COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Yuxuan Zhang,Zaosheng Lv,Guangli Chen,Yuhang Liu,Yang Lei,Yanfen Huang
Hydrogel, a common hydrophilic material, is often used in wastewater treatment. In order to expand the application of hydrogel in superhydrophilic coatings, we chose acrylic acid (AA) and methacryloyloyloxy ethyltrimethylammonium chloride (DMC), two chemical materials commonly used in wastewater treatment, and semi-interpenetrating networks (semi-IPN) based on the metal mesh structure were successfully polymerization, and a superhydrophilic membrane (PAA/PDMC@SSM(stainless steel mesh)) was prepared. The membrane ensures the efficient separation of different types of oil-water mixtures under high flux conditions (up to 99 % separation efficiency) and the effective removal of oil from water-in-oil emulsions. This green polymer material can be used for efficient oil-water separation as well as separation of water-in-oil emulsions (separation efficiency close to 98 %). In order to prevent microorganisms from clogging the separation membrane during wastewater treatment, it was tested for E. coli with 99 % inhibition. PAA/PDMC@SSM was found to be acid-resistant, durable and self-cleaning for viscous oils.
研究领域:
材料科学
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环境工程
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高分子化学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Chang Yang,Hengyu Feng,Xudong Liu,Yuxin Guo,Mengya Sun,Wenhua Wang,Qingyan Kang,Ziyang Su,Wei Zhu,HeYuan Wang,Linghan Xiao
Conventional wound dressings are limited in their application due to the difficulty of maintaining normal use in cold conditions and a lack of functionality. In this study, photopolymerization was employed to fabricate a wound dressing with the capacity to monitor vital signs in cold environments. Utilizing bacterial cellulose (BC) to form an Interpenetrating Network (IPN) structure, the dressing exhibits enhanced water retention and mechanical properties, with a notable increase in mechanical strength to 540.37 KPa. Moreover, it maintains excellent mechanical resilience and electrical conductivity (9.01 × 10 −3 S/cm) even at temperatures as low as −20 ℃. Incorporation of positively charged quaternary ammonium salts imparts potent antibacterial properties to the hydrogel against Staphylococcus aureus and Escherichia coli by electrostatically adsorbing to and disrupting negatively charged bacterial cell membranes, resulting in the leakage of internal fluids. The efficacy of the hydrogel in promoting wound healing was validated through rat-infected wound models. Hematoxylin and eosin (H&E) staining confirmed a reduction in inflammation at the wound site, improved wound healing, and a marked increase in the wound healing rate. Moreover, the hydrogel has remarkable electrical conductivity (1.25 × 10 −2 S/cm), enabling the detection of subtle signals (e.g., strain 0.25 %) crucial for emergency wound management to prevent infections. Of significant importance, these hydrogels can function as electrodes for monitoring electrocardiogram (ECG) signals and respiratory status, facilitating timely assessment of vital signs in casualties. This innovative hydrogel wound dressing holds promise for simultaneously monitoring human vital signs and treating wounds in cold outdoor settings, thus offering broad applications in the realms of wound management and dressing for cold outdoor sports.
研究领域:
生物材料学
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医学工程
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创伤修复
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
·
IF 9.4
Bing Zhang,Chunwang Hu,Mengyuan Wang,Hongliang Wei,Songmao Li,Hui Yu,Yuxuan Wu,Gang Wang,Tao Guo,Hongli Chen
Herein, an interpenetrating network hydrogel (IPN-Gel) based on cellulose and chitosan was synthesized via simultaneous amino-anhydride and azide–alkyne click reaction in water in one pot. The samples were characterized by various analytical methods including FTIR, SEM, XRD, XPS, 1 H NMR and so forth. The fabrication conditions were optimized by single factor experiments with water uptake (WU) and gel mass fraction (GMF) as two indexes. The WU and GMF of the IPN-Gel prepared under optimized conditions were 1192.37 % and 74.00 %, respectively. Its WU descended with the ascension in temperature, and first descended and then gradually ascended with the ascension in pH, confirming that the IPN-Gel had thermal/pH dual responsiveness. Using 5-Fu as a model drug, the release behavior of 5-Fu in IPN-Gel was explored. Its release behavior could be regulated by changing temperature and pH values, and it followed the Korsmeyer Peppas model. The viability of 4 T1 cells and HUVEC cells exceeded 80 % after 48 h of incubation at a high concentration of 200 μg/mL IPN-Gel, and hemolytic percentage was below the allowed limit of 5 %. The study provides a new strategy for the preparation of the IPN-Gel with biocompatibility, swelling reversibility and controllable drug release.
研究领域:
材料科学
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生物医学工程
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药学
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产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
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2025
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IF 6.5
Xiangjuan Wei,Mengyuan Wang,Xiaocong Dong,Yichen He,Wenbin Nan,Shenglu Ji,Mengyuan Zhao,Haodang Chang,Hongliang Wei,Dan Ding,Hongli Chen
Background Oral mucositis (OM) is a common acute side effect among patients undergoing chemotherapy and/or radiotherapy, with complex pathogenesis and limited current treatment efficacy. Rabdosia rubescens, a traditional Chinese herb, contains oridonin (ORI) with antibacterial and anti - inflammatory properties. However, ORI’s poor solubility and low bioavailability hamper its clinical use. Medicinal plant - derived exosome - like nanovesicles (ENs) are emerging as a promising drug delivery system for wound repair. This study aimed to develop a novel therapeutic approach.Methods We fabricated internally-externally homologous drug-loaded exosome-like nanovesicles (ORI/ENs) derived from Rabdosia rubescens and encapsulated them in a semi-interpenetrating network hydrogel system (ORI/ENs/Gel) to repair chemoradiotherapy-induced OM. The morphology, biocompatibility, and antibacterial properties were evaluated. Moreover, the proliferative and migratory capacity were measured using L929 cells. In addition, the pro-healing effects and the underlying molecular mechanisms of ORI/ENs/Gel were assessed in vivo.Results ENs were extracted and purified from Rabdosia rubescens by sequential ultra-centrifugations. The encapsulation efficiency (EE) and loading capacity (LC) of ORI in ORI/ENs were 76.4 ± 3.2% and 9.21 ± 0.45%, respectively, suggesting that ENs had a high loading efficiency for homologous drug ORI. The evaluation of toxicity and antibacterial effects has been proven that ORI/ENs has biocompatibility and antibacterial properties. In vivo, ORI/ENs/Gel promoted collagen deposition, targeted NLRP3 to reduce inflammation, and accelerated OM wound healing.Conclusion The hydrogel composite incorporating internally-externally homologous drug-loaded ENs offers the potential to provide targeted therapy, improve bioavailability, and promote efficient healing of the OM.
研究领域:
药学
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生物医学工程
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2014
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IF 3.916
Xinyu Hu,Liandong Feng,Wei Wei,Aming Xie,Shiming Wang,Jianfa Zhang,Wei Dong
Salecan is a novel water-soluble, high molecular mass extracellular β-glucan produced by Agrobacterium sp. ZX09. Salecan has excellent physicochemical and biological properties, making it very suitable for hydrogel preparation. In this study, a series of novel semi-interpenetrating polymer network (semi-IPN) hydrogels containing Salecan and poly(N,N-dimethylacrylamide-co-2-hydroxyethylmethacrylate) (poly(DMAA-co-HEMA)) were synthesized by radical polymerization and semi-IPN technology. Structure and morphology of the hydrogels were characterized by FTIR, XRD, TGA and SEM. The semi-IPNs had a well-interconnected porous structure with tunable pore size ranging from 6 to 41 μm. Swelling capability of the hydrogels was improved by introducing the hydrophilic Salecan. Rheological results indicated that the incorporation of poly(DMAA-co-HEMA) into hydrogels enhanced the storage modulus. Compression tests revealed that these semi-IPNs were robust materials with compressive modulus between 13.3 and 90.5 kPa, the addition of Salecan increased the fracture strain from 71.1% to 88.8%. Degradation and cytotoxicity tests demonstrated that semi-IPNs were degradable and non-toxic.
研究领域:
材料科学
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高分子化学
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生物医学工程
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生物技术
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DOI
PubMed
高影响因子
IRANIAN POLYMER JOURNAL
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2021
·Vol. 30
·期 4
·343-353
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IF 1.899
Li Shunying,Qin Tingting,Chen Tingting,Wang Jun,Zeng Qingbing
A series of pH-sensitive semi-interpenetrating polymer network (semi-IPN) hydrogels poly(vinyl alcohol)/poly(hydroxypropyl methacrylate- co -methacrylic acid) (PVA/P(HPMA- co -MAA)) were synthesized by free-radical polymerization of HPMA and MAA in the presence of PVA. The physicochemical property of the obtained hydrogels was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, thermogravimetric analyses and scanning electron microscopy (SEM) measurements. The SEM photograph revealed the network formation with uniform pore distribution. The swelling behavior of each hydrogel in buffer solution showed a simultaneous sensitivity to pH and ionic strength: the swelling ratio of all hydrogels was higher in neutral environment than in acidic medium; besides, equilibrium swelling ratio of the hydrogels decreases as the ionic strength increases. Insulin was loaded into the PVA/P(HPMA- co -MAA) semi-IPN hydrogel. The in vitro insulin release experiment was carried out in buffer solutions at pHs 1.2 and 6.8. Results showed that the release of entrapped insulin was inhibited at pH 1.2 but obviously increased at pH 6.8. Cell viability revealed that the hydrogels were biocompatible. After oral administration of insulin-loaded hydrogel to streptozotocin-induced diabetic rats at 75 IU/kg, a sustained reduction in blood glucose level was observed. Therefore, the semi-IPN PVA/P(HPMA- co -MAA) hydrogels are potential vehicles for oral delivery of protein drugs.
研究领域:
药剂学
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生物材料学
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产品关联
DOI
高影响因子
POLYMER BULLETIN
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2023
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IF 3.2
Hua Bingyan,Wei Hongliang,Hu Chunwang,Zhang Yaqi,Yang Shuai,Wang Gang,Guo Tao,Li Jingjing
Herein, a semi-interpenetrating network (semi-IPN) hydrogel (SH/PNA) was prepared by simple free radical polymerization using N-isopropylacrylamide and 2-acrylamide-2-methylpropanesulfonic acid as monomers, poly(ethylene glycol) dimethacrylate as a crosslinking agent, and sodium alginate and humic acid as filled biomolecules. Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray diffraction, and rheometer were used to characterize the structure and properties of the samples. The effect of feeding ratios on the gel mass fraction and swelling properties of the SH/PNA hydrogel was explored to optimize its preparation conditions. The swelling behavior under different pH and temperatures was investigated. The experimental result showed that the SH/PNA hydrogel had excellent water absorption capacity and pH/temperature dual responsiveness. Moreover, SH/PNA hydrogel was used as a carrier of urea to prepare slow-release and water-retention fertilizer by in situ loading method, and slow-release properties of urea in water and soil were measured. Taking into account its good ability for controlled release and water retention, the WSRF was expected to be a promising low-cost, environmentally friendly fertilizer that can be used in agriculture and horticulture.
研究领域:
材料科学
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环境科学
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农业科学
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产品关联
DOI
高影响因子
ACS Applied Bio Materials
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2020
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IF 0
Xuebin Ma,Xin Liu,Penghui Wang,Xiaoxue Wang,Rong Yang,Shuai Liu,Zhiwen Ye,Bo Chi
Reversibly cross-linked adaptable hydrogels show great advantages in tissue engineering. The dynamic adaptable networks can overcome three-dimensional (3D) physical restrictions to enable normal cellular functions without hydrogel degradation. However, because of the dynamic reversibility, adaptable hydrogels typically exhibit weak mechanical properties and rapid erosion behaviors. Herein, we develop a facile strategy to prepare stable adaptable hydrogels using dynamic covalent chemistry, stable covalent chemistry, and the interpenetrating polymeric network (IPN) strategy. The developed IPN HA/γ-PGA adaptable hydrogels have stable structures, good mechanical properties, enzymatic degradability, and injectability. Compression test indicates that although containing 95% water, the IPN HA/γ-PGA adaptable hydrogels can suffer more than 85% compressive strain and show a fast shape recovery capacity and good antifatigue ability. Benefitting from the good cytocompatibility of functionalized HA and γ-PGA and the mild preparation process of IPN HA/γ-PGA adaptable hydrogels, NIH 3T3 cells can tolerate the 3D encapsulation process and show high cell viability. Therefore, owing to their desirable properties, the developed HA/γ-PGA adaptable hydrogels have great potential applications for load-bearing tissue engineering.
研究领域:
材料科学
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生物医学工程
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组织工程
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产品关联
DOI
PubMed
PROGRESS IN ORGANIC COATINGS
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2024
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IF 6.5
Cong Wu,Dongshuai Hou,Bing Yin,Binmeng Chen,Zongjin Li
The polystyrene acrylate (PSA) coating and polysiloxane coatings can protect the durability of cementitious materials through surface barrier and internal hydrophobicity, respectively. However, their composite coating presents a challenge due to the significant difference in molecular structure, molecular polarity, and thermodynamic properties, leading to poor interfacial compatibility. This paper presents a novel multi-component interpenetrating polymer network (IPN) based on the ‘host - guest molecular structure’ theory, which consists of cross-linked PSA as the main molecule and polysiloxane as the guest molecule, interfacially regulated by functionalized nanoparticles. The IPN composite coatings with high microphase separation properties enable dual synergistic protection of the durability of cementitious materials. The IPN emulsions synthesized increased the proportion of harmless pores within the cementitious materials to over 88.3 %. Additionally, they decreased the static capillary water absorption of concrete by over 94.06 % and effectively inhibited the formation of corrosion products, including Friedel's salt, gypsum, ettringite, and CaCO 3 . The adhesion strength of the IPN coating was also improved to 2.7 MPa, and its thermal expansion coefficient was limited to within 5.5 × 10 −5 /K. Moreover, the modified IPN coating contains numerous strong hydrogen bonds and interwoven molecular networks. These features enable stable deformation recovery and surface shielding of cracked concrete.
研究领域:
材料科学
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高分子化学
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土木工程
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涂料与表面处理
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
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2024
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IF 6.3
Yuxuan Zhang,Zaosheng Lv,Wenjun Lv,Kangwei Zhang,Yang Lei,Yanfen Huang
Hydrogels have become a focal point in oil-water separation technologies owing to their pronounced hydrophilicity and manageable viscosity. However, traditional hydrogels often suffer from subpar physical and mechanical strength. Our research introduces a semi-interpenetrating network (Semi-IPN) hydrogel composed of polyacrylamide and chitosan network (PAM/CSn), distinguished by both physical and chemical cross-linking to boost mechanical robustness. Experimental results demonstrate that polyacrylamide/chitosan network-SiO 2 @stainless steel mesh (PAM/CSn-SiO 2 @SSM) not only displays exceptional superoleophobic properties underwater (OCA >150°) but also maintains over 99 % separation efficiency across >20 cycles in diverse conditions including acidic, alkaline, and saline environments. In addition, the composite coating excelled in self-cleaning of viscous oils and in oil-in-water emulsion oil removal (92 %). Compared with previous polyacrylamide (PAM) hydrogels, our composite coating also possesses corrosion resistance to acids and alkalis and excellent ability to separate oil-water mixtures in harsh environments. These findings underscore the substantial potential of polyacrylamide/chitosan network-SiO 2 @stainless steel mesh (PAM/CSn-SiO 2 @SSM) composites in enhancing oil-water separation techniques.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2013
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IF 3.554
Wen-Bo Wang,Da-Jian Huang,Yu-Ru Kang,Ai-Qin Wang
The novel granular semi-IPN hydrogels were in situ prepared in an aqueous solution by the free-radical grafting and crosslinking reactions among chitosan (CTS), acrylic acid (AA), gelatin (GE) and N , N ′-methylene- bis -acrylamide. The FTIR spectra and elemental analysis confirmed that the AA monomers were grafted onto CTS backbone, and the GE macromolecular chains interpenetrated through the CTS- g -PAA network. The hydrogels are granular, which are composed of numerous micro-spheres according to the scanning electron microscope observations. The gel strength, adsorption, reuse and recovery properties of the hydrogels for Cu 2+ ion were systematically investigated. The results indicate the hydrogel with 2 wt% GE has the highest adsorption capacity of 261.08 mg/g with the recovery ratio of 95.2%. And the incorporation of 10 wt% GE enhanced the storage modulus by 103.4% ( ω = 100 rad/s) and 115.1% ( ω = 0.1 rad/s), and the adsorption rate by 5.67%. Moreover, the adsorption capacity of the hydrogel is still as high as 153.9 mg/g, after five cycles of adsorption–desorption. It was found that the ion-exchange and complexation interactions between the functional groups ( COO − and NH 2 ) of the hydrogels and Cu 2+ ion are the predominant adsorption mechanisms.
研究领域:
材料科学
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环境科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2023
·
IF 11.2
Chunwang Hu,Hongliang Wei,Bingyan Hua,Yaqi Zhang,Gang Wang,Tao Guo
A thermal/pH-sensitive interpenetrating network (IPN) hydrogel was prepared facilely from starch and poly(α- l -lysine) through amino-anhydride and azide-alkyne double-click reactions in one pot. The synthesized polymers and hydrogels were systematically characterized using different analytical techniques such as Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), scanning electron microscope (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and rheometer. The preparation conditions of the IPN hydrogel were optimized via one-factor experiments. Experimental results indicated the IPN hydrogel possessed pH and temperature sensitivity. Effect of different parameters (pH, contact time, adsorbent dosage, initial concentration, ionic strength , and temperature) on adsorption behavior were investigated in monocomponent system with cationic methylene blue (MB) and anionic Eosin Y (EY) as model pollutants. The results indicated that the adsorption process of the IPN hydrogel for MB and EY followed pseudo-second-order kinetics. The adsorption data for MB and EY fitted well with the Langmuir isotherm model, indicating monolayer chemisorption. The good adsorption performance was due to various active functional groups (–COOH, –OH, –NH 2 , etc.) in the IPN hydrogel. The strategy described here opens up a new way for preparing IPN hydrogel. The as-prepared hydrogel exhibits potential application and bright prospects as an adsorbent in wastewater treatment.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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