Journal of Engineered Fibers and Fabrics
·
2021
·
IF 1.573
Qijian Niu,Lili Ma,Junxia Guo,Xiaoping Yang
In this study, a temperature responsive PGS/PLLA@PNIPAM core-shell nanofiber membrane was prepared by combining electrospinning with surface ATRP grafting polymer technology, in which the core layer of PGS/PLLA nanofiber was prepared by electrospinning, and then the shell layer of temperature responsive PNIPAM polymer was grafted on the nanofiber surface by ATRP reaction. In the experiment, a macromolecule-initiator PGS-Br was prepared and characterized by FTIR and 1H NMR. The surface morphology, composition, element of the core-shell nanofiber membrane were characterized by SEM, FTIR, and XPS. In addition, it is worth noting that the core-shell nanofiber membrane can respond to temperature in drug release tests.
研究领域:
材料科学
·
高分子化学
·
纳米技术
·
药物传递系统
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2018
·Vol. 10
·期 2
·137
·
IF 2.935
Peihong Li,Xiaoman Hou,Lijie Qu,Xueyan Dai,Chunling Zhang
Poly(N-isopropylacrylamide) (PNIPAM) is a widely-studied polymers due to its excellent temperature sensitivity. PNIPAM-MAPOSS hybrid hydrogel, based on the introduction of acrylolsobutyl polyhedral oligomeric silsesquioxane (MAPOSS) into the PNIPAM matrix in the presence of polyethylene glycol, was prepared via radical polymerization. The modified hydrogels exhibited a thick, heterogeneous porous structure. PEG was used as a pore-forming agent to adjust the pore size. MAPOSS reduced the swelling ratios of gels, and decreased the LCST, causing the hydrogels to shrink at lower temperatures. However, its hydrophobicity helped to improve the temperature response rate. The incorporation of rigid MAPOSS into the polymer network greatly increased the compressive modulus of the hydrogel. It is worth noting that, by adjusting the amount of MAPOSS and PEG, the hydrogel could have both ideal mechanical properties and swelling behavior. In addition, hydrogel containing 8.33 wt % MAPOSS could achieve stable and sustained drug release. Thus, the prepared PNIPAM-MAPOSS hybrid hydrogel can serve as drug carrier for 5-fluorouracil and may have potential application in other biomedical fields.Keywords:hybrid hydrogel;MAPOSS;mechanical properties;swelling;drug release
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Gels
·
2025
·Vol. 11
·期 9
·692
·
IF 5.3
Xiangyu Teng,Zhizheng Gao,Xuehao Feng,Shuliang Zhu,Wenguang Yang
Soft robot motion performance has long been a core focus in scientific research. This study investigates the motion capabilities of soft robots constructed using poly(N-isopropylacrylamide) (PNIPAM) hydrogels, with key innovations in material design and functional enhancement. By optimizing the hydrogel formulation and incorporating molybdenum disulfide (MoS2) to endow it with photothermal response properties, the material achieves muscle-like controllable contraction and expansion deformation—a critical breakthrough in mimicking biological motion mechanics. Building on this material advancement, the research team developed a series of soft robotic prototypes to systematically explore the hydrogel’s motion characteristics. A flytrap-inspired soft robot demonstrates rapid opening–closing movements, replicating the swift responsiveness of natural carnivorous plants. For terrestrial locomotion, a hexapod crawling robot utilizes the photo-induced stretch-recovery mechanism of both horizontally configured and pre-bent feet to achieve stable directional propulsion. Most notably, a magnetically driven rolling robot integrates magnetic units to realize versatile multimodal movement: it achieves a stable rolling speed of 1.8 cm/s across flat surfaces and can surmount obstacles up to 1.5 times its own body size. This work not only validates the strong potential of PNIPAM hydrogel-based soft robots in executing complex motion tasks but also provides valuable new insights for the development of multimodal soft robotic systems, paving the way for future innovations in adaptive and bio-inspired robotics.
研究领域:
软体机器人
·
智能材料
·
仿生学
·
高分子科学
·
驱动器
·
纳米复合材料
·
光热转换
·
磁控系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Qianying Xiao,Yingkai Cui,Yingshuang Meng,Fei Guo,Xuehua Ruan,Gaohong He,Xiaobin Jiang
High-throughput enrichment of biomacromolecules is important in biomedicine, drug release and immobilized enzymes, etc. Herein, two poly-N-isopropylacrylamide (PNIPAm)-based hydrogel composite membrane (HCM), which remarked as PEGDA-PNIPAm and CS-PNIPAm, were fabricated for the adsorption of bovine serum albumin (BSA) under different conditions by introducing using polyethylene glycol diacrylate (PEGDA) and chitosan (CS) as monomers. Fabricated PNIPAm-based HCM exhibits excellent structural stability, thermal stability, and good pH sensitivity. The presence of CS in CS-PNIPAm hindered the temperature response of PNIPAm and possessed stable adsorption capacities over a wide temperature range (average 296.4 ± 50 mg g −1 from 10℃ to 37℃). PEGDA-PNIPAm HCM achieves the highest adsorption capacity (457.0 mg g −1 ) around the transition temperature of 32 °C (457.0 mg g −1 ). The results indicated that the developed HCM materials have potential applications for high-throughput protein adsorption.
研究领域:
生物医学工程
·
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2023
·
IF 6.2
Jing Hu,Xin Liu,Qun Gao,Chunfa Ouyang,Kangsheng Zheng,Xiaoqian Shan
Chronic wounds are prone to produce excessive reactive oxygen species (ROS), which are the main reason for multiple bacterial infections and ulcers at the wound. Therefore, regulating ROS is the key in the process of wound healing. Herein, a new type of thermosensitive hydrogels is developed to improve the scavenging efficiency of ROS and accelerate wound repair. Nano-CeO2 was uniformly dispersed on the surface of mesoporous silica (MSN). The nanocomposite particles were physically crosslinked with poly(N-isopropylacrylamide) (PNIPAM) to form a MSN-CeO2@PNIPAM thermoresponsive hydrogel (PMCTH). The stability, temperature sensitivity, rheological properties, biocompatibility, and wound healing ability of the PMCTH were evaluated in detail. The results showed that the hydrogel could not only maintain the stability of the system for a long time with low biological toxicity but also have a phase transition temperature close to the human body temperature. In addition, the PMCTH was directly applied onto the skin surface. The MSN-CeO2 nanoparticles would be dispersed in the hydrogel to restrict ROS exacerbation effects and promoted the formation of blood vessels as well as surrounding tissues, accelerating the wound healing. More importantly, animal experiments showed that when the mass ratio of CeO2 to MSN was 40%, the wound healing rate reached up to 78% on the 10th day, which was far higher than that of other experimental groups. This study provides a new strategy and experimental basis for the applications of functional hydrogels in wound repair.
研究领域:
材料科学
·
生物医学工程
·
伤口愈合
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Chengdong Zhang,Yachen Fei,Meng Li,Jing Li,Maomao Tang,Guichun Wang,Jiaxin Li,Yuxiao Wang,Yang Ding,Chengjun Peng,Mengjie Li,Shuangying Gui,Jian Guo
Periodontitis is an oral chronic inflammatory disease induced by pathogenic bacteria. Pathogens continuously activate immune cells to express a large number of pro-inflammatory factors and reactive oxygen species, eventually leading to periodontal tissue damage. Poor eradication of pathogenic bacteria, persistent inflammatory response and impaired periodontal tissue regeneration are the main challenges to control the progression of periodontitis. However, current clinical drug treatment fails to comprehensively address these issues. In this paper, a chitosan-P407-PNIPAM scaffold multi-crosslinked hydrogel (A/CQ-ML@Gel) encapsulating AgNPs and lipid complex (CQ-ML) is developed. This hydrogel shows thermo- and pH-sensitive properties, exhibits excellent injectability, high viscosity and reliable post-injection mechanical strength. A/CQ-ML@Gel possesses a significant antibacterial effect to Porphyromonas gingivalis after implantation, and then by virtue of the programmed release of quercetin microemulsion and caffeic acid phenethyl ester in CQ-ML, exerting excellent inflammation regulation and osteogenic differentiation of periodontal ligament stem cells. Notably, A/CQ-ML@Gel could activate mitophagy through PINK1/Parkin in inflammatory macrophages, thereby inhibiting the production of excess reactive oxygen species, ultimately reprogramming M1/M2 macrophages phenotype for inflammation suppression. In summary, we present an innovative insight into periodontal delivery system for trimodal synergistic therapy strategy in periodontitis.
研究领域:
口腔医学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemNanoMat
·
2025
·
IF 2.6
Zhou Zhu,Wei Guo,Shudong Zhang,Nian Li,Min Xi,Jixiang Zhang,Cui Liu,Zhenyang Wang
Smart windows are emerging energy-saving approaches for buildings, dynamically adjusting light transmittance based on weather changes to maintain indoor comfort. However, conventional thermochromic (TC) materials have slow response rates and poor optical sensitivity. Herein, hollow Cu 7 S 4 nanomaterials with broad spectral absorption and high photothermal conversion efficiency are combined with thermoresponsive PNIPAM hydrogel to create a Cu 7 S 4 /PNIPAM hydrogel. This composite enables fast transmittance conversion via photothermal response. The smart window, designed with a glass interlayer, can adaptively adjust transmittance according to real-time light intensity. It is transparent at low light intensity ( T 550 nm = 70.2%) and quickly becomes translucent ( T 550 nm = 39.8%) within 3 min under high light intensity, blocking excess light. This design can reduce indoor temperature by up to 16 °C compared to ordinary glass. Additionally, in cold climates, the smart window can provide heat through photothermal conversion. This approach offers a new way to enhance the performance of traditional TC materials.
研究领域:
材料科学
·
纳米技术
·
光学工程
·
能源效率
·
高分子科学
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Jia Chen,Xuliang Ouyang,Chenxiao Yu,Juan Xiang
Low-mass soluble β-amyloid oligomers (LSAβO) are critical Alzheimer’s disease (AD) biomarkers with significant diagnostic and therapeutic potential. However, their application in early screening and detection is limited by the reliance on complex analytical instruments and procedures. To address this, we developed a visual sensing platform for LSAβO detection using a functionalized pNIPAM-DNA hydrogel. Exploiting the temperature-responsive nature of pNIPAM, the hydrogel selectively incorporates and enriches LSAβO from solution via temperature-induced expansion and contraction. LSAβO binding to aptamers on the hydrogel triggers the formation of G-quadruplex DNAzymes, which catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine to generate a visible colorimetric signal. The hydrogel’s small pore size further enhances selectivity by excluding larger oligomers during real sample analysis. This sensor exhibits a linear detection range of 0.1–7.5 nM for LSAβO and a detection limit of 50 pM. Combining LSAβO enrichment and size exclusion, this functionalized pNIPAM-DNA hydrogel platform provides a cost-effective, highly sensitive, selective, and high-throughput approach for preliminary LSAβO screening and detection.
研究领域:
生物化学
·
医学诊断
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2020
·Vol. 8
·期 35
·12092-12099
·
IF 7.059
Jian Liu,Weizhong Xu,Zhongwen Kuang,Pengli Dong,Youxing Yao,Huaping Wu,Aiping Liu,Fangmin Ye
Smart hydrogels play a vital role in fundamental research and industrial applications in the fields of biosensors, flexible devices and intelligent human–machine technologies; however, developing a simple, low-cost and large-scale method to obtain hydrogel actuators with rapid response and robust and steadily controllable motion remains a big challenge. In this work, a temperature-responsive, gradient structured hydrogel with quick bending and adjustable actuation was fabricated by the copolymerization of the N-isopropylacrylamide (NIPAM) monomer with dispersed montmorillonite (MMT) via a facile precipitation method. The introduction of MMT with good thermal conductivity made the volume phase transition of the PNIPAM-based hydrogel occur earlier, and the deformation degree and bending direction could be adjusted by changing the MMT content. The representative composite hydrogel with 0.2 g MMT in the precursor presented bidirectional bending characteristics with a bending amplitude of about 289° and an average bending speed of about 36.0° s−1, while the composite hydrogel with 0.3 g MMT in the precursor only possessed a unidirectional bending ability with a bending amplitude of about −259° and a bending velocity of about −28.8° s−1 due to the great difference in the shrinking capacity between the top and bottom sides of the composite hydrogel. In addition, flexibly controllable deformation was specially realized by a well-designed patterned hydrogel with a local component and a thickness difference. Our work provides a practical method for the ingenious design of a hydrogel for further development of programmable and versatile hydrogel-based smart actuators and soft robots.
研究领域:
材料科学
·
生物医学工程
·
软体机器人
·
智能材料
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Guangxin Ma,Weiman Li,Xin Zhou,Xiaoze Wang,Mengjie Cao,Wenjun Ma,Jingjing Wang,Hang Yu,Shigang Li,Yunfa Chen
A hygroscopic layer plays an important role in improving the output abilities of energy generation from ubiquitous moisture, whose mechanism is unclear. Herein, three kinds of hydrogels with different pore structures/functional groups are designed as hygroscopic layers, and a universal strategy was proposed to assemble them into hydrogel-based moisture-electric generators (HMEGs). The hydrogels’ pore structure affects the moisture absorption rate, while the functional groups regulate the diffusion path of water. HMEG’s power generation is a synergistic effect of ionic diffusion and streaming potential, which is closely related to the water diffusion within the material and is not directly related to the amount of moisture absorption. HMEG, which absorbs moisture quickly, stores water efficiently, and releases moisture slowly, has an excellent performance and stable voltage output. Based on this mechanism, HMEG employed the calcium chloride-poly(vinyl alcohol)-poly(N-isopropylacrylamide) (CPVPN), semi-interpenetrating network (semi-IPN) hydrogel as the hygroscopic layer showed an open-circuit voltage as high as 0.34 V and a power density of 33.23 μA cm–3. This study opens a perspective on hydrogel HMEG and provides insights into high-performance HMEG design.
研究领域:
材料科学
·
能源工程
·
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Lei Tian,Hualin Jiang,Pinghua Chen,Qi Wang,Pingping Niu,Yangming Shi,Minghui Zhou,Yuancheng Qing,Xvbiao Luo
Competing for adsorption active sites decrease the efficiency of simultaneous adsorption of co-existent adsorbates. On the other hand, different adsorbates being desorbed at the same eluting condition will cause they are mixed together after the desorption, and ruin the recovery. Aim at these problems, a novel adsorbent with two functional domains was designed in this study. This adsorbent is a nano hybrid with two functional domains. One is GO domain which is responsible for the adsorption of inorganic metal ions ; another is PNIPAm domain which is responsible for the adsorption of organic molecules. This two-function-domain structure can avoid organic and inorganic adsorbates to compete the same adsorption active sites. Pb 2+ and 4-NP were taken as the model inorganic and organic adsorbates in this study. The locations of adsorbed Pb 2+ and 4-NP were confirmed by the results of adsorption experiments, BET and XPS analysis. The structure of hybrid was studied by FTIR, Raman spectra and TGA analysis. The hybrid exhibits high adsorption capacity toward Pb 2+ and 4-NP with high anti-inference ability. Furthermore, Pb 2+ and 4-NP can be efficiently desorped one by one with acidic or alkalinous condition, respectively. So they will not be mixed together after the desorption, and can be sequentially recovered. Due to the high efficiency and easy operation, the hybrid is considered as a promising adsorbent to simultaneously adsorb and recover organic and inorganic resources, and the method reported here could provide a new thinking way to develop highly effective adsorbents.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
GOLD BULLETIN
·
2021
·Vol. 54
·期 1
·59-67
·
IF 1.61
Lin Shijun,Jiang Sirui,Zhang Yuchen,Dai Zhengwei,Dai Yu,Xia Fan,Zhang Xiaojin
Gold nanorod (AuNR) nanocomposite hydrogels have attracted increasing attention due to the photothermal effect of AuNRs. However, a facile strategy that avoids multi-step surface modification for synthesis of AuNR crosslinkers is still a critical challenge. Here, AuNRs crosslinking PNIPAM hydrogels were prepared by polymerization of NIPAM with N , N ′-bis(acryloyl)cystamine (BACA)-modified AuNRs as crosslinkers. BACA contains a disulfide bond in the structure. Dynamic and reversible Au-thiolate bonding was formed by directly mixing AuNRs and BACA to facilely prepare AuNR crosslinkers before hydrogel formation. The addition of AuNRs gives hydrogels their photothermal effect and remarkable mechanical behaviors. Hydrogels could repeatedly adhere to the surface of pigskin, metal, plastic, and glass with a relatively stable adhesion. The damaged hydrogels heal within 2 min with near-infrared (NIR) laser (808 nm, 300 mW∙cm −2 ) irradiation. This work provides a line of thinking for improvement of PNIPAM hydrogels, making them promising for further applications in biomedicine.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）