Small
·
2023
·Vol. 19
·期 17
·2207211
·
IF 13.3
Xingchen Li,Xiaoxiao Li,Jielai Yang,Jiawei Lin,Yuan Zhu,Xiangyang Xu,Wenguo Cui
Paracrine is an important mechanism in mesenchymal stem cells (MSCs) that promotes tissue regeneration. However, anoikis is attributed to unsuitable adhesion microenvironment hindered this paracrine effect. In this study, a living and injectable porous hydrogel microsphere with long-term paracrine activity is constructed via the freeze-drying microfluidic technology and the incorporation of platelet-derived growth factor-BB (PDGF-BB) and exogenous MSCs. Benefiting from the porous structure and superior mechanical property of methacrylate gelatin (GelMA) hydrogel microspheres (GMs), exogenous stem cells are able to adhere and proliferate on GMs, thereby facilitating cell-to-extracellular matrix (ECM) and cell-to-cell interactions and enhancing paracrine effect. Furthermore, the sustained release of PDGF-BB can recruit endogenous MSCs to prolong the paracrine activity of the living GMs. In vitro and in vivo experiments validated that the living GMs exhibit superior secretion properties and anti-inflammatory efficacy and can attenuate osteoarthritis (OA) progression by favoring the adherent microenvironment and utilizing the synergistic effect of exogenous and endogenous MSCs. Overall, a living injectable porous hydrogel microsphere that can enhance the paracrine activity of stem cells is fabricated and anticipated to hold the potential of future clinical translation in OA and other diseases.
研究领域:
组织工程
·
再生医学
·
生物医学工程
·
骨科
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2024
·
IF 11.2
Zhongyi Sun,Ningning Cheng,Zhuyun Cai,Zhengran Ying,Haibo Liu,Ziyan Chen,Hua Zeng,Mengting Yin,Haijiang Liu,Shuo Tan,Xuhui Zhou,Xinyu Zhao,Feng Chen
Surgical incision infection is the most common postoperative complication that poses a serious threat to human health. In this work, the iron gallate (GA-Fe) modified hyaluronic acid microspheres (GFe@HAMSs) multifunctional dressings with antibacterial activity, biodegradability, and the ability to promote tissue regeneration for infectious wound healing are prepared via the bonding engineering between bioactive iron ions and ligands from both polyphenol (i.e. gallic acid, GA) and HAMSs matrix. In our strategy, the Fe-HAMS interaction is first constructed, leading to the shrinkage of iron-doped HAMSs (Fe@HAMSs). Then, the addition of GA further tunes the metal-matrix bonding by introducing the competitive equilibrium between Fe-HAMS and Fe-GA chelation, leading to the volume expansion of GFe@HAMSs. The introduction of iron ions can effectively shorten the inflammatory response and reverse the iron-deficient microenvironment, thereby transforming the wound microenvironment into one conducive to tissue regeneration. Benefitting from these bioactive effects of iron ions and the photothermal antibacterial activity of GA-Fe, the GFe@HAMSs significantly accelerate the wound healing process for rat skin-infected wounds by inhibiting the inflammatory response and macrophage polarization and promoting angiogenesis and tissue remodeling. The GFe@HAMSs proposed in this work not only provide a biomaterial for infectious wound healing but also offer a new strategy for designing multifunctional dressing.
研究领域:
生物材料学
·
医学工程
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Advances
·
2024
·
IF 5.5
Xulin Hu,Shuhao Yang,Weiming Zhao,Zhen Zhang,Liang Qiao,Haoming Wu,Qiao Su,Lanyu Che,Kai Zhou,Kainan Li,Jian He
Irregular bone defects caused by trauma and bone diseases provide a complex implant environment for surgery. Traditional implants often fail to integrate well with the surrounding bone defect interface, therefore, developing an artificial bone scaffold that can adapt to irregular bone defect boundaries is of significant importance for bone defect repair. This study successfully utilized a shape memory ternary copolymer polylactic acid-trimethylene carbonate-hydroxyacetic acid (PLLA-TMC-GA) and dopamine-modified nano-hydroxyapatite (PHA) composite to construct a temperature-responsive bone repair scaffold (PTG/PHA), thereby enhancing the interface compatibility between the implant and the surrounding environment. The addition of PHA has effectively improved the hydrophilicity of the stent and significantly increased its mechanical strength. Furthermore, the Sodium alginate (SA) hydrogel loaded with Icariin (Ica) coated on the stent surface promotes the growth and differentiation of bone cells through the drug-scaffold synergistic effect. Both in vivo and in vitro experiments have shown that the synergistic effect of the composite stent with Icariin significantly enhances the repair of bone defects. This study provides a promising tissue engineering method for the repair of irregular bone defects.
研究领域:
生物材料学
·
组织工程学
·
骨科医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Xing-Yu Yue,Yuan-Yuan Wang,Shen Yu,Chun-Mu Guo,Zhan Liu,Yi-Long Wang,Zhi-Yi Hu,Yu Li,Li-Hua Chen,Bao-Lian Su
Bio-inspired catalyst materials with diverse functions and excellent performance are highly demanding for efficient catalytic conversion. However, precisely imitating the natural structure to achieve optimized performance is still highly challenging. Inspired by the fast mass diffusion and exchange ability of an alveolus structure, we prepared hierarchically macro-meso-microporous TS-1 zeolite microspheres with precisely designed alveolus-like structure (HAS-TS-1) by developing a method combining of template and emulsion approaches. The alveolus-like zeolite microspheres possessed interconnected macropores (280 nm) and mesopores (40 nm) with a BET surface area of 484 m2/g. This novel bio-inspired structure showed a significantly enhanced adsorption ability of thiophenic molecules, which was four times of that in a microporous TS-1 zeolite. The HAS-TS-1 exhibited excellent catalytic oxidative desulfurization performance of a series of bulky thiophenic molecules, completely removing 4,6-dimethyldibenzothiophene (DMDBT) in 15 min, which was twelve times faster than a TS-1 microsphere (180 min). The superiority of this bio-inspired hierarchically alveolus-like structure in mass transfer and diffusion might stimulate its advanced functions in the field of catalysis, energy, and sensor.
研究领域:
材料科学
·
催化化学
·
能源化学
✓ 已验证
产品关联
DOI
高影响因子
OPTICS EXPRESS
·
2025
·Vol. 33
·期 6
·13972-13985
·
IF 3.3
Miao Yu,Xiaolei Hao,Shaoshuai Han,Duo Wang,Shanshan Zhang,Mengxiao Li,Peiyao An,Di Lian,Mingxiang Yang,Rensheng Shen,Xin Yang,Xin Yang,Zhenlin Wu,Zhenlin Wu
In the realm of field-programmable gate array (FPGA) design, temperature emerges as a pivotal parameter that critically impacts system stability, reliability, energy efficiency, and fault diagnosis capabilities. Despite continuous advancements in temperature measurement technologies, real-time, rapid, and high-precision monitoring of FPGA surface temperature remains a central challenge in ensuring stable system operation, urgently requiring effective solutions. In this work, a fiber-optic temperature sensor for monitoring the surface temperature of an FPGA has been developed, featuring an upconversion luminescence-enhanced fiber microsphere structure consisting of upconversion nanoparticles (UCNPs) with polymethyl methacrylate (PMMA), ensuring high-precision temperature measurement capability. To investigate its sensing performance, the fiber-optic microsphere sensor was evaluated within the temperature range of 300-350 K using fluorescence intensity ratio (FIR) technology. The results revealed a peak relative sensitivity of 1.27% K-1 at 300 K and demonstrated a detection accuracy superior to 0.5°C. The fiber-optic sensor was positioned on an FPGA chip and monitored for temperature changes through multiple consecutive power-on and cooling cycles. Comparison with the FPGA board's built-in temperature sensor showed high consistency in operating temperatures. Notably, the fiber-optic sensor demonstrated superior resistance to external environmental interference. The results indicate that the developed sensor, from material design to device application, has great potential for precise and stable temperature monitoring in FPGA applications.
研究领域:
光学工程
·
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Xu Chengcheng,Yu Juan,Huang Pei,Wang Xiaodong
Composite electrode materials combining conductive polymers with carbon-based frameworks have shown great potential in advanced energy storage applications. In this work, polyaniline (PANI)-coated polyimide carbon microsphere (PI-C) composites (PANI/PI-C) with optimizing feed ratios were synthesized by in situ polymerization. PI-C serves as an excellent support for PANI, creating a synergistic effect that significantly, achieves superior electrochemical performance. The results show that 50% is the most appropriate addition amount of PI-C, the composite demonstrated an impressive specific capacitance of 540 F g −1 at 0.5 A g −1 , and under a higher current density of 10 A g −1 , it maintained a significant capacitance of 412.9 F g −1 . After 5000 charge–discharge cycles, it preserved 90.4% of its original capacitance. Furthermore, when assembled as a symmetric supercapacitor, it achieved an energy density of 12.7 Wh kg −1 at a power density of 249.9 W kg −1 , retaining 83.1% of its capacitance after 5000 cycles at a current density of 5 A g −1 . These results demonstrate the excellent electrochemical performance and structural stability of PANI/PI-C composites, highlighting their application prospects in high-performance supercapacitors and broader energy storage technologies. Graphical abstract
研究领域:
材料科学
·
电化学
·
能量存储
·
纳米技术
·
高分子科学
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Shuyu Wang,Xiaohui Wu,Lijuan Ren,Xian Pei,Hui Fang,Ping Lv,Ning Nan,Xianwei Lv,Xianming Zheng,Feihe Ma,Yun Wu,Yuping Liu,Linqi Shi
Adsorbents with high selectivity and adsorption capacity are of significant interest for the removal of dye pollutants. Herein, we report a facile low-temperature solvothermal synthesis of clew-like Cu2O/CuO microspheres by using cupric acetate monohydrate as the copper resource and ethylene glycol as the solvent and morphology modulator. The synthesized Cu2O/CuO microspheres showed high selective adsorption to anionic dyes (e.g., methyl orange (MO) and Reactive Red 2 (RR2)) rather than to cationic dyes (e.g., methylene blue (MB), Rhodamine B (RhB)). MO was then selected to evaluate the parameters of adsorption due to the adsorbent exhibiting the highest adsorption capacity for MO. We demonstrate that the adsorption of MO by Cu2O/CuO microspheres has a good correlation with the pseudo-second-order model and Langmuir isotherm with a maximum adsorption capacity of 826.45 mg/g, which is higher than that of previously reported metal oxide material adsorbents. The excellent adsorption ability of clew-like Cu2O/CuO microspheres to MO may be attributed to the synergistic effects of electrostatic attraction, unique hierarchical structure, and crystal defects of the prepared Cu2O/CuO microspheres. We believe our work provides new insight into the synthesis of high-performance adsorbents.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2020
·Vol. 30
·期 52
·2006333
·
IF 16.836
Yichang Xu,Yong Gu,Feng Cai,Kun Xi,Tianwen Xin,Jincheng Tang,Liang Wu,Zhen Wang,Fei Wang,Lianfu Deng,Catarina Leite Pereira,Bruno Sarmento,Wenguo Cui,Liang Chen
Antagonist therapy represents a potential treatment for extracellular matrix (ECM) metabolic imbalance via the specific binding of inflammatory factors resulting from inflammation. However, the short half-life of antagonist bioactivity creates challenges for their clinical application. Herein, bovine serum albumin nanoparticles (BNP) encapsulating recombinant human soluble tumor necrosis factor (TNF) receptor type II (rhsTNFRII) are grafted onto microfluidic poly( l -lactic acid) (PLLA) porous microspheres through chemical bonds, constructing antagonist-functionalized injectable porous microspheres (MS-BNP) for in situ injection into the nucleus pulposus (NP), aimed at regulating the metabolic balance of ECM, thus inhibiting intervertebral disc degeneration. Several binding sites within the BNPs improve encapsulation efficiency, promote the sustained release of rhsTNFRII, and regulate ECM metabolism in the NP. Moreover, PLLA porous microspheres display excellent injectability and porosity and demonstrate efficient and uniform loading of nanoparticles through chemical grafting. By delivering MS-BNP into the NP, a suitable environment is created in situ. Immunohistochemical analysis at 4 and 8 weeks shows that compared with other experimental groups, the expression of TNF-α is significantly inhibited for 6.11–15.65 folds and 4.59–22.14 folds, respectively, and a significant regeneration in NP occurred. This work proposes a novel porous microsphere therapy functionalized by antagonist molecules for the treatment of ECM metabolic disorders, caused by chronic inflammatory responses.
研究领域:
生物医学工程
·
组织工程
·
再生医学
·
炎症
·
骨科
✓ 已验证
DOI
高影响因子
Polymers
·
2021
·Vol. 13
·期 7
·1035
·
IF 4.329
Chengbing Yuan,Yan Zhang,Jinshui Yao,Qinze Liu,Fan-Gong Kong
Herein, a synthetic strategy for a rough microsphere Cr(VI)-adsorbent via the reaction of tannic acid (TA) and 1,6-hexanediamine (HA) and using polyethylene glycol (PEG) as surface modifier was presented. This adsorbent was characterized by a Fourier Transform Infrared spectrometer (FTIR), thermogravimetic analysis (TGA), X-ray photoelectron spectroscopy (XPS), etc. Certain factors, including contact time, PEG@poly(tannin-1,6-hexanediamine) (PEG@PTHA) dosage, initial concentration, and experimental temperature affecting the Cr(VI) adsorption performance of adsorbent were explored. PEG@PTHA can adsorb Cr and the Cr(VI) was reduced up to Cr(III) due to the existence of phenolic hydroxyl groups. Its adsorption capacity can reach up to 300 mg/g within 10 min and approximately 100% removal percentage below the initial concentration of 100 mg/L. Its behavior matched well with the Langmuir isotherm model and pseudo-second-order kinetic model. A PEG@PTHA adsorbent with maximum adsorption capacity (450 mg/g) has great prospects in Cr(VI)-sewage treatment.
✓ 已验证
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2026
·
IF 7.9
Jiajiu Liang,Wenjing Xie,Guangtao Chang,Ruoxin Li
Thermal insulation materials play a crucial role in addressing the energy crisis and mitigating the urban heat island effect. As a hollow material possessing excellent elasticity and thermal insulation potential, thermally expandable microspheres (TEMs) can have their performance further enhanced through surface modification. In this study, bismuth oxide (Bi₂O₃) was innovatively combined with TEMs for the first time. By conducting in-situ polymerization of polyaniline (PANI) on the surface of TEMs, a positive surface charge was induced, enabling the electrostatic attraction and coating of Bi₂O₃ particles. This process successfully constructed Bi₂O₃/PANI/TEMs composite microspheres. The combination of Bi₂O₃ particles, which exhibits far lower thermal conductivity than other metal oxides, with the closed-cell spherical structure of TEMs, effectively suppresses heat convection and radiation. Furthermore, it significantly inhibits phonon conduction and enhances phonon scattering. The fabric coating prepared from these composite microspheres exhibited a thermal conductivity of only 0.042 W/(m·K). Compared to the TEMs, the near-infrared (NIR) transmittance was reduced by 39%, and an ultrathin composite coating of merely 500 μm in thickness increased the thermal insulation temperature of cotton fabric by 7.7 °C. Comparative analysis revealed that the Bi₂O₃/PANI/TEMs composite coating exhibits superior thermal barrier performance to expanded polystyrene (EPS) foam. Moreover, when incorporated into commercial coatings, it further enhanced their thermal insulation capability. This research provides a novel strategy and material system for developing new, highly efficient, and lightweight thermal insulation coatings, positioning the composite as a highly promising thermal insulation material.
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2025
·
IF 14.2
Hongyuan Guo,Qiao Lu,Weicheng Jiao,Xingwen Yuan,Shuxin Ren,Haomiao Sun,Xiaodong He
Phase change materials (PCMs) exhibit high energy density, reversibility, and broad temperature selectivity. Unfortunately, the inherent trade-off between functionality and mechanical strength inevitably arises during application, necessitating the breakthrough of the thermal-mechanical-functional coupling bottleneck to establish an efficient thermal storage system. This work innovatively designs a multi-dimensional composite PCMs based on supramolecular polymers and graphene-encapsulated paraffin microspheres, achieving cross-scale synergy between thermal conduction networks, energy storage units, mechanical support structures, and functional design. The multi-level strong-weak hydrogen bond interactions within the supramolecular construct a physically cross-linked framework that combines toughness and stability, while paraffin-graphene microspheres enhance energy storage density. The three-dimensional thermally conductive and electrically conductive framework endows PCMs with photo/electro-thermal energy conversion and response capabilities. Simultaneously achieving high phase change enthalpy (190.2 J g −1 ), ultra-low leakage rate (<0.47 wt%), and high strength ranging from 16.0 to 29.6 MPa, with programmable shape memory and recyclable molding capabilities, overcoming the bottleneck of synergistically suppressing thermal hysteresis and mechanical fatigue in PCMs. Further construction of intelligent temperature sensing arrays enables interaction between high and low-temperature environments. This work proposes a feasible strategy to promote the evolution of PCMs from passive thermal storage media to embodied intelligent components.
研究领域:
材料科学
·
储能技术
·
智能材料
·
热管理
·
传感器与传感技术
✓ 已验证
产品关联
DOI
高影响因子
Joule
·
2018
·
IF 0
Yuruo Qi,Zizheng Tong,Junmei Zhao,Lu Ma,Tianpin Wu,Huizhou Liu,Chao Yang,Jun Lu,Yong-Sheng Hu
The large-scale application of rechargeable batteries in electric vehicles and energy-storage systems is still hindered by their high cost, particularly from the active materials. Here we proposed a concept of integration of extraction-separation and materials-preparation to further reduce the materials' cost. The power of this concept was demonstrated by the large-scale room-temperature synthesis (150 g per batch) of multi-shelled Na 3 (VOPO 4 ) 2 F microspheres based on in situ generated bubbles as soft templates. The as-prepared Na 3 (VOPO 4 ) 2 F shows superior rate capability with discharge capacity of 81 mAh g −1 at 15 C current rate and capacity retention of 70% after 3,000 cycles. Ex situ UV-vis was first employed to characterize the variation of oxidation state for vanadium during the charging and discharging process. This is the first report of a rapid and facile large-scale room-temperature controllable synthesis of Na 3 (VOPO 4 ) 2 F microspheres, and this approach could be extended to synthesize other similar compounds.
研究领域:
材料科学
·
电化学
·
储能
·
无机合成
✓ 已验证
DOI
危险品化学品经营许可证（带存储）