ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Xin Xu,Jingzhi Yao,Man Deng,Ling Tan,Mingliang Fang
The adverse health effects of fine particulate matter (PM2.5) depend strongly on its chemical composition, yet the specific organic components responsible for its toxicity remain insufficiently elucidated. To identify potential toxic constituents in PM2.5, we collected sixty-two PM2.5 samples from Chongqing, a typical basin city in China, and characterized their chemical composition and toxicity by coupling nontargeted analysis (NTA) with metabolomics. The results revealed 382 organic compounds, with significant seasonal variations, such as polycyclic aromatic hydrocarbons (PAHs) and their derivatives. Exposure of BEAS-2B human lung epithelial cells to PM2.5 extracts induced significant perturbations in energy, nucleotide, and redox metabolism, with winter samples exhibiting greater toxicity compared to summer samples. A total of 59 pollutants were significantly correlated with extensive metabolic alterations, especially heteroatom-containing and aromatic chemicals. Fifteen pollutants, including typical PAHs and emerging derivatives (e.g., dinaphtho[2,1-b:1′,2′-d]furan, 2-methylnaphthalene, and 11H-benzo[a]fluoren-11-one), were prioritized by sparse partial least-squares regression as candidate contributors. We further validated these associations by testing the metabolic disruption effects of individual chemicals and quantifying their contributions to the overall PM mixture effects. Notably, 7H-benz[de]anthracen-7-one and pyrene jointly accounted for 80% of the PM-associated decrease in 2-Thiocytidine, a metabolite involved in nucleotide metabolism. This study offers new insights into the chemical-specific toxicity of PM2.5 and highlights the role of PAHs in cellular metabolic disruption by NTA-Metabolomics pairing and experimental validation.
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DOI
PubMed
高影响因子
CELL BIOLOGY AND TOXICOLOGY
·
2026
·
IF 5.7
Na Zhan,Yufeng Wang,Ru Liang,Yousen Wu,Ting Huang,Yuquan Ling,Xinbei Chen,Jiacheng Deng,LiFen Zhou,Kangni Luo,Yilin Cai,Yong-Sheng Tu,Lihui Qu,Jianhua Li
Wood smoke (WS)-derived PM 2.5 is a major environmental risk factor for emphysema, but the role of macrophage-derived exosomes remains unclear. Here, we show that chronic WS exposure in rats induces emphysematous lesions accompanied by markedly increased exosome release, reflected by elevated CD63 expression in alveoli and increased exosome particle number in bronchoalveolar lavage fluid. Pharmacological inhibition of exosome secretion with GW4869 significantly attenuated alveolar destruction. Moreover, intranasal administration of exosomes from PM 2.5 -exposed macrophages was sufficient to recapitulate emphysematous pathology in vivo. Mechanistically, PM 2.5 exposure upregulated the membrane-trafficking protein SNAP23 in macrophages, enhancing exosome secretion and increasing total abundance of ADAM10 within exosomes. Co-localization of CD63 and ADAM10 was observed in alveolar regions of WS-exposed rats and COPD patient lungs. Silencing ADAM10 suppressed caspase-3 activation and reduced epithelial apoptosis, supporting a role for exosomal ADAM10 in driving caspase-3-dependent alveolar epithelial injury. By defining an exosome-mediated macrophage-epithelium pathway that contributes to PM 2.5 -induced emphysema, this study clarifies how combustion-derived PM 2.5 damages lung structure and offers mechanistic insight to reducing the health burden of biomass-related air pollution.
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PubMed
高影响因子
ENVIRONMENTAL TOXICOLOGY
·
2022
·Vol. 37
·期 9
·2201-2213
·
IF 4.109
Qi Xiong,Xiang Tian,Congyue Xu,Baomiao Ma,Wei Liu,Binlian Sun,Qin Ru,Xiji Shu
PM 2.5 exposure has been demonstrated to correlate with neurological disorders recently. Ferroptosis is recognized as a newly found programmed form of cell death associated with neurodegenerative diseases, while glutathione peroxidase 4 (GPX4) is a key regulator of ferroptosis. However, the relationship between PM 2.5 -induced neurotoxicity and ferroptosis is still unclear. The current study aims to investigate if ferroptosis is involved in neurotoxicity post PM 2.5 exposure and its underlying mechanism. The PM 2.5 -treated neuronal Neuro-2a (N2A) and SH-SY5Y cells were applied to the current study. The results showed that PM 2.5 significantly increased the neuronal cell death, yet the ferroptosis antagonist Ferrostain-1 (Fer-1) markedly decreased the cell death induced by PM 2.5 . Western blot further confirmed that ferroptosis was triggered post PM 2.5 treatment in N2A cells by decreasing expressions of GPX4 and ferritin heavy chain (FTH), as well as enhancing expressions of ferritin light chain (FTL) and transferrin receptor protein (TFRC). Meanwhile, PM 2.5 treatment augmented neuronal oxidative damage and mitochondrial dysfunction. The bioinformatic analysis indicated that CREB could be the regulator of GPX4, and our results showed that ERK/CREB pathway was down-regulated in N2A cells post PM 2.5 treatment. The addition of ERK1/2 agonist post PM 2.5 treatment significantly inhibit ferroptosis via increasing the expression of GPX4. Taken together, the present study demonstrated that PM 2.5 -induced ferroptosis via inhibiting ERK/CREB pathway, and these findings will advance our knowledge of PM 2.5 -induced cytotoxicity in the nervous system.
研究领域:
神经科学
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毒理学
·
细胞生物学
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环境健康
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PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Xue Gao,Zhong-Kun Li,Jian Xue,Yong Qian,Li-Zhi Zhang,Jürgen Caro,Haihui Wang
Highly effective air filters are needed because of the increasing harm caused by air particulate matter pollution. Herein, two-dimensional titanium carbide Ti 3 C 2 T x MXene nanosheets with active surface-terminating groups (O, OH and F) were used to modify the polyacrylonitrile (PAN) nanofiber filters to strengthen their interaction force with PM2.5 . These forces were measured quantitatively through the force-distance curve-based AFM showing that the MXene modification of the PAN fiber induces three times larger interaction forces than before. The obtained filters show high PM2.5 removal efficiency of ∼99.7% with a low pressure drop of ∼42 Pa. Moreover, the presence of MXene nanosheets strongly inhibits the propagation of bacteria (e.g. E. coli and S. aureus ) in the filters. Such filters can significantly improve air quality, especially in public places such as hospitals.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2025
·
IF 2.8
Mingxing Chen,Jiawang Sun,Qian Hu,Xinya Wang,Wei Zhang,Yonggui Li
Particulate matter (PM) pollution is widely recognized as a major threat to public health, making the development of thermally stable filters for particulate removal in high-temperature environments critically important. However, the common polymer-based nanofiber air filters are inadequate stability when exposed to high temperature. In this study, the poly (m-phenylene isophthalamide) (PMIA) and nano barium titanate (BaTiO 3 ) which showed remarkable thermal endurance was utilized to prepare the PMIA/BaTiO 3 composite nanofiber air filter. The structure and performance of nanofibers were regulated by changing the addition of BaTiO 3 . The PMIA/BaTiO 3 nanofiber air filter with nano-protrusion structure exhibits high PM2.5 filtration efficiency (98.7%) and low pressure drop (60.4 Pa). Even after being exposed to treatment at 250°C, the PMIA/BaTiO 3 composite nanofiber air filter can still maintain stable filtration performance. The results showed that PMIA/BaTiO 3 nanofiber materials hold promise for eliminating particulate matter in high-temperature environments.
研究领域:
材料科学
·
环境科学
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高影响因子
Environmental Systems Research
·
2024
·Vol. 13
·期 1
·1-10
·
IF 0
Du Hairong,Zhu Xiaoling,Yao Yunying,Yao Wei
Neonicotinoid insecticides (NNIs), as a new type of insecticide, are widely used in agriculture and daily life. Because of the low volatility of NNIs, few studies have evaluated them in atmospheric particulate matter. In this study, 101 outdoor PM 2.5 samples were collected from the Wuhan urban area from 2019 to 2021, leading to the detection of seven NNIs and three of their metabolites. The detection frequencies of all 10 substances were more than 60%, with DIN (dinotefuran) and IMI (imidacloprid) reaching 100%. DIN (52.4 pg/m 3 ) and IMI (43.0 pg/m 3 ) had higher median concentrations than other substances. Concentration distributions of the four substances ACE (acetamiprid), DIN, IMI, and 5-OH-IMI (5-Hydro-Imidacloprid) exhibited statistically significant differences ( P < 0.05) across the four seasons. Concentration levels of ACE, CLO (clothianidin), and IMI were statistically different between the three years ( P < 0.05). The median concentration of imidacloprid-equivalent total neonicotinoids (IMIeq: generated by the relative potency factor method) was 256.1 pg/m 3 . Finally, the estimated daily intake (EDI) of NNIs via respiration was greater in infants and young children than in the rest of the population, suggesting that infants and young children were more likely to be exposed to the health effects of airborne residual PM 2.5 .
研究领域:
环境科学
·
公共卫生
·
毒理学
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DOI
ACS Applied Nano Materials
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2022
·
IF 6.14
Zhimin Hao,Juntao Wu
A complex air pollution environment requires filters to be multifunctional. Nanofibrous materials with surface-loaded metal–organic frameworks (MOF-fibers) are reasonable structures for multifunctional air filtration. These materials can not only utilize the network structure of fibers to intercept particulate matter (PM) but also retain the porous structure of the MOFs to adsorb toxic gas. Epitaxial growth methods are commonly utilized to prepare MOF-fibers but are uneconomical and time-consuming. Herein, a facile self-assembly strategy is developed to prepare zeolitic imidazolate framework-polyimide (ZIF-PI) nanofibers with an interconnected network structure and high porosity for air filtration applications. Due to their unique structure, the ZIF-PI nanofibrous membrane exhibited high PM2.5 filtration efficiency and enhanced SO2 adsorption capacity. Moreover, by exploring the morphology evolution of the ZIF-PI nanofibrous membrane, a possible “synergistic effect of hydrophobic and electrostatic force” self-assembly mechanism was demonstrated.
研究领域:
材料科学
·
环境科学
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高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Jinwen Li,Chenjie Hua,Wei Ma,Feixue Zheng,Yuzheng Wang,Hongyu Pang,Zhixin Zhao,Wenjun Zhang,Qingcai Chen,Federico Bianchi,Veli-Matti Kerminen,Tuukka Petäjä,Markku Kulmala,Yongchun Liu
The health risks of atmospheric particulate matter (PM) are closely linked to its diurnal variation because of the circadian rhythm of human activity. However, the diurnal variability of the oxidative potential (OP) of PM2.5 (OPPM2.5), which is a key toxicity indicator of PM2.5, and its driving factors remain poorly understood. This study investigated the diurnal patterns and drivers of OPPM2.5 based on both field measurements in Beijing in 2023 and laboratory experiments. The daytime OPPM2.5 was moderately higher (1.2 times) than nighttime levels. While nighttime OPPM2.5 primarily depended on carbonaceous aerosols from vehicles and biomass combustion, the enhanced daytime OPPM2.5 was ascribed to the additional contributions from transition metals, dust, and secondary aerosols. OPPM2.5 on sandstorm days increased by up to 46% after 0.5 h of photochemical aging, due to synergistic interactions between dust and vehicle/biomass combustion aerosols, forming reactive oxygen species (ROS)-facilitating functional groups including aromatic carbonyls and peroxides. In particular, Fe2O3 in dust may catalyze ROS formation under irradiation. However, extended aging (>4 h) reduced OPPM2.5 through photochemical bleaching. These results provide new insights into the health impacts of PM and inform health-oriented air quality control strategies through the coordinated reduction of dust, vehicle, and biomass combustion emissions.
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xianhua Zhang,Yuan Liang,Fan Liu,Jie Liu,Bin Yu,Wenbo Li,Mengyu Yuan,Haozhe Tang,Yanchao Zhao,Dongxiao Ji,Kangkang Ou,Jianxin He,Xiaoyan Sun,Weili Shao
Among indoor air pollutants, particulate matter with a diameter less than 2.5 μm (PM 2.5 ) and volatile organic compounds with small molecules are the greatest threat to human health. However, complete removal of these pollutants is challenging, and the incomplete removal causes secondary pollution. In this study, manganese dioxide nanoparticles (MnO 2 NPs) were controllably grown on the surface of mullite nanofibers (MNFs) using a potassium permanganate (KMnO 4 ) reduction method to prepare MNF@MnO 2 composite membranes that could effectively remove PM 2.5 and formaldehyde from indoor air. After loading the optimal amount of MnO 2 NPs, the filtration efficiency of a nanofiber membrane for salt particles with diameters of 0.3 μm increased from 97.32 % to 99.47 %, and the removal rate of formaldehyde reached 88.3 % within 170 min in the closed laboratory space. After five repeated tests, the formaldehyde decomposition rate remained above 80 %. The MNF@MnO 2 membrane was successfully used to prepare an indoor air purifier filter element, demonstrating considerable potential for improving the indoor air quality and reducing health risks.
研究领域:
材料科学
·
环境科学
·
纳米技术
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Huixian Zhou,Hui Zhong,Yiqing Zeng,Yutang Kang,Bin Chen,Shuanglu Ma,Yifan Li,Yu Zhang,Shasha Feng,Zhaoxiang Zhong,Weihong Xing
The strategy of constructing catalytic membrane has a significant influence on its structure and performance. In this work, Co 3 O 4 -C x @SiO 2 nanofiber membranes (NFMs) were fabricated by an in-situ growth–pyrolysis–oxidation strategy. The Co 3 O 4 -C x catalyst derived from ZIF-67 was wrapped around nanofibers, which helps to maintain a stable membrane structure, then suppressing the reduction of gas permeability. Among the Co 3 O 4 -C x catalyst, the carbon skeleton can prevent the agglomeration of Co 3 O 4 nanoparticles, obtaining an ultra-fine Co 3 O 4 nanoparticles with high dispersibility, redox property and surface area. The obtained Co 3 O 4 -C 300 @SiO 2 NFM exhibits outstanding ammonia selective catalytic reduction (NH 3 -SCR) denitrification activity (T 90 = 225 °C at a GHSV of 77,000 h −1 ). The effect of catalyst loading on PM 2.5 filtration performance of SiO 2 NFM was also tested. Co 3 O 4 -C 300 @SiO 2 NFM has higher filtration efficiency (99.99%) than SiO 2 NFM at a lower pressure drop of 58 Pa, which suggests that catalyst loading via our method can improve the filtration performance of SiO 2 NFM. This work might provide a universal strategy for the design and preparation of highly efficient catalytic membrane.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Qiuyue Hu,Xin Gao,Heng Zhang,Tian Si,Xiaoning Tang,Lincai Peng
Cellulose has attracted much attention in application of air filtration for the excellent ability of degradability and biocompatibility. However, limited by the strength of natural structure, air filters based on native cellulose usually have high pressure drop (ΔP) or thick volume. In this study, an efficient air filter was produced with low ΔP (6.8 Pa) using a low amount of dry material (9 ∼ 12 mg/cm 3 ) through simple preparation process with high-speed shear induced. Analysis showed the chains of regenerated cellulose (RC) were stretched and arranged orderly due to the shear induced during the entire coagulation process, letting to an increasing of crystalline of RC. Furthermore, RC filter exhibited a high PM2.5 capture efficiency (over 99.65 %) with high-quality factor (0.853 Pa −1 ) under high PM concentration conditions. This work gave a novel sight on the potential of air filtration produced by agricultural waste bioresources furthermore, offered an interesting and simple avenue for daily respiratory protective media.
研究领域:
材料科学
·
环境科学
·
生物工程
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DOI
高影响因子
Nano Energy
·
2017
·
IF 12.343
Guoyin Zhu,Tao Chen,Yi Hu,Lianbo Ma,Renpeng Chen,Hongling Lv,Yanrong Wang,Jia Liang,Xiaojie Li,Changzeng Yan,Hongfei Zhu,Haixia Liu,Zuoxiu Tie,Zhong Jin,Jie Liu
Particulate matter (PM) pollution has become a serious environmental problem, especially in developing countries, owing to its severe threat to human health. Particularly, airborne PM 2.5 (mean aerodynamic diameter ≤2.5 µm) particles are extremely harmful, because the tiny particles can enter human respiratory system and even penetrate into circulatory system. Herein, we propose an effective strategy to recycle PM 2.5 carbon nanoparticles generated by diesel vehicle engine for the applications of clean energy. After thermal treatment and purification, the PM 2.5 derived carbon nanoparticles show a diameter distribution between 25 and 40 nm, mesoporous characteristics (with an average pore size of ~3.3 nm), and homogeneous nitrogen incorporation (with N content of ~1.1 at%). The PM 2.5 derived N-doped mesoporous carbon nanoparticles were used as an advanced electrode material in supercapacitors , exhibiting excellent specific capacity and superb stability over long-term cycling. Moreover, the recycled PM 2.5 carbon nanoparticles show attractive electrocatalytic properties for oxygen reduction reaction , presenting high onset potential and good immunity to methanol crossover . We expect this research can provide inspiration for air pollution control and sustainable energy utilization.
研究领域:
环境科学
·
材料科学
·
能源科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）