JOURNAL OF MICROENCAPSULATION
·
2020
·
IF 2.287
Ziling Li,Xiangyuan Xiong,Shengfeng Peng,Xing Chen,Wei Liu,Chengmei Liu
Aim: A novel folated pluronic F127 (FA-F127) was synthesised, so as to modify liposomes with FA group on the surface, and evaluate the effects of FA-F127 modification on the properties of the modified liposomes.Methods: FA was linked to one end of pluronic F127, via the terminal OH group, to obtain FA-F127 and the structure was characterised. FA-F127 modified curcumin liposomes (cur-FA-F127-Lps) were prepared. The physicochemical characteristics of cur-FA-F127-Lps, including morphology and particle size, were studied. The in vitro cytotoxicity of cur-FA-F127-Lps against KB cancer cells was determined by MTT tests.Results: The effects of FA-F127 modification on the average particle size, PDI, curcumin encapsulation efficiency and microstructure were not significant. Compared with nonfolated F127 liposomes (cur-F127-Lps), cur-FA-F127-Lps exhibited significantly higher cytotoxicity towards KB cells.Conclusions: Folic acid modified liposomes provide a novel strategy to improve the chemotherapeutic efficacy of hydrophobic bioactive compounds.
研究领域:
药剂学
·
药物递送系统
·
纳米技术
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2023
·Vol. 15
·期 4
·850
·
IF 5
Linlin Liu,Yue Zhang,Youliang Cheng,Jing Chen,Fengjuan Li
The photocatalytic degradation of organic dyes in waste water using carbon quantum dots (CQDs) remains a hot topic due to the importance of environmental protection. However, identifying suitable carbon resources and successful surface modification are still challenging. Herein, the hydrothermal method and surface modification of ammonia and thionyl chloride were applied to synthesize CQDs with different surface groups using PEO106PPO70PEO106(Pluronic F127) as a carbon source. The average particle size of the as-prepared CQDs was in the range of 2.3–3.5 nm. The unmodified CQDs had the highest relative photoluminescence intensity, while all as-prepared CQDs exhibited abnormal photoluminescence located outside the scope of the visible spectrum. Interestingly, CQDs modified with ammonia achieved a degradation rate of 99.13% (15 d) for 50 mg/L indigo carmine solution, while CQDs modified with thionyl chloride reached a degradation rate of 97.59% (15 d) for light green SF yellowish solution. Therefore, in this work, two typical organic dyes can be effectively photocatalytically degraded by as-prepared CQDs, with suitable surface modification.Keywords:carbon quantum dots;hydrothermal method;photocatalytic activity
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2018
·Vol. 29
·期 34
·345101
·
IF 3.404
Luping Sha,Da Wang,Yuling Mao,Wei Shi,Tianbin Gao,Qinfu Zhao,Siling Wang
In this research, a novel method was used to successfully stably coat Pluronic P123 on mesoporous silica nanoparticles (MSNs). Co-constructing a drug delivery system (DDS) with P123 and MSNs has not been previously reported. In this DDS, the coating of P123 was realized through a hydrophobic interaction with octadecyl chain-modified MSNs. The experiments found only Pluronic with an appropriate ratio of hydrophilic and lipophilic segments could keep the nanoassemblies stable. For comparison, nanoassemblies consisting of P123 and octadecyl chain-modified MSNs with or without a disulfide bond were prepared, which were denoted as PSMSNs and PMSNs, respectively. The disulfide bond was expected to endow the system with redox-responsiveness to enhance the therapeutic effect meanwhile decreasing the toxicity. A series of experiments including characterization of the nanoparticles, in vitro drug release, cell uptake and cellular drug release, in vitro cytotoxicity, cell migration and biodistribution of the nanoparticles were carried out. Compared with the PMSNs, PSMSNs displayed a redox-responsive drug release property not only in in vitro release text, but also on the cellular level. In addition, the cell migration experiments proved that the coating of P123 endowed the system with the ability of anti-metastasis. The accumulation of P123 in the tumor was enhanced after coating the MSNs by virtue of the 'EPR' effect of nanoparticles compared with the solution form.
研究领域:
药物递送系统
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MINERALS ENGINEERING
·
2019
·
IF 3.315
Yupeng Qian,Xukun Qin,Yongjun Peng
Slime coating is a common problem in mineral flotation and this study explored a novel idea to mitigate slime coating to improve mineral flotation. Guided by the previous work, Pluronic triblock copolymer F-127 (PEO 100 PPO 65 PEO 100 ) was chosen to mitigate fine quartz coating in fluorite flotation. Then the mechanism underpinning the mitigation of fine quartz coating on fluorite surface by F-127 and the interaction of F-127 with collector sodium oleate on quartz and fluorite surfaces were studied. It was found that F-127 adsorbed on both quartz and fluorite surfaces and therefore mitigated fine quartz coating on fluorite surface through steric repulsion. The adsorbed F-127 on fluorite surface also enhanced the adsorption of sodium oleate but had little effect on the adsorption of sodium oleate on quartz surface. The mitigation of fine quartz coating and enhanced adsorption of sodium oleate on fluorite surface explain the significantly improved fluorite flotation in the presence of fine quartz particles after the addition of F-127.
研究领域:
矿物加工工程
·
材料科学与工程
✓ 已验证
产品关联
DOI
高影响因子
Nanoscience and Nanotechnology Letters
·
2020
·Vol. 12
·期 8
·1022-1029
·
IF 1.128
Liu Ming,Lin Chen,Huang Xiaoqing,Lin Yuxiang
Natural flavonoid formononetin (FN) has anticancer effects, but the hydrophobic structure, characteristics of the short half-life in vivo, limiting its clinical wide-ranging application. In this study, FN loaded Pluronic (PF)@folic acid (FA) micelles (FN-PF@FA), were prepared
to improve the solubility, bioavailability and targeting. FA coupling PF was prepared by carbodiimide crosslinker chemical method, FN-PF@FA micelles were prepared by modified film hydration method, and compared the antitumor activity of FN loaded micelles with free FN In Vitro. The
spherical smooth surface of FN-PF@FA micelles had smaller particle size (112.3±5.3 nm), high encapsulation efficiency (86.14±2.68%), high negative zeta potential (-25.8±0.57 mV), low critical concentration CMC (0.03 mg/mL), and better sustained release profile. In addition,
FN-PF@FA micelles have a positive targeting effect on oral squamous cell carcinoma cells (SCC3). In 48 hours, the growth inhibition of 50% (GI50) was 28.6±1.2 μg/mL for FN and 17.4±0.78 μg/mL for FN-PF, the dose dropped by nearly 38.46%. In addition, the GI50
value of FN-PF@FA was 9.5±0.3 μg/mL, 66.43% lower than FN and 44.83% lower than FN-PF. Furthermore, the laser scanning confocal microscopy revealed that the conjugation of FA significantly improves the active targeting ability of micelles. FN-PF@FA micelles have the potential
to target the release of anticancer drugs with higher bioavailability, further provides a new avenue for the application of traditional Chinese medicine extract in oral malignant tumor.
研究领域:
药学
·
肿瘤学
·
纳米技术
·
药物递送系统
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2017
·
IF 1.671
Zhang Xiong,Li Yuebin,Cai Yaxuan,Zhang Yi,Tian Yiqun,Wang Lin,Gu Haoshuang,Chen Wei
Fluorescent dye-doped silica nanoparticles (FDSNPs) have exhibited great potential in applications including solid-state lighting, chemical sensing, and biological theranostics. However, the wide application of FDSNPs is still a big challenge due to the lack of efficient synthesis strategy.
Herein, red fluorescent hybrid silica nanocapsules (FHSNCPs) were assembled by a green, convenient, and benign method based on Pluronic®F127 micelles as a soft template. Morphologies, structures, sizes, and fluorescence properties of the as-prepared silica nanocapsules were
characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS), Fourier Transform Infrared Spectroscopy (FTIR) and fluorescence spectroscopy. The size of the silica nanocapsules was well controlled from 20.5 nm to 23.6 nm by varying the concentration of F127 and tetramethylorthosilicate
(TMOS). Further investigations reveal that these nanocapsules exhibit monodisperse size, stable aqueous dispersibility, and novel optical properties, which show great potential for fluorescence imaging and temperature monitoring in biological tissues.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
光学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 48
·30250-30261
·
IF 3.108
Xin Liu,Yuebin Li,Jian He,Tingting Zhao,Changmei Chen,Haoshuang Gu,Xingguo Wang
A novel anticancer drug PFPSNT, paclitaxel (PTX)-loaded polymeric F127/P123 silica nanocapsules conjugated with TRAIL (tumor necrosis factor (TNF)-related apoptosis-inducing ligand), was designed and synthesized. Transmission electron microscopy (TEM), dynamic light scattering (DLS), UV-vis absorption and particle size analysis revealed that the synthesized PFPSNT was a spherical particle with a size of 24 nm and excellent colloidal stability. Drug loading efficiency (DL%) and encapsulation ratio (ER%) were 0.39% and 26.5%, and its cumulative release profile was linear. In vitro study showed that PFPSNT had marked cytotoxic and apoptotic activities towards HepG2 (liver cancer cell line) and CaSki (cervical cell line) cells with the IC50 values of 921.07 ng mL−1 and 236.24 ng mL−1, respectively. The antitumor efficacy of PFPSNT was evaluated by using a HepG2-xenografted BALB/c nu/nu mice model. In vivo study showed PFPSNT markedly inhibited HepG2 hepatocellular carcinoma, and its antitumor efficacy was more superior than those of TRAIL, PTX or PTX/F127/P123 silica nanocapsules. Our studies provided a novel strategy to synthesize anticancer nanodrugs with mutiple functions, and demonstrated that PFPSNT was a very effective anticancer drug. This novel nanodrug should be a promising drug for targeted cancer therapy to treat complex cancers.
研究领域:
药学
·
纳米技术
·
肿瘤学
·
药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
Theranostics
·
2017
·
IF 8.766
Ying Sun,Qi Wang,Jianhua Chen,Lei Liu,Li Ding,Ming Shen,Jin Li,Baoshan Han,Yourong Duan
Gold nanoparticle-coated Pluronic- b -poly(L-lysine) nanoparticles (Pluronic-PLL@Au NPs) were synthesized via an easy one-step method and employed as carriers for the delivery of paclitaxel (PTX) in chemo-photothermal therapy, in which Pluronic-PLL acts as the reductant for the formation of AuNPs without the need for an additional reducing agent. Methods: The deposition of AuNPs on the surface of Pluronic-PLL micelles and the thermal response of the system were followed via ultraviolet-visible spectroscopy and dynamic light scattering. Calcein-AM and MTT assays were used to study the cell viability of MDA-MB-231 cells treated with PTX-loaded Pluronic-PLL@Au NPs, and we then irradiated the cells with NIR light. Results: An obvious temperature response was observed for the Pluronic-PLL@Au NPs. Blood compatibility and in vitro cytotoxicity assays confirmed that the Pluronic-PLL@Au NPs have excellent biocompatibility. Compared to Taxol, the PTX-loaded Pluronic-PLL@Au NPs exhibited higher cytotoxicity in MDA-MB-231 cells. All of these results and confocal laser scanning microscopy analysis results suggest that Pluronic-PLL@Au NPs greatly enhance the cellular uptake efficiency of the drug. Conclusion: As confirmed by in vitro and in vivo studies, the combination of chemotherapy and photothermal therapy can cause more damage than chemo- or photothermal therapy did alone, demonstrating the synergistic effect of chemo-photothermal treatment. Thus, the as-prepared Pluronic-PLL@Au NPs are promising for chemo-photothermal therapy.
研究领域:
纳米技术
·
药物递送
·
癌症治疗
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2021
·
IF 5.816
Borui Du,Ruichi Li,Yanghong Zhang,Xingyu Chen,Rencai Tao,Zihang Qin,ChaoPing Fu,Jingran Xiao
Morphology regulation and surface modification are crucial strategies to improving the photoelectrochemical water oxidation performance of Fe 2 O 3 photoanodes. In this study, Pluronic F127-assisted synthesis and post-treatment were adopted to achieve surface modification of FeOOH nanorods prepared by hydrothermal technique, thereby adjusting the morphology and surface properties of Fe 2 O 3 photoanodes after calcination . Although the morphology of FeOOH barely changed, the creation of porous nanorods through F127-assisted synthesis and morphological change from worm-like nanorods into nanoplates by F127-assisted post-treatment were realized, and the electrochemically active surface area, crystallinity , number of surface disorders, and photoabsorption property were affected. Furthermore, relatively high intensity of lattice defects and low-valent ferrous ions (Fe 2+ ) were generated after F127-assisted synthesis, and charge transfer from the surface states was increased. Consequently, Fe 2 O 3 photoanode subjected to F127-assisted synthesis exhibited a reduction in the onset potential by 60 mV. The photocurrent density of Fe 2 O 3 increased by 77% at 1.23 V versus reversible hydrogen electrode following a synergistic effect of F127-assisted synthesis and post-treatment.
研究领域:
材料科学
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2021
·Vol. 26
·期 19
·5771
·
IF 4.412
Jianfeng Zhan,Feng He,Shuxian Chen,Abishek Jung Poudel,Ying Yang,Lin Xiao,Fu Xiang,Shiming Li
Essential oils (EOs) have been used in cosmetics and food due to their antimicrobial and antiviral effects. However, the applications of EOs are compromised because of their poor aqueous solubility and high volatility. Qiai (Artemisia argyiLevl. et Van. var.argyicv. Qiai) is a traditional Chinese herb and possesses strong antibacterial activity. Herein, we report an innovative formulation of EO as nanohydrogels, which were prepared through co-assembly of Qiai EO (QEO) and Pluronic F108 (PEG-b-PPG-b-PEG, or PF108) in aqueous solution. QEO was efficiently loaded in the PF108 micelles and formed nanohydrogels by heating the QEO/PF108 mixture solution to 37 °C, by the innate thermo-responsive property of PF108. The encapsulation efficiency and loading capacity of QEO reached 80.2% and 6.8%, respectively. QEO nanohydrogels were more stable than the free QEO with respect to volatilization. Sustained QEO release was achieved at body temperature using the QEO nanohydrogels, with the cumulative release rate reaching 95% in 35 h. In vitro antibacterial test indicated that the QEO nanohydrogels showed stronger antimicrobial activity againstS. aureusandE. colithan the free QEO due to the enhanced stability and sustained-release characteristics. It has been attested that thermo-responsive QEO nanohydrogels have good potential as antibacterial cosmetics.Keywords:essential oil;qiai;nanohydrogel;thermo-responsive property;antibacterial activity
研究领域:
药学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Hailong Yang,Hantian Lu,Yueyue Miao,Yang Cong,Yubin Ke,Jun Wang,Hua Yang,Jun Fu
Non-swelling super-tough polymer hydrogels have great potentials for stable applications in wet conditions. It has been challenging since most polymer hydrogels uptake water from the environment and swell, which deteriorates the mechanical strength and toughness. Here, we present multi-responsive non-swelling polymer hydrogels ( PHFGs ) by using amphiphilic triblock copolymer micelles as non-covalent crosslinkers. Pluronic F127 (or polyethylene oxide- block -polypropylene oxide- block -polyethylene oxide, PEO-PPO-PEO) (F-127) micelles are used as a prototype for the synthesis of micelle-crosslinked poly-(2-hydroxyethylene methacrylate) (PHEMA) hydrogels, without using any modification of F-127 or other crosslinkers. FT-IR and 1 H NMR studies provide first evidence that F-127 micelles form extensive hydrogen bonding and hydrophobic association with PHEMA chains. The non-covalent crosslinked hydrogels show a high fracture elongation about 460 %, a fracture strength about 240 kPa, and a fracture toughness about 660 kJ/m 3 . Negligible swelling is observed for the polymer hydrogels in aqueous solutions. The hydrogels are self-healable, and responsive to variations in pH or water content to change volume, shape, and transparency. Such multiple-responsive polymer hydrogels are utilized as smart switches and shape memory materials that are actuated by environmental stimuli in a controllable manner.
研究领域:
材料科学
·
高分子化学
·
智能材料
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2015
·
IF 4.152
Wei Xu,Xiaohui Fan,Yanli Zhao,Lingbing Li
The aim of the present study is to construct a cysteine modified polyion complex micelles made of Pluronic F127-chitosan (PF127-CS), Pluronic F127-cysteine (PF127-cysteine) and sodium cholate (NaC) and to evaluate the potential of the micelles as an oral drug delivery system for paclitaxel. Systematic studies on physicochemical properties including size distribution, zeta-potential and morphology were conducted to validate the formation of micelle structure. Compared with Pluronic micelles, drug-loading capacity of PF127-CS/PF127-cysteine/NaC micelles was increased from 3.35% to 12.77%. Both the critical micelle concentration and the stability test confirmed that the PF127-CS/PF127-cysteine/NaC micelles were more stable in aqueous solution than sodium cholate micelles. Pharmacokinetic study demonstrated that when oral administration the area under the plasma concentration–time curve (AUC 0–∞ ) and the absolute bioavailability of paclitaxel-loaded micelles were five times greater than that of the paclitaxel solution. In general, PF127-CS/PF127-cysteine/NaC micelles were proven to be a potential oral drug delivery system for paclitaxel.
研究领域:
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）