JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 6
·1-13
·
IF 2.8
Zou Yulong,He Qiaobai,Wang Shanrong,Zou Fang,Lu Xili,Sun Zhijie,Li Li
Poly(L-lactide-co-ε-caprolactone) (PLCL) nanocomposites reinforced with graphene oxide modified by poly (L-lactic acid) (g-GO) were prepared by solution casting, where the graft ratio of PLLA to GO is about 11.7%. The results show that the g-GO possesses improved dispersion and interface interactions with the PLCL matrix, therefore, the final mechanical properties of nanocomposites are enhanced. Comparing with neat PLCL, the tensile strength and elongation at break of (1wt%)g-GO/PLCL are increased by 86.4% and 82.4%, respectively. Moreover, the g-GO/PLCL nanocomposite containing 1 wt% g-GO exhibits excellent thermal- induced and NIR light-induced shape memory effects and the shape recovery ratio is all up to 95%. The nanocomposites also have favorable antibacterial properties. The g-GO/PLCL nanocomposites with good NIR light-induced shape memory effect, antibacterial properties, biodegradability and biocompatibility have great potential for minimally invasive surgery.
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ACS Biomaterials Science & Engineering
·
2023
·
IF 5.8
Jinni Luo,Huanxia Wang,Jinfei Wang,Yuan Chen,Chenglong Li,Kejun Zhong,Jie Xiang,Pengxiang Jia
Conductive hydrogels have been in huge demand in biomedical and wearable electronics. However, the application of traditional conductive hydrogels is largely limited due to their poor mechanical properties. Here, a conductive hydrogel with excellent mechanical strength and swelling resistance properties is prepared by ion cross-linking, directional freeze-drying, and rehydration. First, the acrylamide and acrylic acid are polymerized in the κ-carrageenan solution to form the hydrogel. Then, the obtained hydrogel is cross-linked with Fe3+ by soaking in ferric chloride solution. Finally, the ionic cross-linked hydrogels are reinforced by directional freeze-drying and rehydration. The resulting hydrogel has excellent tensile strength (5.67 MPa) and high toughness (7.63 MJ/m3). It is worth noting that the hydrogel also had excellent anti-swelling properties. Its mechanical strength and volume almost show no changes after soaking in deionized water for 40 days. In addition, the hydrogel exhibits good ionic conductivity (0.091 S/m), high sensitivity, and excellent stability when applied as a strain sensor. This work proposes a simple method to fabricate a conductive hydrogel with great mechanical properties and swelling resistance, which displays huge potential in varied fields.
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SEPARATION SCIENCE AND TECHNOLOGY
·
2018
·
IF 1.2
Jun Sang,Kang Liu,Qun Ma,Bing Li,Cui-qin Li
This study aimed at extracting and separating anthocyanins from Nitraria tangutorun Bobr. fruit using deep eutectic solvent (DES) combined with macroporous resins. Choline chloride/1,2-propanediol (ChCl-Prop)-based DESs produced higher extraction yields of total anthocyanins from N. tangutorun fruit than pure water and ethanol/methanol/acetone aqueous solutions did, and LX-32 macroporous resin was used to separate total anthocyanins from the DES (recovery＞95%). Additionally, a green and efficient HPLC-DAD method was used for the analysis of total anthocyanins using ethanol and a tartaric acid aqueous solution as mobile phases, and 13 anthocyanins were identified from N. tangutorun fruit using a UPLC-Q-TOF-MS method.Abbreviations: DES, deep eutectic solvent; ChCl-Prop, choline chloride/1,2-propanediol.
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MOLECULES
·
2019
·Vol. 24
·期 15
·2770
·
IF 3.06
Yunchang Fan,Zeyu Niu,Chen Xu,Lei Yang,Tuojie Yang
Rheum palmatumL. (R. palmatumL.) is a traditional Chinese herb and food, in which rhein and emodin are the main bioactive components. The extraction of the two compounds fromR. palmatumL. is, thus, of great importance. In this work, protic ionic liquids (PILs) were applied in the microwave-assisted extraction (MAE) of rhein and emodin fromR. palmatumL., which avoids the toxicity of organic solvents. The results of the present study indicate that PILs possessing higher polarity exhibit higher extraction ability due to their stronger absorption ability for microwave irradiation. Compared with conventional solvents, such as methanol, trichloromethane, and deep eutectic solvents (DESs), the PIL, 1-butyl-3-himidazolium methanesulfonate ([BHim]MeSO3) reported herein is more efficient. The selected extraction conditions of liquid–solid ratio, microwave irradiation time, microwave irradiation power, and PIL concentration were 40 g·g−1, 50 s, 280 W, and 80%, respectively. Under the selected conditions, the extraction yields of rhein and emodin were 7.8 and 4.0 mg·g−1, respectively. These results suggest that PILs are efficient extraction solvents for the separation of active components from natural products.Keywords:microwave-assisted extraction;protic ionic liquids (PILs);polarity;Rheum palmatumL.
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Chemical Science
·
2019
·Vol. 10
·期 25
·6295-6303
·
IF 9.556
Miao-Miao Chen,Shi-Bo Cheng,Kailun Ji,Jingwen Gao,Yan-Ling Liu,Wei Wen,Xiuhua Zhang,Shengfu Wang,Wei-Hua Huang
Flexible and wearable chemical sensors show great capability and potential in retrieving physiologically related chemical or biochemical information from elastic and curvilinear living bodies. However, so far, no flexible electrochemiluminescence (ECL) device has been reported, though ECL measurements have been extensively investigated and widely applied in many fields. Herein, we for the first time designed and fabricated a flexible ECL sensor by immobilizing highly luminescent nanospheres on Au nanotube (Au NT) networks, and subsequently coating an elastic molecularly imprinted polymer (MIP) thereon. The as-prepared flexible ECL platform displayed successive and desirable mechanical compliance while generating a very stable ECL signal during deformation, facilitating highly selective detection of physiologically relevant chemicals from bodies. On-body wearable sampling and subsequent detection of lactate and urea from sweat showed the ECL performance of this sensor displaying desirable fidelity, reusability and high stability against disturbance. This work successfully incorporated the ECL sensing model into a flexible and wearable device, therefore providing a promising new path for non-invasively monitoring the products of metabolism for health care and biomedical investigations.
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RSC Advances
·
2019
·Vol. 9
·期 16
·9006-9013
·
IF 3.049
Shengli Mi,Jingjing Xia,Yuanyuan Xu,Zhichang Du,Wei Sun
In this study, we developed an electrochemical microchannel biosensor platform to analyse lactate metabolism in cells. This biosensor platform was fabricated by photolithography, thin-film deposition and microfluidic technology. A kind of functional biomaterial was prepared by mixing lactate oxidase, single-walled carbon nanotubes and chitosan, and platinum as working and blank electrodes of the biosensor was modified by a thin Prussian blue layer. The lactate biosensor was obtained by dropping functional biomaterials on the electrode. The results demonstrated that the sensitivity of the electrochemical biosensor was up to 567 nA mM−1 mm−2 and the limit of detection was 4.5 μM (vs. Ag/AgCl as the counter/reference electrode). The biosensor used to quantitatively detect metabolic lactate concentrations in HepG2 cells cultured with cancer drugs showed high sensitivity, selectivity and stability, and has potential applications in organ-on-a-chip and tissue engineering technologies, which typically involve low concentrations of metabolites.
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Processes
·
2018
·Vol. 6
·期 11
·212
·
IF 1.279
Danyu Sun,Runping Wang,Fenfang Li,Lianglei Liu,Zhijian Tan
(1) Background: The environmentally friendly choline-amino acid ionic liquids (ChAAILs) and deep eutectic solvents (DESs) have been used as excellent alternatives to volatile organic compounds (VOCs) and ionic liquids (ILs) in recent years; (2) Methods: Thus, ChAAILs/salt and DESs/salt aqueous two-phase systems (ATPSs) were developed for the chiral extraction of phenylalanine enantiomers. The optimum ATPS of [Ch][L-Pro]/K3PO4was chosen, and the influencing parameters were investigated, including ChAAILs concentration, salt concentration, chiral selector concentration, extraction temperature, phenylalanine concentration, and system pH; (3) Results: The phenylalanine enantiomers were mainly extracted into the top phase (ChAAIL-rich phase), meanwhile, the (S)-phenylalanine [(S)-Phe)] was preferentially recognized by the chiral selector in the top phase. The maximum separation factor (α) of 2.05 was obtained under the optimal conditions; and (4) Conclusions: This ATPS that was used for the chiral extraction of enantiomers is much more environmentally friendly, simple, and rapid, and has the potential to be used in the enantioselective extraction of other enantiomers.Keywords:enantioselective extraction;aqueous two-phase system;ionic liquids;deep eutectic solvents;phenylalanine
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2019
·
IF 3.571
Cun-Duo Tang,Peng-Ju Ding,Hong-Ling Shi,Yuan-yuan Jia,Mao-zhi Zhou,Hui-lei Yu,Jian-He Xu,Lun-Guang Yao,Yun-Chao Kan
Phenylglyoxylic acid (PGA) are key building blocks and widely used to synthesize pharmaceutical intermediates or food additives. However, the existing synthetic methods for PGA generally involve toxic cyanide and complex processes. To explore an alternative method for PGA biosynthesis, we envisaged cascade biocatalysis for the one-pot synthesis of PGA from racemic mandelic acid. A novel mandelate racemase named ArMR showing higher expression level (216.9 U·mL–1 fermentation liquor) was cloned from Agrobacterium radiobacter and identified, and six recombinant Escherichia coli strains were engineered to coexpress three enzymes of mandelate racemase, d-mandelate dehydrogenase and l-lactate dehydrogenase, and transform racemic mandelic acid to PGA. Among them, the recombinant E. coli TCD 04, engineered to coexpress three enzymes of ArMR, LhDMDH, and LhLDH, can transform racemic mandelic acid (100 mM) to PGA with 98% conversion. Taken together, we provide a green approach for one-pot biosynthesis of PGA from racemic mandelic acid.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2018
·
IF 3.412
Cun-Duo Tang,Hong-Ling Shi,Jian-He Xu,Zhu-Jin Jiao,Fei Liu,Peng-Ju Ding,Hong-Fei Shi,Lun-Guang Yao,Yun-Chao Kan
d-Mandelate dehydrogenase (DMDH) has the potential to convert d-mandelic acid to phenylglyoxylic acid (PGA), which is a key building block in the field of chemical synthesis and is widely used to synthesize pharmaceutical intermediates or food additives. A novel NAD+-dependent d-mandelate dehydrogenase was cloned from Lactobacillus harbinensi (LhDMDH) by genome mining and expressed in Escherichia coli BL21. After being purified to homogeneity, the oxidation activity of LhDMDH toward d-mandelic acid was approximately 1200 U·mg–1, which was close to four times the activity of the probe. Meanwhile, the kcat/Km value of LhDMDH was 28.80 S–1·mM–1, which was distinctly higher than the probe. By coculturing two E. coli strains expressing LhDMDH and LcLDH, we developed a system for the efficient synthesis of PGA, achieving a 60% theoretical yield and 99% purity without adding coenzyme or cosubstrate. Our data supports the implementation of a promising strategy for the chiral resolution of racemic mandelic acid and the biosynthesis of PGA.
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MICROCHEMICAL JOURNAL
·
2018
·
IF 2.746
Li Duan,Wei-Hong Zhang,Zhan-Hui Zhang,E-Hu Liu,Long Guo
Nowadays, deep eutectic solvents (DESs) are emerging as a new type of green and sustainable solvents for efficient extraction of bioactive compounds from natural products . In the present study, to evaluation of DESs for the extraction of flavone C -glycosides, a total of twelve choline chloride based DESs were tailored for simultaneous extraction three main bioactive flavone C -glycosides (2″‑ O ‑galactopyranosylorientin, orientin and vitexin) from Flos Trollii. The DES composed of choline chloride and zinc bromide showed the best extraction efficiency for the flavone C -glycosides compared with conventional organic solvents (methanol and 50% methanol). Subsequent, the extraction parameters for the three flavone C -glycosides, including liquid-solid ratios, water content (%) in the selected DESs, and extraction time were optimized using response surface methodology and the optimal extraction condition are liquid-solid ratio, 42 mL/g; water content, 48%; extraction time, 28 min. In addition, the three flavone C -glycosides were recovered from DESs by macroporous resin (D101) with a satisfactory yield between 75.4% and 80.5%. The present research indicated that DESs were efficient and sustainable for extraction main flavone C -glycosides from Flos Trollii and the data acquired in this study could contribute to further DESs application in extraction of bioactive compounds from natural products.
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DALTON TRANSACTIONS
·
2018
·Vol. 47
·期 36
·12671-12683
·
IF 4.099
Sugang Meng,Yanjuan Cui,Hao Wang,Xiuzhen Zheng,Xianliang Fu,Shifu Chen
The development of stable noble metal-free photocatalysts with efficient separation and transportation of the photogenerated electrons–holes is of crucial importance for promoting the application of photocatalysis technology. Herein, we propose an electron transfer strategy by reasonable design and fabrication of novel 0D NiSx nanosheets as a co-catalyst on the surface of 1D CdS nanorods (CdS-NRs) to enhance photocatalytic hydrogen evaluation and contamination (Cr(VI), rhodamine B and bisphenol A) removal in water. Under visible light irradiation, the 0D–1D NiSx/CdS-NR nanocomposite with 1.5% NiSx loading gave a hydrogen evolution rate of 5.98 mmol h−1 g−1, which is about 5.3 times and 1.9 times higher than that of the native CdS-NRs and the optimal 1% Pt/CdS-NRs, respectively. Notably, good stability in the recycling test and a high apparent quantum efficiency of about 69.9% at 420 nm were also obtained. The 1.5% NiSx/CdS-NRs exhibited enhanced photocatalytic contamination degradation efficiency of about 2 times higher than pure CdS-NRs. In this hybrid photocatalyst, 0D NiSx nanosheets came into intimate interfacial contact with the surface of 1D CdS-NRs and played a similar role as noble metals, which could effectively improve the separation, transportation efficiencies and lifetime of photogenerated charge, and thus enhance the photocatalytic performance of CdS-NRs with more efficient conversion of solar energy. This work shows not only a possibility for the utilization of noble metal-free NiSx as a co-catalyst in the photocatalysis, but also provides new insight into the design and fabrication of high-performance composite photocatalysts (such as NiSx/g-C3N4 and NiSx/Zn3In2S6).
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Biosensors-Basel
·
2025
·Vol. 15
·期 1
·49
·
IF 5.6
Yijiong Xue,Chengqi Bao,Hui Liu,Fanghui Ma,Minghui Yang,Xiaoqing Li
A fluorescence probe for “switch-on” detection of alkaline phosphatase (ALP) was developed based on Au nanoclusters anchored MnO2nanosheets (Au NCs-MnO2NSs), which were synthesized using bovine serum albumin (BSA) as template through a simple one-pot approach. In the sensing system, MnO2NSs function as both energy acceptors and target identifiers, effectively quenches the fluorescence of Au NCs via fluorescence resonance energy transfer (FRET). The presence of ALP catalyzes the hydrolysis of L-ascorbic acid-2-phosphate (AAP) to ascorbic acid (AA), reducing MnO2NSs to Mn2+and facilitate the fluorescence recovery of Au NCs. The fluorescence assay offers the advantages of facile preparation, cost-effectiveness, good specificity, and high sensitivity. Moreover, the assay exhibits a broad linear range (0.005 U/mL to 8 U/mL) for ALP detection with a remarkable limit of detection of 0.0015 U/mL. Notably, this assay demonstrates promising applicability for detection ALP in human serum samples, thereby providing valuable potential for clinical applications.
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