PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2023
·Vol. 25
·期 45
·30993-31002
·
IF 3.3
Siqi Dai,Xiaoyan Gan,Kegui Li,Qiang Huang,Liling Guo,Hanxing Liu
Lead-free metal halide perovskites have received widespread attention due to their composition of minimal hazardous components, excellent air stability, and long carrier lifetimes. However, the majority of the lead-free metal halide perovskites, such as Cs3Bi2Br9, have wide bandgaps, which limits their photoelectric in solar cells and optoelectronic devices. To address this issue, attempts have been made to adjust the bandgap through material alloying. Based on a solution approach, a pure phase of Cs3Bi2−xSbxBr9 crystals has been synthesized, with the alloying parameter x changing over the full range of composition. It is found that the mixed alloy has a smaller bandgap than pure Bi-based and Sb-based perovskites, with the smallest bandgap of 2.22 eV near x = 1, and there is a phenomenon of bandgap bowing throughout the alloying process. The electronic structure of Cs3Bi2−xSbxBr9 has been investigated using DFT calculations and the bandgap bowing of Cs3Bi2−xSbxBr9 is deduced to be related to the type-II band alignment between the Cs3Bi2Br9 and Cs3Sb2Br9. Owing to the mismatch of s and p orbital energies of Bi and Sb, the mixed alloy has a smaller bandgap. Our work demonstrated a method for achieving bandgap reduction and explained the phenomenon of bandgap bowing by pairing materials into type-II band alignment, which may also be found in other lead-free metal perovskites.
研究领域:
材料科学
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物理学
·
化学
·
太阳能
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DOI
高影响因子
JOURNAL OF CATALYSIS
·
2025
·
IF 6.5
Qi Chen,Xingxing Huang,Cheng Liu,Yueling Chen,Jionghua Wu,Jimmy C. Yu,Ling Wu
The attainment of rapid charge mobility and effective N 2 activation is of critical importance for photocatalytic nitrogen fixation but it has always been a challenge. Such challenge may be met by the construction of a Type II MoS 2 nanoparticles/ MIL-100(Fe) heterojunction photocatalyst. The new material possesses charge migration channels that facilitate the separation of photogenerated carriers. This charge redistribution during photocatalysis is confirmed by experimental results showing a decrease of charge density on the Fe species and an increase of that on Mo. Moreover, DFT calculations show that the adsorption of N 2 and H 2 O is more likely to occur on Fe sites and Mo sites, respectively. These findings clearly suggest a drastically improved spatial isolation of reduction and oxidation sites on the photocatalyst as compared to pristine MIL-100(Fe). The optimized MoS 2 /MIL-100(Fe) exhibits a NH 4 + yield rate of 1.29 μmol·h −1 as excellent utilization of photoinduced electron-hole pairs and effective adsorption and activation of N 2 become possible. This work offers an insight on the synergy of heterojunction engineering with coordinated activation for photocatalytic ammonia synthesis.
研究领域:
材料科学
·
催化
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纳米技术
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化学工程
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理论化学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xingping Fu,Qianqian Chen,Ye Zhang,Feng Yu,Junjie Pan,Xiaobing Yang
The overuse of antibiotics, coupled with inadequate wastewater treatment, has led to widespread environmental contamination, posing significant risks to ecosystems and public health. In this study, a novel BiOCl/Bi 2 MoO 6 /MIL-125(Ti) heterojunction catalyst featuring a Z -scheme and II-type dual-functional junctions was prepared via a two-step solvothermal method and employed for the degradation of tetracycline (TC). The synthesized samples were thoroughly characterized by XRD, SEM, BET, TEM, and UV–vis spectroscopy. The results indicate that the incorporation of BiOCl and Bi 2 MoO 6 effectively tunes the band structure of MIL-125(Ti), enhancing its visible-light absorption. Moreover, the formation of the heterojunction interfaces significantly suppresses recombination of photogenerated charge carriers, thereby improving photocatalytic performance. Under visible-light irradiation, the BiOCl/Bi 2 MoO 6 /MIL-125(Ti) catalyst generates reactive radicals (·OH and ·O₂ − ), enabling efficient degradation of TC with a removal efficiency of 95.71 %. The synergistic effect of the Z -scheme and II-type heterojunctions plays a crucial role in the efficient photocatalytic degradation of TC. This study provides new insights into the degradation mechanisms of bifunctional heterojunctions and presents a promising strategy for designing high-performance photocatalysts for tetracycline degradation.
研究领域:
环境科学
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材料化学
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光催化
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环境污染治理
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纳米材料
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药物降解
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半导体异质结
✓ 已验证
产品关联
DOI
高影响因子
COPD-Journal of Chronic Obstructive Pulmonary Disease
·
2023
·
IF 2.2
Chuanxin Yang,Libing Deng,Fang Bao,Hui Jiang,Long Zhang
Chronic obstructive pulmonary disease (COPD) is a difficult-to-cure disease that mainly affects the respiratory system. Inhaled anesthetic drug such as sevoflurane plays a controversial role in COPD by different concentration, but the underlying epigenetic mechanism remains unclear. Here, we prepared lipopolysaccharide (LPS)-induced COPD rat model, and isolated Alveolar type II (ATII) cells. We mainly focused DNA methylation on the promoter of COPD-related genes including Sftpa1, Napsa, Ca2, Sfta2, Lamp3, Wif1, Pgc, and Etv5. We observed COPD rat treated by sevoflurane with low (0.5%) and high (2%) concentrations displayed an opposite DNA methylation pattern. These six genes' promoter were all hypomethylated by 0.5% sevoflurane whereas hypermethylated by 2% sevoflurane, accompanied with the opposite transcriptional activity. We further verified that the DNMT1 binding ability contributed to DNA methylation these six genes' promoter. Moreover, we also captured DNMT1 and identified REC8 meiotic recombination protein (REC8) as the specific binding protein only existed in ATII cells treated with 0.5% sevoflurane rather than 2% and control. The binding ability of REC8 on these target genes' promoter showed highly positive correlation with DNMT1. In summary, we uncovered a potential epigenetic role of sevoflurane with low concentration in ATII cells of COPD that may help us deeply understand the pathogenesis and treatment mechanism of inhaled anesthesia drugs in COPD via a dose-dependent manner.
研究领域:
肺病学
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分子生物学
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表观遗传学
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药理学
✓ 已验证
DOI
高影响因子
JOURNAL OF PHARMACOLOGICAL SCIENCES
·
2024
·
IF 3
Zhihang Zhang,Yalan Luo,Xijing Zhuang,Haifeng Gao,Qi Yang,Hailong Chen
Acute lung injury (ALI) is closely related to high mortality in severe acute pancreatitis (SAP). This study unveils the therapeutic effect and mechanism of miR-217-5p on SAP-associated ALI. The miR-217-5p RNA expression was significantly up-regulated in lipopolysaccharide (LPS)-stimulated primary rat alveolar epithelial type II cells (AEC II) and sodium taurocholate-treated pancreas and lung in SAP rats. miR-217 inhibition protected AEC II from LPS-induced damage by inhibiting apoptosis and reducing the TNF-α, IL-6, and ROS levels. miR-217 inhibition suppressed apoptosis and alleviated mitochondrial damage through mitochondria-mediated apoptotic pathway in vitro . Sirt1 is a direct target of miR-217-5p. Dual-luciferase reporter assay confirmed the binding of miR-217-5p to Sirt1 mRNA 3′-UTR. The rescue experiment identified that the anti-apoptotic, anti-inflammatory, and anti-oxidative effects of miR-217 inhibition were mediated by Sirt1 in vitro . Emodin (EMO) protected AEC II from LPS-induced damage and alleviated pancreatic and lung tissue injuries. EMO exerted similar effects as miR-217 inhibition in vitro and in vivo . The effects of EMO were abolished by miR-217 overexpression. In conclusion, miR-217-5p inhibition exerts protective effects on SAP-ALI in vitro and in vivo by repressing apoptosis, inflammation, and oxidative stress through Sirt1 activation. EMO protects against lung injuries in SAP-associated ALI rats through miR-217-5p/Sirt1 axis.
研究领域:
药理学
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分子生物学
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病理生理学
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内科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2022
·
IF 9.965
Han Zhang,Xuefeng Bai
Photocatalytic H 2 O 2 production is an eco-friendly technique because only H 2 O, molecular O 2 and light are involved. However, it still confronts the challenges of the unsatisfactory productivity of H 2 O 2 and the dependence on organic electron donors or high purity O 2 , which restrict the practical application. Herein, we construct a type-II heterojunction of the protonated g-C 3 N 4 coated Co 9 S 8 semiconductor for photocatalytic H 2 O 2 production. The ultrathin g-C 3 N 4 uniformly spreads on the surface of the dispersed Co 9 S 8 nanosheets by a two-step method of protonation and dip-coating, and exhibits improved photogenerated electrons transportability and e - -h + pairs separation ability. The photocatalytic system can achieve a considerable productivity of H 2 O 2 to 2.17 mM for 5 h in alkaline medium in the absence of the organic electron donors and pure O 2 . The optimal photocatalyst also obtains the highest apparent quantum yield (AQY) of 18.10% under 450 nm of light irradiation, as well as a good reusability. The contribution of the type-II heterojunction is that the migrations of electrons and holes within the interface between g-C 3 N 4 and Co 9 S 8 matrix promote the separation of photocarriers, and another channel is also opened for H 2 O 2 generation. The accumulated electrons in conduction band (CB) of Co 9 S 8 contribute to the major channel of two-electron reduction of O 2 for H 2 O 2 production. Meanwhile, the electrons in CB of g-C 3 N 4 participate in the single electron reduction of O 2 as an auxiliary channel to enhance the H 2 O 2 production.
研究领域:
材料科学
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环境科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Energy Materials
·
2021
·Vol. 11
·期 18
·2100292
·
IF 29.368
Xiayan Chen,Yongkang Xia,Qingyi Huang,Zhe Li,Anyi Mei,Yue Hu,Ti Wang,Rongrong Cheacharoen,Yaoguang Rong,Hongwei Han
Printable hole-conductor-free perovskite solar cells (PSCs) have attracted intensive research attention due to their high stability and simple manufacturing process. However, the cells have suffered severe potential loss in the absence of the hole transporting layer. The dimensionality of the perovskite absorber in the mesoporous carbon electrodes by conducting post-treatments is reduced. The low-dimensional perovskites possess wide-bandgaps and form type-II band alignment, favoring directional charge transportation and thus enhancing the device performance. For the cells using MAPbI 3 (MA = methylammonium) as the light absorber, the open-circuit voltage ( V OC ) is significantly enhanced from 0.92 to 0.98 V after posttreatment, delivering an overall efficiency of 16.24%. For the cells based on FAPbI 3 (FA = formamadinium), a high efficiency of 17.47% is achieved with V OC of 1.02 V, which are both the highest reported values for printable hole-conductor-free PSCs. This strategy provides a facile method for tuning the energy level alignment for mesoscopic perovskite-based optoelectronics.
研究领域:
材料科学
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光伏技术
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纳米结构材料
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能源化学
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半导体物理
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表面与界面工程
·
功能材料
✓ 已验证
DOI
高影响因子
TOXICOLOGY LETTERS
·
2022
·
IF 4.271
Shuhong Guan,Hui Liu,Jun Zhou,Qiudi Zhang,Hui Bi
Transforming growth factor (TGF)-β1-induced fibrotic changes in alveolar epithelium is a critical event in pulmonary fibrosis . Herein, we recognized that lncRNA mir-100-let-7a-2-mir-125b-1 cluster host gene (MIR100HG) was abnormally upregulated within human idiopathic pulmonary fibrosis (IPF) lung tissue, bleomycin (BLM)-caused pulmonary fibrotic model mice and TGF-β1-stimulated mice type II alveolar epithelial cells. In vivo , MIR100HG knockdown attenuated BLM-caused lung fibrogenesis in mice; in vitro , MIR100HG knockdown attenuated TGF-β1-induced fibrotic changes in mice type II alveolar epithelial cells. Through direct binding, MIR100HG knockdown upregulated microRNA-29a-3p (miR-29a-3p) expression; through serving as competing endogenous RNA for miR-29a-3p, MIR100HG knockdown downregulated TGF-beta activated kinase 1/MAP3K7 binding protein 1 (Tab1) expression. Finally, under TGF-β1 stimulation, Tab1 knockdown attenuated TGF-β1-induced fibrotic changes and partially attenuated the effects of miR-29a-3p inhibition. In conclusion, we demonstrated the aberrant upregulation of lncRNA MIR100HG in BLM-caused lung fibrogenesis and TGF-β1-stimulated MLE 12 cells. The MIR100HG/miR-29a-3p/Tab1 axis could modulate TGF-β1-induced fibrotic changes in type II alveolar epithelial cells and, thus, might be promising targets for pulmonary fibrosis therapy.
研究领域:
肺科学
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分子生物学
·
细胞生物学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Kai Ren,Xiang Ke,Zhu Chen,Yao Zhao,Lu He,Peng Yu,Jiaqi Xing,Jun Luo,Jing Xie,Jianshu Li
High friction of damaged cartilage requires long-acting lubricated additive, which can also effectively scavenge reactive oxidative species (ROS) produced by mechanically stimulated chondrocytes . In this study, xanthan gum (XG) was grafted by poly (sulfobetaine methacrylate) (PSBMA) (the [XG]/[SBMA] molar ratio is 1:5 or 1:10), forming nanoparticles and then conjugated with collagen II-binding peptide, finally obtaining CBPXGSB1/5 or CBPXGSB1/10. Therein, the CBPXGSB1/5 was chosen as optimal lubricated additive. The results show that hydrated effect of PSBMA side chains endows CBPXGSB1/5 with favorable lubrication property (COF is 0.063). Furthermore, the CBPXGSB1/5 combining lubrication property and specific binding capability together may achieve the long-acting lubrication for injured cartilage in medical field. The CBPXGSB1/5 also possesses antioxidation verified by DPPH assay and exhibits synergistically enhanced ROS ( OH, O 2 − and H 2 O 2 ) scavenging. Besides, cytotoxicity experiment demonstrates that CBPXGSB1/5 has good biocompatibility. Therefore, multifunctional CBPXGSB1/5 developed here may have promising application potential in osteoarthritis treatment.
研究领域:
材料科学
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生物医学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Physics
·
2016
·Vol. 12
·期 12
·1105-1110
·
IF 18.791
Deng Ke,Wan Guoliang,Deng Peng,Zhang Kenan,Ding Shijie,Wang Eryin,Yan Mingzhe,Huang Huaqing,Zhang Hongyun,Xu Zhilin,Denlinger Jonathan,Fedorov Alexei,Yang Haitao,Duan Wenhui,Yao Hong,Wu Yang,Fan Shoushan,Zhang Haijun,Chen Xi,Zhou Shuyun
Weyl semimetal is a new quantum state of matter1,2,3,4,5,6,7,8,9,10,11,12 hosting the condensed matter physics counterpart of the relativistic Weyl fermions13 originally introduced in high-energy physics. The Weyl semimetal phase realized in the TaAs class of materials features multiple Fermi arcs arising from topological surface states10,11,14,15,16 and exhibits novel quantum phenomena, such as a chiral anomaly-induced negative magnetoresistance17,18,19 and possibly emergent supersymmetry20. Recently it was proposed theoretically that a new type (type-II) of Weyl fermion21,22 that arises due to the breaking of Lorentz invariance, which does not have a counterpart in high-energy physics, can emerge as topologically protected touching between electron and hole pockets. Here, we report direct experimental evidence of topological Fermi arcs in the predicted type-II Weyl semimetal MoTe2 (refs 23,24,25). The topological surface states are confirmed by directly observing the surface states using bulk- and surface-sensitive angle-resolved photoemission spectroscopy, and the quasi-particle interference pattern between the putative topological Fermi arcs in scanning tunnelling microscopy. By establishing MoTe2 as an experimental realization of a type-II Weyl semimetal, our work opens up opportunities for probing the physical properties of this exciting new state.
研究领域:
凝聚态物理学
·
量子材料
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拓扑材料
·
表面科学
✓ 已验证
DOI
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2024
·
IF 7
Jiali Wu,Yaokun Pang,Dan Liu,Jianxia Sun,Weibin Bai
Aloe-emodin (AE) is a natural compound with photodynamic properties. The aim of this study was to investigate the inhibitory effect of AE-mediated photodynamic inactivation (PDI) on Staphylococcus aureus ( S. aureus ). The bacteriostatic efficiency under different photodynamic conditions and photosensitizing mechanism was studied in detail. The results showed that AE-mediated PDI exhibited a typical concentration and time-dependent characteristics. In terms of bactericidal mechanism, disruption of membrane integrity and increase of cell membrane permeability was observed. Type II reaction was assumed as the main photochemical reaction involved in AE-mediated PDI as evidenced by the action of different ROS quenching agents. Furthermore, AE-mediated PDI decreased the bacterial survival in freshly squeezed apple juice and maintained its quality. The combination of blue light and AE enlarged the application of AE as an effective natural photosensitizer suitable for a food system.
研究领域:
微生物学
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食品科学
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2018
·
IF 6.383
Xiaopeng Zhou,Jingkai Wang,Weijing Fang,Yiqing Tao,Tengfei Zhao,Kaishun Xia,Chengzhen Liang,Jianming Hua,Fangcai Li,Qixin Chen
Nucleus pulposus (NP) degeneration is usually the origin of intervertebral disc degeneration and consequent lower back pain. Although adipose-derived stem cell (ADSC)-based therapy is regarded to be promising for the treatment of degenerated NP, there is a lack of viable cell carriers to transplant ADSCs into the NP while maintaining cell function. In this study, we developed a type II collagen/chondroitin sulfate (CS) composite hydrogel-like ADSC (CCSA) delivery system with genipin as the cross-linking agent. The induction effect of the scaffold on ADSC differentiation was studied in vitro , and a rat coccygeal vertebrae degeneration model was used to investigate the regenerative effect of the CCSA system on the degenerated NP in vivo . The results showed that the CCSA delivery system cross-linked with 0.02% genipin was biocompatible and promoted the expressions of NP-specific genes. After the injection of the CCSA system, the disc height, water content, extracellular matrix synthesis, and structure of the degenerated NP were partly restored. Our CCSA delivery system uses minimally invasive approaches to promote the regeneration of degenerated NP and provides an exciting new avenue for the treatment of degenerative disc disease. Statement of Significance Nucleus pulposus (NP) degeneration is usually the origin of intervertebral disc degeneration and consequent lower back pain. Stem cell-based tissue engineering is a promising method in NP regeneration, but there is a lack of viable cell carriers to transplant ADSCs into the NP while maintaining cell function. In this study, we developed a type II collagen/chondroitin sulfate (CS) composite hydrogel-like ADSC (CCSA) delivery system with genipin as the cross-linking agent. Although several research groups have studied the fabrication of injectable hydrogel with biological matrix, our study differs from other works. We chose type II collagen and CS, the two primary native components in the NP, as the main materials and combined them according to the natural ratio of collagen and sGAG in the NP. The delivery system is preloaded with ADSCs and can be injected into the NP with a needle, followed by in situ gelation . Genipin is used as a cross-linker to improve the bio-stability of the scaffold, with low cytotoxicity. We investigated the stimulatory effects of our scaffold on the differentiation of ADSCs in vitro and the regenerative effect of the CCSA delivery system on degenerated NP in vivo .
研究领域:
组织工程
·
干细胞生物学
·
再生医学
·
骨科
·
生物医学材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）