Precision Chemistry
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2026
·
IF 7.7
Lejie Tian,Huidan Xue,Michael Gradzielski,Li Shang,Shuanhong Ma,Peiwei Gong,Long Wang,Jianxi Liu,Weimin Liu
Metal–organic frameworks (MOFs) demonstrate considerable potential for biomedical applications. Due to their high porosity and photoactive porphyrin ligands, PCN-224 is considered an ideal drug delivery nanocarrier. However, the synthesis strategy for tailoring the application of PCN-224 in complex pathological diseases remains unclear. In this study, we investigated the structure–activity relationship of PCN-224 nanoparticles as bifunctional nanocarriers for osteoarthritis (OA) treatment under a precisely controlled temperature gradient. By tuning the temperatures, a series of PCN-224 nanoparticles with adjustable sizes were synthesized and their morphologies transitioned from a spindle-shaped to a spherical-shaped structure. The photoluminescence intensity of PCN-224 nanoparticles decreased as the synthesis temperatures increased. Using PCN-224 nanoparticles as aqueous lubricating additives, both the friction coefficient and wear volume were significantly reduced. Among the MOFs, PCN-224 (synthesized at 105 °C) exhibited excellent antifriction performances and acid-responsive drug release properties, demonstrating their promise as bifunctional OA treatment nanocarriers. Our work enhanced the understanding of the relationships between PCN-224 synthesis conditions and its physicochemical properties relationships, expanding their potential for multifunctional biomedical applications.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Yixian Zang,Xiaorong Cai,Shaohong Zang,Lili Ji,Feng Lin,Tong Wang,Xue Dang,Senyang Yu,Shaozheng Zhang,Liuye Mo
Photocatalytic water splitting is one of the effective ways to solve environmental problems and energy crisis. However, the sloughy kinetics of 4e - transfer in water oxidation reaction (WOR) severely limits the efficiency of overall water splitting. Herein, S-scheme heterojunction is constructed by decorating cobalt molybdate on polymeric carbon nitride (CoMoO 4 /PCN) to accelerate the carrier kinetics in WOR. The CoMoO 4 /PCN heterojunction is characterized by XRD, TEM, SEM, XPS and electrochemical tests. Experimental analysis and theoretical calculations reveal that S-scheme heterojunction increases the charge transfer kinetics and the photo-redox ability. Moreover, the decreased Gibbs free energies of intermediate species scale down the overpotential of WOR. Therefore, 2 wt% CoMoO 4 /PCN exhibits outstanding O 2 evolution rate of 34.6 (λ > 300 nm) and 6.2 μmol h −1 (λ > 420 nm), which are 10.8 and 3.6 times than PCN, respectively. This study reveals the key characteristics of PCN by using charge conducting materials to regulate carrier dynamics, which will lay a foundation for the development of photocatalytic O 2 reaction.
研究领域:
材料科学
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环境科学
·
能源科学
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Polymers
·
2023
·Vol. 15
·期 20
·4145
·
IF 5
Guichuan Xu,Zhuhan Wang,Yefeng Chen,Li Qin,Limei Zhou
Porous carbon nitride/bismuth oxychloride (PCN/BiOCl-x) polymer-based heterojunction photocatalysts were successfully synthesized via a simple in situ hydrothermal method. A PCN/BiOCl heterojunction with rich chlorine defects is prepared by adjusting the chlorine content of the BiOCl unit in the heterojunction by changing the solvent. The as-prepared catalysts were characterized via BET, SEM, TEM, XRD, XPS and optical testing, and they were used for a photocatalytic amine oxidation reaction. The results indicated that the catalytic performance of the PCN/BiOCl heterojunction was significantly enhanced due to the rich chlorine vacancies in the samples. The enhanced catalytic activity may be attributed to the Z-scheme heterojunction, abundant chlorine defects and large specific surface area. At the same time, the catalyst circulation experiment shows that the PCN/BiOCl heterojunction has good circulation performance.Keywords:chlorine vacancy;Z-scheme heterojunction;amine oxidation;polymer-based;photocatalysis
研究领域:
材料科学
·
环境科学
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ENVIRONMENTAL TECHNOLOGY
·
2018
·
IF 1.666
Shufeng Liu,Ming Wang,Tingting Li,Qian Chen
The cytotoxicity of titanium dioxide nanoparticles (TiO2 NPs) to microorganisms has attracted great attention over the past few decades. As an important participator in the nitrogen cycle, aerobic denitrifiers have been proven to be negatively affected by TiO2 NPs, but the mechanism of this effect remains unclear. In this study, the bacteria-nanoparticle interaction was investigated by exposing an aerobic denitrifier, Pseudomonas stutzeri PCN-1 to different concentrations of TiO2 NPs at the dark condition, in order to investigate the cytotoxicity mechanism. The results illustrated that aerobic denitrification was inhibited at different TiO2 NPs concentrations from 1 to 128 mg/L, accompanied by the postponement of nitrate reduction and the accumulations of nitrite and nitrous oxide. But this inhibitory effect was mitigated with increasing TiO2 NPs concentrations. Further studies revealed that expressions of aerobic denitrification genes were also inhibited with the presence of TiO2 NPs, and the inhibition effect on napA and nirS genes was more significant than that on nosZ and cnorB, which might directly bring about the delayed nitrate reduction and hindered nitrite transfer. Moreover, the decreased toxicities at higher TiO2 NPs concentrations could be attributed to the formation of larger aggregates (>1000 nm), which greatly reduced the chance for direct interactions between NPs and bacterial membranes, as well as the interruption of denitrifying genes expressions. These findings were meaningful for the formation of deep insights into the mechanism of TiO2 NPs cytotoxicity as well as the development of strategies to control the negative effect of nanoparticles in the environment.Aerobic denitrification characteristics of strain PCN-1 under different carbon sources.
研究领域:
环境科学
·
微生物学
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ACS Applied Energy Materials
·
2026
·
IF 5.5
Xinran Huang,Tao Ma,Ronggui Yu,Qinghe Xiao,Qi Liu,Jianpeng Dong,Huitao Fan,Liya Wang,Bo Li
Utilizing solar energy to achieve photocatalytic CO2 reduction represents a potential method for CO2 conversion. As an emerging semiconductor material, metal halide perovskites offer advantages such as a broad light absorption range, long carrier lifetime, and tunable energy band, demonstrating good application prospects in the field of photocatalysis. CsPbBr3 (CPB) is a representative metal halide perovskite, possessing stable active sites and excellent photocatalytic activity. However, CPB tends to suffer from structural instability in certain environments, and its high carrier recombination rate leads to inadequate photocatalytic performance. To address these issues, we loaded CsPbBr3 quantum dots (CPB QDs) onto porous polygonal tubular carbon nitride (PCN) to construct a CPB-CN composite photocatalyst with a type-II heterojunction, which enables efficient photocatalytic CO2 reduction. Compared with pristine CPB QDs, the CPB-CN heterojunction significantly enhances carrier separation. By further optimizing the CPB-CN ratio, the optimal 20% CPB-CN composite photocatalyst exhibited improved photocatalytic reduction performance and charge separation efficiency. The CO2-to-CO reduction rate reached 20.94 μmol g–1 h–1, almost 3-fold of pure CPB. The improved photocatalytic properties can be ascribed to efficient electron extraction and migration at the interface of PCN and CPB QDs, the high specific surface area, and enhanced visible-light harvesting. This work demonstrates the potential for the design of highly catalytically active perovskite-based systems.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Qi Liu,Chenxi Tang,Jiafeng Liu,Yuan Gao,Lin Peng
Periodontitis is a chronic inflammatory disease driven by microbial dysbiosis and a dysregulated host response, leading to soft-tissue destruction and alveolar bone loss. Antibacterial photodynamic therapy (aPDT) can rapidly suppress pathogens via light-triggered reactive oxygen species (ROS). Here, we report zirconium-based porphyrinic metal–organic framework (MOF) nanoparticles, PCN-224, as a bifunctional platform that couples early antibacterial aPDT with subsequent immunomodulation within the periodontal microenvironment. PCN-224 demonstrated excellent biocompatibility in vitro and in vivo . Under 660 nm irradiation, PCN-224 effectively generated singlet oxygen ( 1 O 2 ) and reduced Porphyromonas gingivalis burden. After uptake by RAW 264.7 macrophages, PCN-224 attenuated lipopolysaccharide-induced inflammation by lowering intracellular ROS levels, restoring superoxide dismutase activity, decreasing nitric oxide release, suppressing NF-κB signaling, accompanied by reduced IL-6, IL-1β, and iNOS and partial recovery of anti-inflammatory mediators. In a ligature-induced mouse model, local PCN-224 injection combined with 660 nm illumination decreased inflammatory infiltration and alleviated alveolar bone resorption. Collectively, PCN-224 provides a time-sequenced antibacterial-to-anti-inflammatory therapeutic effect and represents a potential MOF-enabled strategy for periodontitis management.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Lanjie Li,Xinmin Yu,Lei Xu,Yahui Zhao
Metalloporphyrinic metal-organic framework (PCN-222) is a promising photocatalytic material due to its large surface area and 1D channel, exceptional stability, high visible-light capture capability, and semiconductor properties. Herein, we constructed a highly efficient visible-light-driven type II heterojunction photocatalyst PCN-222-PW 12 /TiO 2 by one step solvothermal method. The 5 wt% PCN-222-PW 12 /TiO 2 showed the superior photocatalytic properties for degrading rhodamine B (RhB) and Ofloxacin, which are 10.69 and 10.48 times higher than pure TiO 2 under same conditions. The excellent photocatalytic performance of PCN-222-PW 12 /TiO 2 ternary composite material was attributed to the improved adsorption capacity of organic pollutants, optical absorption in the entire visible light region, and highly-efficient separation of photoinduced carriers. Besides, we found that h + , O 2 − , and OH are the main active elements in the photocatalytic degradation process. This will back up the higher photocatalytic activity of PCN-222-PW 12 /TiO 2 compared with pure TiO 2 . The photocatalytic efficiency of composite maintained a similar level of photoactivity after four times recovery, which showed excellent stability and recyclability of PCN-222-PW 12 /TiO 2 . This work provides new insights into the fabrication porphyrin-MOF composite materials with high photocatalytic efficiency for environmental remediation.
研究领域:
环境科学
·
材料科学
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Nanoscale Horizons
·
2024
·
IF 8
Yue Chen,Tong Ding,Zhengzheng Qian,Zerui Ma,Liming Zhou,Zhiling Li,Runkai Lv,Yinghui Xu,Yingjie Xu,Linhui Hao,Chen Zhu,Xikuang Yao,Wenying Yu,Wenpei Fan
Sonodynamic therapy (SDT) is gaining popularity in cancer treatment due to its superior controllability and high tissue permeability. Nonetheless, the efficacy of SDT is severely diminished by the transient generation of limited reactive oxygen species (ROS). Herein, we introduce an acid-activated nanosonosensitizer, CaO2@PCN, by the controllable coating of porphyrinic metal-organic frameworks (PCN-224) on CaO2 to induce cascaded oxidative stress in tumors. The PCN-224 doping could generate ROS during SDT to induce intracellular oxidative stress and abnormal calcium channels. Meanwhile, the ultrasound also promotes extracellular calcium influx. In addition, the CaO2@PCN will sequentially degrade in the tumor cell lysosomes, releasing Ca2+ and H2O2 to induce further abnormal calcium channels and elevate the levels of Ca2+. Insufficient catalase (CAT) in tumor cells promotes intracellular calcium overload, which can induce persistent ROS generation and mitochondrial dysfunction through ion interference therapy (IIT). More importantly, PCN-224 also protects CaO2 against significant degradation under neutral conditions. Hence, the well-designed CaO2@PCN produces synergistic SDT/IIT effects and persistent ROS against cancer. More notably, the acidity-responsive biodegradability endows CaO2@PCN with excellent biosafety and promising clinical potential.
研究领域:
癌症治疗
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纳米技术
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生物医学工程
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材料科学
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PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Zhe Sun,Yuanyuan Hui,Ding Yang,Lusha Wei,Ke Ren,Qianyi Mi,Bingqian Liu,Yiran Tian,Bini Wang
Aflatoxin M 1 (AFM 1 ) contamination in milk and dairy products poses a serious food safety concern, especially in regions with limited regulatory oversight. This study developed a zinc oxide–zirconium metal–organic framework (ZnO@PCN-777) for efficient AFM 1 removal from goat milk. The composite exhibited a high adsorption capacity of 112.87 mg g −1 . Kinetic modeling indicated that the adsorption followed a pseudo-second-order model, while isotherm analysis conformed to the Freundlich model, suggesting multilayer adsorption on a heterogeneous surface. X-ray photoelectron spectroscopy (XPS) analysis identified hydrogen bonding, π–π stacking interactions, and pore-filling effects as the primary mechanisms of AFM 1 adsorption, with their synergistic action enhancing overall efficiency. ZnO@PCN-777 maintained excellent reusability across 15 adsorption–desorption cycles. In real milk samples, adding 0.075 % ( w /w) of the adsorbent achieved a 93 % AFM 1 removal rate without affecting milk quality, demonstrating a strong potential for dairy detoxification applications.
研究领域:
食品科学与技术
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环境化学
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材料科学
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毒理学
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乳品安全
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PubMed
高影响因子
Materials Today Advances
·
2026
·
IF 8
Xiao Wang,Yanan Ren,Yuhao Yang,Hui Tu,Dandan Fan,Yuchuan Zhuang,Jing Li,Yanbo Dong,Andrey Tulupov,Ying Hu,Yong Zhang,Jianfeng Bao
The accelerating global crisis of multidrug-resistant infections and the physical intractability of dense bacterial biofilms demand therapeutic platforms that are both functionally active and externally controllable. Here we report the rational design and synthesis of a fuel-free, near-infrared (NIR) propelled Janus nanomotor, PCN-224@Au, that unites photothermal therapy (PTT) with sonodynamic therapy (SDT) in a single construct. Asymmetric deposition of gold onto a porphyrinic PCN-224 metal-organic framework (MOF) establishes the geometric anisotropy required for propulsion and a metal–MOF interface that promotes charge separation. Under low-power 808-nm irradiation, the Au cap converts light to heat and drives self-thermophoretic motion, yielding directed transport with ensemble speeds of ∼10 μm s −1 and super-diffusive MSD of ∼60 μm 2 at 4 s while producing a local temperature rise of 35 + °C within 600 s at 100 μg mL −1 . Ultrasound (US) activates ROS formation in PCN-224, and the Janus architecture simultaneously delivers NIR photothermal input to amplify the effect. Dual activation with NIR and US therefore delivers localized thermal stress (PTT) together with high ROS flux (SDT), producing broad-spectrum antibacterial effects against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) . Light-driven motility enhances deep biofilm penetration and nanomotor-bacteria contact, while US-activated ROS disrupt membranes and trigger cytoplasmic leakage, translating into rapid, depth-resolved sterilization with favorable hemocompatibility and cytocompatibility. By coupling controllable propulsion with sonocatalysis, this Janus nanomotor approach overcomes transport and resistance barriers and provides an effective, fuel-free platform for broad-spectrum antibacterial therapy.
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RSC Advances
·
2024
·Vol. 14
·期 2
·1150-1155
·
IF 3.9
Shuangying Chen,Fushui Guo,Liantao Hao,Xuliang Zhang
Photocatalysis has received much attention as an environmentally friendly route to manage the emerging organic pollution problems. Herein, BiOBr nanosheets have been synthesized by a hydrothermal method, and then PCN/BiOBr hybrids are designed via a facile wet chemical method. The as-prepared PCN/BiOBr hybrids are characterized by X-ray diffraction (XRD), UV-vis diffuse reflectance spectra (UV-vis DRS), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The PCN/BiOBr composite exhibits remarkable improved activity in the degradation of 2,4-dichlorophenol (2,4-DCP) as compared to the pristine BiOBr. Based on the ·OH amount-related fluorescence spectra fluorescence and the photoelectrochemistry (PEC) tests, it is confirmed that the enhanced photocatalytic performance of PCN/BiOBr is attributed to the promoted charge separation. Moreover, by means of the radical-trapping experiments it is demonstrated that the formed ·O2− species, as the electron-modulated direct products, are the primary active species during the photocatalytic degradation of 2,4-DCP. This work would provide a feasible design strategy to fabricate high-activity photocatalysts for 2,4-DCP degradation.
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高影响因子
DYES AND PIGMENTS
·
2025
·
IF 4.2
Meng Tian,Jiaxiong Li,Weiru Li,Zheng Liu,Rui Jin,Chunyan Sun,Junyang Wang
Fluorescence-enhanced PCN-224 (FE-PCN-224) was prepared by modifying porphyrin MOF PCN-224 by 1 M Tris-HCl. We found that FE-PCN-224 was able to significantly enhance the fluorescence intensity of 6-FAM-labelled aptamer (FAM-Apt) in pure water, while its own fluorescence intensity was not disturbed. Based on the above, a ratiometric fluorescence biosensing platform was constructed relying on the specific recognition of Hg 2+ by T (thymine)-rich aptamers and the PET effect between T-Hg 2+ -T and FAM. The emission of FE-PCN-224 was used as the reference signal, and the emission of FAM-Apt was used as the sensitive response signal for detecting Hg 2+ . Hence, the concentration gradient of Hg 2+ could be accurately identified by the difference of the ratiometric signals F 518 / F 650 . The sensing system has good reliability and high stability. With the support of ImageJ software and mobile phone colour analysis software, convenient quantitative detection was realized through RGB channel analysis of real colour images. Meanwhile the prepared fluorescent colourimetric card can be applied to achieve semi-quantitative detection by the naked eye. The developed convenient biosensor provides a potential route for rapid detection of mercury ion contamination.
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