Materials Science & Engineering C-Materials for Biological Applications
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2020
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IF 5.88
Wanling Cai,Xiulan Weng,Wei Zhang,Zuliang Chen
The increased efflux of fluoroquinolone antibiotics to the environment has become of worldwide concern due to their potential to disturb aquatic ecosystems. How to improve the antibiotic release is a challenge. In this work, magnetic Fe 3 O 4 nanoparticles as a drug release vehicle were prepared using the green synthesis method. It is a simple and environmental friendly technique that employs the plant extract as a reducing and coating agent during the preparation process. Antibiotics ofloxacin and pefloxacin served as the drug model and the drug release behavior was tested at various pH levels. The release efficiency of ofloxacin from Fe 3 O 4 reached 99.6% and for pefloxacin it was 57.0% at 310 K after 120 h (pH 10.5). The scanning electron microscope images show that Fe 3 O 4 particles ranged in size from 10 to 40 nm and magnetism testing indicated that saturation magnetization was 58.7 emu/g. Furthermore, zeta potential, FTIR, UV-VIS, XRD and XPS were used to provide the evidence to support the release mechanism, where was based on the pH control. Our work clearly demonstrated that Fe 3 O 4 nanoparticles were a potential as a targeted drug delivery system.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Liusha Cen,Fan Yu,Yunying Luo,Chengcai Li,Guojin Liu,Wangyong Jin,Hailin Zhu,Yuhai Guo
The construction of a novel ofloxacin degradation catalyst coupled with photocatalysis and PMS activation is of great significance for the regeneration of water resources. A ternary metal (Co, Zn and Mo) sulfide heterojunction with biomimetic flower structure was synthesized using the solvent heat method. And then PVDF@CoZnMoSx membranes were synthetised by researched solvent-assisted nanoparticle embedding (SANE) method, which yielded efficient ofloxacian (OFX) degradation (97.1 %) by PMS activation. The effects of actual environment (such as co-exist ions, organic matter, and actual water matrices) on OFX degradation were observed, and PVDF@CoZnMoSx-3 (Zn:Co = 3:1, PCZM3) exhibited good tolerance for these factors and application value in practice. The pathways of OFX degradation were clarified by LC-MS analysis, and T.E.S.T software simulated the toxicity of the intermediates (P1-P20) gained from LC-MS, which substantiated the efficacy and safety of the PCZM3/PMS system in OFX degradation. The reusability and stability analysis displayed that the OFX degradation of PCZM3/PMS system was maintained in 5 consecutive cycles without additional treatment, and a small number of ions (Co, Zn and Mo) were leached during the OFX degradation. Totally, a new strategy was raised to construct multivariate metal sulfide membranes and couple the photocatalysis and PMS activation, which provided new insights for catalyst membranes to optimize performance.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
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IF 3.8
Hui Minyi,Ma Xi,Yuan Jiayu,Wang Zhouping,Ma Xiaoyuan
Ofloxacin is a commonly used quinolone antibiotic that is also used as a feed supplement in livestock production and in plant disease prevention and treatment. However, the excessive use and abuse of ofloxacin will accumulate along the food chain and endanger human health. Therefore, the development of a simple, rapid, and sensitive detection method for the determination of ofloxacin is critical. Herein, a detection method combining molecularly imprinted magnetic solid-phase extraction (MISPE) and surface-enhanced Raman spectroscopy (SERS) was developed for the detection of ofloxacin. Graphene oxide supported by magnetic beads was synthesized by a one-pot method, producing what was subsequently referred to as magnetic graphene oxide (MGO), and a molecularly imprinted membrane was synthesized on its surface by exploiting the ability of dopamine to self-polymerize under alkaline conditions. MGO@MIPs were obtained as the adsorbent for magnetic solid-phase extraction, which was used for the extraction and enrichment of ofloxacin in complex sample matrix, and then quantitative analysis was conducted by SERS. The developed method exhibited an excellent linear relationship with respect to ofloxacin concentration (10 –5 to 10 2 μg mL −1 ), with a detection limit of 9.7 × 10 –6 μg mL −1 in ultrapure water. Blank honey, milk, and pork samples spiked with ofloxacin at concentrations of 0.005, 0.1, 1, and 10 μg mL −1 were extracted and determined using the developed method, with recoveries ranging from 93.1% to 105.6%. The results support the strong application prospects for the method, demonstrating simple and time-efficient operation and high accuracy.
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INTERNATIONAL BIODETERIORATION & BIODEGRADATION
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2025
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IF 4.1
Jinghua Lv,Shujia Zhang,Siqi He,Tianyu Shi,Yuge Liang,Yunbei Li,Kaili Ma
Antibiotics significantly impact the anaerobic fermentation of waste activated sludge (WAS). However, only a few studies have been conducted on the influence of ofloxacin (OFL) on the production of short-chain fatty acids (SCFAs) and its underlying mechanisms during WAS anaerobic fermentation. This study aimed to elucidate the impact of OFL on SCFA production from alkaline-pretreated WAS fermentation. The results showed that the addition of 10 mg OFL/kg SS led to a peak concentration of 2931.85 mg COD/L, resulting in a 1.1-fold increase in SCFA production compared to the control group. Further exploration revealed that OFL simultaneously promoted WAS solubilization, hydrolysis and acidification. Additionally, a low concentration of OFL increased the abundance of hydrolytic acidifying bacteria but decreased the abundance of SCFA-consuming bacteria. Metagenomic analysis revealed an enhanced abundance (103.76–134.56%) of critical genes related to extracellular hydrolysis (i.e., malZ , bglX , and degP ), membrane transport (i.e., msmX , gtsA , and gltI ), substrate metabolism (i.e., glk , glnA , and gdhA ), and SCFAs biosynthesis (i.e., ackA and fabG ) in the presence of low OFL concentration. These findings broadened our understanding regarding the influence exerted by OFL on WAS anaerobic fermentation.
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PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2025
·
IF 7.8
Bingbing Feng,Juan Chen,Chao Wang,Peifang Wang,Han Gao,Bo Zhang,Jingjing Zhang,Sheng Sheng
Controlling antibiotic resistance genes (ARGs) requires understanding their dissemination potential during treatment of antibiotic-laden rural sewage. However, the mechanisms of ARG spread during aerobic biofilm treatment of antibiotic-containing rural domestic sewage remain unclear. Here, we constructed the aerobic biofilm systems to examine the ARG spread in response to ofloxacin (OFL) with increasing exposure concentrations during rural domestic sewage treatment. Metagenomic analysis revealed that after 35 days of exposure, 0.1, 1, and 10 mg/L OFL increased total ARG abundance by 7.32 %, 10.82 %, and 16.37 %, respectively, compared to the control group. Potential ARG host analysis revealed that OFL stimulates the acquisition of ARGs by pathogens with Acinetobacter baumannii and Escherichia coli being the main pathogenic-resistant bacteria. Network analysis indicated that host bacteria potentially acquire ARGs through horizontal gene transfer (HGT) in OFL-stressed aerobic biofilm systems. Functional analysis showed that SOS response, high cell membrane permeability, adenosine triphosphate synthesis, extracellular polymeric substances secretion, and the enrichment of mobile genetic elements (MGEs) were triggered by OFL, which subsequently promoted the HGT of ARGs. Partial least-squares path modeling suggested MGEs might be primarily driven by ARG spread under OFL exposure in aerobic biofilm systems. These findings provide advanced insights into the unique role of OFL to the host and the HGT of ARGs during aerobic biofilm systems treatment of rural domestic sewage.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Menglong Liu,Litao Chen,Jinyang Li,Jiayan Gao,Xue Gao
The excessive use of ofloxacin (OFL) leads to residues in animal-derived foods and poses a threat to human health. Therefore, it is crucial to design a sensitive and reliable detection platform for ofloxacin. In this study, we established a multi-mode sensing platform based on manganese and cerium-doped oxidase-like active carbon dots (Mn, Ce-CDs) for the detection of OFL. The yellow fluorescent substance 2,3-diaminophenothiazine (DAP), produced by the oxidation of o-phenylenediamine (OPD), is used as a colorimetric signal while quenching the fluorescence of Mn, Ce-CDs via fluorescence resonance energy transfer (FRET). Furthermore, the OPD polymer nanoparticles formed by DAP self-aggregation also have excellent photothermal effect. The developed colorimetric/fluorescence/photothermal multi-mode biosensor showed a wide detection range (10 −7 -10 −2 mg/mL) and low detection limit (colorimetric: 2.55 ×10 −9 mg/mL, ratiometric fluorescence: 19.1 ×10 −9 mg/mL, photothermal: 58.6 ×10 −9 mg/mL) in the quantitative detection of OFL. It could be applied to the detection of actual samples with satisfactory results.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2026
·
IF 7.1
Chen Wang,Ying Guo,Xiao-Qi Dong
NDI-modified MOF material (NDI/MFe) was synthesized by strong covalent amide bonds. • NDI/MFe = 1:1.5 exhibited great OFL photodegradation efficiency, which was two times for NH 2 -MIL-53(Fe). • The modification of NDI provides an effective pathway of electron transmission and accelerates the transformation of electron. Given the excessive enrichment of fluoroquinolone antibiotic ofloxacin (OFL) in aqueous ecosystems, naphthalimide derivative H 4 BINDI (H 4 BINDI = N , N ’-Bis(5-isophthalic acid) naphthalenediimide) covalently modified NH 2 -MIL-53(Fe) (denoted as NDI/MFe) was synthesized through a solvothermal strategy, grafted onto the framework via covalent amide bonds. The physicochemical properties of the modified MOF composites were comprehensively characterized, and their photocatalytic degradation capability for OFL was assessed under complex aqueous solutions and coexisting ions. In addition, NDI/MFe = 1:1.5 composite achieved a two-fold improvement in OFL photodegradation efficiency relative to initial NH 2 -MIL-53(Fe). Such a prominent performance enhancement originates from the introduction of NDI moieties and the construction of covalent amide bonds. Free radicals and electron capture experiments verified that •O 2 ⁻, •OH, and e⁻ served as active species with distinct functions in the photocatalytic system. The refractory OFL molecules could be eventually mineralized into low-toxicity small molecular substances. This study not only provides an effective strategy for mitigating antibiotic water pollution and also offers a new insight into the further development of high-performance MOF composites. This study prepared a covalently modified MOF photocatalyst NDI/MFe by grafting naphthalimide derivative H 4 BINDI onto NH 2 -MIL-53(Fe) via amide bonds for ofloxacin (OFL) degradation. Characterizations confirmed successful amide linkage formation, improved visible-light absorption and charge separation. The 1:1.5 composite doubled degradation efficiency, removing over 80% OFL in 50 min. Active species included •O 2 ⁻, •OH and photogenerated charges. The catalyst showed good stability after four cycles. OFL was mineralized into CO 2 and H 2 O. This work provides a feasible covalent modification strategy for high-performance MOF photocatalysts in antibiotic wastewater treatment. Download: Download high-res image (115KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
·
2023
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IF 15.1
Yang Wu,Jing-ying Zhu,Jia-wen Bai,Li-feng Lin,Chang-ping Yu
Pre-magnetization can boost the activity of zero-valent iron (ZVI), facilitating the removal of contaminants by pre-magnetized ZVI (Pre-ZVI) activated peroxides. However, Pre-ZVI’s persistence and stability in the activation of peroxides are little known. In this work, we investigated the ability of dry and wet Pre-ZVI activated peroxymonosulfate (Pre-ZVI/PMS) to enhance the removal of ofloxacin (OFX), the influence of environmental parameters as well as the evaluation of the long-term performance of Pre-ZVI/PMS. The results showed that the dry Pre-ZVI/PMS system had better removal performance in the wide pH range (4–9), with OFX removal efficiencies of over 90 % and high PMS utilization within 120 min. The presence of different environmental factors significantly affected the degradation process. Remarkably, the ability of dry and wet Pre-ZVI to activate PMS decreased over time, with all systems experiencing a decrease of reaction rate constant ( k ) of approximately 20–47 % from day 1 to day 30. The catalytic efficacy could be considerably recovered by re-magnetization, but it dropped again with time. The vulnerable sites and degradation mechanism of OFX were determined by liquid chromatography–tandem mass spectrometry analysis and density functional theory calculation, and the toxicities of the transformation products in the system were predicted. This work is a guide for clarifying the long-term viability of the Pre-ZVI-activated peroxides used in environmental remediation.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2022
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IF 5.518
Qian Zhang,Dan Zheng,Bo Bai,Na Hu,Honglun Wang
The solar-driven photothermal-Fenton catalytic is demonstrated to be a promising technology to remove pollutants from wastewater benefiting from their low cost and high removal efficiency. Here, we constructed a photothermal-Fenton system using waste natural pyrite as dual-function material with Fenton catalytic and photothermal functions for the first time to remove ofloxacin . The removal efficiency was up to 94.7% and the removal rate was 6.85 times higher than that in conventional Fenton reaction, which was attributed to the synergistic interaction of the photothermal conversion and the Fenton of pyrite. The quenching experiments demonstrated •OH and h + were the dominantly active free radicals . The pyrite had performed substantial removal efficiency during a wide pH range (3−9) and exhibited excellent stability after six cycles. Besides, the continuous flow experiment under natural solar irradiation was also conducted to evaluate the ability of actual application. The research realizes the full utilization of waste pyrite and provides new avenues for the application of solar-driven photothermal effect in environmental remediation.
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APPLIED CATALYSIS B-ENVIRONMENTAL
·
2019
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IF 14.229
Xiyang Liu,Fei Huang,Yang Yu,Peng Zhao,Yuanbo Zhou,Yide He,Yanhua Xu,Yongjun Zhang
In this study, the degradation of ofloxacin (OFX) over Cu–Ce tyre carbon catalysts by the microwave assisted persulfate process was examined for the first time. The results showed that the Cu–Ce tyre carbon catalysts dramatically improved OFX decay efficiency. The optimal reaction conditions were the Cu–Ce tyre carbon catalysts of 2.0 g/L and the persulfate dosage of 12.0 g/L under microwave power of 400 W at 60 °C. The OFX conversion and total organic carbon (TOC) removal reached 95.8% and 87.6%, respectively, after 60 min catalytic oxidation under optimal conditions. To identify the properties of Cu–Ce tyre carbon catalyst, scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), the Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and the ultraviolet–visible (UV–vis) diffuse reflectance spectra studies have been carried out. Eleven kinds of degradation products and five pathways during degradation process of OFX and degradation products were identified by GC–MS and HRMS.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Jiayu Lu,Alu Ouyang,Zixin Wang,Yu Li,Xin Qin,Bo Su,Xuejing Huang,Kefeng Li,Jun Luo,Guorong Xu,Ling Fan,Ronghua Jin
The broad utilization of metal–organic frameworks (MOFs) in advanced oxidation processes (AOPs) for wastewater remediation is impeded by toxic ligands, the challenging recovery of catalysts, and the low cycling efficiency of metal redox pairs. In this study, we fabricated a highly efficient and self-degradable bimetallic catalyst with coordinatively unsaturated metal sites (CUMSs) using non-toxic Olsalazine (Olsa) as a ligand to effectively eliminate the antibiotic ofloxacin (OFL). Under optimal conditions, the OFL removal efficiency approached nearly 100 % within 100 min, with the degradation rate of bimetallic MOFs being 4 times than that of monometallic MOFs. The significant enhancement in catalytic performance of the catalyst was ascribed to its reduced charge transfer resistance (Rct), coordinatively unsaturated metal sites, and accelerated cycling of high valence metal to low valence metal, facilitated by the introduction of bimetallic and reducing non-toxic ligands. Moreover, we investigated the effects of H 2 O 2 concentration, catalytic dose, and pH on pollutant degradation. Additionally, results from quenching experiments and electron spin resonance (ESR) tests demonstrated that the three types of free radicals generated during the catalyst activation process played a key role in pollutant degradation.
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Nanomaterials
·
2025
·Vol. 15
·期 11
·792
·
IF 4.3
Xuan Liu,Jie Chao,Feifei Guo,Liangliang Chang,Xinyang Zhang,Wei Long,Zengzhe Xi
Addressing the limitations of poor piezoelectric photocatalytic activity and insufficient magnetic recovery in pure BiFeO 3 nanoparticles, Gd and Zr co-doped BiFeO 3 nanoparticles were synthesized via the sol-gel method. The structural characterization revealed a rhombohedral-to-orthorhombic phase transition with reduced grain size (~35 nm) and lattice distortion due to dopant incorporation. An XPS analysis confirmed Fe 3+ dominance and oxygen vacancy enrichment, while optimized BGFZ9 exhibited enhanced remanent magnetization (0.1753 emu/g, 14.14 increase) compared to undoped BFO. The synergistic piezo-photocatalytic system achieved 81.08% Ofloxacin degradation within 120 min (rate constant: 0.0136 min −1 , 1.26 higher than BFO) through stress-induced piezoelectric fields that promoted electron transfer for ·O 2 − /·OH radical generation via O 2 reduction. The Ofloxacin degradation efficiency decreased to 24.36% after four cycles, with structural integrity confirmed by XRD phase stability. This work demonstrates a triple-optimization mechanism (crystal phase engineering, defect modulation, and magnetic enhancement) for designing magnetically recoverable multiferroic catalysts in pharmaceutical wastewater treatment.
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