CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Bo Tang,Xuewen Yang,Aiwen Zhang,Qiuxiang Wang,Lei Fan,Guihua Fang
Low molecular weight heparin (LMWH), an anionic polysaccharide , has been widely used as a clinical anticoagulant . However, repeated subcutaneous injection is sometimes required due to its short half-life. To reduce the dosing frequency, the injectable polypseudorotaxane hydrogel was fabricated by inclusion complexation formation between Tween 80 and α-Cyclodextrin (αCD) for sustained release of LMWH. The physicochemical properties of such hydrogel were characterized by SEM, XRD, DSC , and FTIR . This hydrogel showed shear-thinning and thixotropic behavior and was easily injected through standard syringe needles. The gelation time, mechanical strength, shear viscosity, in vitro drug release rate, in vitro hydrogel dissolution rate, and in vivo hydrogel retention could be tuned by αCD concentration in the hydrogel. In vivo safety evaluation indicated that the polypseudorotaxane hydrogel was biocompatible. Most importantly, this polypseudorotaxane hydrogel could sustain release of LMWH after subcutaneous injection.
研究领域:
药学
·
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2021
·
IF 9.147
Junmeng Lu,Xinglian Xu,Xue Zhao
In the current study, the interfacial rheological properties of alkali pH-shifted MP under pH 11.0 → 7.0, pH 11.5 → 7.0 and pH 12.0 → 7.0 have been firstly investigated. The molecular weight and microstructure of myofibrillar protein (MP) treated by alkali pH-shifting were investigated by gel-permeation chromatography (GPC) and transmission electron microscopy (TEM). Results indicated a swollen, organized and aggregated structure of refolded MP. Overall, the molecular change in refolded MP led to faster protein adsorption towards the O/W interface, enhanced intermolecular interaction between adsorbed proteins and improved elasticity of interfacial film compared to native MP. After β-mercaptoethanol (β-ME) was added, the advantage of refolded MP in diffusion phase no more existed due to the disruption of aggregation and decreased molecular size, besides the penetration and rearrangement were interfered because the disruption of disulfide bond inhibited the formation of interfacial protein layers. With the protein concentration increasing, MP molecules crowding at O/W (oil in water) surface limited the development of a highly elastic network. As revealed by Tween 20 displacement, MP layers with higher interfacial elasticity were more resistant to displacement. Moreover, after displacement the coalescence stability of emulsion droplet was enhanced but the mechanical strength of interfacial MP layer was reduced. Altogether MP (0.04 or 0.2 mg/mL) treated by pH 11.0 → 7.0 exhibited the best adsorption performance and interfacial properties, which were important in stablizing emulsions. Thus, interfacial behavior regulation by alkali pH-shifting may be a applicable process for developing meat protein-based emulsions in food industry.
研究领域:
食品科学
·
蛋白质化学
·
胶体科学
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DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Zhenbao Zhu,Ying Wen,Jianhua Yi,Yungang Cao,Fuguo Liu,David Julian McClements
Hypothesis This study compared the interfacial and emulsification properties of tea saponins , quillaja saponins, and Tween 80. We hypothesized that tea saponins are an effective and sustainable source of plant-based emulsifiers that could replace synthetic or animal-based emulsifiers in many commercial applications. Experiments Interfacial tension measurements were used to characterize the behavior of the three surfactants at an oil-water interface. The emulsifying properties of the surfactants were determined by preparing oil-in-water emulsions containing 10 wt% medium chain triglycerides (MCT) and varying surfactant levels (0.1–2 wt%) using high-pressure homogenization (pH 7). The impact of surfactant type on emulsion formation and stability was determined by measuring particle size, zeta–potential, microstructure, and creaming stability. Findings The tea saponins were capable of producing nano-scale droplets ( d 32 < 200 nm) at low surfactant-to-oil ratios (SOR < 0.1). Emulsions containing tea saponins remained stable to droplet aggregation when exposed to various temperatures (30–90 °C), salt levels (0–200 mM NaCl), and pH values (3–9). However, droplet flocculation and/or coalescence occurred under highly acidic (pH 2) and high ionic strength (300–500 mM NaCl) conditions. Tea saponin-coated oil droplets appeared to be mainly stabilized by a combination of electrostatic and steric repulsion. The tea saponins behaved similarly or better than the other two emulsifiers under most conditions. These results suggest that tea saponins are effective plant-based surfactants that may have applications in commercial products.
研究领域:
食品科学
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表面化学
·
植物化学
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DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 3
·123073
·
IF 7.5
Dongyun Ye,Changjie Shi,Kashif Hayat,Zeyu Wang,Qingyan Wang,Yu Mei,Pathmalal Marakkale Manage,Dzmitry Hrynsphan,Tatsiana Savitskaya,Jun Chen
n -Hexane, a recalcitrant hydrophobic volatile organic compound (VOC), exhibits low bioavailability that limits its biodegradation in engineered bioreactors. This study incorporated a non-ionic surfactant (i.e., Tween 80) into a rotating drum biofilter (RDB) to enhance its removal efficiency. Tween 80 significantly reduced surface tension (from 72 to 45.15 mN·m −1 ), enhanced gas-liquid mass transfer and increased n -hexane removal efficiency from 42.93% to 87.83% (elimination capacity from 3.4 to 31.62 g·m −3 ·h −1 ). High-throughput sequencing revealed that Tween 80 shaped a resilient community structure across operational phases, the microbial community was dominated by Actinobacteria and Proteobacteria . At the genus level, Mycobacterium remained the dominant alkane degrader (>57%), maintaining degradation capacity even under substrate stress. Molecular ecological network analysis showed that ecosystem stability relied not only on dominant taxa but also on keystone genus with strong interaction capacity, including Bacillus , Nocardia , Microbacterium , Enterobacter , and Chujaibacter . Their presence indicates robust functional redundancy and interaction-based resilience, enabling rapid restoration of degradation performance once n -hexane a n d Tween 80 were resupplied. Overall, Tween 80 enhanced n -hexane biodegradation through two synergistic pathways: improving hydrophobic-substrate bioavailability and strengthening the ecological resilience of the microbial consortium by supporting functional persistence, cooperative metabolism, and rapid recovery. These findings provide a resilience-oriented mechanistic basis for optimizing surfactant-assisted RDB systems treating hydrophobic VOCs.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2018
·
IF 3.909
Cihui Tian,Sajid Asghar,Yurui Xu,Zhipeng Chen,Jingwei Zhang,Qineng Ping,Yanyu Xiao
Redox-sensitive micelles based onhydrophilic hyaluronic acid-ss-hydrophobic curcumin conjugate were designed as a novel delivery system for gliomas targeting. Furthermore, the obtained micelles were further functionalized with Tween 80 (CUR-THSC) for better brain penetration. Dynamic light scattering experiment and in vitro release study showed that the synthetic disulfide-linked conjugate possessed redox-sensitivity under high glutathione conditions. Spherical micelles with a mean particle size of 74.2 nm, negative zeta potential (−30.25 mV), high entrapment efficiency (94.12%) and drug loading (8.9%) were obtained. XRD analysis of micelles revealed amorphous form of the encapsulated drug. CUR-THSC micelles showed good plasma stability and did not induce any hemolysis in erythrocytes. In addition, highest cytotoxicity in G422 cells was observed compared to the free curcumin group and non-sensitive micelles group. These results indicate that the Tween 80-modified hyaluronic acid-ss-curcumin micelles could emerge as a promising platform for the delivery of curcumin in the treatment of gliomas.
研究领域:
药剂学
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肿瘤学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Xiangning He,Xueying Duan,Wei Gao,Zhichao Zhang,Yi Gao,Hailin Diao,Jianju Luo
Cellulose, hemicellulose, and lignin interweave to form a dense network structure that makes lignocellulosic biomass difficult to degrade. Tween-80 is a non-ionic surfactant that can be used to promote microbial growth and increase the rate of microbial metabolism in compost. In this study, different doses of Tween-80 were presented as additives in the composting process to reduce the composting time and improve the maturity of the compost. The composting trial was conducted in a 10 L reactor for 46 days. The results showed that the addition of the chemical surfactant Tween-80 increased the temperature in the composting process and could effectively promote the degradation of lignocellulose and reduce phytotoxicity. During the composting process, the microbial population showed exponential growth followed by a gradual decline. At the end of composting, Tween-80 added at 0.35% reduced the C/N ratio to 9.61, much lower than that of the CK group at 12.3. Meanwhile, the degradation rates of cellulose and hemicellulose increased by 2.76% and 7.86%, respectively. Toxicity experiments on compost products also proved that the seed germination index of compost with 0.35% Tween-80 addition increased to 98.57%, which is 17.33% higher than that without the addition. FT-IR and TG experiments showed that the addition of Tween-80 could effectively accelerate the composting process and promote the rapid maturation of the heap. In conclusion, the addition of 0.35% Tween-80 was most conducive to promoting the rapid decomposition of organic matter in cassava residue compost and improving the maturity of the heap.
研究领域:
环境科学
·
微生物学
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2014
·
IF 2.538
Songbo Xie,Baolin Zhang,Lei Wang,Jun Wang,Xuan Li,Gao Yang,Fabao Gao
PEG and PEG/PEI modified superparamagnetic iron oxide nanoparticles (SPIONs) were synthesized by the thermal decomposition of iron (III) acetylacetonate (Fe(acac) 3 ) in poly (ethylene glycol) (PEG) containing poly (ethylene imine) (PEI) (0 or 0.3 g). PEG/PEI-SPIONs were coated with Tween 80 (PEG/PEI/Tween 80-SPIONs). Fourier transform infrared spectroscopy (FTIR) analyses indicated that PEG , PEG/PEI and PEG/PEI/Tween 80 were attached to the surfaces of the SPIONs. The PEG-SPIONs, PEG/PEI-SPIONs and PEG/PEI/Tween 80-SPIONs performed excellent colloidal stability in the phosphate buffered saline (PBS), and in deionized water with the mean hydrodynamic sizes of 19.5, 21.0, 24.0 nm and the zeta potentials of -5.0, 35.0, 19.0 mV, respectively. All the SPIONs showed low cytotoxicity assessed by the MTT assay. In vivo magnetic resonance imaging (MRI) of the Kunming (KM) mouse brains were performed, the PEG-SPIONs, PEG/PEI-SPIONs and PEG/PEI/Tween 80-SPIONs exhibited vascular imaging effects in bulbus olfactorius, frontal cortex, temporal, thalamus and brain stem of the mouse brains after 24 h intravenous injection of the nanoparticles . The SPIONs have potentials as MRI contrast agents in the mouse brains.
研究领域:
生物医学工程
·
纳米医学
·
影像学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Jiaxin Chen,Yangyang Feng,Baohua Kong,Xiufang Xia,Qian Liu
The present study established an eco-friendly extraction method for adsorbed proteins from the interfacial layers of oil-in-water (O/W) emulsions which stabilized by whey protein isolate. Tween 20, a typical food-grade low molecular weight surfactant , could sufficiently extract adsorbed proteins. Then, ultra-filtered centrifugation was applied to purify the adsorbed proteins. The results showed that the concentration of Tween 20 solution was a crucial factor impacting extraction efficiency, and concentration of Tween 20 from 0.5 % (v/v) could efficiently extract the adsorbed proteins from the oil-water interface. Moreover, when compared with the traditional isopropyl alcohol precipitation method, our developed method could efficiently extract, as well as maintain the unaltered structure of adsorbed proteins from different emulsions prepared with different concentrations of protein solution and different homogenization methods. Our method could substantially decrease the use of organic solvent within the laboratory setting, thereby minimizing the potential risks to the environment and human health.
研究领域:
食品科学
·
环境科学
·
蛋白质化学
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DOI
高影响因子
GREEN CHEMISTRY
·
2026
·
IF 9.2
Rutong Jiang,Bin Bian,Ruoyan Li,Qijun Wu,Daihui Zhang,Caoxing Huang,Chenhuan Lai,Mi Li,Qiang Yong
Developing a clean, efficient, and economically viable pretreatment strategy that enables the co-production of xylooligosaccharides (XOS) and fermentable sugars from woody biomass remains a major challenge in sustainable biorefinery. Although hydrothermal and dilute organic acid pretreatments are effective for XOS production, their ability to enhance subsequent enzymatic hydrolysis is often limited. Post- delignification treatments can improve saccharification, but they typically require large solvent inputs, resulting in environmental and economic burdens. Here, we present a green and facile Tween-assisted tartaric acid pretreatment that achieves both high yield of XOS and significantly enhanced enzymatic digestibility of birch. Under optimized conditions (0.4% tartaric acid, 0.5% Tween 80, 170 °C, 40 min), this process produced 43.2% XOS and enabled 77.7% glucose release from pretreated residues. Structural characterization revealed that Tween molecules etherify with lignin hydroxyl groups, reducing lignin hydrophobicity and enhancing cellulose accessibility of pretreated residues. Surface plasmon resonance, fluorescence quenching, and molecular docking analyses collectively confirmed that this in situ lignin modification mitigates the non-productive binding between enzyme and lignin, boosting enzymatic hydrolysis efficiency without an additional delignification step. This clean, low-cost, and scalable strategy effectively integrates the valorization of hemicellulose and cellulose in a single and sustainable process. Our study also offers molecular-level insights into surfactant-enabled lignin modification that could be widely deployed in the biorefining field.
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产品关联
DOI
高影响因子
AAPS PHARMSCITECH
·
2024
·Vol. 25
·期 6
·1-15
·
IF 3.4
Chen Jiasheng,Chen Zhenzhen,Wang Wentao,Wang Liyang,Zheng Jiaqi,Wu Shiqiong,Pan Yuru,Li Sai,Zhao Jie,Cai Zheng
Some glycoside drugs can be transported through intestinal glucose transporters (IGTs). The surfactants used in oral drug preparations can affect the function of transporter proteins. This study aimed to investigate the effect of commonly used surfactants, Poloxamer 188 and Tween 80, on the drug transport capacity of IGTs. Previous studies have shown that gastrodin is the optimal drug substrate for IGTs. Gastrodin was used as a probe drug to evaluate the effect of these two surfactants on intestinal absorption in SD rats through pharmacokinetic and in situ single-pass intestinal perfusion. Then, the effects of the two surfactants on the expression of glucose transporters and tight-junction proteins were examined using RT-PCR and western blotting. Additionally, the effect of surfactants on intestinal permeability was evaluated through hematoxylin-eosin staining. The results found that all experimental for Poloxamer 188 (0.5%, 2.0% and 8.0%) and Tween 80 (0.1% and 2.0%) were not significantly different from those of the blank group. However, the AUC (0-∞) of gastrodin increased by approximately 32% when 0.5% Tween 80 was used. The changes in IGT expression correlated with the intestinal absorption of gastrodin. A significant increase in the expression of IGTs was observed at 0.5% Tween 80. In conclusion, Poloxamer 188 had minimal effect on the drug transport capacity of IGTs within the recommended limits of use. However, the expression of IGTs increased in response to 0.5% Tween 80, which significantly enhanced the drug transport capacity of IGTs. However, 0.1% and 2.0% Tween 80 had no significant effect. Graphical Abstract
研究领域:
药剂学
·
药理学
·
肠道吸收
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产品关联
DOI
PubMed
高影响因子
Food Biophysics
·
2022
·Vol. 17
·期 4
·545-556
·
IF 3.34
Lv Danyu,Dai Chenming,Wang Muyun,Chen Huaiqiong,Guan Yongguang
Aqueous and photo stability of bixin are challenges in practical applications. Herein, transparent nanoemulsion can be self-emulsified to improve 9'- cis -bixin aqueous and photo stability. The 0.25 g carvacrol with 0.5% w/w 9'- cis -bixin, 2.08 g 12-% soybean lecithin, 2.25 g Tween 20, and 0.42 g water were mixed and stored overnight to fabricate transparent oil-in-water (O/W) nanoemulsion. The O/W nanoemulsion droplets had an average dimeter of 12.03 nm and equivalent spherical diameter of 6.78 nm. Photo stability of 9'- cis -bixin was improved after encapsulating in nanoemulsion droplets, demonstrated by significant improvement of 9'- cis -bixin degradation rate constant under ultraviolet. Nanoemulsion droplets significantly improved cell uptake of 9'- cis -bixin especially at the first 15 min after cocultivation of Caco-2 cells and 9'- cis -bixin encapsulated nanoemulsion. This study provides a comprehensive understanding of bixin protection by nanoemulsion fabricated by a self-emulsification method with potential cellular uptake.
研究领域:
药学
·
纳米技术
·
食品科学
·
光化学
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产品关联
DOI
高影响因子
BIOORGANIC & MEDICINAL CHEMISTRY
·
2022
·
IF 3.461
Chunyan Yang,Zhongzhen Yang,Siqi Wang,Jinxia Chen,Qijun Liu,Tianle Huang,Li Hai,Runxin Lu,Yong Wu
Chemotherapy is a conventional treatment for glioma, but its efficacy is greatly limited due to low blood–brain barrier (BBB) permeability and lack of specificity. Herein, intelligent and tumor microenvironment (TME)-responsive folic acid (FA) derivatives and mitochondria-targeting berberine (BBR) derivatives co-modified liposome coated with Tween 80 loading paclitaxel (PTX-Tween 80-BBR + FA-Lip) was constructed. Specifically speaking, liposomes modified by FA can be effectively target ed to glioma cells. BBR, due to its delocalized positive electricity and lipophilicity, can be attracted by mitochondrial membrane potential and concentrate on mitochondria to achieve mitochondrial targeting and induce cell apoptosis. By simultaneously modifying the liposome with FA and BBR to deliver drugs, leads to a good therapeutic effect of glioma through FA-based glioma targeting and BBR-based mitochondrial targeting. In addition, the surface of the liposome was coated with Tween 80 to further improve BBB penetration. All results exhibited that PTX-Tween 80-BBR + FA-Lip can observably improve the chemotherapy therapeutic efficacy through the highly specific tumor targeting and mitochondrial targeting, which can provide new ideas and methods for the targeted therapy of glioma.
研究领域:
药学
·
神经肿瘤学
·
药物递送系统
·
纳米技术
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）