INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Qianqian Tang,Qing Chen,Mingsong Zhou,Dongjie Yang
The molecular simulation software was firstly applied to analyze the adsorption of sulfomethylated lignin (SAL) on dye surfaces. Then, SALs with different sulfonic group contents were prepared and characterized by FTIR, NMR, EA and GPC measurements using alkali lignin (AL) as raw materials and sodium sulfite as sulfonating agents. Next, SAL 1.53 was determined to the optimum dispersant by TSI, particle size and thermal storage stability measurements, which had the smallest particle size of 173 nm and highest stability, comparable to the commercial Reax 85A lignin dispersant and basically satisfying the requirement of nano disperse dyes used in the digital printing technology. QCM, AFM and zeta potential results indicated that as the sulfonic group content of SAL increased, the adsorption mass, rigidity of the adsorbed layer, adsorption force and absolute zeta potential value all showed a gradually increasing tendency due to an enhanced hydrophilicity, and thus a decreased intermolecular agglomeration and an increased molecular chain stretching degree. A maximum was observed for SAL 1.53 . This research not only provided a novel approach to the preparation of high-performance lignin dispersants for nano disperse dyes, but also would broaden the high value-added industrial applications of biomass lignin into the digital printing and dyeing field.
研究领域:
化学工程
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材料科学
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纳米技术
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纺织工程
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数字印刷
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Dejun Feng,Yuanmiaoliang Chen,Zhangxin Wang
Membrane distillation (MD) has emerged as a promising thermal desalination technology for hypersaline wastewater reclamation. However, the practical implementations of MD face a critical challenge of membrane fouling . Conventional strategy to address membrane fouling is to emphasize the progress in developing composite MD membranes, but these membranes are commercially unavailable. In this study, we introduce a new operation strategy to mitigate fouling by using surfactant pretreatment. We demonstrate that after being pretreated by 0.05 mM Triton X-100 feed solution for 10 min, a commercial polyvinylidene fluoride (PVDF) membrane can exhibit outstanding fouling resistance in MD process. Further, we elucidate the underlying working mechanism using quartz crystal microbalance (QCM) experiments, oil contact angle measurements, and force spectroscopy determinations. Specifically, in the pretreatment process, the amphiphilic surfactant adsorbs onto the hydrophobic membrane, altering the membrane surface to be hydrophilic. During the MD operations, a hydration layer forms on the hydrophilic surface, eliminating the foulant-membrane interaction and thereby achieving fouling mitigation. For effective fouling mitigation, a surfactant exhibiting a moderate hydrophilic-lipophilic balance (HLB) value (e.g., Triton X-100 with an HLB of ∼14) is required. As an easy-to-implement but effective strategy to mitigate membrane fouling, surfactant pretreatment can substantially improve the fouling resistances of commercial hydrophobic membranes, greatly facilitating the practical applications of MD and membrane contactor technologies.
研究领域:
环境工程
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水处理
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膜技术
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脱盐
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Yibang Zhang,Dong Chen,Yang Liu,Aisha Labaran Ammani,Atena Ahmadian,Aftab Ullah
Protein-lipid interactions are pivotal in various biological processes, including membrane trafficking, signal transduction, and cellular compartmentalization. This study investigates how fatty acid modification alters the physicochemical properties of ovalbumin (OVA) and its interactions with lipid bilayers, with implications for controlled release applications. We hypothesize that modifying OVA with different fatty acids will significantly alter its surface hydrophobicity and membrane affinity, thereby influencing its potential for targeted drug delivery. OVA was chemically modified with four fatty acids (myristic, palmitic, stearic, and oleic acids) using N-hydroxysuccinimide (NHS) esters. Surface hydrophobicity was assessed via 8-Anilino-1-naphthalenesulfonic acid ammonium (ANS) fluorescence assays, revealing that modifications increased hydrophobicity, particularly with longer fatty acid chains. Interactions with liposomes were characterized using dynamic light scattering (DLS) and zeta potential measurements, indicating enhanced liposome binding and altered bilayer properties due to fatty acid modifications. Quartz crystal microbalance with dissipation (QCM-D) analysis confirmed the insertion of fatty acid chains into the lipid bilayer. In vitro release experiments demonstrated that fatty acid modification significantly affected the release kinetics of OVA, with oleic acid-modified OVA showing the lowest cumulative release. Our findings highlight the role of fatty acid structure in modulating protein-lipid interactions and underscore the potential of fatty acid-modified OVA for developing targeted drug delivery systems. Future work will explore the underlying mechanisms and evaluate the therapeutic potential of these modified proteins in vivo.
研究领域:
生物物理学
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生物化学
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药学
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分子生物学
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胶体与界面科学
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Qian Wang,Juan Li,Qiuyueming Zhou,Ting He,Zhaoliang Cui,Young Moo Lee,Weihong Xing
Dissolved organic matter (DOM) is recognized as a crucial factor contributing to the irreversible fouling of ultrafiltration membranes. Quartz crystal microbalance with dissipation (QCM-D) offers insights into the kinetics of fouling layer formation and its structure in-situ on a model membrane. However, a clear correlation between the membrane fouling process and the adsorption-desorption results obtained from QCM-D has yet to be established. In this study, piezoelectric β-phase PVDF membranes were prepared, and their fouling behavior in response to three model compounds (humic acid (HA), dextran (DEX), bovine serum albumin (BSA), and their mixed solutions was examined. It was firstly proposed that the spin-coated model PVDF membrane surface exhibited a typical β-phase structure, characterized by regular undulations resulting from strong stretching effects. A novel double layer piezoelectric sensor, consisting of a β-phase layer over a piezoelectric quartz substrate, was designed for QCM-D analysis to assess the mass and stiffness variations of the absorbed DOM layer. The fouling tendency followed the order of BSA > Mixture > DEX > HA, with the foulant monomeric units having a similar molecular mass of around tens of kDa. Irreversible fouling resistance in series model as well as frequency drop in QCM-D were listed as indicators of irreversible fouling caused by foulant-membrane interaction, which realized a well-defined match for the first time.
研究领域:
膜科学
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环境工程
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材料科学
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分析化学
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产品关联
DOI
高影响因子
npj Science of Food
·
2022
·Vol. 6
·期 1
·1-8
·
IF 7
Chong Pik Han,Chen Jianshe,Yin Danting,Qin Lanxi
Huigan is an important sensory attribute which is commonly used as a quality indicator evaluation of tea products. Previous studies showed a strong correlation between the lubrication behavior of saliva-tea compound mixture and the sensory perception of Huigan from trained panelists. This work was further designed to investigate how the effect of tea consumption on the rate of saliva secretion and its functional properties including total protein content of saliva (TPC), salivary α-amylase (AMY) and lipase activity (LP). A quartz crystal microbalance with dissipation monitoring (QCM-D) was applied to reveal the adsorption behavior of human whole saliva and how the salivary film is affected by the presence of tea compounds. Results showed a significant positive correlation among TPC, LP and Huigan intensity for subjects who are Huigan-sensitive. Compared to the desorption of salivary film, the desorption of saliva-EC/EGC (epicatechin/epigallocatechin) mixture from the gold surface by QCM-D observation showed a significant effect on Huigan intensity in sensitive group when comparing to the salivary layer (blank).
研究领域:
食品科学
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感官评价
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生物化学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yueling Tian,Manyan Qiu,Yu Shen,Yaping Zheng,Xinyan Yang,Wei Zhang,Yujun Jiang
Whey protein hydrolysate (WPH) can be used to develop hypoallergenic foods. However, the stabilization mechanism of WPH-stabilized emulsion is not fully understood. Here, a real-time quartz crystal microbalance with dissipation monitoring (QCM-D) was used in conjunction with a rheometer to investigate the interfacial properties of WPH. Initially, the properties of WPH with different (6 %, 8 %, 10 %, 12 % and 14 %) degree of hydrolysis (DH) were investigated. 8 %-WPH demonstrated superior emulsifying (11.49 m 2 /g, 81.34 min) and foaming properties (14.00 %, 7.78 %). Subsequently, the stability of different WPH-stabilized emulsions were examined. 8 %-WPH emulsion exhibited the lowest centrifugal precipitation rate (4.50 %) and Turbiscan stability index (2.24). Additionally, the 8 %-WPH promoted the adsorption and retention of molecules at the interface, which effectively reduced the interfacial tension. QCM-D measurement further proved that the 8 %-WPH possessed excellent adsorption mass and viscoelasticity. Finally, we characterized the interface-adsorbed WPH. The 8 %-WPH exhibited the highest surface hydrophobicity (1072.60) and flexibility (0.22). Notably, the 8 %-WPH showed the highest β-sheet (41.11 %). This led to stronger interactions between neighboring interfacial WPH molecules, which protected the emulsion droplets from destabilizing factors. Nevertheless, excessive hydrolysis (10 %–14 %) caused WPH molecules aggregation, which consequently diminished the viscoelasticity of the interfacial film and the emulsion stability.
研究领域:
食品科学
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胶体与界面化学
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生物物理学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Qiqi Hong,Lan Zhao,Fengcai Lin,Ningning Tan,Xinda You,Beili Lu,Biao Huang,Jianhua Lv,Yandan Chen,Lirong Tang
Two-dimensional (2D) nanostructures have the advantages of high specific surface area, easy surface functionalization, abundant active sites, and good compatibility with device integration and can be assembled into three-dimensional structures, which are key to the development of high-performance gas sensors. In this study, 2D vermiculite (VMT) nanosheets and guanine (G), two renewable resources with unique chemical structures, were organically combined to fully use the specificity of their molecular structures and functional activities. Driven by the regulation of 2D VMT nanosheets, guanine/vermiculite (G/VMT)-based 2D nanocomposites with controllable pore structure, multiple binding sites, and unobstructed mass transfer were designed and synthesized. The G/VMT nanocomposite material was used as a quartz crystal microbalance (QCM) electrode-sensitive film material to build a QCM-based humidity sensor. G/VMT-based QCM humidity sensor had good logarithmic linear relation (0.9971), high sensitivity (24.49 Hz/% relative humidity), low hysteresis (1.75% RH), fast response/recovery time (39/6 s), and good stability. Furthermore, with a QCM sensor and a specially designed wireless circuit, a wireless humidity detection system transmitting via Wi-Fi allows real-time monitoring of nut storage. This study presents an environmentally friendly, high-performance, miniature 2D nanocomposite sensor strategy for real-time monitoring.
研究领域:
材料科学
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纳米技术
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传感器
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环境监测
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食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2013
·
IF 4.187
Tao Wang,Xiaowen Wang,Yunchao Long,Guangming Liu,Guangzhao Zhang
The conformation of polyzwitterionic brushes plays a crucial role in the adsorption/desorption of proteins on solid surfaces. By use of quartz crystal microbalance with dissipation (QCM-D) and surface plasmon resonance (SPR), we have systematically investigated the conformational behavior of poly(sulfobetaine methacrylate) (PSBMA) brushes as a function of ionic strength in the presence of different ions. The frequency change demonstrates that the effectiveness of anions to weaken the inter/intrachain association and to enhance the hydration of the grafted chains increases from kosmotrope to chaotrope in the low ionic strength regime, but the ordering of anions is almost reversed at the high ionic strengths. The dissipation change indicates that some heterogeneous structures are formed inside the brushes in the presence of chaotropic anions with the increase of ionic strength. In SPR studies, the change of resonance unit (ΔRU) with ionic strength is determined by the balance between the increase of thickness and the decrease of refractive index of the brushes. No anion specificity is observed in the SPR measurements because ΔRU is insensitive to the coupled water molecules inside the brushes. For the control of protein adsorption/desorption, our studies show that the brushes can more effectively resist the protein adsorption in the presence of a more chaotropic anion and a more chaotropic anion can also more effectively induce the protein desorption from the surface of the brushes. In addition, no obvious cation specificity can be observed in the conformational change of the brushes in either QCM-D or SPR measurements.
研究领域:
材料科学
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生物物理学
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表面化学
·
高分子科学
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DOI
PubMed
高影响因子
WOOD SCIENCE AND TECHNOLOGY
·
2022
·Vol. 56
·期 1
·305-322
·
IF 2.898
Li Mingfu,Liu Yi,Chen Chunlin,Zhang Jian,Wang Shuangfei,Min Douyong
The hot water and green liquor pretreatments were conducted on Eucalyptus wood in the current study. The cellulase adsorption behavior on the isolated lignins and model compounds was clarified by a quartz crystal microbalance with dissipation (QCM-D) and atomic force microscopy (AFM). The QCM-D analysis indicated that the hot water pretreated lignin (HPL) adsorbed more cellulase than the green liquor pretreated lignin (GPL) and the protolignin (PL). The AFM analysis revealed that the interaction force between lignin and cellulase was in the order of HPL > GPL > PL which was consistent with the cellulase adsorption. The monomeric lignin model with the ketone group adsorbed more cellulase than the counterpart with the hydroxyl group or aldehyde group. The dimeric lignin models adsorbed more cellulase than the monomeric lignin models. Furthermore, the β – β dimer model adsorbed more cellulase than the β–5 and 5–5′ dimer models. This study provides fundamental knowledge for developing more efficient pretreatment technologies.
研究领域:
生物化学
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生物技术
·
材料科学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Miaolu He,Lei Wang,Yongtao Lv,Xudong Wang,Zhe Zhang,Qi Cui,Jiani Zhu
A thin-film composite (TFC) membrane with hydrophilic double-skinned support layer was developed to improve anti-fouling performance. The double-skinned separate casting technology was applied to obtain the double-skinned support layer and the polyacrylonitrile (PAN) concentration in the bottom casting solution was adjusted. Then, the support layer was carboxylated by immersing in a 1.5 M NaOH solution for 2 h. Finally, TFC membrane with hydrophilic double-skinned support layer was obtained by the interfacial polymerization. When the PAN concentration in the bottom casting solution was 10 wt%. TFC membrane with hydrophilic double-skinned support layer (TFC-10 %) showed the best performance. The water flux of TFC-10 % reached 17.6 LMH and the reverse salt flux was 5.6 gMH. Under the double interception effect of the double-skinned structure and the steric hindrance of the hydration layer on the support layer, good anti-fouling property of TFC-10 % was observed under bovine serum albumin (BSA) foulant. Compared to the traditional TFC membrane, the normalized flux of TFC-10 % increased by 80 %. The anti-fouling performance was also analyzed by microaction mechanisms using AFM and QCM-D. It was found that the adhesion force between TFC-10 % and BSA was small, therefore fewer pollutants were adsorbed on TFC-10 %, and its adsorption layer was loose and easy-cleaning.
研究领域:
膜科学
·
水处理
·
材料科学
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2017
·
IF 4.95
Ziyu Han,Yanyan Wang,Xuexin Duan
This paper reports a surface functionalization strategy for protein detections based on biotin-derivatized poly( l -lysine)-grafted oligo-ethylene glycol (PLL- g -OEG x -Biotin) copolymers . Such strategy can be used to attach the biomolecule receptors in a reproducible way simply by incubation of the transducer element in a solution containing such copolymers which largely facilitated the sensor functionalization at an industrial scale. As the synthesized copolymers are cationic in physiology pH, surface biotinylation can be easily achieved via electrostatic adsorption on negatively charged sensor surface. Biotinylated receptors can be subsequently attached through well-defined biotin-streptavidin interaction. In this work, the bioactive sensor surfaces were applied for mouse IgG and prostate specific antigen (PSA) detections using quartz crystal microbalance (QCM), optical sensor (BioLayer Interferometry) and conventional ELISA test (colorimetry). A limit of detection (LOD) of 0.5 nM was achieved for PSA detections both in HEPES buffer and serum dilutions in ELISA tests. The synthesized PLL- g -OEG x -Biotin copolymers with different OEG chain length were also compared for their biosensing performance. Moreover, the surface regeneration was achieved by pH stimulation to remove the copolymers and the bonded analytes , while maintaining the sensor reusability as well. Thus, the developed PLL- g -OEG x -Biotin surface assembling strategy is believed to be a versatile surface coating method for protein detections with multi-sensor compatibility.
研究领域:
生物技术
·
生物传感器
·
分析化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2022
·
IF 11.504
Zhenyu Yang,Lei Dai,Qingjie Sun,David Julian McClements,Xingfeng Xu
Previously, it has been shown that rice glutelin with a degree of hydrolysis of 2% (DH2) can form stable oil-in-water emulsions, but the stabilization mechanism has not yet been elucidated. In this study, the molecular, interfacial, and emulsifying properties of DH2 were investigated to better understand the structure-function relationships of this emulsifier. Peptides with relatively small (<5 kDa), medium (5–10 kDa), and large (>10 kDa) molecular weights were separated from DH2 by ultrafiltration . The large and medium peptides exhibited the highest surface hydrophobicity and intrinsic fluorescence intensity, respectively. Dynamic interfacial tension and quartz crystal microbalance with dissipation (QCM-D) analysis was utilized to characterize the interfacial properties. The large peptides exhibited a faster adsorption rate and a greater reduction in interfacial tension than the others. QCM-D indicated that the properties of the interfacial layers formed by the peptides were different during adsorption or desorption for all samples. The properties of the emulsions formed using the different peptides were characterized by confocal laser scanning microscopy, particle size, flocculation index, and coalescence index analysis. The storage stability of the emulsions increased as the molecular weight of the peptides used to coat the oil droplets increased, which may have been due to an increase in the steric repulsion caused by thicker interfacial layers. These results indicate that the large peptides in DH2 play the most important role in forming and stabilizing emulsions. This knowledge may be used to increase the utilization of hydrolyzed rice proteins as plant-based emulsifiers in foods and beverages.
研究领域:
食品科学
·
胶体科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）