RSC Advances
·
2023
·Vol. 13
·期 34
·23976-23983
·
IF 3.9
Shiyi Tang,Ruohan Li,Tao Luo,Tianhao Huang,Xiaotong Lu,Xinyao Wu,Yulin Dong,Changyu Wu,Kai Xu,Yong Wang
Under near-infrared (NIR) light, gold nanobipyramids (AuNBPs) exhibit a high photothermal conversion rate and photothermal stability, making them ideal mediators for photothermal therapy (PTT). In this study, highly purified AuNBPs are prepared, followed by coating their surfaces with mesoporous silica (mSiO2). The obtained AuNBP@mSiO2 nanocomplex exhibits an ellipsoidal shape with a relatively large specific surface, pore diameter and pore volume. To achieve MRI guided chemo-photothermal therapy of breast cancer cells, the nanocomplex is further coupled with the MRI contrast agent Gd-DTTA and the chemotherapeutic drug doxorubicin (DOX). The results indicated that under NIR light irradiation, AuNBPs exhibited promising PTT effects, while the cumulative release rate of DOX was significantly enhanced to 81.40%. Moreover, the chemo-photothermal therapy approach effectively eradicated 4T1 breast cancer cells. This work successfully confirms that chemo-photothermal synergistic therapy is an effective tumor treatment strategy and demonstrates the potential application of AuNBP@mSiO2 as a nano-drug delivery platform. Additionally, it introduces new ideas for the integrated study of breast cancer diagnosis and treatment.
研究领域:
癌症治疗
·
材料科学
·
医学影像
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 4
·期 4
·743-751
·
IF 4.726
Ya Wen,Haiqing Dong,Yan Li,Aijun Shen,Yongyong Li
Biomineralization of a rare earth ion (Gd) is first employed to assemble bovine serum albumin (BSA) into sub-50 nm nanoparticles (Gd@BSA) for theranostic applications, via a straightforward and reproducible strategy. Combination of Gd ions with BSA under mild conditions results in the formation of the Gd@BSA nanosystem, which has been used as the scaffold material to encapsulate a photosensitiser (Ce6) with high efficiency up to 20 wt%. Beyond playing an important role in the assembled process, the incorporation of Gd affords the potential MRI and fluorescence imaging capability of Gd@BSA-Ce6 nanoparticles. In vivo MRI allowed real-time imaging in tumor-bearing mice and showed advantages in terms of circulation time, compared with commercially used Gd–DTPA. Gd@BSA-Ce6 nanoparticles exhibited enhanced tumor-specific distribution, through enhanced permeability and retention effect, and complete cure of tumor-bearing mice after intravenous injection. The nanoparticles did not produce systemic toxicity as revealed by biodistribution and histology toxicity analyses. The results demonstrate the great potential of Gd@BSA-Ce6 nanoparticles as theranostic agents due to their excellent imaging and tumor-growth-inhibition properties.
研究领域:
纳米医学
·
癌症治疗
·
分子影像
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2016
·Vol. 4
·期 22
·3903-3910
·
IF 4.872
Genxing Zhu,Ruibo Zhao,Yaling Li,Ruikang Tang
Multifunctional Gd,Ce,Tb co-doped β-tricalcium phosphate (TCP) porous nanospheres are prepared by a facile solvothermal strategy with trimethyl phosphate as the phosphorus source. The as-prepared nanomaterial (average diameter of 100 nm) has a multiple level pore size distribution with the specific surface area of 124.33 m2 g−1, which benefits drug loading. Its photoluminescent and magnetic multifunctions are realized by the co-doping of Gd3+, Ce3+ and Tb3+ ions, which make the nanomaterial promising for both fluorescence and magnetic resonance imaging techniques. Furthermore, the nanomaterial exhibits excellent cytocompatibility and a relatively high doxorubicin loading capacity as well as sustained pH-sensitive drug release behaviour. It is suggested that the Gd,Ce,Tb co-doped β-TCP porous nanospheres are promising for applications in the biomedical fields such as multifunctional drug delivery systems and tissue engineering scaffolds with bioimaging guidance.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2023
·Vol. 39
·期 4
·690-696
·
IF 3.1
Xu Pengfei,Hua Yezhen,Jin Kangpeng,Xu Biao
Tin selenide(SnSe) material exhibits very excellent thermoelectric properties in both p- and n-type single crystals, benefiting from advantageous electronic structure and ultra-low lattice thermal conductivity. However, poor mechanical properties and time-consuming production limit its practical application, and polycrystalline SnSe has attracted great attention in recent years. Herein, the SnSe microplates are prepared by a facile solvothermal method and compacted by spark plasma sintering (SPS). With enhanced electrical conductivity( σ ) and optimized Seebeck coefficient( S ) benefited from the Sn vacancies and increased density of states effective mass by the incorporating of heavy rare earth element Gd, an enhanced power factor(PF) value of about 0.86 mW/(m·K 2 ) is realized in the p-type polycrystalline Sn 0.985 Gd 0.015 Se sample. Combined with the medium total thermal conductivity k tot and lattice thermal conductivity k lat of 0.7 and 0.56 W/(m·K), respectively, an enhanced peak dimensionless figure of merit( ZT ) of ca. 1.1 was achieved at 873 K along vertical to the SPS pressing direction. The average ZT was also improved as compared to that of the pristine SnSe sample.
研究领域:
材料科学
·
热电学
·
固体物理
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Xin Wang,Xiaoling Ye,Bountheva Louangsouphom,Wenbin Qu,Bingxu Zhang,Huimei Liu
To address the critical limitations of TiO 2 photocatalysts, including insufficient visible-light response and rapid carrier recombination, this study developed a Gd-N co-doped hierarchical porous TiO 2 -macroporous resin (Gd/N/TiO 2 -MAR) composite via a sol-gel hydrothermal method. Multi-scale characterizations (XRD, XPS, BET) revealed that Gd 3 ⁺ doping modulates the band structure and surface properties through 4f-2p orbital hybridization, extending the light response range while suppressing carrier recombination via electron trapping. The hierarchical porous architecture and interfacial synergy significantly enhanced the adsorption-photocatalytic degradation efficiency. Under visible light, the composite exhibited a 1.6-fold higher degradation rate constant for Rhodamine B compared to single N-doped systems, alongside stable performance across a broad pH range (2−12) and under coexisting ion interference. Radical trapping and adsorption-photodegradation kinetic analyses elucidated the cooperative mechanism of interfacial charge transfer and reactive species generation. This work provides new structural design principles for developing efficient multifunctional materials for environmental remediation.
研究领域:
环境科学
·
材料科学
·
化学工程
·
纳米技术
·
光催化
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Jiahao Liu,Xiaojie Jin,Xi Lu,Xinyu Huang,Hongyan Chen,Long Qiu,Xiaowei Huang,Yongxiu Li,Jing Li
The application of rare earth micro-nano materials requires first formulating them into slurries with high dispersion stability, including polishing powders, catalysts, phosphors, ceramics, and other materials. To achieve this, it is essential not only to prepare monodisperse micro-nano particles but also incorporate appropriate dispersants to prevent particle aggregation. For this purpose, the study designed and synthesized a core-shell structured Gd 3 + -doped CeO 2 -coated SiO 2 composite abrasive: SiO 2 /CeO 2 :Gd. Low-field nuclear magnetic resonance technique was employed to investigate the sedimentation behavior of polishing slurries and explore the mechanism by which different dispersants enhance slurry dispersion stability, achieving real-time nuclear magnetic resonance imaging tracking of the sedimentation process. Results show that: The strong paramagnetic properties of Gd 3+ significantly enhance the relaxation efficiency of water molecules within the particle surface region, thereby serving as a sensitive probe for characterizing the liquid environment at the particle surface. Based on the T 2 distributions, settling can be divided into three stages: homogenization, sedimentation, and agglomeration. In polishing slurries, water molecules primarily exist in three forms: bulk water (P1), hydration layer water (P4) and surface-bound water (P5), attributing to different peaks of T 2 relaxation times. However, only one T 2 peak (P2) was observed for the homogenization slurry due to the rapid exchange among the three kind of water molecules. With the sedimentation proceeding, P2 transforms into two peaks of P1 and P3. The rate of change in the peak areas of P1 and P2 can reflect the sedimentation rate of the slurry. In the agglomeration stage, the overlapping of hydration layers forms interstitial water, leading to an increase in its T 2 relaxation time. Therefore, the P3 can further split into two peaks of P4 and P5, corresponding to interstitial water and surface-bound water in the sediment layer.
研究领域:
材料科学
·
核磁共振（NMR）
·
化学机械抛光（CMP）
·
胶体与界面科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
·
IF 7.2
Yajing Cai,Guojie Zhang,Jun Liu,Yunfei Zhang,Tianshan Li,Xiaodi Zhang,Ying Wang,Yuqiong Zhao,Guoqiang Li
Dry reforming of methane (DRM) is an effective method for achieving carbon reduction and carbon neutrality by directly converting two greenhouse gases , CH 4 and CO 2 , into value-added products. However, catalysts used in this process are prone to metal sintering and carbon deposition , which are major obstacles. Thus, the design of high-performance catalysts is crucial for the success of dry reforming technology. In this paper, a series of Co-based catalysts modified with different rare earth metals (Y, Tb, Gd) and γ-Al 2 O 3 as the support were prepared using the conventional co-impregnation method. The effects of the introduction of rare earth metals additives on the activity and resistance to carbon build-up of the catalysts were investigated. The catalysts were analyzed using various characterization techniques. The results showed that Y and Tb as additives could effectively improve the activity and stability of the catalyst. However, the Gd modified Co-based catalyst had a large specific surface area but was less favorable for the DRM reaction. The best performance catalyst was achieved with the 10Co–5Y/γ-Al 2 O 3 under 750 °C with CH 4 and CO 2 conversions of 91.79% and 98.33%, respectively. This is mainly due to the fact that the introduction of Y enhances the electron transfer between Co and metal oxides , generating more oxygen vacancies and base vacancies on the surface, thus enhancing the adsorption and activation of CO 2 . The 10Co–5Y/γ-Al 2 O 3 catalyst demonstrated excellent DRM performance even after 20 h at 750 °C. Moreover, we proposed a hypothesis regarding the mechanism of resistance to carbon build-up. This study provides a reasonable idea to design Co-based catalysts with resistance to sintering and carbon accumulation to improve the performance of reforming catalysts.
研究领域:
催化
·
化学工程
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
BIOCONJUGATE CHEMISTRY
·
2024
·
IF 4
Ningxin Yang,Yuelin Huang,Xiaoyu Wang,Dengbin Wang,Defan Yao,Gang Ren
The prevalence and fatality rates of gastric cancer (GC) remain elevated, with advanced stages presenting a grim prognosis. Noninvasive diagnosis of GC cancer often proves challenging until the disease has progressed to an advanced stage or metastasized. Initially, the level of fibronectin (FN) in cancer-associated fibroblasts (CAFs) of GC was at least 3.7 times higher than that in normal fibroblasts. Herein, two FN-targeting magnetic resonance/near-infrared fluorescence (MR/NIRF) imaging contrast agents were developed to detect GC and peritoneal metastasis noninvasively. The probes CREKA-Cy7-(Gd-DOTA) and CREKA-Cy7-(Gd-DOTA)3 demonstrated significant FN-targeting capability (with dissociation constants of 1.0 and 2.1 mM) and effective MR imaging performance (with proton relaxivity values of 9.66 and 27.44 mM–1 s–1 at 9.4 T, 37 °C). In vivo imaging revealed a high signal-to-noise ratio and successful visualization of GC metastasis using NIRF imaging as well as successful tumor detection in MR imaging. Therefore, this study highlights the potential of FN-targeting probes for GC diagnosis and aids in the advancement of new diagnostic strategies for the clinical detection of GC.
研究领域:
医学影像学
·
肿瘤学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
·
2020
·Vol. 37
·期 3
·1900427
·
IF 3.099
Jia Zhou,Tianliang Li,Yiran Zhang,Xiaoyu Xu,Chunlei Zhang,Yuehua Li,Daxiang Cui,Yingsheng Cheng
Magnetic resonance imaging (MRI) contrast agents are broadly employed for better clinical trials in MR imaging. Magnevist solution (Gd-DTPA), a clinical MRI contrast agent, possesses inherent shortcomings like poor r 1 relaxation, short half-time, nephrotoxicity, etc. To overcome these problems, Gd-DTPA-grafted protein assemblies (Gd-P-ABs) loading with anticancer drug cisplatin and photosentizer IR-780 are constructed via chelation of Gd 3+ . Gd-P-ABs exhibit dual MR/fluorescence (FL) imaging–guided chemo/photothermal therapy. Interestingly, Gd-P-ABs behave as aggregation-enhanced magnetic resonance imaging with an extremely high r 1 value of 26.391 s −1 m m −1 , which is about 5.5-fold larger than Gd-DTPA (≈4.8 s −1 m m −1 ). Consequently, better MRI performance is presented with the same concentration of Gd ions. When exposed to acidic tumor microenvironment and light irradiation, Gd-P-ABs show significant drug release capacity. Good cell killing ability in vitro is also determined due to effective folate-targeting ability and high photo–heat conversion. In vivo MR/FL imaging results reveal that Gd-P-ABs possess high-sensitivity tumor-targeting imaging and long tumor retention, which are attributed to the folate-targeting ability and small size effect. Combined chemo/photothermal therapy in vivo demonstrates that the tumor can be eventually ablated. Altogether, the Gd-P-ABs possess great potential for clinical imaging-guided tumor therapy.
研究领域:
放射学
·
分子影像
·
癌症治疗
·
纳米医学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2020
·Vol. 167
·期 14
·142505
·
IF 3.721
Wei Han,Wenjuan Wang,Mei Li,Yangyang Meng,Wenjing Ji,Yang Sun
To recover Gd from LiCl-KCl eutectic, the coreduction mechanism of Gd(III) with Pb(II) was investigated using electrochemical methods. The formation potentials related to the formation of three Gd-Pb intermetallics were detected by cyclic voltammetry, square wave voltammetry and chronopotentiometry, and the formation mechanism of Gd-Pb compounds could be described as xPb(II) + 2xe− = xPb. Meanwhile, the electroreduction of Gd on liquid Pb electrode was explored. The diffusion coefficient of Gd metal in liquid metallic Pb was determined by anodic chronopotentiometry. The kinetic parameters of Gd(III)/Gd(in Pb) couple in the temperature range from 723 K to 873 K were determined employing linear polarization (LP) method. Based on the relationship of exchange current density and temperature, the reaction activation energy was estimated to be 23.17 kJ mol−1. In addition, the recovery of Gd from molten salts was performed assisted by liquid Pb electrode by constant potential electrolysis (CPE) and constant current electrolysis (CCE). The products characterized using XRD, SEM with EDS are comprised of GdPb3 and Pb phases. The concentration change of Gd during CCE process was monitored by ICP-AES, and the recovery rate was estimated. The results showed that Gd concentration decreased and recovery rate increased with the duration.
研究领域:
材料科学
·
电化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2013
·
IF 2.39
Liangliang Li,Yongfei Liu,Xiaoying Qin,Di Li,Jian Zhang,Chunjun Song,Ling Wang
Highly dense and fine-grained (Sr 1− x Gd x )TiO 3− δ ceramics ( x = 0.05–0.12) were fabricated by a sol–gel process plus spark plasma sintering, and their thermoelectric properties were investigated from ∼300 K to 1100 K. The results show that the electrical resistivity of the (Sr 1− x Gd x )TiO 3− δ ceramics decreases greatly while maintaining large absolute value of the Seebeck coefficient | S | upon Gd doping. As a result, a large power factor ( PF ) greater than 10 μW cm −1 K −2 is obtained in (Sr 0.9 Gd 0.1 )TiO 3− δ in the temperature range from 400 K to 1000 K, and peak PF reaches 16 μW cm −1 K −2 at ∼570 K. Simultaneously, the lattice thermal conductivity κ L reduces remarkably (e.g. κ L decreases from 2.7 to 2.13 W m −1 K −1 at ∼1000 K). Owing to the large PF and low κ L , a record value of figure of merit ZT = 0.37 is achieved at 1006 K for (Sr 0.9 Gd 0.1 )TiO 3− δ , indicating that appropriate combinations of fine-grained microstructure with both high densities and proper doping as well as oxygen deficiency are essential to the effective enhancement of thermoelectric performance of STO-based ceramics.
研究领域:
材料科学
·
物理学
✓ 已验证
DOI
高影响因子
NANOTECHNOLOGY
·
2018
·Vol. 30
·期 7
·075101
·
IF 3.404
Hongying Guo,Xiaoshuang Zhao,Hongmei Sun,Hongda Zhu,Honghao Sun
Development of a safe, efficient and inexpensive multifunctional nanoplatform using a facile approach for multimodal imaging and therapeutic functions becomes more and more practically relevant but challenging. In this work, we demonstrated a novel nanocomposites (Bi2S3-Gd) for computed tomography (CT)/magnetic resonance (MR) imaging-guided photothermal therapy (PTT) for cancer in vitro. It was achieved by modification of hydrophobic Bi2S3 with a smart amphiphilic gadolinium-chelated ligand. The as-prepared nanocomposites composed of low-cost Bi2S3 and gadolinium complexes, showed high stability, excellent biocompatibility and good photostability. It was observed that Bi2S3-Gd nanocomposites can efficiently convert the NIR light into heat, and then suppressed the growth of tumor cells under NIR laser irradiation. Apart from serving as an effective photothermal agent, the as-prepared nanomaterials could induce an efficient contrast enhancement for both CT and MR imaging at low concentrations of Bi and Gd, rendering more accurate diagnosis. This work suggests the potential of Bi2S3-Gd nanomaterials as a novel multifunctional nanoplatform for CT/MR imaging-guided PTT for cancer.
研究领域:
医学影像学
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）