EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
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2022
·Vol. 49
·期 8
·2655-2667
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IF 10.057
Hou Zhenyu,Zhou Mei,Ma Yuanyuan,Xu Xiaoxuan,Zhang Zhiqi,Lai Shiwei,Fan Wenpei,Xie Jinbing,Ju Shenghong
Purpose Radiation therapy (RT) and photodynamic therapy (PDT) are promising while challenging in treating tumors. The potential radiation resistance of tumor cells and side effects to healthy tissues restrict their clinical treatment efficacy. Effective delivery of therapeutic agents to the deep tumor tissues would be available for tumor-accurate therapy and promising for the tumor therapy. Thus, developing nanoprobes with effectively delivering radiotherapy sensitizers and photosensitizers to the interior of tumors is needed for the accurate combined RT and PDT of tumor. Methods The size-changeable nanoprobes of Gd 2 O 3 @BSA-BSA-Ce6 (BGBC) were synthesized with a crosslinking method. Magnetic resonance imaging (MRI) and in vivo near-infrared (NIR) imaging were measured to evaluate the nanoprobes’ tumor accumulation and intratumor penetration effect. The tumor suppression effect of combined RT and PDT with these nanoprobes was also studied for the 4T1 bearing Balb/c mice. Results The nanoprobes BGBC showed high tumor accumulation and disintegrated into small particles responding to the photo-irradiation-produced reactive oxygen species (ROS), allowing for tumor penetration. Abundant radiotherapy sensitizers and photosensitizers were delivered to the deep tumor tissues, which is available for the accurate therapy of tumor. In addition, the BGBC displayed outstanding MRI and fluorescence imaging effects for evaluating the biodistribution and tumor suppression effect of nanoprobes. Consequently, significant tumor suppression effect was obtained based on the accurate tumor treatment with the combined RT and PDT. Conclusion The designed size-changeable nanoprobes BGBC showed excellent tumor accumulation and deep tumor penetration, resulting in a significant tumor suppression effect based on the combined RT and PDT. This study provides a novel strategy for dual delivery of radiotherapy sensitizers and photosensitizers into the deep tumor tissues and is promising for the accurate theranostics of tumor.
研究领域:
癌症治疗
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放射医学
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纳米医学
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医学影像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small Methods
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2025
·
IF 9.1
Yun Zhang,Yiwen Guo,Lu Liu,Kaibo Sun,Fengyue Guo,Qingquan Guo,Jinhua Zhu
Superior aqueous dispersibility mitigates nanoparticle toxicity in biological systems while preventing agglomeration. Herein, a hydrogen-bond-mediated aqueous synthesis strategy is proposed, utilizing β-cyclodextrin (β-CD) and sodium citrate (SC) to directly fabricate metal oxide nanoparticles in a single step. This approach not only suppresses particle aggregation but also preserves the molecular integrity of surface modifiers under high-temperature reaction conditions. Taking the preparation of gadolinium oxide as an example. Through modifier molecules on Gd 2 O 3 surfaces, the hydrophilicity is markedly enhanced, enabling stable dispersion in aqueous media, which is a critical prerequisite for biomedical applications. This green synthesis method, regulated by hydrogen-bonding interactions, overcomes safety concerns associated with organic solvents in traditional solvothermal techniques and gadolinium ion leakage in co-precipitation methods, while eliminating complex post-modification steps. The longitudinal relaxation rate (r1) of Gd 2 O 3 UPs-220, prepared by this method, achieves 8.43 m m −1 s −1 at a magnetic field strength of 7.0 T, demonstrating excellent magnetic resonance imaging (MRI) enhancement performance. This synthetic strategy provides an approach for preparing water-dispersible metal oxides.
研究领域:
纳米材料
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磁共振成像
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生物医学工程
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无机合成
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纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2017
·
IF 3.473
Ya-Ru Lu,Ming-Yu Gou,Ling-Yu Zhang,Lu Li,Ting-ting Wang,Chun-Gang Wang,Zhong-Min Su
The hollow nanospheres (NSs) composed of lanthanides have become a hot topic owing to their uncommon magnetic and optical properties arising from the 4f electrons. However, only a few novel methods have been developed for effectively integrating small calcium phosphate (CaP) nanoparticles and rare earth oxide drug carriers into an individual hollow mesoporous nanosphere. Herein, we report a facile, reproducible, room-temperature solution method to prepare multifunctional fluorescent hollow mesoporous Gd 2 O 3 :Eu/CaP (designated as HM-Gd 2 O 3 :Eu/CaP) NSs by using polyacrylic acid calcium (PAA-Ca) as a template. The excellent luminescent property and obvious T 1 -enhancement effect as well as the HM structure endow the HM-Gd 2 O 3 :Eu/CaP NSs with the capacity of simultaneous dual-modal fluorescence, magnetic resonance (MR) imaging and drug delivery. The nanocontainer-functionality of the HM-Gd 2 O 3 :Eu/CaP NSs is further validated upon filling with the anti-cancerogenic agent doxorubicin (drug-loading capacity is 749 μg mg −1 ). In addition, the HM-Gd 2 O 3 :Eu/CaP NSs display excellent pH-responsive and sustained drug release property. In vitro cell cytotoxicity tests verify the HM-Gd 2 O 3 :Eu/CaP NSs have good biocompatibility when the concentration ≤25 mg mL −1 . Taken together, the results suggested that the HM-Gd 2 O 3 :Eu/CaP NSs can be applied as fluorescence and MR dual-modal imaging contrast agents and drug delivery vehicles.
研究领域:
生物医学工程
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材料科学
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纳米医学
✓ 已验证
产品关联
DOI
高影响因子
Coatings
·
2026
·Vol. 16
·期 3
·327
·
IF 3.4
Ronghui Mao,Shuang Huang,Yilan Dou,Xinyi Mo,Tianquan Liang
HighlightsWhat are the main findings?•The dense double reaction layer of anorthite–spinel exhibits a positive effect on inhibiting the infiltration of calcium–magnesium–aluminum-silicate.•The thickness of the reaction layer increases with reaction time, while the growth rate rapidly decreases.•More Gd2O3doping enhances the outward diffusion of Gd3+and promotes the crystallization of the CMAS and apatite phases.•The inward infiltration of CMAS and outward diffusion of Al3+and Gd3+along the grain boundaries of the anorthite and/or spinel phases thicken the reaction layers.What are the implications of the main findings?•They clarify the reaction mechanism between Al2O3-based ceramics and CMAS in a high-temperature environment.•Doping with rare-earth Gd2O3can serve as an effective strategy for enhancing the CMAS corrosion resistance of Al2O3-based ceramics.•This study provides valuable reference guidance for the compositional design and research development of CMAS corrosion-resistant materials.The exploration of new materials with stable molten calcium–magnesium–aluminum-silicate (CMAS) resistance at elevated temperatures is of great significance to the development of advanced aero-engines. In the present study, Al2O3−xGd2O3(x = 5, 10, 20, 30 mol.%) ceramic samples were prepared by the high-temperature solid-state synthesis method. The thermochemical reaction behavior, reaction products, and growth kinetics of the reaction layer for the ceramics with molten CMAS at 1300 °C were investigated. The results reveal that the primary reaction products between Al2O3−xGd2O3ceramics and molten CMAS are anorthite (CaAl2Si2O8), gehlenite (Ca2Al(AlSi)O7), spinel (MgAl2O4), and Gd-apatite (Ca2Gd8(SiO4)6O2). In the initial reaction stage, a dense double-layer reaction layer composed of anorthite and spinel is formed at the ceramic/CMAS interface, while its growth rate decreases with increasing reaction time. Increasing the Gd2O3doping content inhibits the growth of the reaction layer and enhances the CMAS penetration resistance of Al2O3−xGd2O3ceramics. The mechanism is discussed systematically.
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2021
·Vol. 14
·期 21
·6716
·
IF 3.623
Shiyu Ma,Yan Lu,Bo Wang,Jinkai Li
White LEDs were encapsulated using Cs4PbBr6quantum dots and Gd2O3:Eu red phosphor as lamp powder. Under the excitation of a GaN chip, the color coordinates of the W-LED were (0.33, 0.34), and the color temperature was 5752 K, which is close to the color coordinate and color temperature range of standard sunlight. The electric current stability was excellent with an increase in the electric current, voltage, and luminescence intensity of the quantum dots and phosphors by more than 10 times. However, the stability of the quantum dots was slightly insufficient over long working periods. The photocatalytic devices were constructed using TiO2, CsPbBr3, and NiO as an electron transport layer, light absorption layer, and catalyst, respectively. The Cs–Pb–Br-based perovskite quantum dot photocatalytic devices were constructed using a two-step spin coating method, one-step spin coating method, and full PLD technology. In order to improve the water stability of the device, a hydrophobic carbon paste and carbon film were selected as the hole transport layer. The TiO2layer and perovskite layer with different thicknesses and film forming qualities were obtained by changing the spin coating speed. The influence of the spin coating speed on the device’s performance was explored through SEM and a J–V curve to find the best spin coating process. The device constructed by the two-step spin coating method had a higher current density but no obvious increase in the current density under light, while the other two methods could obtain a more obvious light response, but the current density was very low.
研究领域:
材料科学
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光电
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光催化
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）