Advanced Science
·
2025
·
IF 14.1
Yibo Du,Chenxu Zhu,Ruifeng Wang,Shi Chen,Chuang Li,Defang OuYang,Lixin Liu,Yongming Chen
Pulmonary fibrosis resulting from recurrent lung inflammation due to pathogen infection may lead to serious problems and death. Neutrophil extracellular traps (NETs), consisting of DNAs and proteins released by neutrophils in response to infection, are major pathogenesis factors for pathogen-associated pulmonary fibrosis. By mimicking nucleic acid hydrolase, polymeric artificial DNases bearing imidazole units (PEG-PIm) are developed to degrade the DNAs and thus deconstruct NETs, inhibiting pulmonary fibrosis. By tailoring the PIm segments with varied imidazole units, the polymer hydrolase with a defined number of imidazole units outperforms other samples in the cleavage of DNAs and inhibits the transition of pulmonary fibroblasts to myofibroblasts. This polymer digests the DNAs complexed with cationic peptides, unlike natural DNase I. By aerosol inhalation, it reduces NET infiltration in lungs and significantly alleviates inflammatory cytokines and fibrosis. Molecular dynamics simulations indicate that the optimized polymer may expose more effective imidazole units to the DNA backbones and thus enhance the affinity and hydrolysis of phosphodiester linkages. The function is also confirmed by systematic administration of PEG-PIm to rheumatoid arthritis. Thus, a strategy is provided for treating pulmonary fibrosis that can be applied in a pandemic to reduce high mortality because of pathogen infection.
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2021
·Vol. 33
·期 8
·2007215
·
IF 30.849
Tianxin Bai,Bin Yang,Junsheng Chen,Daoyuan Zheng,Zhe Tang,Xiaochen Wang,Yang Zhao,Ruifeng Lu,Keli Han
The colloidal synthesis of a new type of lead-free halide quadruple-perovskite nanocrystals (NCs) is reported. The photoluminescence quantum yield and charge-carrier lifetime of quadruple-perovskite NCs can be enhanced by 96 and 77-fold, respectively, via metal alloying. Study of charge-carrier dynamics provide solid demonstrate that the PL enhancement is due to the elimination of ultrafast (1.4 ps) charge-carrier trapping processes in the alloyed NCs. Thanks to the high crystallinity, low trap-state density, and long carrier lifetime (193.4 μs), the alloyed quadruple-perovskite NCs can serve as the active material for high-performance photodetectors, which exhibit high responsivity (up to 0.98 × 10 4 A W −1 ) and an external quantum efficiency (EQE) of 3 × 10 6 %. These numbers are among the highest for perovskite-NC-based photodetectors.
研究领域:
材料科学
·
光学工程
·
纳米技术
✓ 已验证
DOI
高影响因子
ACS Nano
·
2023
·
IF 17.1
Dingming Yu,Lifang Liu,Jianyong Yu,Yang Si,Bin Ding
The tremendous menace of the COVID-19 pandemic has underscored the urgency for antipathogen masks to stop the transmission of airborne infectious diseases. Most prevailing antipathogen masks manifest a slower sterilization rate that lags behind the pathogen momentum traversing the masks, thereby engendering an elevated susceptibility to infection. Here we tailor nanofibrous meta-aerogel electric traps, 3D-assembled from self-knotted carbon nanotube networks in an all rigid nanofibrous skeleton. This superior configuration revolves around the creation of numerous “dielectrophoretic–aerodynamic grippers”, which are capable of directional manipulation of microbes toward the region of the lethal intensive electric field. Based on this, we present a disinfection unit comprising a pair of aerogel electrodes that demonstrate a rapid killing rate (>99.99% biocidal efficacy within 0.016 s) and long-term durability (12 h of continuous operation). Additionally, a microbutton lithium cell is employed as a power supply to fabricate an antipathogen face mask with this disinfection unit, which exhibits superior pathogen inactivation efficacy compared to commercial masks. This scalable biocidal protective equipment holds great potential for use in emergency medical services.
研究领域:
生物医学工程
·
材料科学
·
传染病防控
✓ 已验证
DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-8
·
IF 17.694
Zhang Peixin,Yang Lifeng,Liu Xing,Wang Jun,Suo Xian,Chen Liyuan,Cui Xili,Xing Huabin
Selective paraffin capture from olefin/paraffin mixtures could afford high-purity olefins directly, but suffers from the issues of low separation selectivity and olefin productivity. Herein, we report an ultramicroporous material (PCP-IPA) with parallel-aligned linearly extending isophthalic acid units along the one-dimensional channel, realizing the efficient production of ultra-high purity C 2 H 4 and C 3 H 6 (99.99%). The periodically expanded and parallel-aligned aromatic-based units served as a paraffin nano-trap to contact with the exposed hydrogen atoms of both C 2 H 6 and C 3 H 8 , as demonstrated by the simulation studies. PCP-IPA exhibits record separation selectivity of 2.48 and separation potential of 1.20 mol/L for C 3 H 8 /C 3 H 6 (50/50) mixture, meanwhile the excellent C 2 H 6 /C 2 H 4 mixture separation performance. Ultra-high purity C 3 H 6 (99.99%) and C 2 H 4 (99.99%) can be directly obtained through fixed-bed column from C 3 H 8 /C 3 H 6 and C 2 H 6 /C 2 H 4 mixtures, respectively. The record C 3 H 6 productivity is up to 15.23 L/kg from the equimolar of C 3 H 8 /C 3 H 6 , which is 3.85 times of the previous benchmark material, demonstrating its great potential for those important industrial separations.
研究领域:
化学工程
·
材料科学
·
分离技术
✓ 已验证
DOI
PubMed
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2023
·Vol. 129
·期 11
·1-7
·
IF 2.7
Yin Qianliu,Zhang Fanfan,Teng Yanlin,Peng Cong,Wang Chaonan,Jin Yonglong,Xu Meifeng,Xu Tian
Different concentrations of NH 4 Cl are introduced to MAPbI 3 precursor solution, planar MAPbI 3 perovskite films, and solar cells’ performance with or without NH 4 Cl have been studied. The NH 4 Cl/MAPbI 3 films exhibit increased grain size and narrowed grain boundaries. The light absorption of perovskite films with different concentrations of NH 4 Cl was also evaluated. To understand the growth of perovskite films with NH 4 Cl added to perovskite precursor solutions, XRD and XPS spectroscopy were conducted on different perovskite film samples. By adding NH 4 Cl, the MAPbI 3 film shows good crystal quality and the shift of Pb peaks indicates that NH 4 Cl is not physically mixed but chemically incorporated into MAPbI 3 films. We attribute the effect to Cl ions of NH 4 Cl combining with free lead ions of MAPbI 3 so as to fill the vacancy of volatile I ions in the NH 4 Cl–MAPbI 3 films. The 20 mg NH 4 Cl-based device showed an enhanced performance of a PCE of 13.67% compared to the device without adding NH 4 Cl with a PCE of 10.24%. The introduction of 20 mg NH 4 Cl achieved the best passivation effect. Using a 20 mg NH 4 Cl device, the trap density can be reduced to 0.84 × 10 16 cm −3 , resulting in more efficient charge removal from the surface and improved performance.
研究领域:
材料科学
·
太阳能
·
化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jun Zhong,Qing Yang,Xiaodan Gou,Mengchen Xu,Qingyun Ma,Lin Kai,Haoyu Li,Mingyong Luo,Feng Chen
Blood-contacting medical devices are essential for sustaining cardiovascular patients' lives. Advanced antithrombotic materials serve as pivotal components to enhance device reliability, as non-physiological hemodynamics and materials provoke thrombus that compromises device functionality and patient safety. Liquid-infused surfaces (LIS), as a bioinert surface modification technology, have been proven effective in inhibiting thrombus formation by suppressing the adhesion of plasma components. However, the loss of lubricants under hemodynamic shear stresses imposes limitations on their clinical application. Enhancing the durability of LIS in blood-contacting environments remains a critical challenge. Natural fluid-retentive systems, such as mucus cells, utilize secretory mechanisms and microvilli structures to anchor fluids effectively. Inspired by these biological paradigms, this study engineered a microstructured lubricant-secreting antithrombotic surface (ms-LSAS) to address the sustained antithrombogenicity requirements of medical devices. The gel-based laser-induced periodic surface structures (LIPSS) fabricated via femtosecond laser and soft lithography mitigate surface lubricant displacement caused by hemodynamic shear stress through enhanced surface area and capillary forces, while continuous secretion of the gel ensures sustained lubricant replenishment. Furthermore, the surface topographic microstructures maintain platelet adhesion suppression through steric hindrance even under lubricant-depleted conditions. Synergistic effects of the lubricating layer and flexible submicron topology suppress protein adsorption and platelet adhesion, achieving robust static and dynamic antithrombogenicity. ms-LSAS can mitigate the critical challenge in blood-contacting devices: thrombus formation induced by platelet activation on material surfaces under non-physiological hemodynamics. This bioinspired strategy may thus pave the way for achieving anticoagulation equilibrium in next-generation medical implants.
✓ 已验证
产品关联
DOI
高影响因子
Materials Chemistry Frontiers
·
2019
·Vol. 3
·期 7
·1357-1364
·
IF 0
Jiaxu Yao,Hui Wang,Pang Wang,Robert S. Gurney,Akarin Intaniwet,Pipat Ruankham,Supab Choopun,Dan Liu,Tao Wang
A photoactive layer with efficient charge transport and low charge recombination is critical to prepare perovskite solar cells with high efficiency and superior stability. We demonstrate that the incorporation of an effective additive 1,3-diaminoguanidine monohydrochloride (DAGCl) in the MAPbI3 film can increase the perovskite grain size and reduce trap density, consequently increasing the carrier lifetime and reducing charge recombination. This leads to an improvement in maximum power conversion efficiency from 19.1% to 20.3% as well as increased lifetime, with an inverted device structure of glass/ITO/PolyTPD/MAPbI3/PC61BM/ZrAcac/Ag.
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
·
2016
·
IF 3.031
Fuxing Xu,Qiankun Dang,Xinhua Dai,Xiang Fang,Yuanyuan Wang,Li Ding,Chuan-Fan Ding
Collision induced dissociation (CID) is one of the most established techniques for tandem mass spectrometry analysis. The CID of mass selected ion could be realized by ion resonance excitation with a digital rectangular waveform. The method is simple, and highly efficient CID result could be obtained by optimizing the experimental parameters, such as digital waveform voltage, frequency, and q value. In this work, the relationship between ion trapping waveform voltage and frequency at preselected q value, the relationship between waveform frequency and the q value at certain ion trapping voltage for optimum CID efficiency were investigated. Experiment results showed that the max CID efficiency of precursor reserpine ions can be obtained at different trapping waveform voltage and frequency when q and β are different. Based on systematic experimental analysis, the optimum experimental conditions for high CID efficiency can be calculated at any selected β or q. By using digital ion trap technology, the CID process and efficient fragmentation of parent ions can be realized by simply changing the trapping waveform amplitude, frequency, and the β values in the digital ion trap mass spectrometry. The technology and method are simple. It has potential use in ion trap mass spectrometry.
研究领域:
分析化学
·
质谱学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ORGANIC ELECTRONICS
·
2018
·
IF 3.68
Yue Wang,Lijie Zhu,Tiening Wang,Yufeng Hu,Zhenbo Deng,Qiuhong Cui,Zhidong Lou,Yanbing Hou,Feng Teng
In this work, we synthesized ligand-free anatase TiO 2 nanocrystals with clean surface and excellent electron extraction. By introducing the trap states between the TiO 2 nanocrystals and the photoactive layer of poly (3-hexylthiophene) (P3HT): (phenyl-C61-butyric-acid-methyl-ester) (PC 61 BM) bulk heterojunction (BHJ), a high performance solution-processed broadband OPD in the visible wavelength is realized and characterized. The OPD shows near spectrally flat response from 350 to 650 nm with high EQE (113%), high responsivity (0.5 A/W) and high detectivity (1.9 × 10 12 Jones) at −1 V. The device also exhibits a high −3 dB bandwidth of 902 kHz and a respectable response speed with a rise time and fall time of 34 μs and 26 μs, respectively. The photocurrent retention measurement at a bias voltage of −1 V implies that the device photoresponse is significantly stable. These OPD performance parameters are sufficient for use in the machine vision or imaging systems. With the help of the J-V curves and light assisted C-V measurements, the underlying working mechanism is proposed as well.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
高影响因子
Plasmonics
·
2014
·Vol. 9
·期 5
·1039-1047
·
IF 2.738
Xu Pei,Li Qiang,Li Tao,Rao Wenye,Wang Yuanzhao,Lan Sheng,Wu Lijun
It is well known that surface plasmon resonance (SPR) can selectively enhance the photoluminescence (PL) from nearby chromophores with a single emission peak at an appropriate distance. Here, we combine white light-emitting CdS quantum dot nanocrystals containing band-edge and surface-state emissions simultaneously with Ag nanoparticles and study the interaction between them. It is found that the surface-state emission is always enhanced while the band-edge emission quenched regardless of the SPR wavelength of Ag nanoparticles. This phenomenon reveals that the SPR of Ag nanoparticles is not enhancing the emission from a wavelength-matched state. We propose that the surface plasmon of Ag nanoparticles is first excited by the energy of the band-edge emission and then the excited energetic electrons transfer to the surface-state of CdS. Through this energy transfer process, the surface-state emission is enhanced and band-edge emission quenched. This investigation can not only deliver understanding of the complicated interaction between metallic nanoparticles and nearby multi-emission-peak contained chromophores, but it also has potential applications in tuning the color temperature of white light-emitting materials.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED PHYSICS
·
2022
·Vol. 132
·期 3
·
IF 2.877
Guo Heng,Zhu Yizhi,Chen Jinping,Xie Xiaoyu,Jiang Qingsong,Xu Chunxiang,Cui Qiannan,Shi Zengliang
As an effective means to endow lead halide perovskite nanocrystals (NCs) with new properties, ion doping has been widely applied. Transition metal Mn-doped CsPbCl 3 is of particular interest, as the Mn doping introduces new emission bands, improves photoluminescence quantum yield (PLQY), and even enhances stability. However, it is still insufficient to catch insight of the energy transfer process and luminescence characteristics of these high defect tolerance NCs doped with Mn ion. Here, we systematically studied the energy transfer from exciton to Mn 2+ ions in Mn-doped CsPbCl 3 NCs by variable temperature steady-state fluorescence spectra and time-resolved spectra. The abnormal attenuation behavior of the exciton and Mn 2+ with the change of temperature was observed, from which we predict the existence of shallow traps near the conduction band and these shallow traps will affect the luminescence properties by influencing the energy transfer process. We show a simple physical model invoking only shallow trap states that uniquely describe the temperature-dependent energy transfer between the exciton and the Mn 2+ ion. The thermometric performance (30–290 K) was studied in terms of relative thermal sensitivity, in which the calculated relative sensitivity range is ∼0.12%–1% K −1 .
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-16
·
IF 17.694
Meng Yun,Chen Lijie,Chen Yang,Shi Jieyun,Zhang Zheng,Wang Yiwen,Wu Fan,Jiang Xingwu,Yang Wei,Zhang Li,Wang Chaochao,Meng Xianfu,Wu Yelin,Bu Wenbo
Bacteria and excessive inflammation are two main factors causing non-healing wounds. However, current studies have mainly focused on the inhibition of bacteria survival for wound healing while ignoring the excessive inflammation induced by dead bacteria-released lipopolysaccharide (LPS) or peptidoglycan (PGN). Herein, a boron-trapping strategy has been proposed to prevent both infection and excessive inflammation by synthesizing a class of reactive metal boride nanoparticles (MB NPs). Our results show that the MB NPs are gradually hydrolyzed to generate boron dihydroxy groups and metal cations while generating a local alkaline microenvironment. This microenvironment greatly enhances boron dihydroxy groups to trap LPS or PGN through an esterification reaction, which not only enhances metal cation-induced bacterial death but also inhibits dead bacteria-induced excessive inflammation both in vitro and in vivo, finally accelerating wound healing. Taken together, this boron-trapping strategy provides an approach to the treatment of bacterial infection and the accompanying inflammation.
研究领域:
纳米技术
·
生物医学工程
·
伤口愈合
·
炎症
·
细菌感染
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）