Marine Drugs
·
2026
·Vol. 24
·期 4
·125
·
IF 5.7
Zi-Han Xu,Zheng-Biao Zou,Chun-Xiu Wang,Chen Li,Xian-Wen Yang,Jun-Song Wang
Inhibition of inflammation and oxidative stress is increasingly recognized as a promising therapeutic strategy for neurodegenerative diseases. In this study, we isolated two new dimeric naphtho-γ-pyrone (aS)-fonsecinones B and D (1and2) and 14 known compounds (3–16) from the deep-sea-derived fungusAspergillus niger3A00562. Their structures were unambiguously determined through integrated physicochemical and spectroscopic analyses. Screening for neuroinflammatory inhibitors using a BV2 microglial cell model identified TMC 256 A1 (10) as the most potent candidate. Compound10significantly suppressed LPS-induced inflammation in BV2 cells without cytotoxicity. It concurrently inhibited LPS-triggered ROS overproduction and neutrophilic infiltration in zebrafish. Subsequent proteomics revealed that10targets NOS2 to modulate Alzheimer’s disease (AD)-associated pathways and the KEAP1-NRF2 axis. Molecular docking and dynamics simulations demonstrated that10occupies the NOS2 heme-binding pocket, thereby preventing dimerization and inhibiting enzymatic activity. Finally,10ameliorated locomotor deficits in an AD zebrafish model. Collectively, these findings highlight compound10as a candidate compound for preventing inflammatory and oxidative stress damage during treatment of neurodegenerative diseases, particularly AD.
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NANO
·
2025
·
IF 1.1
Jingtong An,Xiangyan Chen,Xintao Gao,Yifei Zhang,Jiqing Dong,Yan Lei,Yantao Li
This study aimed to develop novel urolithin–gelatin nanoparticles for cancer treatment. Urolithin–gelatin nanoparticles with stick-like (UG-S nanoparticles) and sea urchin-like (UG-U nanoparticles) morphologies were prepared by the anti-solvent method. Transmission electron microscopy showed that the particle size of UG-U nanoparticles was approximately 4 3 4 . 3 ± 8 . 5 nm. UG-U nanoparticles demonstrated a higher drug loading rate of 49.32%, along with a significantly increased encapsulation efficiency of 98.64%. The changes in surface charge and crystal structure were explored through zeta potential and X-ray diffraction analyses. Fourier transform infrared spectroscopy confirmed the successful encapsulation of each component and the interaction between them. In vitro studies indicated that both UG-S and UG-U nanoparticles could reduce cell viability, but UG-U nanoparticles had superior cell uptake ability. The scratch assay showed that UG-U nanoparticles had a stronger inhibitory effect on the migration of tumor cells. Further studies revealed that compared with UG-S nanoparticles and free urolithin A, UG-U nanoparticles could more effectively promote the accumulation of reactive oxygen species, damage mitochondria and induce apoptosis in A549 cells. In conclusion, sea urchin-like UG-U nanoparticles hold great promise for cancer treatment due to their exceptional properties and potent anti-cancer mechanisms.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-16
·
IF 12.6
Mou Yixuan,Liu Zhenghong,Xu Wentao,Zheng Bin,Ma Minghai,Qin Xiaowen,Zheng Jiajia,Ni Ran,Li Haichang,Wang Lei,Bai Yuchen,Fan Jinhai,Qi Xiaolong,Zhang Qi,Zhang Pu,Zhang Dahong
Bladder cancer (BCa) ranks as the 9th most prevalent malignancy worldwide, featured by its high risk of recurrence. Intravesical therapy constitutes the most important modality to tackle BCa, but its efficiency is often compromised due to the dense physiological barriers in BCa, the instability of the catalytic environment, and the rapid clearance facilitated by periodic urination. Here, we present a dual-source powered sea urchin-like nanomotor, which feature a gold nanocore decorated with ultrasmall platinum nanoparticles and ureases, enable rapid propulsion through the catalytic conversion of abundant urea and hydrogen peroxide present in the bladder cavity and BCa microenvironment, respectively. Our dual-source powered Au-Pt@ur NPs nanoparticles translocated across the mucus barrier rapidly, deeply penetrated tumor and hence chemo-resected bladder tumors in all cases. These results hold substantial promise for the development of biocompatible nanomotors for improved BCa intravesical therapy. Graphical abstract
研究领域:
肿瘤学
·
纳米医学
·
生物工程
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PubMed
高影响因子
Cell Reports Physical Science
·
2025
·
IF 7.3
Yun Hu,Ye Sha,Yan Fang,Meng Zhang,Yonghong Zhou,Puyou Jia,Tianyu Zhu
The widespread adoption of polyurethane (PU) materials in adhesives and ultraviolet (UV)-resistant applications is limited by the challenge of balancing stretchability, recyclability, and self-healing capabilities, which requires an advanced molecular structural design. Here, we synthesize a castor-oil-based PU (COPUSD) that integrates disulfide bonds and multiple hydrogen bonds, drawing inspiration from the remarkable self-healing capabilities and stretchability of sea cucumbers. This biomimetic approach facilitates the development of a multifunctional PU material with excellent self-healing properties, tunable stretchability, and recyclable processing characteristics. The resulting PUs are employed as adhesion and anti-UV radiation materials and exhibit excellent adhesion properties. The transmittance of the PU is close to 0% in the range of 200–400 nm, indicating a strong blocking ability against UV. This study presents a pioneering approach for developing versatile and scalable PU materials that combine adjustable self-healing capabilities and efficient recyclability for adhesive and UV-resistant applications.
研究领域:
材料科学
·
仿生学
·
化学工程
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DOI
高影响因子
Biosensors-Basel
·
2025
·Vol. 15
·期 4
·225
·
IF 5.6
Bin Chen,Xiaosu Yuan,Enze Tian,Yunjie Tan,Le Li,Ru Huang
Analyzing metabolite levels in bodily fluids is essential for disease diagnosis and surveillance. Electrochemical biosensors are ideal for monitoring metabolite levels due to their high sensitivity, rapid response, and low cost. The magnetic microbeads-based electrode functionalization method further promotes the automation development of electrochemical biosensors by eliminating the tedious electrode polishing process. In this study, we presented sea urchin-like magnetic microbeads (SMMBs) and constructed an SMMB-based electrochemical biosensor. The specific morphology of SMMBs provides a larger specific surface area and abundant enzyme binding sites, thereby expanding the active reaction interface on the electrode and improving the sensitivity of the biosensor. Experiment results demonstrated that the SMMB-based electrochemical biosensor achieves μM level detection sensitivity for glucose. Furthermore, by replacing the anchored oxidase on SMMBs, the biosensor can be extended to detect other metabolites, such as cholesterol. In summary, the SMMBs provide a new path to handily construct electrochemical biosensors and hold a great potential for metabolite detection and further development.
研究领域:
生物医学工程
·
分析化学
·
医学诊断
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PubMed
高影响因子
Nanoscale
·
2025
·
IF 5.1
Kaishen Chen,Duoduo Yang,Yiping Cheng,Jianyong Luo,Zhiyu Liu,Weiwei Xing,Shusheng Pan,Chengyun Zhang
Conventional photocatalytic materials, predominantly in powder form, face challenges such as difficulty in recovery and secondary pollution, limiting their practical applications. In this study, a three-dimensional porous graphene framework (3DGF) nanostructure was induced on the surface of polyimide (PI) using laser processing, providing abundant binding sites for zinc oxide (ZnO). By adjusting the laser parameters, 3DGF nanostructures with varying crystallinity and framework characteristics were fabricated, and sea urchin-like ZnO nanoflowers were grown on the surface through a hydrothermal method. Different ZnO morphologies, such as orchid-like nanoflowers and nanorods, were achieved by varying the precursor concentrations. Under UV LED irradiation, 3DGF@ZnO/HMTA (2 : 2) exhibited remarkable photocatalytic degradation efficiencies of 89.62%, 100%, and 92.96% for methylene blue (MB), rhodamine B (RhB), and methyl orange (MO) within 90, 120, and 180 min, respectively. After multiple cycles of RhB photodegradation, the efficiency remained at 96.53%, and even after 20 tape adhesion tests, the photocatalytic degradation efficiency for RhB was sustained at 89.81%. The superior performance and stability highlight the potential of 3DGF@ZnO/HMTA for sustainable water pollution remediation.
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高影响因子
Nature Communications
·
2021
·Vol. 12
·期 1
·1-9
·
IF 14.919
Wang Xiu-man,Tao Lu-qi,Yuan Min,Wang Ze-ping,Yu Jiabing,Xie Dingli,Luo Feng,Chen Xianping,Wong ChingPing
Sensitivity and pressure range are two significant parameters of pressure sensors. Existing pressure sensors have difficulty achieving both high sensitivity and a wide pressure range. Therefore, we propose a new pressure sensor with a ternary nanocomposite Fe 2 O 3 /C@SnO 2 . The sea urchin-like Fe 2 O 3 structure promotes signal transduction and protects Fe 2 O 3 needles from mechanical breaking, while the acetylene carbon black improves the conductivity of Fe 2 O 3 . Moreover, one part of the SnO 2 nanoparticles adheres to the surfaces of Fe 2 O 3 needles and forms Fe 2 O 3 /SnO 2 heterostructures, while its other part disperses into the carbon layer to form SnO 2 @C structure. Collectively, the synergistic effects of the three structures (Fe 2 O 3 /C, Fe 2 O 3 /SnO 2 and SnO 2 @C) improves on the limited pressure response range of a single structure. The experimental results demonstrate that the Fe 2 O 3 /C@SnO 2 pressure sensor exhibits high sensitivity (680 kPa −1 ), fast response (10 ms), broad range (up to 150 kPa), and good reproducibility (over 3500 cycles under a pressure of 110 kPa), implying that the new pressure sensor has wide application prospects especially in wearable electronic devices and health monitoring.
研究领域:
材料科学
·
电子工程
·
纳米技术
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高影响因子
ESTUARINE COASTAL AND SHELF SCIENCE
·
2016
·
IF 2.335
Dong-Yang Cui,Jiang-Tao Wang,Li-Ju Tan,Ze-Yi Dong
The South China Sea (SCS), which is the largest marginal sea in East Asia, plays a significant role in regional climate change . However, research on the phytoplankton community structure (PCS) response to atmospheric wet deposition remains inadequate. In this study, field incubation experiments were performed to survey the impact of atmospheric wet deposition on the PCS in the SCS in December 2013. Results indicate that the mean dissolved inorganic nitrogen/dissolved inorganic phosphorous (DIN/DIP) ratio in rainwater was 136, which was higher than that in seawater. Under low initial nutrient concentrations, rainwater inputs not only significantly increased total chlorophyll a (Chl a ) concentrations but also potentially altered the PCS. The total Chl a concentration increased 1.7-, 1.9-, and 1.6-fold; microphytoplankton increased 2.6-, 3.2-, and 1.7-fold with respect to their initial values in the 5%, 10% addition, and 10% addition (filtered) treatment samples, respectively. Finally, microphytoplankton contributed 61% to the total Chl a concentration in 10% addition treatment samples. Differences in the nutrients induced by atmospheric wet deposition resulted in a shift in the advantage from picophytoplankton to microphytoplankton. Diatoms became the predominant species, accounting for 55% of the total abundance after rainwater addition.
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Scientific Reports
·
2023
·Vol. 13
·期 1
·14507
·
IF 4.6
Zhou Yao,Chen Dengkai,Xiao Jianghao,Wang Hanyu
Improving the human reliability of the human–machine interface (HMI) of deep-sea manned submersible is of great importance for the development of the deep-sea field. Based on the SHEL (Software S, Hardware H, Environment E, Liveware L) model, this study classifies the performance shaping factors (PSF) that affect the human reliability of submersible HMIs and builds a PSF system. The interpretative structural model (ISM) is used to matrix the interactions between the elements that make up the system of PSF. A multi-level recursive structure is obtained by building the corresponding adjacency matrix. The Noisy-OR model is introduced to construct a Bayesian network in order to build a new HMI evaluation method. A real case of Bayesian network causal inference verifies the validity of the built method. This study proposes a set of HMI human reliability evaluation methods applicable to deep-sea manned submersible, which provides a new idea for human reliability assessment.
研究领域:
海洋工程
·
人因工程
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可靠性工程
·
水下机器人
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2019
·
IF 3.571
Zhenjun Zhu,Xiuping Dong,Chunhong Yan,Chunqing Ai,Dayong Zhou,Jingfeng Yang,Hui Zhang,Xiaoling Liu,Shuang Song,Hang Xiao,Beiwei Zhu
Fucosylated chondroitin sulfate from sea cucumber Stichopus japonicus (FCSSJ) has been demonstrated with various biological activities; however, its precise structure is still controversial, and digestive behavior remains poorly understood. FCSSJ was purified, and its detailed structure was elucidated mainly based on the NMR spectroscopic methods. Its main chain was characterized as →4)-β-d-GlcA-(1 → 3)-β-d-GalNAc-(1→ with GalNAc4S6S:GalNAc4S in a ratio of 1.5:1, and three types of sulfated fucosyl branches attaching C-3 of GlcA, namely, Fucp2S4S, Fucp3S4S, and Fucp4S, were found in a ratio of 2:1.5:1. The digestibility of FCSSJ was investigated in vitro, and the unchanged molecular weight and reducing sugar content indicated that FCSSJ was not broken down under salivary and gastrointestinal digestion. Furthermore, FCSSJ showed a significant inhibitory impact on pancreatic lipase dose-dependently but not on α-amylase, indicating that the inhibition of pancreatic lipase by FCSSJ might be a pathway for its hypolipidemic effect. These findings propose a fucosylated chondroitin sulfate and provide insight into the mechanism of its physiological effects in the digestion system.
研究领域:
生物化学
·
海洋生物学
·
药理学
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高影响因子
RSC Advances
·
2013
·Vol. 4
·期 18
·9031-9038
·
IF 2.562
Delin Cheng,Xiaodong Cao,Huichang Gao,Xiaoling Ye,Wenxiu Li,Yingjun Wang
Composite polymer devices have gained considerable interest in biomedical applications. In this work, a composite poly(lactic-co-glycolic acid)/poly(ε-caprolactone) (PLGA/PCL) microsphere with a layered architecture and an island–sea topography was developed. PCL was found to occupy the shell layer of the microsphere, while PLGA constituted surface islands and the internal core. This subtle structure was derived from the different external and internal rates of phase separation between PCL and PLGA. The existence of the PLGA islands enhanced the hydrophilicity of the PCL shell. Mouse mesenchymal stem cells (mMSCs) were cultured and they grew well on the PLGA/PCL microspheres. The surface of the microsphere was microscopically composed of PCL sea and PLGA islands, and the mMSCs showed a trend to attach to the more hydrophilic PLGA islands and bridged between adjacent microspheres. This paper provides a new alternative to design functional microspheres for potential application in tissue repair.
研究领域:
生物医学工程
·
材料科学
·
细胞生物学
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2019
·Vol. 99
·期 14
·6400-6407
·
IF 2.422
Xiaoyang Liu,Zixu Wang,Jing Zhang,Liang Song,Deyang Li,Zixuan Wu,Beiwei Zhu,Yoshimasa Nakamura,Fereidoon Shahidi,Chenxu Yu,Dayong Zhou
BACKGROUND Zinc is known to play an essential role in the biological activities in the human body. In this study, a zinc-chelating peptide (ZCP) produced by Alcalase-assisted hydrolysis of the body wall of sea cucumber was isolated and identified. The ZCP was purified stepwise by ultrafiltration, anion-exchange chromatography, and gel filtration chromatography, in conjunction with ultraviolet–visual (UV–visual) spectrophotometry, which was used to analyze each purified fraction. RESULTS Analysis of the purified ZCP revealed that its zinc-chelating ability was 33.31%. Analysis of isothermal titration calorimetry suggested that the binding of ZCP and zinc (N ≈ 2) was endothermic, with weak binding affinity. Fourier transform infrared spectroscopy spectra (FTIR) indicated that carboxylic and amide groups in ZCP were the primary binding sites of Zn. Sequencing the result by ultra-performance liquid chromatography-quadrupole/time of flight mass spectrometry (UPLC-Q-TOF-MS/MS) showed that a representative ZCP had the sequence WLTPTYPE with a molecular weight of 1005.5 Da. CONCLUSION These results provide a promising foundation for the production of zinc supplements from sea-cucumber-derived ZCPs. © 2019 Society of Chemical Industry
研究领域:
食品科学
·
生物化学
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PubMed
高影响因子
危险品化学品经营许可证（带存储）