JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Xiaoxi Yu,Zhi Yang,Hao Li,Ruoyu Wang,Jingping Liu,Yining Wu
A novel CO 2 responsive self-assembled surfactants system was prepared using N - [3 - (dimethylamino) propyl] docosanamide (NDPD) and sodium salicylate (NaSal). Rheological measurements were performed to study the phase behaviors of NDPD/NaSal system. It was found that gels and wormlike micelles can be formed in the NDPD/NaSal system. The phase behaviors were found to be influenced by changing temperature or by involving different anions. Through increasing the temperature, gels can transform to wormlike micelles . When HCl and CO 2 were used to adjust pH, NDPD/NaSal system performed decidedly different rheological behaviors at the same pH. By theoretical calculation, it was found that the binding energy between NDPD and Cl − is larger than that of NDPD and HCO 3 − , indicating a stronger shielding ability of Cl − ions. Due to the weakened electrostatic repulsion interactions, the internal structure of NDPD/NaSal switchable system wrapped more tightly through adding HCl compared with adding CO 2 .
研究领域:
化学
·
材料科学
·
胶体与界面化学
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产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 12
·期 6
·2202150
·
IF 11.092
Ying Chen,Zengqiu Yang,Sibu Wang,Qin Ma,Lingyan Li,Xingjie Wu,Qianqian Guo,Ling Tao,Xiangchun Shen
Due to the deficient catalase, abundant reduced iron and low acidic environment in lysosomes, inducing lysosomal membrane permeabilization (LMP) through Fenton reaction-based reactive oxygen species (ROS) generation recently attracts increasing attention in cancer therapy. However, the lysosomal membranes are protected by highly glycosylated membrane proteins and several endolysosomal damage-response mechanisms can rapidly repair the injured lysosomes. To produce sufficient ROS and cause complete lysosomal membranes rupture, a lysosome-targeted ROS inducer, N -(3-Aminopropyl) morpholine grafted cross-linked lipoic acid vesicles with vitamin C-loading (VC@ N3AM cLAVs), is developed. VC@ N3AM cLAVs efficiently accumulate in lysosomes and convert into two redox couples LA/DHLA (dihydrolipoic acid, reduced form of LA) and VC/DHA (dehydroascorbic acid, oxidized form of VC) by the lysosomal glutathione, which can not only produce a large amount of H 2 O 2 by pro-oxidant action but also accelerate iron transformation through the cyclic redox reactions between each other and cause the efficient conversion of the generated H 2 O 2 into highly toxic •OH. Both in vitro and in vivo experiments demonstrate that VC@ N3AM cLAVs can effectively enhance ROS production and boost LMP, finally initiation irreversible death of tumor cells via ferroptosis pathway, thus representing a potential anticancer drug for cancer therapy.
研究领域:
癌症生物学
·
药学
·
治疗学
·
生物化学
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产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2023
·
IF 3.1
Jun Zhou,Chengyue Zou,Danqun Huo,Chengxiang Chu,Shasha Liu,Mei Yang,Suyi Zhang,Xianfeng Wang,Changjun Hou
Mercury is a heavy metal with extreme toxicity. Thus, it is of significance to develop an effective method for mercury ion detection with high performance. In this study, carbon dots doped with nitrogen and silicon (N,Si/CQDs) were successfully prepared from folic acid and N-[3-(trimethoxysily)propyl]-ethylenediamine. The N,Si/CQDs show an obvious cyan fluorescence of 460 nm with the radiation of 350 nm. The existence of mercury ions induces the fluorescence quenching of N,Si/CQDs due to photoinduced electron transfer, which was applied for the sensitive sensing of Hg(II). More importantly, the practical application of the N,Si/CQD probe was confirmed by measurements of Hg(II) in real samples of lake water, sorghum and rice. In addition, the N,Si/CQD nanoprobe was integrated on a sensing strip for specific detection of Hg(II). Quantitative measurement of Hg(II) was realized by the outstanding linearity between the diameter (or fluorescence intensity) of the fluorescence quenching ring and the concentration of mercury ions. The sensor shows potential for rapid detection with a triple signal readout on-site and represents a larger step towards practical applications.
研究领域:
分析化学
·
环境科学
·
材料科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Chemistry-X
·
2023
·
IF 6.1
Chao Zhu,Qimin Liu,Yang Wang,Xiaolin Wang,Yuxuan Ma,Fangxia Yang,Wuzi Dong,Hong Ji
The production of selenium-enriched fish contributes to alleviating selenium deficiency for humans. In this study, selenium nanoparticles (SeNPs) comparable in bioavailability to selenomethionine (SeMet), increased SeMet content in O. macrolepis ( Onychostoma macrolepis ) muscle. Additionally, dietary SeNPs significantly enhanced selenocysteine (SeCys 2 ) and methylselenocysteine (MeSeCys) levels in O. macrolepis muscle. The effect of SeNPs on selenium speciation in grass carp muscle was consistent with O. macrolepis results. SeCys 2 and MeSeCys showed antioxidant capacity in HEK293T cells, indicating enhanced health benefits of Se-enriched fish produced using SeNPs. Furthermore, the addition of 0.3 mg/kg SeNPs significantly improved the flesh quality of O. macrolepis by reducing the content of crude fat and heavy metals, as well as increasing the levels of crude protein, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and the ratio of n-3/n-6 polyunsaturated fatty acids (PUFAs). Therefore, selenium-enriched fish produced from SeNPs is a good source for improving human dietary selenium intake.
研究领域:
水产养殖
·
营养学
·
分析化学
·
食品科学
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产品关联
DOI
PubMed
高影响因子
AQUACULTURE RESEARCH
·
2021
·Vol. 53
·期 5
·1814-1822
·
IF 2.082
Bin Xue,Huirong Lv,Yanli Liu,Yang Gao
This study was conducted to investigate the effects of replacing dietary lipid source FO with a terrestrial lipid blend (LB) on the growth performance, body composition and immunity of juvenile Japanese sea bass when the dietary n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) requirements are met ( Lateolabrax japonicus ). Two types of experimental diets were formulated with the total FO (the control) or the LB (linseed oil and lard = 1:1). A 56-day feeding trial was conducted in floating cages with three replicates for each treatment. The results indicated that a significantly higher specific growth rate (SGR) and feed efficiency ratio (FER) occurred in fish that were fed the LB diet compared with the control group ( p < 0.05). There was no significant difference in the survival rate, body composition or body indicates between the groups ( p > 0.05). The respiratory burst, alternative complement pathway activity, lysozyme activity, cytokine genes expression and air exposure test results indicated that the replacement of FO with LB did not significantly affect the nonspecific immunity or stress resistance ( p > 0.05). The serum antioxidant enzyme activities and liver tissue antioxidant-related gene expression were significantly higher in the control group than in the other group ( p < 0.05). Therefore, the terrestrial lipid blends from linseed and lard (1:1) could be used as an alternative for dietary fish oil without compromising the growth performance, nonspecific immunity and resistance to stress in juvenile Japanese sea bass.
研究领域:
水产养殖学
·
营养学
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Jiaqiang Ding,Yiming Han,Jinqiu Wu,Dongliang Chen,Chengdong Xiong,Dongling Huang,Zuochun Xiong
Inspired by the amino acid residues in mussel adhesion proteins, vinyl polymer underwater adhesives containing dopamine structures have gradually become a research hot spot. Researchers have done a lot of work on how to improve the bonding properties, mechanical properties, and rapid response properties of dopamine-based adhesives. However, vinyl polymers are not degradable, which limit their application in the biomedical field. It is considered to be the most promising method to achieve the degradation of vinyl polymers by free radical ring-opening polymerization of vinyl monomers and cyclic ketene acetals. In this study, we used N-(3,4-dihydroxyphenethyl) methacrylamide (DMA) and 2-methyl-1,3-dioxane (MDO) as raw materials to synthesize biodegradable copolymers P(MDO–DMA) with different compositions by free radical ring-opening polymerization. We carried out adhesion strength and in vitro degradation experiments on polymer adhesives under different conditions. The results showed that the prepared copolymers had good adhesion and biodegradability. This is the result of the synergistic effect of the two functional monomers in the system. DMA achieves adhesion performance and MDO gives effective degradability. We believe that this will expand the current limited application scenarios and provide exciting prospects for applications in areas such as drug delivery and tissue engineering.
研究领域:
材料科学
·
高分子化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Jingyu Wang,Yuling Ren,Huiru Zhang,Jianquan Luo,John M. Woodley,Yinhua Wan
Separation of monosaccharides and monovalent salts is important in the biorefinery and food industry. Nanofiltration (NF) technology is promising for this purpose but its poor selectivity still needs to be addressed. In this work, the separation of monosaccharides and monovalent salts by NF is improved by regulating the surface charge and pore size distribution of polyamide NF membranes. The carboxyl groups on the polyamide membrane are selectively activated by N-(3-Dimethylaminopropyl)-N′-ethyl carbodiimide (EDC) and N-hydroxy succinimide (NHS), and subsequently molecules with amino groups are grafted on the membrane to reduce the effective pore size and electronegativity. The conditions and grafted molecules are optimized, and polyethyleneimine (600 Da) is selected as the best for enhancing the separation of glucose/fructose and KCl. Such targeted modification is found to reduce the effective mean pore size while maintaining the porosity of the NF270 membrane, due to pore segmentation. This results in a remarkable improvement in glucose/fructose rejection (from 67.96% to 84.14%) and separation factor (from 2.20 to 6.78), with only a 4.70% permeability loss. The modified membrane also maintains separation performance in crossflow filtration and after alkaline cleaning (pH 12), which outperforms the pristine NF270 and those modified by mussel-inspired coating and simple physical adsorption.
研究领域:
生物精炼
·
食品工业
·
纳滤技术
·
膜科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER COMPOSITES
·
2022
·Vol. 43
·期 10
·7130-7142
·
IF 3.531
Guorui Yang,Yan Ma,Chen Liu,Lanyue Zhang,Xiangwei Li,Weifeng Du,Lei Shang,Yuhui Ao
Inspired by the strengthening effect of nanoparticles and the toughening effect of block polymers, we prepared a block polymer filler with graphene oxide (GO) as the main body by surface initiate atom transfer radical polymerization (SI-ATRP). In the side groups of the main molecular segment of this block polymer, glycidyl methacrylate (GMA) fragment and N-(3,4-bis([tert-butyldimethylsilyl]oxy)phenethyl)methacrylamide (DOPAm TBDMS ) fragment can promote dispersion and toughening respectively. The molecular structure was characterized by Fourier transform infrared and X-ray photoelectron spectroscopy. After the modified GO was added to the epoxy composite, the mechanical properties of the composite could be significantly improved. The toughness of epoxy composites was enhanced by crack deflection of the matrix. When the added amount of modified GO was 0.25 wt%, the flexural strength reached 151 MPa, which was 37.27% higher than pure epoxy composite. The tensile strength and izod impact strength were increased by 50.56% and 69.89%, respectively. These are attributed to the strengthening and toughening effects of GO and the side groups on it. This research had potential application value in the field of resin fillers and in combination with carbon fiber, metal and other materials.
研究领域:
材料科学
·
高分子化学
·
复合材料
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DOI
高影响因子
Oncotarget
·
2016
·
IF 5.008
Jingnan Chen,Yan Wei,Xinyu Chen,Jingjing Jiao,Yu Zhang
Polyunsaturated fatty acids (PUFA), a group of nourishing and health-promoting nutrients, ameliorate age-related chronic diseases. However, how PUFA especially n-3 PUFA exert anti-aging functions remains poorly understood. Here we link fish oil, docosahexaenoic acid (DHA) and arachidonic acid (AA) to the aging etiology via a redox-telomere-antioncogene axis based on D-galactose-induced aging mice. Both fish oil and PUFA enhanced hepatic superoxide dismutase (SOD) and catalase activities and cardiac SOD activities within the range of 18%-46%, 26%-65% and 19%-58%, respectively, whereas reduced cerebral monoamine oxidase activity, plasma F 2 -isoprostane level and cerebral lipid peroxidation level by 56%-90%, 20%-79% and 16%-54%, respectively. Thus, PUFA improve the in vivo redox and oxidative stress induced aging process, which however does not exhibit a dose-dependent manner. Notably, both PUFA and fish oil effectively inactivated testicular telomerase and inhibited c-Myc -mediated telomerase reverse transcriptase expression, whereas n-3 PUFA rather than n-6 PUFA protected liver and testes against telomere shortening within the range of 13%-25% and 25%-27%, respectively. Therefore, n-3 PUFA may be better at inhibiting the DNA damage induced aging process. Surprisingly, only DHA significantly suppressed cellular senescence pathway evidenced by testicular antioncogene p16 and p53 expression. This work provides evident support for the crosstalk between PUFA especially n-3 PUFA and the aging process via maintaining the in vivo redox homeostasis, rescuing age-related telomere attrition and down-regulating the antioncogene expression.
研究领域:
营养学
·
衰老研究
·
分子生物学
·
生物化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2018
·Vol. 7
·期 1
·336-346
·
IF 5.831
Dong Chen,Huangyong Jiang,Dongbo Guo,Wumaier Yasen,Junping Ao,Yue Su,Dongsheng Pan,Xin Jin,Xinyuan Zhu
Cationic gelatin nanoparticles ((+)nGNPs) were prepared by in situ polymerization upon the surfaces of monodispersed gelatin nanoparticles (GNPs) using N-(3-Aminopropyl)methacrylamide (APm) as monomer, which were then decorated with doxorubicin terminated poly(2-methylacryloyloxyethyl phosphorylcholine) (DOX-pMPC) via EDC/NHS conjugation to obtain core–shell nanoparticles ((+)nGNPs@DOX-pMPC) for cancer therapy. The non-fouling pMPC shell could effectively shield the positively charged surface of inner nanoparticle and prevent non-specific protein adsorption, thus endowing the materials with potential for long-acting cancer treatment. Furthermore, the acyl hydrazone bond connecting DOX and pMPC chain could be easily hydrolyzed in the weakly acidic tumor microenvironment. After decladding of the pMPC shell, electropositive (+)nGNPs carrying the drugs can be effectively internalized by cancer cells to induce apoptosis, avoiding undesirable hindrance caused by the superhydrophilic outer layer. On combining the above properties, this drug delivery system can be a promising candidate for long-acting, low-toxicity and high-efficiency cancer therapy.
研究领域:
纳米技术
·
药学
·
癌症治疗
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2022
·
IF 6.206
Xueya Liu,Yingqin Wei,Furong Tao,Xue Zhang,Ligang Gai,Libin Liu
Superhydrophobic surfaces with reversible switchable wettability have great application value in the treatment of oily wastewater. However, the advancement of switchable wettability surfaces is limited by the complexity of the manufacturing process and the excessive use of environmentally unfriendly solvents. Herein, an all-water-based reversible wettability coating was fabricated by simply spraying a water suspension consisting of N-[3-(trimethoxysilyl) propyl] ethylenediamine (AS)-, 3-(trimethoxysilyl) propyl methacrylate (KH-570)-, and 1H,1H,2H,2H-perfluorodecyltrimethoxysilane (FAS)-modified titanium dioxide (TiO 2 ) nanoparticles and cellulose . The coating possesses good adhesion with various substrates and exhibits stable mechanical and chemical stability as well as good resistance to harsh environments such as various organic solvents , strongly corrosive environments and extreme temperature environments. The coating can be switched between having superhydrophobicity (160°) and superhydrophilicity under UV irradiation and heating treatment. The coated cotton fabric can separate heavy/light oil-water mixtures and water-in-oil/oil-in-water emulsions with a high efficiency of greater than 95%. Due to the photocatalytic properties of TiO 2 , the coating can degrade soluble pollutants in water during UV irradiation, and the degradation efficiency is over 97%. This study provides a green industrial route for designing a simple, switchable wettability coating, which is expected to promote the large-scale industrial production and application of functional smart surfaces.
研究领域:
材料科学
·
环境科学
·
化学工程
·
表面化学
✓ 已验证
产品关联
DOI
高影响因子
Bioactive Materials
·
2022
·
IF 16.874
Dun Liu,Lei Li,Ben-Long Shi,Bo Shi,Ming-Ding Li,Yong Qiu,Di Zhao,Qun-Dong Shen,Ze-Zhang Zhu
Wound healing has become one of the basic issues faced by the medical community because of the susceptibility of skin wounds to bacterial infection. As such, it is highly desired to design a nanocomposite hydrogel with excellent antibacterial activity to achieve high wound closure effectiveness. Here, based on ultrasound-triggered piezocatalytic therapy, a multifunctional hydrogel is designed to promote bacteria-infected wound healing. Under ultrasonic vibration, the surface of barium titanate (BaTiO 3 , BT) nanoparticles embedded in the hydrogel rapidly generate reactive oxygen species (ROS) owing to the established strong built-in electric field, endowing the hydrogel with superior antibacterial efficacy. This modality shows intriguing advantages over conventional photodynamic therapy, such as prominent soft tissue penetration ability and the avoidance of serious skin phototoxicity after systemic administration of photosensitizers. Moreover, the hydrogel based on N-[tris(hydroxymethyl)methyl]acrylamide (THM), N-(3-aminopropyl)methacrylamide hydrochloride (APMH) and oxidized hyaluronic acid (OHA) exhibits outstanding self-healing and bioadhesive properties able to accelerate full-thickness skin wound healing. Notably, compared with the widely reported mussel-inspired adhesive hydrogels, OHA/THM-APMH hydrogel due to the multiple hydrogen bonds from unique tri-hydroxyl structure overcomes the shortage that catechol groups are easily oxidized, giving it long-term and repeatable adhesion performance. Importantly, this hybrid hydrogel confines BT nanoparticles to wound area and locally induced piezoelectric catalysis under ultrasound to eradicate bacteria, markedly improving the therapeutic biosafety and exhibits great potential for harmless treatment of bacteria-infected tissues.
研究领域:
生物医学工程
·
材料科学
·
纳米技术
·
伤口愈合
·
抗菌治疗
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）