respectively, exhibiting excellent cycling stability. Kinetic analysis indicated that the adsorption process followed the Avrami model (R 2 = 0.999), suggesting a dual mechanism involving both physisorption and chemisorption. Infrared spectroscopy further confirmed the formation of carbamate and hydrogen bonding during the CO 2 adsorption, highlighting the critical synergistic role played by amine groups and hydroxyl groups in the CO 2 adsorption mechanism. It can therefore be inferred that the CO 2 adsorption mechanism is consistent with the zwitterion mechanism. These findings highlight the potential of amine-functionalized Fe Zr cyanide frameworks as robust, regenerable adsorbents for moderate-temperature CO 2 capture.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）