Nanoscale
·
2024
·
IF 5.8
Mengjia Cen,Jiawei Wang,Ming Cheng,Ziyan Lei,Ye Li,Zhenming Wang,Xueqian Zhao,Zixuan Wu,Huanian Zhang,Yan Jun Liu
Manipulating circular dichroism in chiral metasurfaces has been increasingly important for a wide range of polarization-sensitive photonic applications. However, simple methods for presenting chiral nanostructures with tunable and considerable chiroptical responses in the near-infrared-I regime remains underexplored. Herein, two sheets of suspended symmetric bilayer metagratings fabricated via single-step electron beam lithography are stacked into a moiré metasurface with its circular dichroism value reaching up to 20.9°. The chirality of the moiré metasurface can be fully tuned in terms of both its sign and magnitude by adjusting the in-plane angle between the two twisted sheets of metagratings. The multilayered design is accessible to the coupling of hybridized plasmons for governing the chiroptical properties in the near-infrared-I regime. The ratio between the resonance wavelength and the grating period is about 1.65, which is much lower compared to that in most existing moiré metasurfaces with strong chiroptical responses. Furthermore, the superchiral fields in the inter-sheet region are further exploited for label-free enantiodiscrimination with ultrahigh sensitivity of 10.17 nm fmol−1 mm2. The proposed moiré metasurfaces with strong near-infrared-I chirality hold great potential for supporting polarization engineering and biomolecular detection, paving a way for advanced applications in medical diagnosis, biomedical imaging, and display technologies.
研究领域:
纳米光子学
·
生物医学检测
·
光学工程
✓ 已验证
DOI
PubMed
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2018
·Vol. 16
·期 48
·9402-9408
·
IF 3.423
Pan Li,Zhe Chen,Yishun Huang,Jing Li,Fan Xiao,Shiyao Zhai,Zhiming Wang,Xuanjun Zhang,Leilei Tian
A new DNA-based fluorescent probe, which is a hybrid molecule of an i-motif forming sequence (IFS) and mono-functionalized tetraphenylethene (TPE), has been synthesized and investigated. A distinct pH-responsive aggregation-induced emission (AIE) effect has been observed from this hybrid molecule, i.e. the fluorescence of TPE will be turned on when the IFS part folds up under acidic conditions. According to the fact that a hybrid molecule with a relatively rigid structure shows a more obvious AIE effect, and whose nano-sized aggregates are formed at a high concentration, we assume that the solubility of the hybrid molecule in water will be reduced due to IFS folding, resulting in aggregation and the resultant AIE effect. Finally, due to its excellent pH responsiveness, this DNA-based probe employing an AIEgen has been applied in monitoring intracellular pH.
研究领域:
生物化学
·
分子生物学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Optical Materials
·
2022
·Vol. 10
·期 16
·2200724
·
IF 10.05
Jun-Hua Wei,Yong-Wei Yu,Jian-Bin Luo,Zhi-Zhong Zhang,Dai-Bin Kuang
Anti-counterfeiting has become a serious issue around the global world; fluorescence-based tags are praised for the low-cost and facile decryption process. However, the high-level anti-counterfeiting application requires incorporating multifunctional luminescent materials with response to different excitation sources. Herein, a dimeric Cu(I)-halide-clusters-assembled single-crystal (AEP) 2 Cu 2 I 6 ·2I·2H 2 O (AEP = N -aminoethylpiperazinium) concerning a high down-conversion photoluminescence quantum yield (PLQY) value of near unity is reported (λ ex = 305 nm), which can also be activated by the near-infrared light and X-ray. The ultrafast spectroscopy and density functional theory calculations reveal that the broad-band emission originates from the recombination of self-trapped excitons. Remarkably, the high PLQY and excellent attenuation capability for X-ray confers an outstanding light yield of 55 650 photons MeV −1 to (AEP) 2 Cu 2 I 6 ·2I·2H 2 O, which is 5.25 times higher than the standard bismuth germaniumoxide scintillator. Such multi-light-stimulus response endows (AEP) 2 Cu 2 I 6 ·2I·2H 2 O with great application potential in anti-counterfeiting, solid-state lighting devices, and digital radiography.
研究领域:
材料科学
·
光学
·
物理学
✓ 已验证
DOI
高影响因子
ChemNanoMat
·
2020
·Vol. 7
·期 3
·270-276
·
IF 3.384
Shengrui Zhang,Yang Yu,Shujue Xu,Jun Liu,Mo Liu,He Su,Yajiao Hao,Minjie Li,Sean Xiao-An Zhang
Graphical Au(I)-thiolate nanosheets have been studied as new and efficient water-dispersible UV absorbents. UV screening is very important for the prevention of skin cancer and the elongation of the lifetime of organic/polymeric stuff. To overcome the main problems of poor hydrophilicity and easy leakage of organic UV absorbents, water-dispersible Au(I)-thiolate nanosheets have been studied as a new type of UV absorbents. The results show that Au(I)-thiolate nanosheets have i) very high molar absorption coefficients (>15000 mol/L . cm), ii) comparable or superior photostability to typical organic UV absorbents, and iii) high transparency and nearly no leakage in polymer matrix. So far, no other UV absorbents have been reported to have all the above good performances simultaneously. The transparent and colorless Au(I)-thiolate/polymer thin films can effectively block UV light, and such a material will surely extend the types and the application scenarios of UV absorbents.
研究领域:
材料科学
·
化学
·
医学
✓ 已验证
产品关联
DOI
高影响因子
ANALYST
·
2019
·Vol. 145
·期 3
·873-879
·
IF 4.019
Minghan Wang,Junjie Liu,Xiaoli Qin,Xin Nie,Yifan Dong,Xu Liang,Zhiwei Zhu,Di Yang,Yuanhua Shao
In this work, an Au–Ag alloy nanourchin (Au–Ag alloy NU) based electrochemiluminescent (ECL) sensor for the measurement of cardiac troponin I (cTnI) was developed. The as-prepared Au–Ag alloy NUs exhibited higher specific surface area and better conductivity owing to their unique urchin-like morphology, which resulted in excellent electrocatalytic activity towards H2O2 in the luminol–H2O2 ECL system. We have found that the Au–Ag alloy NUs could enhance the ECL signal in the luminol–H2O2 solution. Based on these facts, a facile and label-free ECL immunosensor has been constructed for the analysis of cTnI, a cardiac biomarker, with a wide linear range of 3.5 pg mL−1–350 μg mL−1. This novel ECL immunosensor has good stability and reproducibility, showing potential application in clinical diagnostics. In addition, a non-enzymatic electrochemical sensor for H2O2 was also fabricated, with a wide linear detection range of 100 nM–200 μM, a low limit of detection of 45 nM and a fast response time (less than 2 s).
研究领域:
生物医学工程
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL PAPERS
·
2017
·Vol. 72
·期 1
·51-56
·
IF 1.258
Wei Mengyi,Qian Chao,Chen Xinzhi
Based on the recycling of NO
x
, the Cu(I)- and HNO 3 -catalyzed oxidation of 2-chloro-4-(methylsulfonyl)toluene to 2-chloro-4-(methylsulfonyl)benzoic acid has been developed with an excellent yield of 84.2% and a purity of 99.7%. The optimized reaction conditions (160 °C, oxygen pressure 1.5 MPa, HNO 3 concentration 25 wt%, HNO 3 : substrate 0.5:1) use 1.0 mol% CuI as catalyst. The dosage of HNO 3 in the new process is only 25% of the stoichiometric amount and 12.5% of the amount of the traditional process. The NO
x
emission is 5% amount of the traditional process. The oxidation of several additional toluene derivatives with comparable yields demonstrates the generality to these reaction conditions.
研究领域:
化学
·
环境科学
✓ 已验证
DOI
高影响因子
Biochar
·
2023
·Vol. 5
·期 1
·1-16
·
IF 12.7
Liu Fenglei,Wang Shanshan,Zhao Chaofeng,Hu Baowei
Herein, a biochar-based composite (Ti 3 C 2 T x @biochar-PDA/PEI) was constructed by decorating Ti 3 C 2 T x and polydopamine on coconut shell biochar via electrostatic self-assembly method. Different characterization techniques were applied to explore the structure, morphology and composition of the sorbents. It was found that the higher porosity and diverse functional groups were conducive for Ti 3 C 2 T x @biochar-PDA/PEI to capture radionuclides, and the water environmental conditions made a great contribution to the adsorption process. The process of removing U(VI)/Cs(I) well complied with the Langmuir isotherm and Pseudo-second-order equations, which indicated that the single layer chemical adsorption occurred on the solid liquid interface. Meanwhile, this produced composite exhibited superior removal performance under complex co-existing ion environment, and the maximum adsorption amounts of U(VI) and Cs(I) reached up to 239.7 and 40.3 mg g −1 . Impressively, this adsorbent still exhibited good adsorption performance after three cycles of regeneration. The spectral analysis and DFT calculation demonstrated that adsorption of U(VI) might be a chemical process, while the adsorption of Cs(I) should be ion exchange or electrostatic attraction. This study demonstrated the potential application of Ti 3 C 2 T x @biochar-PDA/PEI as an effective remediation strategy for radioactive wastewater cleanup. Graphical Abstract
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Yuejiao Wu,Jian Yang,Ke Shen,Liyan Liu,Jing Cao,Zhaomei Wang
Curcumin (Cur) is a bioactive nutraceutical with great potential in biological, nutritional, and medical applications. However, these applications are limited by various factors such as insufficient ingestion, low aqueous solubility, and relatively high toxicity to normal cells. To tackle these obstacles, we synthesized a novel Cur-modified-rhamnogalacturonan (RG-C) nano-micelle carrier to target-deliver Cur to hepatocellular carcinoma HepG2 cells via specific recognition of RG-I by the overexpressed surface galactin-3 receptor. Fourier transfer infrared, UV–vis, and 1 H NMR analyses confirmed the conjugation between RG and Cur RG-C loaded with Cur (RG-CC) was formed via self-assembly in an aqueous solution with a drug loading efficiency of 12.2%. RG-CC micelle was ellipsoidal or cubic with a size ranging between 100 and 200 nm by scanning electron microscopy observation. Cur release from RG-CC exhibited a controlled and pH-dependent manner with 50% at pH 5.0 in contrast to 5% at pH 7.4 after 24 h exposure. RG-CC possessed more potent anti-proliferative activity against HepG2 cells than normal embryonic kidney 293T cells. Compared to free Cur, both the anti-proliferative effect and uptake of RG-CC were significantly higher in HepG2 cells as revealed from laser confocal microscopy and flow cytometry analyses. RG-CC was a promising anticancer candidate and deserves further preclinical and clinical investigations.
研究领域:
药剂学
·
肿瘤学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Zhenzhao Wang,Lili Liu,Zhen Li,Linna Li,Xingtong Liu,Rikun Cui,Fujun Yao,Lei Tian,Xiaofeng Kang,YanLi Guo
Intercalated binding of anthracycline anticancer drugs to DNA is associated with anticancer mechanisms. The i-motif, a cytosine-rich DNA secondary structure found in the promoter region of oncogenes, is a primary target for anticancer drugs action. Therefore, it is significant to study the interaction between anthracycline drugs and i-motif for cancer therapy using simple, rapid and low-cost analytical methods. Here, we utilized α-HL protein nanopore, which offers high sensitivity and high signal-to-noise ratio to investigate the conformational transition of human telomere i-motif induced by various anthracycline drugs at the single-molecule level. Our results revealed for the first time that anthracyclines drugs could induced the unfolding of i-motif into hairpin DNA. Additionally, our experiment captured the current signal of the intermediate state during the unfolding of i-motif into hairpin DNA, a signal difficult to obtain by conventional analytical tools such as circular dichroism (CD) and UV–visible spectroscopy (UV–vis). This research provides a novel tool for investigating the interaction between small molecule and DNA and lays the foundation for future screening of drugs acting on i-motif targets, as well as analyzing their therapeutic mechanism.
研究领域:
生物化学
·
分子生物学
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2017
·Vol. 27
·期 1
·101-109
·
IF 1.577
Li Qian,Liu Li,Zhong Xin-Xin,Li Fa-Bao,Asiri Abdullah M.,Alamry Khalid A.,Zhu Nian-Yong,Wong Wai-Yeung,Qin Hai-Mei
Abstract A series of neutral luminescent tetranuclear and mononuclear copper(I) halide complexes, [Cu 4 I 4 (dpna) 4 ] ( 1 ) and [CuX(dpna) 2 ] dpna = 1-(diphenylphosphino)naphthalene, X = Br ( 2 ), Cl ( 3 ), were synthesized, and their molecular structures and photophysical properties were investigated. Complex 1 has a cubane-like structure with four Cu atoms pseudo -tetrahedral and four I atoms serving as μ 3 -bridges. The coordination geometry of the copper centers in 2–3 are trigonal-planar. In the solid state, complexes 1–3 display blue photoluminescence (λ max = 423–463 nm) at 298 K. The emission of the complexes originate from the (σ+X)→π* transition. All three complexes displayed good thermal stability. Graphical Abstract
研究领域:
无机化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
BMC CANCER
·
2022
·Vol. 22
·期 1
·1-12
·
IF 4.638
Chen Xueqin,Wang Yan,Liu Hancong,Zhang Jingjing,Wang Jie,Jin Xiaobao,Ma Yan
Background In our previous study, N end of the Circumsporozoite protein (CSP I-plus) modified recombinant human Endostatin (rEndostatin, endostar) (rES-CSP) was constructed, which had antiangiogenic capability and bound to hepatocellular carcinoma in vivo and in vitro. In this study, the inhibition of rES-CSP on hepatocellular carcinoma metastasis was verified in vivo and in vitro, and its possible mechanism was explored. Methods Firstly, the impact of rES-CSP on the migration, adhesion of hepatoma cell HCCLM3 was identified by wound healing, transwell, and on metastasis of orthotopic xenograft model was identified in nude mouse. Then the expression of metastasis-associated molecules (MMP2, E-cadherin, integrinβ1) and angiogenesis-related factors (VEGFA) in vitro and in vivo were detected by real-time PCR, western blotting, immunohistochemistry. Results Finally, we found that rES-CSP could inhibit the migration and invasion of HCCLM3, and decrease tumor metastasis and growth in nude mouse orthotopic xenograft models. The tumor inhibiting rates of rES-CSP and Endostar were 42.46 ± 5.39% and 11.1 ± 1.88%. The lung metastasis rates of the control, Endostar and rES-CSP were 71, 50, and 42.8%, respectively. Compared with Endostar, rES-CSP significantly down-regulated the expression of VEGFA and integrinβ1. Heparin, a competitive inhibitor of CSP I-plus, which can be bind to the highly-sulfated heparan sulfate proteoglycans (HSPGs) over-expressed in liver and hepatocellular carcinoma, alleviated the down-regulation of VEGFA and integrinβ1. Conclusions These indicate that rES-CSP may play a role in inhibiting tumor growth and metastasis by down-regulating the angiogenic factor VEGF and the metastasis-related molecules or by interfering with HSPGs-mediated tumor metastasis.
研究领域:
肿瘤学
·
分子生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2025
·
IF 6.1
Xilin Chen,Yanli Li,Ling Chen,Junrong Tu,Jianbin Pan,Xiaoru Zeng,Yu Fu,Duanping Sun
Acute myocardial infarction (AMI) is the most common cause of death in individuals with cardiovascular disease. Cardiac troponin I (cTnI) is acknowledged as the most prominent biomarker for AMI. However, the key problem of practical applications is how to effectively improve the detection speed and sensitivity. In this study, we designed a novel electrochemiluminescence (ECL) aptasensor for the rapid and quantitative determination of cTnI. This sensor employs self-luminous europium-based metal-organic framework@CdS quantum dots (Eu-MOF@CdS QDs) as a signal probe. The Eu-MOF@CdS QDs can produce a robust cathodic ECL signal via a synergistic effect. Furthermore, a ferrocene-labeled aptamer was used as a quenching probe for quenching the ECL emission of the Eu-MOF@CdS QDs. In the presence of cTnI, the ECL intensity increased with increasing cTnI concentration after ferrocene-labeled aptamer specifically recognized AFB1 and was detached from the electrode interface. Under optimal conditions, the aptasensor demonstrated precise analytical capabilities for cTnI ranging from 1.0 pg/mL to 1.0 ng/mL with a notably low detection limit of 0.08 pg/mL within 60 min. The results show that the developed ECL sensing device demonstrates the potential applications and perspectives for the detection of cTnI in serum samples as well as in the field of biomedical analyses.
研究领域:
医学诊断
·
生物传感
·
心血管疾病研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）