ANALYTICAL LETTERS
·
2019
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IF 1.248
Xiaoyan Wang,Weiyang Shen,Xiaolei Zhang,Siyan Guo,Ye Gao,Xiaotong Li,Fang Feng,Gongjun Yang
A novel method for the indirect electrochemical determination of ribavirin based on boronic acid-diol recognition was developed using the platform as the sensing element. The device was constructed using a 3-aminophenylboronic acid (APBA)-electrochemically reduced graphene oxide (ERGO) modified electrode. When the electrode was immersed in a solution of ribavirin, complexation of boronic acid groups of APBA with ribavirin occurred at the surface of the electrode and simultaneously caused steric hindrance, resulting in a current decrease because the ferricyanide redox probe was unable access the surface. Under the optimized conditions, a linear relationship was obtained between the relative change in current (%Δi) of [Fe(CN)6]3−/4−and the concentration of ribavirin at levels from 10.0 to 7.50 × 102 ng mL−1. The proposed electrochemical sensor performed with acceptable sensitivity and reproducibility and was successfully used to determine the content of ribavirin in an injection with satisfactory results.
研究领域:
分析化学
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药物分析
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生物医学工程
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2023
·
IF 8.4
Ming Sui,Yanni Huang,Yang Tang,Jiaoyang Luo,Yiyang Dong,Yifei Guo,Yonggui Ma,Wei Gu,Mengyue Guo,Jingdan Huang,Dandan Kong,Jinping Li,Meihua Yang
Medicinal teas (MT) were popular in Asian countries for its various effective components. However, Pb pollution poses a serious threat to MT consumption due to the irreversible effect on enzyme activity and neurodegenerative disease. Owing to its toxicity and matrix interference, a rapid screening method for Pb at trace level with high sensitivity and accuracy is urgent for MT consumers. Herein, a simple and ultra-sensitive AuNPs/MWCNTs-MB/DNA-GCE quadruplex biosensor was developed and investigated. Specifically, the monitoring technology of scanning electrochemical microscope was utilized to analyze the assembly and application process for screening key parameters in complex matrix , through in-situ characterization of the microstructure changes on stepwise modified sensors. According to the combined results of electrochemical test and Randles-Sevcik equation, the proposed sensor showed a wide linear range from 5.0 * 10 −15 to 5.0 * 10 −13 M with LOD of 0.9 fM. In addition, the optimized sensor exhibited an excellent selectivity under the inference of metals and medicinal components. The proposed biosensor was successfully implemented for the ultrasensitive monitoring Pb pollution in MT while its water infusions recoveries maintained within acceptable range (81–118 %, 82–129 %). In all, AuNPs/MWCNTs-MB/DNA-GCE provided a new insight into the design, optimization, application and mechanism analysis of sensor for reliable sensing in controlling MT pollution and consumption safety.
研究领域:
分析化学
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环境科学
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材料科学
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生物技术
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产品关联
DOI
高影响因子
ANALYTICAL LETTERS
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2022
·
IF 2.267
Chunya Yu,Na Li,Ruiying Zhang,Dezhen Xie,Fei Li,Qiue Cao
Kanamycin (KAN) is a widely used aminoglycoside antibiotic that has attracted attention due to its presence in food and the environment. In order to obtain a simple, rapid, and sensitive method for kanamycin, an electrochemical sensor was fabricated by successively modifying a glassy carbon electrode (GCE) with reduced graphene oxide (rGO), poly(2-aminopyridine) (pAP) film, and a KAN molecularly imprinted membrane (KAN-MIM) that was prepared by electroreduction of graphene oxide and the electropolymerization of 2-aminopyridine and dopamine. The morphology and electrochemical parameters were characterized for the sensor designated by KAN-MIM/pAP/rGO/GCE. As a result of the amplification of the modified electrode, excellent analytical performance was obtained on the bases of sensitivity, selectivity, repeatability, and stability. The linear range and limit of detection for kanamycin were from 0.02 to 250.0 μmol·L−1 and 7.0 nmol·L−1, respectively. The sensor was employed to determine KAN in pork and milk with recoveries from 89.2% to 109.0% and a relative standard deviation less than 6.0%.
研究领域:
分析化学
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食品科学
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环境科学
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产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2025
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IF 1.8
Qinqin Sun,Jing Wang,Zhengzheng Liu,Lujie Wang,Jun Zhang,Biaowei Liu,Liqiong Huang,Fei Yan,Jinsong Liu
Convenient and sensitive detection of hydroquinone (HQ) and catechol (CC) in environmental samples holds great importance for monitoring. Herein, a vertically-ordered mesoporous silica film (VMSF) supported on the electrochemically pretreated glassy carbon electrode (p-GCE) is prepared by a simple and environmentally friendly electrochemical method and employed to construct a sensitive and anti-fouling sensing interface for quantitative detection of HQ and CC. In virtue of a simple electrochemical polarization, the p-GCE shows enhanced electroactive area and promoted electrochemical activity, as well as oxygen-containing groups, rendering a sensitive electrode substrate with improved analytical performance and the functional interface for stable growth of VMSF. The obtained VMSF/p-GCE has superior electroanalytical capacity toward HQ and CC due to the synergistic effect of hydrogen bonding of VMSF and the sensitive p-GCE electrode substrate. The developed VMSF/p-GCE sensor enables the determination of HQ and CC with a wide linear range (1 ∼ 120 μM), high sensitivity (0.368 μA/μM for HQ and 0.404 μA/μM) and low limit of detection (268 nM for HQ and 80 nM for CC). Furthermore, the capacity of the prepared VMSF/p-GCE in the analysis of HQ and CC in environmental water samples and soil leaching solutions has been studied, showing acceptable results and therefore offering a simple and low-cost way for environmental analysis.
研究领域:
环境分析化学
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电分析化学
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传感器与生物传感器
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环境监测
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产品关联
DOI
高影响因子
ANALYTICAL LETTERS
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2024
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IF 1.6
Yan Li,Yaru Li,Fubin Wu,Jie Zhou,Yaoyao Wang,Guoliang Li,Jing Lan,Zongshan Zhao,Rongguang Shi
Hydrogen peroxide (H2O2) is widely used in the food industry as a bactericide due to its strong oxidizing ability. However, excess H2O2 in food can lead to chronic diseases, making it necessary to develop a rapid monitoring method. An electrochemical electrode based upon a glassy carbon electrode (GCE) modified with combined covalent organic framework (COF) and amino-modified multi-walled carbon nanotubes (MWNT-NH2) has been developed. The modifier was prepared by assembling the COF onto the surface of MWNT-NH2. Under optimal conditions, the performance of the modified electrode was evaluated by differential pulse voltammetry (DPV) with a linear range from 20 to 140 μM and a detection limit of 0.14 μM. In addition, the modified electrode had good stability and reproducibility. Good selectivity in presence of potential interferences and the successful application for the determination H2O2 in environmental water and chicken feet suggest its potential for practical analysis.
研究领域:
分析化学
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电化学
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纳米材料
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环境科学
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食品安全
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产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2021
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IF 6.901
Cuizhu Ye,Xingguang Chen,Dong Zhang,Junjun Xu,Huiting Xi,Tiantian Wu,Danwen Deng,Chunhong Xiong,Jinsheng Zhang,Ganhui Huang
Coated with polypyrrole (Ppy)-based molecularly imprinted polymer (MIP), 3D CoFe-metal organic frameworks (CoFe-MOFs) with gold nanoparticles (AuNPs) was developed for electrochemical trace detection of norfloxacin (NOR). On one hand, the trace detection of NOR was realized with MIP/CoFe-MOFs/AuNPs/Glassy carbon electrode (GCE). The effective surface area of the imprinted cavities capable of identifying NOR on MIP/CoFe-MOFs/AuNPs/GCE increased to 0.1058 cm 2 after 3D CoFe-MOFs/AuNPs was modified, which indicates that CoFe-MOFs/AuNPs could generate more imprinted cavities, thus contributing to a lower limit of detection (LOD) of 0.131 pmol L −1 (S/N = 3) with a wider linear range (5–100, 100–1000 and 1000–6000 pmol L −1 ). On the other hand, the recognition reaction to NOR by MIP/CoFe-MOFs/AuNPs/GCE is an irreversible electrochemical oxidation reaction involving an electron and a proton, controlled by a mixed adsorption-diffusion mechanism. Rapid and precise detection of NOR in prescription (norfloxacin capsules with the specification of 0.1 g) and pure milk with the recovery rates between 97.04 and 110.2% and the relative standard deviations (RSD) were less than 5.7%. The measured results by MIP/CoFe-MOFs/AuNPs/GCE were close to the commercial norfloxacin enzyme-linked immunosorbent assay (ELISA) kit, demonstrates its high potential to NOR trace detection in environmental and animal foods.
研究领域:
分析化学
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电化学
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材料科学
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环境科学
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食品科学
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产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
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2024
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IF 5.5
Qing Zhou,Kaiyu Lin,Yongxin Liu,Guohan Sun,Shumei Wang,Haiyun Zhai
A novel nonenzymatic electrochemical sensor with high sensitivity for detecting organic phosphate (OPS) in medicinal herbs was fabricated based on a Mg-Al layered double hydroxide (Mg-Al LDH) nanocomposite glassy carbon electrode (GCE) modified with a poly-m-amino-benzenesulfonic acid (p-m-ABSA) film. Depositing Mg-Al LDH nanocomposites onto the surface of the p-m-ABSA composite resulted in an effective electrical response by increasing the electrode surface area and enhancing the electron transfer process, so the electrocatalytic activity was significantly enhanced. The research illustrated that the fabricated sensor (Mg-Al LDH/p-m-ABSA/GCE) exhibited strong affinity, high sensitivity, and selectivity towards methyl parathion (MP) and fenitrothion (FNT). Scanning electron microscopy (SEM) was used to characterize the surface morphology of the modified electrode and showed that the p-m-ABSA film and a few p-m-ABSA nanoparticles were coated on the surface. The surface area of the electrode was further enlarged by Mg-Al LDH owing to their layered nanostructure. Under optimal conditions, the anodic current had a linear relation equal to 0.1∼20.0 µM MP and 0.01∼50.0 µM FNT, with detection limits (S/ N = 3) of 33.0 nM MP and 3.5 nM FNT, respectively. Furthermore, Mg-Al LDH/p-m-ABSA/GCE was successfully used for the detection of MP and FNT in Astragalus and Magnolia medicinal herb samples.
研究领域:
分析化学
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环境科学
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药学
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产品关联
DOI
高影响因子
International Journal of Electrochemical Science
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2023
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IF 1.5
Tianxiao Yu,Shikuan Hou,Xizhenzi Fan,Yanxia Qiao,Guohua Zhang,Lingli Wang,Jun Ge
In this work, an enzyme-free electrochemical immunosensor based on metal-organic framework (MOF) and single-wall carbon nanotube (SWCN) nanocomposite coated glassy carbon electrode (GCE) for rapid and sensitive detection of fibroblast growth factor 21 (FGF-21) was proposed. The synthesized MOF/SWCN were characterized by transmission electron microscopy (TEM). It exhibited high-speed charge mobility, excellent conductivity and high surface area, significantly amplifying the current signal response. Furthermore, to immobilize the FGF-21 capture antibody on the MOF/SWCN electrode surface in an ordered orientation, staphylococcal protein A (SPA) was introduced as a connecting element, which significantly increased the antigen-binding ability and immunosensor stability. Under optimal conditions, the wide linear range of the immunosensor was 1.00 pg mL -1 to 500 ng mL -1 , with a low detection limit was 0.35 pg mL -1 . Additionally, the immunosensor also showed excellent reproducibility and selectivity. It was also successfully used to detect FGF-21 in human serum samples with satisfying recoveries. Thus, the strategy provides a simple and sensitive method for FGF-21 detection, indicating significant potential applications in clinical diagnostics.
研究领域:
电化学
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纳米技术
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生物传感器
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临床诊断
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分析化学
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产品关联
DOI
高影响因子
ANALYTICAL LETTERS
·
2022
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IF 2.267
Wentang Zhao,Mei Wu,Lisha Mei,Hongling Li
An ultra-sensitive electrochemical immunosensor for detecting carcinoembryonic antigen was prepared. Graphene oxide-gold was used as the substrate modifier of the sandwich immunosensor. The high conductivity of graphene oxide effectively enhanced the electron transfer rate. The large specific surface area of graphene and the biocompatibility of gold nanoparticles increased the number of primary antibodies. The bovine serum albumin coated silver – platinum composite was used as a secondary antibody tag to prepare signal probes. The excellent biocompatibility of bovine serum albumin increased the number of secondary antibody connections. Silver nanoparticles increased the speed of electron transfer, and platinum further enhanced electrochemical sensing capabilities by catalyzing hydrogen peroxide. The immunosensor showed good performance for detecting carcinoembryonic antigen. Under the optimal conditions, the dynamic response range for carcinoembryonic antigen was from 0.005 ng·mL−1 to 100 ng·mL−1 with a detection limit of 0.76 pg·mL−1. The immunosensor also shown high selectivity, suitable stability, and good reproducibility, which provides new capabilities for clinical carcinoembryonic antigen detection.
研究领域:
生物医学工程
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肿瘤学
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分析化学
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 6
·1-12
·
IF 5.3
Xue Jinyan,Jia Yuzhen,Qi Linying,Yang Huaixia,Wang Yanzhi,Guo Liang
A novel aptamer-based sensor was developed using the signal amplification strategy of ring-opening metathesis polymerization (ROMP) and polyethyleneimine modified graphene oxide to achieve trace detection of carbendazim (CBZ). The dual identification of aptamer and antibody was used to avoid false positive results and improve the selectivity. Polyethyleneimine modified graphene oxide (GO-PEI), as a substrate material with excellent conductivity, was modified on the surface of a glassy carbon electrode (GCE) to increase the grafting amount of aptamer on the electrode surface. Moreover, a large number of cyclopentenyl ferrocene (CFc) was aggregated to form long polymer chains through ring-opening metathesis polymerization (ROMP), so as to significantly improve the detection sensitivity of the biosensor. The linear range of this sensor was 1 pg/mL–100 ng/mL with a detection limit as low as 7.80 fg/mL. The sensor exhibited excellent reproducibility and stability, and also achieved satisfactory results in actual sample detection. The design principle of such a sensor could provide innovative ideas for sensors in the detection of other types of targets. Graphical abstract
研究领域:
分析化学
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电化学
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生物传感器
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环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2020
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IF 6.306
Shanshan Wu,Zheng-Zhi Yin,Xiaohui Chen,Xueqing Wang,Datong Wu,Yong Kong
Poly(melamine) (PMel) was synthesized via the electropolymerization of melamine monomer, which was then characterized by field-emission scanning electron microscopy (FESEM), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The possible polymerization mechanisms of melamine were also revealed by FT-IR spectroscopy and UV–Vis spectroscopy. Next, the PMel modified GCE (PMel/GCE) was used for the simultaneous determination of nitrite (NO 2 − ) and tartrazine, and the parameters were optimized. The kinetic study showed that the electrochemical oxidation of nitrite and tartrazine at the surface of PMel/GCE is a typical surface-controlled electrode process. Under the optimun conditions, the developed sensor outperformed those previously reported, and it also exhibited high selectivity and reproducibility. Finally, the PMel/GCE was used for the simultaneous determination of nitrite and tartrazine in foodstuffs, and the results indicated that the proposed sensor could be a promising candidate for accurate determination of nitrite and tartrazine in real food samples.
研究领域:
分析化学
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电化学
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食品科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL LETTERS
·
2022
·
IF 2.267
Haiyang Wang,Yan Wang,Cuijie Zhang
A sensitive electrochemical platform for the determination of bisphenol A (BPA) was constructed. A hybrid of MoS2 quantum dots decorated poly sodium styrene sulfonate functionalized reduced graphene oxide (MoS2 QDS@PSS-rGO) was prepared by a simple method. The hybrid was cast on a bare glassy carbon electrode (GCE) to form the MoS2 QDs@PSS-rGO/GCE. The electrochemical response of BPA on the MoS2 QDs@PSS-rGO/GCE was significantly enhanced compared to the unmodified electrode, indicating that the nanocomposite possessed an electrocatalytic effect. A novel method was established to determine BPA with a detection limit of 0.008 μM. The applicability of the prepared sensor was demonstrated to determine BPA in real samples with high recoveries.
研究领域:
分析化学
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环境科学
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材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）