MACROMOLECULAR BIOSCIENCE
·
2016
·Vol. 16
·期 11
·1632-1642
·
IF 3.68
Yuankun Dai,Zhenzhen Gao,Lie Ma,Dongan Wang,Changyou Gao
A bioactive scaffold with desired microstructure is of great importance to induce infiltration of somatic and stem cells, and thereby to achieve the in situ inductive tissue regeneration. In this study, a scaffold with oriented pores in the radial direction is prepared by using methacrylated hyaluronic acid (HA-MA) via controlled directional cooling of a HA-MA solution, and followed with photo-crosslinking to stabilize the structure. Poly(lactide- co -glycolide) (PLGA) is further infiltrated to enhance the mechanical strength, resulting in a compressive modulus of 120 kPa. In vitro culture of bone marrow stem cells (BMSCs) reveals spontaneous cell aggregation inside this type of scaffold with a spherical morphology. In vivo transplantation of the cell-free scaffold in rabbit knees for 12 w regenerates simultaneously both cartilage and subchondral bone with a Wakitani score of 2.8. Moreover, the expression of inflammatory factor interleukin-1β (IL-1β) is down regulated, although tumor necrosis factor-α (TNF-α) is remarkably up regulated. With the anti-inflammatory, bioactive properties and good restoration of full thickness cartilage defect in vivo, the oriented macroporous HA-MA/PLGA hybrid scaffold has a great potential for the practical application in the in situ cartilage regeneration.
研究领域:
组织工程学
·
再生医学
·
生物材料科学
✓ 已验证
DOI
PubMed
高影响因子
ACS Catalysis
·
2025
·
IF 13.1
Wei An,Zeyang Liu,Tongjun Shen,Yizhang Du,Cun Huang,Boyuan Duan,Chunxia Wang,Guoyong Huang,Yiming Yan,Shengming Xu
To overcome the low current-density efficiency and long-term stability issues of industrial overall water splitting at ampere-level current density, a kind of superwetting Mo-doped nanoarray anchored on nickel foam (NF) (Mo-CoP/NC) with three-dimensional (3D) nanoflower structure is constructed. The incorporation of Mo species induces thermoneutral hydrogen adsorption free energy and creates favorable empty d-orbitals, which enhances the d–p hybridization of Co–O bonds, thereby accelerating the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) kinetics in alkaline media. The optimized Mo-CoP/NC exhibits exceptional electrocatalytic performance, requiring low overpotentials of 198 mV for HER and 384 mV for OER at a current density of 1000 mA cm–2 and achieving maintains robust operation in overall water splitting at 3000 mA cm–2. When employed as a bifunctional catalyst in an alkaline electrolyzer, a cell voltage of 1.87 V can be realized at 1000 mA cm–2 , outperforming commercial benchmarks. Density functional theory (DFT) calculations reveal that Mo doping optimizes hydrogen adsorption energy and reduces energy barriers for water dissociation. The superwetting surface ensures rapid gas bubble detachment and efficient active site regeneration, while N-doped carbon encapsulation endows long-term stability with negligible activity decay over 100 h of continuous operation.
研究领域:
材料科学
·
能源化学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Dong Anrui,Lin Gaoxin,Li Zhiheng,Wu Wen,Cao Xing,Li Wenlong,Wang Linqin,Zhao Yilong,Chen Dexin,Sun Licheng
The mechanical stability of the catalytic electrodes used for hydrogen evolution reactions (HER) is crucial for their industrial applications in anion exchange membrane water electrolysis (AEM-WE). This study develops a corrosion strategy to construct a self-supported electrocatalyst (Int-Ni/MoO 2 ) with high mechanical stability by anchoring the Ni/MoO 2 catalytic layer with a dense interlayer of MoO 2 nanoparticles. The Int-Ni/MoO 2 exhibits a strengthened homostructural interface between the interlayer and catalytic layer, preventing the detachment of the catalyst during ultrasonic treatment. The blade-shaped catalytic layer reduces bubble shock and potential fluctuations at high current densities up to −6000 mA cm −2 . As a result, the Int-Ni/MoO 2 electrode exhibits a low overpotential of 73.2 ± 14.2 mV and long-term stability for 6000 h at −1000 mA cm −2 in a 1 M KOH solution. The Int-Ni/MoO 2 assembled AEM-WE device demonstrates long-term stability at 1000 mA cm −2 for 1000 h with a very low degradation rate of 3.96 µV h −1 .
研究领域:
材料科学
·
电化学
·
可再生能源
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2022
·
IF 4.119
Chunying Li,Fang Nie,Changyin Feng,Mengfei Tian,Meiting Yu,Chunjian Zhao,Yujie Fu
A creative dual-template molecularly imprinted polymer (Fe 3 O 4 @MCM-41-MIPs) with good magnetic properties and specific recognition of echinacoside and acteoside was prepared by surface imprinting. Echinacoside and acteoside served as dual templates, 4-vinylpyridine (4-VP) was used as a functional monomer , the cross-linker was ethylene glycol dimethacrylate (EGDMA), and the selected initiator was azobisisobutyronitrile (AIBN). The prepared Fe 3 O 4 @MCM-41-MIPs were applied to the selective separation and enrichment of echinacoside and acteoside from Cistanche deserticola Y. C. Ma ( C. deserticola ). The resulting Fe 3 O 4 @MCM-41-MIPs were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR), laser particle size scanning and vibration sample magnetometry (VSM). The results of the isotherm adsorption experiment showed that the maximum adsorption capacities of Fe 3 O 4 @MCM-41-MIPs for echinacoside and acteoside were 6.02 and 1.63 mg·g -1 , respectively, at 298 K. The pseudo-second-order reaction mechanism showed that the equilibrium adsorption capacities of Fe 3 O 4 @MCM-41-MIPs for echinacoside and acteoside were 4.81 and 0.93 mg·g -1 , respectively. The characterization of Fe 3 O 4 @MCM-41-MIPs showed that the imprinted layer with dual-template molecules was wrapped on the outside of the carrier, and the obtained Fe 3 O 4 @MCM-41-MIPs showed good saturation magnetization , desirable capacity for echinacoside and acteoside adsorption, and satisfactory reuse (echinacoside and acteoside maintained relative adsorption rates of 97.5% and 95.8% after five cycles). After separation, the purities of echinacoside and acteoside were 33.50% and 27.00%, respectively. In addition, in the selective adsorption experiment, the synthesized Fe 3 O 4 @MCM-41-MIPs showed better selectivity for echinacoside and acteoside than their structural analogs. Therefore, this method proved to be sustainable, rapid and highly efficient for the separation and enrichment of echinacoside and acteoside.
研究领域:
中药化学
·
分离科学
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 11
·2212606
·
IF 19
Zhijun Li,Meizi Wu,Lu Yang,Kunpeng Guo,Yuwei Duan,Yong Li,Kun He,Yifan Xing,Zheng Zhang,Hui Zhou,Dongfang Xu,Jungang Wang,Hong Zou,Da Li,Zhike Liu
High density of defects at interface severely affects the performance of perovskite solar cells (PSCs). Herein, cobalt (II) hexafluoro-2,4-pentanedionat (CoFAc), a hinge-type fluorine-rich complex, is introduced onto the surface of formamidinium cesium lead iodide (FACsPbI 3 ) film to address the issues of perovskite/Spiro-OMeTAD interface. The existence of CoFAc passivates both organic cation and halide anion vacancies by establishing powerful hydrogen bonds with HC(NH 2 ) 2 + (FA + ) and strong ionic bonds with Pb 2+ in perovskite films. In addition, CoFAc serves as a connecting link to enhance interfacial hole-transport kinetics via interacting with Spiro-OMeTAD. Consequently, FACsPbI 3 PSCs with CoFAc modification display a champion power conversion efficiency (PCE) of 24.64% with a charming open-circuit voltage ( V OC ) of 1.191 V, which is the record V OC among all the reported organic-inorganic hybrid PSCs with TiO 2 as electron transport layer. Furthermore, CoFAc-modified devices exhibit an outstanding long-term stability, which can maintain 95% of their initial PCEs after exposure to ambient atmosphere for 1500 h without any encapsulation.
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Kai Zhang,Qingmei Su,Bin Han,Yvjie Lv,Weihao Shi,Yongle Wang,Pinpin Wang,Zhiyong Wang,Wenqi Zhao,Miao Zhang,Shukai Ding,Shufang Ma,Gaohui Du,Rui Ye,Bingshe Xu
Designing highly efficient nonprecious metal electrocatalyst for the hydrogen evolution reaction (HER) in seawater electrolyte, particularly under ultra-high current density conditions, remains a formidable challenge. In this study, we successfully synthesized a crystalline/amorphous heterostructured CoNi/MoO 3-x electrocatalyst through a facile hydrothermal method followed by a calcination-reduction process. The as-prepared CoNi/MoO 3-x catalyst exhibited remarkable HER catalytic performance in both alkaline water and seawater electrolytes. Notably, the catalyst achieved impressively low overpotentials of 343 mV in 1 M KOH aqueous solution and 294 mV in alkaline natural seawater electrolyte at an ultra-high current density of 4000 mA/cm 2 . Furthermore, the CoNi/MoO 3-x electrocatalyst demonstrated outstanding long-term stability, maintaining robust performance at current densities of 3000 and 2000 mA/cm 2 . Density functional theory calculations revealed that the synergetic effect between crystalline CoNi and amorphous MoO 3-x accelerates water dissociation kinetics and optimizes hydrogen adsorption. These findings not only provide a promising strategy for developing cost-effective, nonprecious metal electrocatalysts with superior HER performance at ampere-level current densities, particularly for seawater splitting applications.
研究领域:
材料科学
·
能源化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2023
·Vol. 53
·期 1
·136-147
·
IF 4
Hao Gao,Minghui Zhang,Zicong Xu,Yichuan Chen,Yuehui Hu,Zhijie Yi,Jiayu Huang,Hua Zhu
Due to the hydrophilicity and black-phase instability of FA perovskites, ambient humidity is an unavoidable issue in the processing of perovskite solar cells (PSCs). MACl is among the most popular additives for improving perovskite films, but our experiments confirm that the direct addition of MACl into the precursor solution deteriorates the stability of the final α-FAPbI3 films in humid air, which is attributed to the unwanted pinholes induced by MACl volatilization. To solve this problem, a novel confined-space annealing strategy (CSA) is intentionally developed to control the amount of MACl at a low level. Through retarding the volatilization of MACl and blocking moisture ingress, dense and δ-phase-free FAPbI3 films with excellent crystallinity and stability are achieved at 100 °C under high humidity (RH: 60 ± 10%). We further compare the same amounts of MAI and FACl additives with MACl, discovering that only when MA and Cl work together can pure α-FAPbI3 films be obtained; therefore, a mechanism of MA-assisted nucleation and Cl-induced diffusion recrystallization is inferred. As a result, the PSCs employing optimal films yield a champion power conversion efficiency (PCE) of 17.27% and retain over 90% of the initial PCE after exposure to high humidity for 480 h. Our results offer deep insights into the thermodynamic and kinetic behaviors of MA and Cl in film growth and are beneficial for air-processed FA-based PSCs for commercial application.
研究领域:
材料科学
·
能源技术
·
光伏器件
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2025
·
IF 3.1
Abulimiti Yasen,Yuxia Zhou,Wenhan Gao,Zhongxin Zhang,Reyihan Tudi,Mei Xiang,Bumaliya Abulimiti
Laser-Induced Breakdown Spectroscopy (LIBS) holds significant value for rapid elemental detection; however, strong spectral interference, matrix effects, and high-dimensional data characteristics pose considerable challenges to accurate quantitative analysis. To enhance the performance of LIBS quantitative analysis, this study proposes a novel machine learning framework that integrates XGBoost and Multilayer Perceptron (MLP), optimized by a Multi-dimensional Adaptive Sparrow Search Algorithm (MA-SSA). The framework employs XGBoost for automated feature selection, eliminating redundant spectral variables while retaining critical information, and utilizes MA-SSA to optimize the hyperparameters of the MLP in regression tasks, significantly improving model stability and prediction accuracy. Experimental results demonstrate that the proposed method achieves 100% accuracy in multi-class classification, outperforming traditional classifiers such as Random Forest, XGBoost, and standalone MLP. In terms of quantitative detection, the MA-SSA-optimized model achieves an RMSE of 4.43 µg/g, surpassing other hybrid optimization models including XGBoost-SSA-MLP (RMSE=4.62 µg/g), XGBoost-PSO-MLP (RMSE=5.225 µg/g), and XGBoost-GA-MLP (RMSE=5.584 µg/g). XGBoost-based feature selection effectively reduces spectral dimensionality while maintaining predictive performance. The proposed MA-SSA algorithm further enhances convergence efficiency and generalization capability. This study provides a robust, efficient, and scalable solution for LIBS analysis, with broad application potential in the field of real-time quantitative detection.
研究领域:
分析化学
·
机器学习
·
光谱学
·
环境监测
·
药物分析
·
食品安全
✓ 已验证
DOI
PubMed
高影响因子
FASEB JOURNAL
·
2025
·Vol. 39
·期 16
·e70906
·
IF 4.2
Lina Wei,Lei Wang,Yang Yu,Xiaozhou Sun,Liang Liu,Jing Han,Yongji Wang,Yinan Guo
Pediatric bacterial pneumonia continues to pose a significant global health burden, often resulting in serious complications. Recent studies have emphasized the pivotal role of the gut-lung axis in the progression of respiratory diseases, wherein disruptions in gut microbiota can aggravate pulmonary inflammation. This research investigates the underlying mechanisms by which Ma-Xing-Shi-Gan Decoction (MXSG), a classical formula in traditional Chinese medicine, influences the gut-lung axis in the context of childhood bacterial pneumonia. Clinical data indicated pronounced alterations in intestinal microbial composition and a marked decline in short-chain fatty acid (SCFA) levels among affected pediatric patients—changes that coincided with dysfunctional gut-lung signaling. In a murine model of bacterial pneumonia, MXSG administration restored microbial diversity, elevated SCFA production, and attenuated inflammatory responses by suppressing the HDAC3/NF-κB signaling cascade. Key bioactive constituents of MXSG—namely, quercetin, osajin, nobiletin, and solasodine—were identified as critical regulators, modulating lipid metabolism and promoting SCFA biosynthesis. These results highlight the therapeutic promise of MXSG in reestablishing gut-lung homeostasis and shed light on its mechanistic potential in the treatment of pediatric bacterial pneumonia. Graphical This schematic illustrates how MXSG restores gut microbiota diversity and SCFA levels, suppresses HDAC3/NF-κB signaling, and alleviates lung inflammation in pediatric bacterial pneumonia. Integrated multi-omics and mouse model experiments reveal that MXSG modulates the gut-lung axis and provides a novel mechanism for its clinical efficacy.
研究领域:
中医药学
·
微生物学
·
免疫学
·
药理学
·
分子生物学
·
儿科学
·
呼吸疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food & Function
·
2020
·Vol. 11
·期 5
·4193-4201
·
IF 4.171
Xianghe Meng,Chaosheng Xia,Qin Ye,Xiaohua Nie
tert-Butyl-p-benzoquinone (TBBQ), a metabolite of tert-butylhydroquinone from food, has cytotoxicity, the underlying mechanism of which is not clear. In this study, the viability of RAW 264.7 cells exposed to TBBQ at concentrations of 0.5–10 μg mL−1 was assayed by MTT. Results suggest that TBBQ decreased the viability in a dose-dependent manner. Monodansylcadaverine (MDC) staining results indicate the occurrence of autophagy induced by TBBQ, which was manifested by activation of LC3-II concurrent with the increased levels of Beclin1 and reduced levels of p62. Elevated lipid peroxide and decreased SOD activity by TBBQ exposure suggest the overproduction of ROS, which may account for the increase in the genotoxic stress protein p53. Both upregulation of p53 and reduction of Akt levels inhibited mTOR, which activated autophagy. Addition of 3-MA counteracted the impact of TBBQ on ATG proteins and cell viability. All of these results suggest that TBBQ induces autophagy of RAW 264.7 cells principally by inhibition of the Akt/mTOR signaling pathway, and they implicate ROS in this regulation.
研究领域:
药理学
·
细胞生物学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Chinese Journal of Natural Medicines
·
2022
·
IF 3.887
Si-Li ZHENG,Dong-Ning ZHANG,Yan-Fen DUAN,Fang HUANG,Lin-Tao HAN,Guo-Yan MO
Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) is traditional Chinese medicine that has been used to treat diarrhea caused by acute enteritis (AE) and bacillary dysentery in Xinjiang (China) for many years. However, the potential therapeutic mechanism of MMRAC for AE and its regulatory mechanism on host metabolism is unclear. This study used fecal metabolomics profiling with GC/MS and 16S rRNA gene sequencing analysis to explore the potential regulatory mechanisms of MMRAC on a dextran sulfate sodium salt (DSS)-induced mouse model of AE. Fecal metabolomics-based analyses were performed to detect the differentially expressed metabolites and metabolic pathways. The 16S rRNA gene sequencing analysis was used to assess the altered gut microbes at the genus level and for functional prediction. Moreover, Pearson correlation analysis was used to integrate differentially expressed metabolites and altered bacterial genera. The results revealed that six intestinal bacteria and seven metabolites mediated metabolic disorders (i.e., metabolism of amino acid, carbohydrate, cofactors and vitamins, and lipid) in AE mice. Besides, ten altered microbes mediated the differential expression of eight metabolites and regulated these metabolisms after MMRAC administration. Overall, these findings demonstrate that AE is associated with metabolic disorders and microbial dysbiosis. Further, we present that MMRAC exerts protective effects against AE by improving host metabolism through the intestinal flora.
研究领域:
药理学
·
微生物学
·
代谢组学
·
胃肠病学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 10
·3826-3837
·
IF 8.067
Qing Yao,Jie Zhang,Kaiyu Wang,Changqian Li,Chenyu Shang,Haiqing Sun,Weiwei Zhang,Tianliang Zhou,Huiling Zhu,Jianxu Ding
Recently, quasi-two-dimensional (quasi-2D) organic–inorganic hybrid perovskites, such as those obtained by introducing long-chain organic cations like n-butylammonium (BA) into 3D MAPbI3 perovskites, have been widely investigated as optoelectronic devices owing to their high light absorption coefficient, ultra-long carrier diffusion length, and high defect tolerance. Controlling the BA content to obtain (BA)2(MA)n−1PbnI3n+1 with homogeneous n values is crucial for extraction of photo-carriers because volatile n value related interior heterojunctions are unfavorable for extraction of photo-carriers. Here, we revealed the fundamental growth mechanism of (BA)2(MA)n−1PbnI3n+1. The growth mechanism of (BA)2(MA)n-1PbnI3n+1 SCs is controlled by the evolution of macroscopic spiro dislocations and its derived growth steps. In terms of the understanding of the surface growth mechanism, we grew a series of single crystals with individual n values, avoiding interior heterojunctions, and obtained a lower dark current of 0.247 nA, a high photocurrent (74.5 nA) and high responsiveness (0.064 A W−1) and an external quantum efficiency of 19.5% for a photodetector based on the (BA)2(MA)3Pb4I13 SC. This contributes to an in-depth understanding of the growth mechanism of quasi-2D (BA)2(MA)n−1PbnI3n+1 SCs and the development and optimization of quasi-2D layered materials and devices for optoelectronics.
研究领域:
材料科学
·
光电子学
·
晶体生长
·
半导体器件
·
钙钛矿材料
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）