ACS Sensors
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2026
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IF 10.9
Jun-Jie Qu,Ze-Jie Zhu,Jing-Yan Zhou,Hao-Ran Yuan,Quan Zong,Mei-Mei Zhang,Yue Li,Jia-Ning Yan,Jing-Ji Zhang,Guo-Ying Wei,Jiang-Ying Wang,Fa-He Cao
Dendrite growth and parasitic reactions in aqueous zinc-ion batteries (AZIBs) are intrinsically driven by heterogeneous interfacial Zn2+ distribution, but conventional characterization techniques cannot achieve real-time, micron-scale quantitative tracking of dynamic Zn2+ evolution. Herein, we report a high-performance Zn2+-selective scanning electrochemical microscopy (SECM) probe based on a multiwalled carbon nanotube (MWCNT)-modified all-solid-state ion-selective membrane. The MWCNT-modified interface effectively suppresses the water-layer effect, reducing the fitted interfacial resistance component from 17,442 to 389 Ω. The optimized probe exhibits a wide linear response range of 10-5-1 × 10-1 M (R2 = 0.999, slope = -19.8 mV·dec-1), an ultrafast response time of <10 s, low potential drift (<10 mV/2000 s), excellent anti-interference against common interfering ions (Na+, K+, Mg2+, Al3+), and a long service life of 45 days. Notably, in situ SECM mapping reveals severe Zn2+ concentration fluctuations (0.178-0.303 M) at the Zn anode in blank electrolyte, which are effectively homogenized to a narrow range of 0.235-0.255 M by 0.01 M mesylacetone additive. This work provides a powerful in situ platform for deciphering AZIB interfacial dynamics and guiding advanced electrolyte design.
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Qiu-Ya Ji,Ran Meng,Si-Jie Wu,Ran Feng,Bao Zhang
Abstract Exosomes derived from probiotics are emerging as innovative oral nanocarriers but face challenges in targeted delivery and stability. Here, Lactobacillus helveticus-derived exosomes (LHexo) were dual-functionalized with mannose and cRGD (McRLHexo), yielding improved membrane lipid ordering, denser PEG brush layer, and distinct “cloud-like” surface nanostructure. McRLHexo exhibited enhanced stability under UV (transmittance reduction > 98%), thermal, and digestive conditions (drug retention >86%), and increased pterostilbene (PTS) loading. Functionally, McRLHexo@PTS achieved efficient epithelial translocation via cRGD-integrin pathways and macrophage targeting via Man/cRGD dual-recognition. In DSS-induced colitis mice, McRLHexo showed optimal targeting accumulation and uptake in the colon. Importantly, McRLHexo@PTS markedly alleviated colitis, restoring body weight, colon length, and epithelial integrity while reducing inflammatory cytokines and oxidative stress and enhancing antioxidant defenses. This study establishes a dual-targeted probiotic exosome platform for oral therapy and provides insights into ligand-membrane engineering for precision intestinal delivery.
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高影响因子
Chem & Bio Engineering
·
2026
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IF 8.4
Balamurali Ravichandran,Soujanya Prakash Bammanalli,Muthu Austeria P,Sabarinathan Ravichandran,Huiyuan Liu,Weiqi Zhang,Narayanamoorthy Bhuvanendran,Huaneng Su
Abstract Rechargeable zinc–air batteries (ZABs) require efficient and durable bifunctional oxygen electrocatalysts to accelerate both the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER). Herein, we report a hierarchical N, S, and P co-doped carbon catalyst (CoFe/NSP-HC) featuring CoFe core–shell alloy nanoparticles and Fe–Nx coordination motifs, synthesized through a pyrolysis strategy using heteroatom-enriched g-C3N4 as both template and dopant source. Structural characterization reveals a hierarchical porous architecture with uniformly distributed heteroatoms, strong metal–support interactions, and a well-defined Co-rich core/Fe-rich shell configuration. The synergistic integration of CoFe alloy interfaces, Fe–Nx coordination sites, and a defect-rich carbon framework effectively modulates the electronic structure and optimizes the adsorption/desorption behavior of oxygenated intermediates. Consequently, the optimized CoFe/NSP-HC catalyst exhibits bifunctional activity with an ORR half-wave potential of 0.82 V and an OER overpotential of 260 mV at 10 mA cm–2, delivering a low bifunctional potential gap (ΔE) of 0.67 V. Furthermore, the catalyst demonstrates robust electrochemical durability, maintaining stable ORR/OER performance after prolonged cycling. Density functional theory calculations reveal that Fe–Nx sites and Fe-based interfacial centers provide favorable reaction energetics for oxygen electrocatalysis, while Co species contribute to electronic modulation and kinetic enhancement. When employed as the air cathode in a rechargeable ZAB, CoFe/NSP-HC delivers a peak power density of 158.7 mW cm–2 and long-term cycling stability exceeding 350 h. This work provides an effective strategy for constructing multi-component electrocatalysts with synergistically engineered active sites for advanced metal–air energy storage systems.
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ACS Applied Bio Materials
·
2026
·
IF 5.6
Qi Cai,Yue Li,Xuewei Ba,Piaoping Yang
The aberrant vascularization and uneven vascular distribution stemming from rapid tumor cell proliferation culminate arouse intra-tumoral hypoxia, which substantially compromises the therapeutic response to conventional chemotherapy, as well as photothermal therapy (PTT) and photodynamic therapy (PDT). In this work, we present an innovative α-NaYbF4:Tm@Cu2-xSe@ZnFe2O4-DOX nanoplatform that synergistically integrates PTT, Fenton reaction-enhanced chemodynamic therapy, PDT, and doxorubicin (DOX)-based chemotherapy under 980 nm near-infrared (NIR) light activation and weakly acidic environment-initiation. The 10 nm cubic-phase α-NaYbF4:Tm up-conversion cores were initially synthesized. Subsequently, low atomic number (Z) Cu2-xSe nanocrystal grown as photo-thermal conversion agent demonstrated significantly stronger X-radiation (X-ray) attenuation capabilities and enhanced computed tomography (CT) imaging performance compared to clinically used iopromide. Furthermore, zinc ferrite (ZnFe2O4) shell was obtained in hydrothermal synthesis manner. The 980 nm NIR-excited α-NaYbF4:Tm nanoparticles undergo efficient energy down-conversion, emitting photons that perfectly match the absorption spectrum of ZnFe2O4, thereby maximizing reactive oxygen species (ROS) generation through bandgap-engineered photoconversion. The tumor's glycolytic activity creates a hydrogen peroxide (H2O2)-rich microenvironment, enabling ZnFe2O4-mediated Fenton-like reactions that produce hydroxyl radicals (•OH) radicals, ultimately triggering oxidative damage and apoptotic cell death. It is noted that dual-mode photothermal therapeutic efficacy was achieved by Cu2-xSe and ZnFe2O4 as photothermal nanocrystal with up-conversion luminescence (UCL), magnetic resonance imaging (MRI) and CT multimodal imaging. DOX as anticancer chemotherapeutics was conjugated to form α-NaYbF4:Tm@Cu2-xSe@ZnFe2O4-DOX nanoplatforms. It remains effectively release of large quantities of DOX at tumor part conferred response to excessive lactic and carbonic acids generated in cancer cells. Our research may provide an insight for generalizing enhanced synergetic performance by NIR light-mediated PTT, Fenton reaction, PDT and chemotherapy. It is not a simple assembly of known components, but rather a multi-functional synergistic system constructed through ingenious core-shell structural design, capable of responding to near-infrared light and the tumor microenvironment. For the first time, this system seamlessly integrates up-conversion luminescence-mediated PDT, dual photothermal agent-enhanced PTT, self-supplying H2O2 Fenton reactions, and acid/heat dual-responsive chemotherapy into a single nanoplatform. Additionally, it incorporates multimodal imaging capabilities, providing an innovative and comprehensive solution to overcome the clinical challenge of tumor hypoxia.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2016
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IF 2.653
Yong Hu,Hai-Long Wu,Xiao-Li Yin,Hui-Wen Gu,Rong Xiao,Li Wang,Huan Fang,Ru-Qin Yu
A rapid interference-free spectrofluorometric method combined with the excitation-emission matrix fluorescence and the second-order calibration methods based on the alternating penalty trilinear decomposition (APTLD) and the self-weighted alternating trilinear decomposition (SWATLD) algorithms, was proposed for the simultaneous determination of nephrotoxic aristolochic acid I (AA-I) and aristololactam I (AL-I) in five Chinese herbal medicines. The method was based on a chemical derivatization that converts the non-fluorescent AA-I to high-fluorescent AL-I, achieving a high sensitive and simultaneous quantification of the analytes. The variables of the derivatization reaction that conducted by using zinc powder in acetose methanol aqueous solution, were studied and optimized for best quantification results of AA-I and AL-I. The satisfactory results of AA-I and AL-I for the spiked recovery assay were achieved with average recoveries in the range of 100.4–103.8% and RMSEPs < 0.78 ng mL − 1 , which validate the accuracy and reliability of the proposed method. The contents of AA-I and AL-I in five herbal medicines obtained from the proposed method were also in good accordance with those of the validated LC-MS/MS method. In light of high sensitive fluorescence detection, the limits of detection (LODs) of AA-I and AL-I for the proposed method compare favorably with that of the LC-MS/MS method, with the LODs < 0.35 and 0.29 ng mL − 1 , respectively. The proposed strategy based on the APTLD and SWATLD algorithms by virtue of the “second-order advantage”, can be considered as an attractive and green alternative for the quantification of AA-I and AL-I in complex herbal medicine matrices without any prior separations and clear-up processes.
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PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
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IF 4.3
Siwei Wang,Jin Du,Zhanquan Zhang,Yan Wang,Zhijie Yuan,Yuhan Wang,Tianpei Yi,Fusheng Pan,Zhongyi Jiang
Separating aromatic and aliphatic hydrocarbons can produce high-quality cracking feedstocks and recover value-added aromatic products. Covalent organic framework (COF) may find promising application owing to its exceptional structures and functionalities. In this study, Cu(I)-COF was designed and integrated into Pebax matrix to fabricate facilitated transport membranes. The immobilization of Cu(I) ions onto the COF framework effectively mitigates leaching. Additionally, the COF building blocks provides a stable electron cloud environment for Cu(I), ensuring long-term stability for over 6 months. The vertical channels in the COF afford rapid mass transfer, and the uniformly distributed Cu(I) enhances toluene affinity, thereby intensifying the transfer of toluene. For a 50 wt% toluene/n-heptane mixture, the Cu 3 L 3 -Pa-Pebax-2 membrane demonstrated a permeation flux of 1100 g·m −2 ·h −1 and a separation factor of 5.44. This study provides a new example for the application of multifunctional organic framework materials to fabricate facilitated transport membranes.
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CHEMOSPHERE
·
2021
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IF 7.086
Lingxiao Fu,Xiaofeng Wu,Yongbin Zhu,Lei Yao,Chengqiang Wu,Haixiang Cheng,Yiran Xu,Jun Hu,Weijun Gao
Manganese dioxide (MnO 2 ) is a Mn deposit widely accumulated in the corrosion layer of pipelines, and iodide (I − ) is a halogen ion frequently detected in waters. The biofilm dwelling on the corrosion scales often secretes extracellular polymeric substances (EPS) into drinking water . The paper aimed to study the I − oxidation by MnO 2 and iodinated disinfection byproducts (I-DBPs) formation with biofilm EPS as a precursor. More than 93% of formed free iodine was finally converted into organic iodine in the MnO 2 /I − /EPS system. Compared with humic acid , EPS had a lower carbonaceous I-DBPs (C-IDBPs) formation while a higher nitrogenous I-DBPs (N-IDBPs) formation. The formation of iodomethanes (I-THMs), iodoacetonitriles (I-HANs) and iodoacetic acids (I-HAAs) decreased with the increase of pH due to the weakening of polarization effect and redox potential , while the iodoacetamides (I-HAcAms) formation achieved the maximum at pH 6.0 due to the difference between the hydrolysis rate of I-HANs and decomposition rate of I-HAcAms. The I-DBPs formation was positively correlated with I − concentration, while negatively correlated with MnO 2 dose. Protein components displayed a higher formation of N-IDBPs and C-IDBPs than polysaccharide components due to higher nitrogen proportion and more iodination sites. Among 20 protein monomers , aspartic acid was considered as the most important precursor of the four investigated I-DBPs species. The paper is helpful to understand the I-DBPs formation when I − in the bulk water come into contact with Mn deposits attached by biofilm.
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高影响因子
FREE RADICAL BIOLOGY AND MEDICINE
·
2024
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IF 7.1
Ya-Long Zheng,Yuan Ji,Yan Li,Shuai Yan,Xiao-Rong Ren,Wei Tang,Fang Dai,Bo Zhou
The development of Cu(II) ionophores for targeted disruption of aberrant redox homeostasis in cancer cells has been considered an appealing strategy in the field of anticancer research. This study presents the first identification of tanshinone I ( Ts1 ), a natural o -quinone, as a Cu(II) ionophore. Structure-activity relationship studies on tanshinones and mechanistic investigations reveal that the presence of Cu(II) effectively promotes the tautomerization of Ts1 from its diketo to keto-enol forms, thereby facilitating its sequential proton-loss Cu(II) chelation, and enabling it to function as a Cu(II) ionophore due to its structural features including the presence of an o -quinone moiety, a benzyl hydrogen, and a large conjugated system. The unique property allows Ts1 to preferentially induce copper accumulation in human hepatoma HepG2 cells over human umbilical vein endothelial cells, by releasing copper driven by reduced glutathione (GSH). This copper accumulation leads to a reduction in the GSH-to-oxidized glutathione ratio and the generation of reactive oxygen species, ultimately triggering apoptosis of HepG2 cells. The findings not only provide support for o -quinones as innovative types of anticancer Cu(II) ionophores, but also shed light on the previously unrecognized role of Ts1 as a potent Cu(II) ionophore for eradicating cancer cells by selectively disrupting their redox regulation programs, resembling a "Trojan horse".
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Extreme Mechanics Letters
·
2020
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IF 4.806
Wenlei Zhang,Yang Gao,Hang Yang,Zhigang Suo,Tongqing Lu
Tough adhesion is often achieved by using inelastic dissipaters. However, inelastic dissipaters fail to enhance adhesion under cyclic loads . Here we achieve fatigue-resistant adhesion by using a particularly simple kind of elastic dissipater: long-chain polymers. Each polymer chain is elastic before rupture. When a single covalent bond of the chain breaks, the elastic energy stored in the entire chain dissipates, amplifying the adhesion energy by the number of links on the chain. So far as the adherends provide the stiffness of an adhered sample, the adhesive can be made of polymer chains of extremely long length. As a proof of concept , we use polyacrylamide hydrogels to adhere two pieces of polyester cloth through topological entanglement . We find that both the adhesion energy and fatigue threshold increase with the polymer chain length and can reach 1400 J/m 2 and 300 J/m 2 , respectively. The measured fatigue threshold of adhesion is linearly proportional to the square root of the chain length, in agreement with the Lake–Thomas model. This fatigue-resistant design can be extended to a variety of adhesion topologies for different adherends and adhesives.
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高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
·
2026
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IF 3.2
Xiaonan Li,Xirong Huang
Abstract An oil-in-water microemulsion is an excellent candidate medium for the electrochemical regeneration of the coenzyme NADH and its subsequent coupled conversion application due to its good electrical conductivity and solubilization capacity for hydrophobic substrates. In this work, the reduced methyl viologen (MV+•)-mediated electrochemical reduction of coenzyme NAD+ was studied in a Triton X-100 (TX-100)-stabilized methyl tert-butyl ether (MTBE)-in-water microemulsion. The effects of the surfactant concentration and the oil content on the electrochemical behavior of the MV2+/MV+• couple and the activity of diaphorase (DH) were systematically investigated. The results show that in the microemulsion, the couple exhibits excellent reversibility. Compared with the aqueous buffer system, the couple in the microemulsion system has a more positive formal potential and a lower redox peak current, depending on the levels of both the surfactant and the oil. The positive shift of the formal potential is attributed to the stabilizing effect of the surfactant aggregates on the relatively hydrophobic MV+• species, and the decrease of the redox currents is ascribed to the decrease of the electroactive area of the electrode due to the adsorption of the surfactant and the oil as well as the decrease of the diffusion coefficients of MV species associated with or solubilized in the surfactant aggregates. The activity of DH in the microemulsion system also depends on the TX-100 concentration and the MTBE content. Increases in both [TX-100] and [MTBE] result in a decrease in DH activity. This phenomenon could be explained based on the [TX-100]/[MTBE]-dependent changes in the local acidity and the local concentration of the substrate DCPIP in the microemulsions. Based on cyclic voltammetry, the MV+•-mediated electroreduction of NAD+ in the TX-100-stabilized MTBE/H2O (0.1 M PB, pH = 7.0) microemulsion was studied. For the microemulsion system containing 0.5 mM MV2+, 5 mM NAD+, and 26.6 μM DH, when a scan rate of 2 mV s–1 was applied, a typical steady-state S-shaped CV curve was obtained. UV–vis spectroscopy confirms that the NADH generated by the mediated reaction is bioactive. By coupling the MV+•-mediated NADH electrochemical regeneration reaction with the horse liver alcohol dehydrogenase (HLADH)-catalyzed reduction of the hydrophobic substrate 4-phenyl-2-butanone, the enantiomerically pure (S)-4-phenyl-2-butanol can be selectively obtained. After 12 h, the yield of the product in the microemulsion is approximately 10 times that in the DMSO-buffer mixed homogeneous system. This difference in yield is caused by the differences in enzyme activity and stability, as well as in the substrate local concentration and reactivity in the two systems. The present study indicates that the TX-100-stabilized MTBE-in-water microemulsion is a suitable medium for the electrochemical regeneration of NADH and the electroenzymatic conversion of water-insoluble substrates catalyzed by NADH-dependent oxidoreductases.
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高影响因子
JOURNAL OF ORGANIC CHEMISTRY
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2026
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IF 3.3
Zhengyu Jiang,Zhaohui Xu,Qing-Yan Liu,Junmin Chen
Herein, we report a visible-light-mediated photoredox reaction for the synthesis of sulfonyl 4-(thio)chromones and 4-quinolone derivatives. This transformation employs easily accessible 2-alkynyl benzaldehydes and sodium sulfinates as starting materials, enabling a one-pot cascade process involving radical sulfonylation, cyclization, and isomerization under mild conditions. Notably, this strategy allows the straightforward assembly of protecting-group-free sulfonyl 4-quinolones. Benefiting from its operational simplicity, broad substrate scope, and excellent functional group compatibility, this protocol provides a practical approach for the construction of valuable 4-(thio)chromones and 4-quinolone derivatives with potential biological and synthetic applications.
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高影响因子
JOURNAL OF BIOSCIENCE AND BIOENGINEERING
·
2019
·
IF 2.032
Xiaohong Lu,Juhua Chen,Linshu Jiao,Lei Zhong,Zhaoxin Lu,Chong Zhang,Fengxia Lu
Directed evolution methodologies have been used as promising strategies for improving the catalytic properties of many existing enzymes . In the presented work, this approach was applied to improve the enzyme activity of l -asparaginase I obtained from Bacillus megaterium H-1. After two rounds of error-prone polymerase chain reaction (epPCR) and two generations of sequential DNA shuffling , all of 5 different mutants showed a significant increase in the enzyme activity of l -asparaginase I, ranging from 6.27 to 22.78 IU/mL. Among these mutants, D-9B and DD-12G displayed the relatively high catalytic activity , which were 20.22-fold and 21.33-fold higher than the wild-type enzyme (WT), respectively. Furthermore, the catalytic efficiency ( k cat / K m ) of D-9B and DD-12G were also improved, which were 132.73 min −1 mM −1 and 146.39 min −1 mM −1 , respectively, in comparison to that of WT (3.39 min −1 mM −1 ). In addition, mutant DD-12G showed tolerance toward wider range of pH values and higher temperatures than its WT counterpart. Homology modeling of above two mutants reflected a reduction of hydrogen bonds and an introduction of flexible residues in the loops near the active catalytic site Thr15. These changes contributed to the flexibility of loops, which may lead to further enhancement in catalytic efficiency. Results also showed that approximately 88.5% (0.978 mg/kg) acrylamide could be removed from mutant DD-12G pre-treated fried potato chips. This study clearly shows that directional evolution methods can indeed be utilized to improve the activity of l -asparaginase, which could also provide research basis for future application in food industry.
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高影响因子
危险品化学品经营许可证（带存储）