ACS Applied Materials & Interfaces
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2015
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IF 6.723
Yang Wang,Ding Wang,Minghui Tan,Bo Jiang,Jingtang Zheng,Noritatsu Tsubaki,Mingbo Wu
SO3H-functionalized monodispersed hollow carbon/silica spheres (HS/C-SO3H) with primary mesopores were prepared with polystyrene as a template and p-toluenesulfonic acid (TsOH) as a carbon precursor and −SO3H source simultaneously. The physical and chemical properties of HS/C-SO3H were characterized by N2 adsorption, TEM, SEM, XPS, XRD, Raman spectrum, NH3-TPD, element analysis and acid–base titration techniques. As a solid acid catalyst, HS/C-SO3H shows excellent performance in the esterification of oleic acid with methanol, which is a crucial reaction in biodiesel production. The well-defined hollow architecture and enhanced active sites accessibility of HS/C-SO3H guarantee the highest catalytic performance compared with the catalysts prepared by activation of TsOH deposited on the ordered mesoporous silicas SBA-15 and MCM-41. At the optimized conditions, high conversion (96.9%) was achieved and no distinct activity drop was observed after 5 recycles. This synthesis strategy will provide a highly effective solid acid catalyst for green chemical processes.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2024
·Vol. 104
·期 11
·6787-6798
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IF 3.3
Xinyuan Huang,Xin Li,Yufeng Zhang,Xiefei Li,Pei Zhang,Hongbo Song,Qun Huang,Guiming Fu
BACKGROUND Gel property is among the crucial functional properties of egg yolk (EY), which determines the texture and flavor of EY products. In the present study, the effects of two unsaturated fatty acids [monounsaturated fatty acid oleic acid (OA) and diunsaturated fatty acid linoleic acid (LA)] on the gel properties of EY protein were investigated. RESULTS Compared with the blank group, the addition of LA and OA (10–50 g kg −1 ) improved the gel hardness (from 270.54 g to 385.85 g and 414.38 g, respectively) and viscosity coefficient (from 0.015 Pa.s n to 11.892 Pa.s n and 1.812 Pa.s n , respectively). The surface hydrophobicity of EY protein increased to a maximum value of 40 g kg −1 with the addition of both fatty acids (39.06 μg and 41.58 μg, respectively). However, excess unsaturated fatty acids (≥ 50 g kg −1 ) disrupted the completeness of the gel matrix and weakened the structural properties of the EY gel. CONCLUSION Both fatty acids improved the gel properties of EY protein. At the same addition level, OA was superior to LA in improving gel properties. The present study provides a theoretical underpinning for the sensible application of unsaturated fatty acids in improving EY gel properties. © 2024 Society of Chemical Industry.
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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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2024
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IF 2.5
Mengyun Dong,Tianliang Zhang,Xueli Liang,Xinyi Cheng,Fuyan Shi,Hang Yuan,Fengxiang Zhang,Qiqi Jiang,Xia Wang
Sesamin, a special compound present in sesame and sesame oil, has been reported a role in regulating lipid metabolism, while the underlying mechanisms remain unclear. Autophagy has been reported associated with lipid metabolism and regarded as a key modulator in liver steatosis. The present work aimed to investigate whether sesamin could exert its protective effects against lipid accumulation via modulating autophagy in HepG2 cells stimulated with oleic acid (OA). Cell viability was evaluated using the CCK-8 method, and triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein, cholesterol (LDL-C), alanine aminotransferase (ALT), along with aspartate aminotransferase (AST) were assessed by oil red O staining, transmission electron microscopy (TEM), and biochemical kits to investigate the lipid-lowering effects of sesamin. Differentially expressed genes were screened by RNA sequencing and validated using real-time quantitative PCR and Western blot. Autophagy and mitophagy related molecules were analyzed employing TEM, Western blot, and immunofluorescence. The data shows that in HepG2 cells stimulated by OA, sesamin reduces levels of TG, TC, LDL-C, ALT, and AST while elevating HDL-C, alleviates the lipid accumulation and improves fatty acid metabolism through modulating the levels of fat metabolism related genes including PCSK9, FABP1, CD36, and SOX4. Sesamin restores the suppressed autophagy in HepG2 cells caused by OA, which could be blocked by autophagy inhibitors. This indicates that sesamin improves fatty acid metabolism by enhancing autophagy levels, thereby mitigating the intracellular lipid accumulation. Furthermore, sesamin significantly enhances the mitophagy and improves mitochondrial homeostasis via activating the PINK/Parkin pathway. These data suggest that sesamin alleviates the excessive lipid accumulation in HepG2 caused by OA by restoring the impaired mitophagy via the PINK1/Parkin pathway, probably playing a preventive or therapeutic role in hepatic steatosis.
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ACS Omega
·
2025
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IF 4.3
Xuwei Shang,Fuqiang Hu
Quercetin (Que), a bioactive flavonoid with anti-inflammatory and antioxidant effects, faces limited use due to its poor solubility and instability. To overcome these limitations, a novel glyceryl monostearate (GM)-based solid lipid nanocomplex was developed, incorporating oleic acid (OA) to improve stability and Que delivery. GM, aided by positively charged octadecylamine, encapsulated Que (forming LNP@Que), which was then electrostatically coated with OA to yield LNP@Que/OA. Optimizing the GM-to-OA mass ratio to 9:1 yielded a nanocomplex with a particle size of 183.3 ± 20.6 nm and a reduced zeta potential. The OA modification significantly improved the antioxidant properties, degradation resistance, and overall stability of the Que nanocomplex. Notably, LNP@Que/OA (10% OA + 90% GM) demonstrated the highest encapsulation efficiency (97.49%) and enabled effective controlled release of Que during in vitro simulated digestion. This study highlights the potential of LNP@Que/OA for pharmaceutical applications.
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RSC Advances
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2020
·Vol. 10
·期 15
·8766-8772
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IF 3.119
Qiuyun Zhang,Dandan Lei,Qizhi Luo,Jialu Wang,Taoli Deng,Yutao Zhang,Peihua Ma
According to the need of sustainable development, solid catalysts are critical materials for green biodiesel production. In this study, a hydrothermal method was used to develop a reusable and highly active Fe-BTC and UiO-66 metal–organic framework encapsulated Zr-doped polyoxometalate nano-hybrid catalysts (ZrSiW/Fe-BTC and ZrSiW/UiO-66) for the acid-catalyzed esterification of oleic acid with methanol. The structural and compositional characterization of the synthesized catalysts were characterized using various techniques such as Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), nitrogen adsorption–desorption, scanning electron microscopy (SEM), and thermogravimetric (TG) and temperature programmed desorption (NH3-TPD) analysis. The as-prepared ZrSiW/UiO-66 had excellent catalytic activity in the esterification of oleic acid with methanol, higher than that of ZrSiW/Fe-BTC catalyst, owing to the fact that ZrSiW/UiO-66 nano-hybrids have high acidity, large specific surface area and pore volumes, and relatively large average pore sizes. Furthermore, the reusability and stability of nano-hybrids were also evaluated, and it was found that the stability of ZrSiW/UiO-66 catalyst was better.
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LANGMUIR
·
2025
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IF 3.9
Anni Yang,Yumeng Jiang,Huiqun Ju,Tianyu Li,Jiafei Lyu,Xianghai Guo
This study proposed a precise synthetic strategy for tailoring the surface chemistry of magnetic nanomaterials and established a structure–performance relationship between surface hydroxyl density and boric acid adsorption. By modulation of the molar ratio of oleic acid to the iron source in the solvothermal reaction, a gradient control of hydroxyl density on the surface of Fe3O4 nanoparticles was systematically achieved. A novel fluorine substitution XPS method was employed to quantitatively characterize the hydroxyl density, yielding a normalized F/Fe ratio range of 0.195–0.326, which validated the feasibility and controllability of the “fine-tuning” approach. As the hydroxyl density increased, the adsorption capacity of the material increased from 0.7 to 1.5 mmol/g. Comprehensive analysis of boric acid adsorption, including adsorption kinetics, isotherms, thermodynamics, and material characterization before and after adsorption, demonstrated that the adsorption mechanism primarily involved bidentate hydroxyl complexation via a trigonal coordination configuration. These findings provide a reproducible framework for surface modification of magnetic nanomaterials and offer experimental guidance for designing high-performance boric acid adsorbents.
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Drug Design Development and Therapy
·
2022
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IF 4.319
Hong Chen,Yongjie Ding,Wei Chen,Yun Feng,Guochao Shi
Background: Pulmonary fat embolism (PFE) is one of the important causes of acute lung injury (ALI), but its pathogenesis is unclear. In recent years, it has been found that the NLRP3 inflammasome is closely related to inflammatory response. However, there are no reports about the involvement of NLRP3 in PFE- associated ALI. Glibenclamide is a kind of hypoglycaemic drug with anti-inflammatory effect. It has been reported to have the anti-inflammatory effect related to inhibiting NLRP3.Objective: To determine whether NLRP3 inflammasome was involved in ALI induced by PFE or whether glibenclamide had therapeutic effects on such lung injury, we designed this experiment.Materials and methods: The rat model of intravenous injection of oleic acid (OA) was used to simulate PFE. Rats were divided into three groups: control, OA and glibenclamide treatment group. Blood free fatty acid (FFA) concentration was determined by ACS-ACOD. Histopathological examinations were taken to assess the severity of lung injury. The expression of NLRP3 pathway and its downstream products were analyzed by IHC, WB, qPCR and ELISA.Results: Four hours after intravenous OA injection, the typical pathological manifestations of ALI accompanied by elevated levels of plasma FFAs were found. The activity of NLRP3 inflammasomes increased in OA group, too. Pretreatment with glibenclamide partly inhibited the increase in NLRP3, caspase-1 and IL-1β expression induced by OA, simultaneously attenuated the lung injury. But it has little effect on the expression of Toll-like receptor 4 (TLR4) expression in this experiment.Conclusion: NLRP3 inflammasome, one of the main components of innate immune response, involved in ALI induced by OA. Glibenclamide can alleviate this kind of ALI by inhibiting rather the NLRP3/caspase-1/IL-1β signaling pathway than the levels of FFAs or TLR4 pathway.
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MINERALS ENGINEERING
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2025
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IF 5
Zhihui Shen,Jianlong Wang,Hao Zhang,Qingxia Liang,Song Mao,Hui Xie
Enhanced flotation of rhodochrosite fines via hydrophobic agglomeration offers a viable strategy for utilizing manganese carbonate ores and minimizing electrolytic manganese residue. Understanding the mechanism of hydrophobic modifiers is essential for controlling agglomeration behavior. This study investigated the synergistic effect of oleic acid (OA) and kerosene in enhancing rhodochrosite agglomeration through analysis of agglomerates properties, interfacial wettability, adsorption behavior, and interaction forces. The results show that kerosene alone exhibits negligible agglomeration effects on rhodochrosite at a lower concentration of 0.03 wt%, due to the weak adhesion and easy detachment of oil droplets on particles under shear. As kerosene increases to 0.3 wt%, coverage of oil droplets on rhodochrosite increases. However, the limited deformability and the greater critical coalescence force of oil droplets in aqueous solution result in weak agglomeration. Interestingly, agglomerates become larger and more compact with addition of OA-emulsified kerosene, mainly attributed to the dual significant enhancement of rhodochrosite hydrophobicity and bridging effect of oil droplets between particles. Hydrophobic association between OA nonpolar tail and kerosene, along with the strong adsorption of its polar head onto rhodochrosite, results in the improved deformability and spreading of oil droplets, further enhancing rhodochrosite hydrophobicity. Furthermore, changes in OA concentration at the oil–water interface during collision cause tension gradient, inducing stable oil bridges at lower critical coalescence forces. As a result, the co-effect of OA and kerosene enhances rhodochrosite agglomeration. This study offers fundamental insights into the synergistic mechanism of OA and kerosene in promoting the agglomeration of rhodochrosite and other fine particles.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2026
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IF 4.5
Yan Jin,Hui Zhang,Tengfei Li,Shaojie Lei,Meier Jiaerheng,Dezhang Ren,Zhibao Huo
Biodiesel has emerged as a promising alternative to conventional diesel due to its renewability and environmental friendliness. In this study, a MIL-101(Cr) featuring synergistic acid sites was developed through a combined defect engineering and post-sulfonation strategy, enabling efficient esterification of oleic acid under mild conditions. Defects were introduced in the MIL-101(Cr) through a mixed-ligand approach. The existence of abundant oxygen vacancies in the defect-engineered MIL-101(Cr) was confirmed by electron paramagnetic resonance (EPR), which could provide adequate grafting sites for the subsequent sulfonation. The sulfonic acid-functionalized MIL-101(Cr) catalyst (MRBSX) was then synthesized by post-sulfonation with chlorosulfonic acid as the sulfonation agent. The chemical structure and sulfonic acid density of MRBSX were systematically investigated by X-ray diffraction (XRD), scanning electron microscope (SEM), brunauer-emmett-teller (BET), and Fourier-transform infrared spectra (FT-IR), and other characterization techniques. Acid-base titration combined with elemental analysis (EA) demonstrated the successful loading of sulfonic acid groups in MRBSX, highlighting the promotional role of oxygen vacancies in enhancing acid site density and catalytic efficiency. Under optimized reaction conditions (100 °C, 6 wt%, 3 h, and M/O = 8:1), the MRBSX with 10 mol% benzoic acid achieved a high oleic acid conversion of 96.7 % and a corresponding biodiesel yield of 91.5 %. Therefore, the proposed synergistic strategy of defect engineering and post-sulfonation is effective in constructing high-performance solid acid catalysts, demonstrating promising potential in green energy conversion applications.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2026
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IF 19.7
Chunya Wang,Zhentao Liu,Shanbin Gao,Jiyuan Fan,Zhaoqing wang,Chunyang Han,Zhidan Huang,Zhengkai Cao,Chunming Xu,Xilong Wang
A core-shell ZSM-22@meso-SiO 2 support alleviates diffusion constraints for fatty acid hydrogenation. • NiCo alloy formation induces electron transfer from Co to Ni, optimizing the electronic properties. • Enhanced H 2 dissociation and H⁎ spillover over NiCo alloy boost the hydrogenation activity. • The 9Ni6Co/Z@MS catalyst achieves a superior bio-jet fuel yield of 57.2% from oleic acid. Reducing carbon emissions from the aviation sector represented a pressing environmental challenge, and the hydrogenation of vegetable oils to produce high‑value bio-jet fuel offered one of the most promising and economically viable pathways. Herein, we reported a novel bimetallic alloy catalyst with a tunable Ni/Co ratio, specifically designed for the selective hydrogenation of oleic acid to bio-jet fuel. This system delivered 100% conversion of oleic acid and a higher bio-jet fuel yield of 57.2%, while maintaining high iso-alkanes selectivity, which demonstrated superior performance compared to previously reported dazzling heterogeneous catalysts. The introduction of Co promoted the formation of a NiCo alloy phase and facilitated electron transfer from Co to Ni species. The resulting electronic and geometric synergies collectively enhance the dissociation and activation of H 2 , as well as the hydrogenation activity of substrates. Moreover, the Ni/Co ratio directly modulated the catalyst acidity, and the optimized acid properties played a critical role in the subsequent cracking and isomerization of deoxygenated intermediates. Collectively, these findings established a foundation for the rational design of efficient catalysts for bio-jet fuel production derived from oils. Download: Download high-res image (280KB) Download: Download full-size image
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APPLIED SURFACE SCIENCE
·
2026
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IF 6.6
Yixin Chen,Yisimayili Tuersun,Pingjun Luo,Tong Wu,Zexi Chen,Yubin Ke,Sheng Chu
Water-based lubrication systems are increasingly attractive due to their environmental friendliness, cost-effectiveness, and safety merits. While oleic acid-modified magnetite nanoparticles (Fe 3 O 4 -OA) have demonstrated promising properties as lubricant additives in oil-based systems, their performance in water-based lubrication systems remains largely unexplored, as the Fe 3 O 4 -OA nanoparticles exhibit limited dispersion stability and tribological performance in aqueous environments. In this study, Fe 3 O 4 -OA was combined with amine-functionalized silica (SiO 2 -NH 2 ) nanoparticles to enhance the anti-friction and anti-wear properties in water-based lubrication. Comparative tribological tests showed that adding 1 wt% Fe 3 O 4 -OA and 1 wt% SiO 2 -NH 2 reduced the coefficient of friction by 72.4% and the wear volume by 81.7% under a 100 N load compared with pure water. Small-angle neutron scattering (SANS) analysis reveals that increasing Fe 3 O 4 -OA concentration led to a more extended configuration of oleic acid molecular chains, facilitating interactions with surface amine groups on SiO 2 -NH 2 . These interactions promote the formation of a stable and compact tribofilm through combined Lewis acid–base coordination, hydrogen bonding, and electrostatic attraction. The improved frictional performance provides insights into the rational design of high-performance, water-based lubrication systems via nanoparticle additives.
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Journal of Animal Science and Biotechnology
·
2022
·Vol. 13
·期 1
·1-13
·
IF 6.175
Zhou Xiaoge,Mo Zhaoyi,Li Yankun,Huang Liang,Yu Sihai,Ge Lan,Hu Yamei,Shi Shengjie,Zhang Lutong,Wang Liguang,Gao Lei,Yang Gongshe,Chu Guiyan
Background Oleic acid is an abundant free fatty acid present in livestock that are in a negative energy-balance state, and it may have detrimental effects on female reproduction and fertility. Oleic acid induces lipid accumulation in bovine granulosa cells, which leads to a foam cell-like morphology and reduced steroidogenesis. However, why oleic acid increases lipid accumulation but decreases steroidogenesis remains unclear. This study focused on oleic acid’s effects on lipid type and steroidogenesis. Results Oleic acid increased the lipid accumulation in a concentration-dependent manner and mainly increased the triglyceride level and decreased the cholesterol ester level. Oleic acid also led to a decline in estradiol and progesterone production in porcine granulosa cells in vitro. In addition, oleic acid up-regulated the expression of CD36 and diacylglycerol acyltransferase 2, but down-regulated the expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase, scavenger receptor class B member 1 and acetyl-Coenzyme A acetyltransferase 2, as well as steroidogenesis-related genes, including cytochrome P450 family 11 subfamily A member 1, cytochrome P450 family 19 subfamily A member 1 and 3 as well as steroidogenic acute regulatory protein at the mRNA and protein levels. An oleic acid-rich diet also enhanced the triglyceride levels and reduced the cholesterol levels in ovarian tissues of female mice, which resulted in lower estradiol levels than in control-fed mice. Compared with the control, decreases in estrus days and the numbers of antral follicles and corpora lutea, as well as an increase in the numbers of the atretic follicles, were found in the oleic acid-fed female mice. Conclusions Oleic acid changed the lipid type stored in lipid droplets of ovarian granulosa cells, and led to a decrease in steroidogenesis. These results improve our understanding of fertility decline in livestock that are in a negative energy-balance state.
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