AQUACULTURE RESEARCH
·
2021
·Vol. 53
·期 5
·1814-1822
·
IF 2.082
Bin Xue,Huirong Lv,Yanli Liu,Yang Gao
This study was conducted to investigate the effects of replacing dietary lipid source FO with a terrestrial lipid blend (LB) on the growth performance, body composition and immunity of juvenile Japanese sea bass when the dietary n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) requirements are met ( Lateolabrax japonicus ). Two types of experimental diets were formulated with the total FO (the control) or the LB (linseed oil and lard = 1:1). A 56-day feeding trial was conducted in floating cages with three replicates for each treatment. The results indicated that a significantly higher specific growth rate (SGR) and feed efficiency ratio (FER) occurred in fish that were fed the LB diet compared with the control group ( p < 0.05). There was no significant difference in the survival rate, body composition or body indicates between the groups ( p > 0.05). The respiratory burst, alternative complement pathway activity, lysozyme activity, cytokine genes expression and air exposure test results indicated that the replacement of FO with LB did not significantly affect the nonspecific immunity or stress resistance ( p > 0.05). The serum antioxidant enzyme activities and liver tissue antioxidant-related gene expression were significantly higher in the control group than in the other group ( p < 0.05). Therefore, the terrestrial lipid blends from linseed and lard (1:1) could be used as an alternative for dietary fish oil without compromising the growth performance, nonspecific immunity and resistance to stress in juvenile Japanese sea bass.
研究领域:
水产养殖学
·
营养学
✓ 已验证
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Jiaqiang Ding,Yiming Han,Jinqiu Wu,Dongliang Chen,Chengdong Xiong,Dongling Huang,Zuochun Xiong
Inspired by the amino acid residues in mussel adhesion proteins, vinyl polymer underwater adhesives containing dopamine structures have gradually become a research hot spot. Researchers have done a lot of work on how to improve the bonding properties, mechanical properties, and rapid response properties of dopamine-based adhesives. However, vinyl polymers are not degradable, which limit their application in the biomedical field. It is considered to be the most promising method to achieve the degradation of vinyl polymers by free radical ring-opening polymerization of vinyl monomers and cyclic ketene acetals. In this study, we used N-(3,4-dihydroxyphenethyl) methacrylamide (DMA) and 2-methyl-1,3-dioxane (MDO) as raw materials to synthesize biodegradable copolymers P(MDO–DMA) with different compositions by free radical ring-opening polymerization. We carried out adhesion strength and in vitro degradation experiments on polymer adhesives under different conditions. The results showed that the prepared copolymers had good adhesion and biodegradability. This is the result of the synergistic effect of the two functional monomers in the system. DMA achieves adhesion performance and MDO gives effective degradability. We believe that this will expand the current limited application scenarios and provide exciting prospects for applications in areas such as drug delivery and tissue engineering.
研究领域:
材料科学
·
高分子化学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
POLYMER COMPOSITES
·
2022
·Vol. 43
·期 10
·7130-7142
·
IF 3.531
Guorui Yang,Yan Ma,Chen Liu,Lanyue Zhang,Xiangwei Li,Weifeng Du,Lei Shang,Yuhui Ao
Inspired by the strengthening effect of nanoparticles and the toughening effect of block polymers, we prepared a block polymer filler with graphene oxide (GO) as the main body by surface initiate atom transfer radical polymerization (SI-ATRP). In the side groups of the main molecular segment of this block polymer, glycidyl methacrylate (GMA) fragment and N-(3,4-bis([tert-butyldimethylsilyl]oxy)phenethyl)methacrylamide (DOPAm TBDMS ) fragment can promote dispersion and toughening respectively. The molecular structure was characterized by Fourier transform infrared and X-ray photoelectron spectroscopy. After the modified GO was added to the epoxy composite, the mechanical properties of the composite could be significantly improved. The toughness of epoxy composites was enhanced by crack deflection of the matrix. When the added amount of modified GO was 0.25 wt%, the flexural strength reached 151 MPa, which was 37.27% higher than pure epoxy composite. The tensile strength and izod impact strength were increased by 50.56% and 69.89%, respectively. These are attributed to the strengthening and toughening effects of GO and the side groups on it. This research had potential application value in the field of resin fillers and in combination with carbon fiber, metal and other materials.
研究领域:
材料科学
·
高分子化学
·
复合材料
✓ 已验证
DOI
高影响因子
Oncotarget
·
2016
·
IF 5.008
Jingnan Chen,Yan Wei,Xinyu Chen,Jingjing Jiao,Yu Zhang
Polyunsaturated fatty acids (PUFA), a group of nourishing and health-promoting nutrients, ameliorate age-related chronic diseases. However, how PUFA especially n-3 PUFA exert anti-aging functions remains poorly understood. Here we link fish oil, docosahexaenoic acid (DHA) and arachidonic acid (AA) to the aging etiology via a redox-telomere-antioncogene axis based on D-galactose-induced aging mice. Both fish oil and PUFA enhanced hepatic superoxide dismutase (SOD) and catalase activities and cardiac SOD activities within the range of 18%-46%, 26%-65% and 19%-58%, respectively, whereas reduced cerebral monoamine oxidase activity, plasma F 2 -isoprostane level and cerebral lipid peroxidation level by 56%-90%, 20%-79% and 16%-54%, respectively. Thus, PUFA improve the in vivo redox and oxidative stress induced aging process, which however does not exhibit a dose-dependent manner. Notably, both PUFA and fish oil effectively inactivated testicular telomerase and inhibited c-Myc -mediated telomerase reverse transcriptase expression, whereas n-3 PUFA rather than n-6 PUFA protected liver and testes against telomere shortening within the range of 13%-25% and 25%-27%, respectively. Therefore, n-3 PUFA may be better at inhibiting the DNA damage induced aging process. Surprisingly, only DHA significantly suppressed cellular senescence pathway evidenced by testicular antioncogene p16 and p53 expression. This work provides evident support for the crosstalk between PUFA especially n-3 PUFA and the aging process via maintaining the in vivo redox homeostasis, rescuing age-related telomere attrition and down-regulating the antioncogene expression.
研究领域:
营养学
·
衰老研究
·
分子生物学
·
生物化学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2018
·Vol. 7
·期 1
·336-346
·
IF 5.831
Dong Chen,Huangyong Jiang,Dongbo Guo,Wumaier Yasen,Junping Ao,Yue Su,Dongsheng Pan,Xin Jin,Xinyuan Zhu
Cationic gelatin nanoparticles ((+)nGNPs) were prepared by in situ polymerization upon the surfaces of monodispersed gelatin nanoparticles (GNPs) using N-(3-Aminopropyl)methacrylamide (APm) as monomer, which were then decorated with doxorubicin terminated poly(2-methylacryloyloxyethyl phosphorylcholine) (DOX-pMPC) via EDC/NHS conjugation to obtain core–shell nanoparticles ((+)nGNPs@DOX-pMPC) for cancer therapy. The non-fouling pMPC shell could effectively shield the positively charged surface of inner nanoparticle and prevent non-specific protein adsorption, thus endowing the materials with potential for long-acting cancer treatment. Furthermore, the acyl hydrazone bond connecting DOX and pMPC chain could be easily hydrolyzed in the weakly acidic tumor microenvironment. After decladding of the pMPC shell, electropositive (+)nGNPs carrying the drugs can be effectively internalized by cancer cells to induce apoptosis, avoiding undesirable hindrance caused by the superhydrophilic outer layer. On combining the above properties, this drug delivery system can be a promising candidate for long-acting, low-toxicity and high-efficiency cancer therapy.
研究领域:
纳米技术
·
药学
·
癌症治疗
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Bioactive Materials
·
2022
·
IF 16.874
Dun Liu,Lei Li,Ben-Long Shi,Bo Shi,Ming-Ding Li,Yong Qiu,Di Zhao,Qun-Dong Shen,Ze-Zhang Zhu
Wound healing has become one of the basic issues faced by the medical community because of the susceptibility of skin wounds to bacterial infection. As such, it is highly desired to design a nanocomposite hydrogel with excellent antibacterial activity to achieve high wound closure effectiveness. Here, based on ultrasound-triggered piezocatalytic therapy, a multifunctional hydrogel is designed to promote bacteria-infected wound healing. Under ultrasonic vibration, the surface of barium titanate (BaTiO 3 , BT) nanoparticles embedded in the hydrogel rapidly generate reactive oxygen species (ROS) owing to the established strong built-in electric field, endowing the hydrogel with superior antibacterial efficacy. This modality shows intriguing advantages over conventional photodynamic therapy, such as prominent soft tissue penetration ability and the avoidance of serious skin phototoxicity after systemic administration of photosensitizers. Moreover, the hydrogel based on N-[tris(hydroxymethyl)methyl]acrylamide (THM), N-(3-aminopropyl)methacrylamide hydrochloride (APMH) and oxidized hyaluronic acid (OHA) exhibits outstanding self-healing and bioadhesive properties able to accelerate full-thickness skin wound healing. Notably, compared with the widely reported mussel-inspired adhesive hydrogels, OHA/THM-APMH hydrogel due to the multiple hydrogen bonds from unique tri-hydroxyl structure overcomes the shortage that catechol groups are easily oxidized, giving it long-term and repeatable adhesion performance. Importantly, this hybrid hydrogel confines BT nanoparticles to wound area and locally induced piezoelectric catalysis under ultrasound to eradicate bacteria, markedly improving the therapeutic biosafety and exhibits great potential for harmless treatment of bacteria-infected tissues.
研究领域:
生物医学工程
·
材料科学
·
纳米技术
·
伤口愈合
·
抗菌治疗
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）