MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 10
·1-14
·
IF 5.7
Liu Jian,Wen Changchun,Hu Miaomiao,Leng Nan,Lin Xiang-Cheng
MnO 2 nanosheets (MnO 2 NSs) were synthesized by one-step method, and MnO 2 NSs were applied to A549 cell chemodynamic Therapy (CDT). The cytotoxicity, redox ability, and reactive oxygen species production of MnO 2 NSs have been investigated, and differences in cell metabolism during CDT were determined using liquid chromatography-mass spectrometry (LC–MS/MS). In addition, the metabolites of A549 lung cancer cells affected by MnO 2 NSs treatment are identified; metabolite differences were identified by PCA, PLS-DA, orthogonal PLS-DA, and other methods; and these differences were analyzed using non-targeted metabolomics. We found that A549 cells which were treated by MnO 2 NSs have 17 different metabolites and 9 metabolic pathways that varied markedly. Owing to their unique composition, structure, and physicochemical properties, MnO 2 NSs and their composites have become a favored type of nanomaterial used for CDT in cancer therapy. This work provides insights into the mechanism underlying the effects of MnO 2 NSs on the tumor microenvironment of A549 lung cancer cells, effectively making up for the deficiency of the study on cellular mechanism of CDT-induced apoptosis of cancer cells. It could aid the development of cancer CDT treatment strategies and help improve the use of nanomaterials in the clinical field. Graphical Abstract
研究领域:
纳米技术
·
癌症生物学
·
代谢组学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2022
·
IF 6.959
Shumin Zheng,Dianming Li,Wenbiao Li,Jun Chen,Xianfa Rao,Nü Wang,Jian Qi,Bao Wang,Shuangjiang Luo,Yong Zhao
Freestanding electrodes are critical for lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs) with high energy density and long cycling stability. We fabricated freestanding MnO2 nanosheet-coated carbon nanofibers by synchronous in situ spraying of MnO2 nanosheets onto electrospinning polymer nanofibers, which might be a high-voltage electric field-induced assembly process. The designed film is used as anode material for LIBs and SIBs. It demonstrates good cycling stability without capacity loss after long cycling for LIBs, delivers a capacity of 256.4 mAh g–1 at 1.00 A g–1, and has an extremely stable cycle life for over 200 cycles at 0.05 A g–1. For SIBs, it delivers a capacity of 135.0 mAh g–1 at 1.00 A g–1 and has a stable cycle life for over 500 cycles at 0.50 A g–1. The capacitive contribution ratio increases from 44.4 to 76.2% (0.2–1.0 mV s–1), and the capacitive process plays a major role in the total capacity. The enhancement of the electrochemical performance is attributed to the good conductivity of the carbon nanofiber network and the one-dimensional (1D)/two-dimensional (2D) composite structure of the electrode, in which the high performance of carbon nanofibers and MnO2 nanosheets is fully exploited. Importantly, the combination of in situ spraying and electrospinning can be extended to two or more materials with different polarities, ζ-potential values, or solubilities, broadening the applications of composites.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Fei Tong,Zan Yang,Zheng Wang,Wenya Liu,Wanqi Jiang,Lu Zhu,Lei Wang,Mingming Zheng,Ruyan Hou,Yibin Zhou,Yingnan Liu
In view of the potential hazards of organophosphorus pesticides (OPs), this paper constructed a ratiometric fluorescent probe utilizing a functionalized metal–organic framework to detect OPs. Ru(bpy) 3 Cl 2 was encapsulated inside UiO-66 as a reference signal, and MnO 2 nanosheets (MnO 2 NSs) were grown on the surface to obtain [email protected] @MnO 2 NSs. Acetylcholinesterase catalyzed the decomposition of acetylcholine into reductive thiocholine, which consumed MnO 2 NSs, thus restoring the [email protected] fluorescence. Due to the enzymatic inhibition of OPs and the redox reaction between MnO 2 NSs and thiamine, this probe emitted blue fluorescence in the presence of OPs. The probe achieved linear responses to dichlorvos and chlorpyrifos with LODs of 9.99 × 10 -6 μg mL −1 and 9.99 × 10 -5 μg mL −1 . The probe exhibited a satisfactory recovery rate for OPs in green tea. Furthermore, a hydrogel detection platform was developed by embedding the probe into sodium alginate. Overall, this work provides a visual approach to detect OPs in agricultural products.
研究领域:
分析化学
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环境科学
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材料科学
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农业科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2024
·
IF 12.8
Feilong Zhao,Zhibo Jia,Liyang Zhang,Guodong Liu,Junfei Li,Jianming Zhao,Yajie Xie,Lu Chen,Hongyu Jiang,Wei He,Aiyuan Wang,Jiang Peng,Yudong Zheng
The inflammatory microenvironment and inferior chondrogenesis are major symptoms after cartilage defect. Although various modifications strategies associated with hydrogels exhibit remarkable capacity of pro-cartilage regeneration, the adverse effect by prolonging inflammation is still formidable to hamper potential biomedical applications of different hydrogel implants. Herein, inspired by the repair microenvironment of articular cartilage defects, an injectable, immunomodulatory, and chondrogenic L-MNS-CMDA hydrogel is prepared through grafting vinyl and catechol groups to chitosan macromolecules using amide reaction, then further loading MnO 2 nanosheets (MNS). The double crosslinking of photopolymerization and catechol oxidative polymerization endows L-MNS-CMDA hydrogel with preferable mechanical property, affording a suitable mechanical support for cartilage defect repair. Additionally, the robust tissue adhesion capability stemming from catechol groups guarantees the long-term retention of the hydrogel in the defect site. Meanwhile, L-MNS-CMDA hydrogel decomposes exogenous and intracellular H 2 O 2 into O 2 and H 2 O, to effectively alleviate cellular oxidative stress caused by long-term hypoxia. Under the synergies of catechol groups and MNS, L-MNS-CMDA hydrogel not only inhibits macrophages polarizing into M1 phenotype, but encourages them turn into M2 phenotype, thereby, reconstructing an immunization friendly microenvironment to ultimately enhance cartilage regeneration. Predictably, the hydrogel markedly induces rat bone marrow mesenchymal stem cells differentiating into chondrocytes by expressing abundant glycosaminoglycan and type II collagen. A cartilage defect model of rat knee joint indicates that L-MNS-CMDA hydrogel visually regulate the early inflammatory response of post-implantation, and facilitate cartilage regeneration and recovery of joint function after 12 weeks of post-implantation. All in all, this multifunctional L-MNS-CMDA hydrogel exhibits superior immunomodulatory and chondrogenic properties, holding immense clinical potential in the treatment of cartilage defects.
研究领域:
生物医学工程
·
组织工程
·
再生医学
·
骨科
·
免疫学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Shanshan Li,Kunpeng Lin,Peng Hu,Shaochen Wang,Shuang Zhao,Ying Gan,Lei Liu,Shuling Yu,Jiahua Shi
Phototherapies, including photothermal therapy (PTT) and photodynamic therapy (PDT) have been potential noninvasive therapeutic modality with high efficiency, however, there still exist some intrinsic limitations that impede their clinical applications. Herein, taking the advantages of the synergistic effect and high reactivity of manganese dioxide (MnO 2 ) nanosheets and glucose oxidase (GOx), multifunctional [email protected] 2 -MB-GOx nanoamplifier was constructed for enhanced PTT, PDT, and starvation therapy. In tumor microenvironment (TME), MnO 2 nanosheets on the surface of mesoporous polydopamine (MPDA) could react with endogenous hydrogen peroxide (H 2 O 2 ) and generate oxygen (O 2 ) to relieve tumor hypoxia, thus enhancing the efficacy of PDT and GOx catalysis. Glucose consumption under the catalysis of GOx will enhance the acidity of TME and increase intracellular H 2 O 2 concentration, which in turn promotes the production of O 2 by MnO 2 nanosheets, thus forming efficient cascade reaction and maximizing the efficacy of the functional agents. Furthermore, the heat generated by MPDA under the irradiation of 808 nm laser can accelerate chemical reactions, thus further enhancing synergistic therapeutic efficacy. In vitro/vivo results emphasize that enhanced cancer cell death and tumor inhibition are gained by modulating unfavorable TME with the functional nanosystem, which highlights the promise of the synthesized [email protected] 2 -MB-GOx nanomaterial to overcome the limitations of phototherapy.
研究领域:
纳米技术
·
癌症治疗
·
生物医学工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）