JOURNAL OF CHROMATOGRAPHY A
·
2025
·
IF 4
Qi Peng,Yan Ye,Xinglin Wu,Chenchen Lin,Xucong Lin,Qibiao Weng,Qinai Chen
Developing a functional media for precise identification of trace shellfish toxin would underpin the effective assessment of marine pollution. Herein, a novel monolithic column with a dual-mode strategy integrating antifouling and aptamer bionic affinity recognition was proposed for online specific identification of the marine toxin okadaic acid (OA). The zwitterionic monomer 2-(methacryloyloxy)ethylphosphorylcholine (MPC) and aptamers were synergistically employed to enable efficient reduction of matrix interferences and selective capture of target OA. Preparation optimization, characterization, and fouling-resistant mechanism of the dual-mode bionic monolith were evaluated. The zwitterion phosphorylcholine MPC introduced into the monolith significantly improved the fouling resistance to biomass substrates, meanwhile the aptamers were able to provide a high specific recognition capacity. Coupled with LC-MS, the as-prepared monolith provided an effective approach for highly selective and sensitive identification of OA. Good recovery yields of over 90% in shellfish tissue extracts and human serum were achieved with a sensitive limit of detection (LOD) as low as 0.1 ng/mL, as well as excellent specificity and low interference from proteins, fatty acids and analogues. Applied to popular shellfishes (such as clams, mussels, and oysters) and serum samples, trace OA toxin was accurately distinguished and quantified with satisfactory recoveries as 93.8 ± 2.2% – 99.8 ± 2.0% (n=3). Compared to the traditional HLB cartridge and other materials in the LC-MS method, the resulting anti-fouling aptamer monolith provided a more advanced online analysis mode with higher sensitivity and better resolution of OA in biological samples. It might provide an attractive access to an online bionic recognition platform with LC-MS for efficient, anti-interference and sensitive specific detection of trace marine toxin OA in biological samples.
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高影响因子
Nanomaterials
·
2025
·Vol. 15
·期 13
·1027
·
IF 4.3
Qingyun Zheng,Jingyuan Liu,Rongrong Chen,Qi Liu,Jing Yu,Jiahui Zhu,Peili Liu
Hydrogel sensors show unique advantages in underwater detection, ocean monitoring, and human–computer interaction because of their excellent flexibility, biocompatibility, high sensitivity, and environmental adaptability. However, due to the water environment, hydrogels will dissolve to a certain extent, resulting in insufficient mechanical strength, poor long-term stability, and signal interference. In this paper, a double-network structure was constructed by polyvinyl alcohol (PVA) and poly([2-(methacryloyloxy) ethyl]7 dimethyl-(3-sulfopropyl) ammonium hydroxide) (PSBMA). The resultant PVA/PSBMA-PA hydrogel demonstrated notable swelling resistance, a property attributable to the incorporation of non-covalent interactions (electrostatic interactions and hydrogen bonding) through the addition of phytic acid (PA). The hydrogel exhibited high stretchability (maximum tensile strength up to 304 kPa), high conductivity (5.8 mS/cm), and anti-swelling (only 1.8% swelling occurred after 14 days of immersion in artificial seawater). Assembled as a sensor, it exhibited high strain sensitivity (0.77), a low detection limit (1%), and stable electrical properties after multiple tensile cycles. The utilization of PVA/PSBMA-PA hydrogel as a wearable sensor shows promise for detecting human joint movements, including those of the fingers, wrists, elbows, and knees. Due to the excellent resistance to swelling, the PVA/PSBMA-PA-based sensors are also suitable for underwater applications, enabling the detection of underwater mannequin motion. This study proposes an uncomplicated and pragmatic methodology for producing hydrogel sensors suitable for use within subaquatic environments, thereby concomitantly broadening the scope of applications for wearable electronic devices.
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JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Yuzhe Guo,Qingyuan Shi,Jiaxin Li,Youwei Huang,Jingmei Xu
In this paper, the zwitterion ADPS was modified on UiO-66-COOH by amidation reaction, and the functional UiO-66-ADPS that was produced was added to the matrix of sulfonated poly(aryl ether ketone sulfone) (SPAEKS), and the series of composite membranes of SPAEKS-UiO-66-ADPS (abbreviated as SPAEKS-U-A-X%) were successfully prepared. The UiO-66-ADPS and the series of composite membranes were characterized and evaluated. The composite membranes created exhibit excellent electrochemical performance, as well as superior water uptake and mechanical properties. Among them, at 90 °C, the proton conductivity of SPAEKS-U-A-0.75% reached 268.31 mS cm -1 , and the power density was 1553.10 mW/cm 2 , which was much higher than that of the SPAEKS membrane (302.65 mW/cm 2 ). The results show that UiO-66-ADPS significantly improved the electrochemical performance of the PEMs.
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BIOMACROMOLECULES
·
2025
·
IF 5.4
Yu Sun,Yushuang Shang,Xinyu Zhang,Zhaoyan Ge,Fengni Liu,Jian Shen,Jiang Yuan
Mimicked by the structure of dimethyl sulfoxide propionate (DMSP), a novel zwitterion monomer of N-methylacryloyl S-methyl l-cysteine methyl sulfonium salt (NMASMCMS) was synthesized and characterized for the first time through three steps using l-cysteine as a starting material. Poly(NMASMCMS) brushes were constructed on PET sheets via surface-initiated reversible addition–fragmentation chain-transfer (SI-RAFT) polymerization. The physical and chemical structures were characterized by water contact angle (WCA), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), and atomic force microscopy (AFM). The polymer brush grafted sheets (PET-B) had good hydrophilicity and high lubricity. Moreover, PET-B sheets exhibited excellent antifouling and hemocompatible properties with low protein adsorption, bacterial adhesion, platelet adhesion, and hemolysis.
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Energy Storage Materials
·
2023
·
IF 20.4
Zhengtai Zha,Tianjiang Sun,Diantao Li,Tao Ma,Weijia Zhang,Zhanliang Tao
The issues of serious corrosion and dendrite growth in electrode surface hinder the commercialization of aqueous zinc batteries . A stable solid electrolyte interphase (SEI) on electrode surface is critical to improve electrochemical performance of Zn anode. Here, a novel zwitterion additive as an electrical double layer (EDL) regulator with SEI-forming capability is developed. The zwitterion exhibits preferential adsorption with Zn anode to construct a fast Zn 2+ migration channel. More importantly, a ZnF 2 SEI layer can be in-situ generated on the anode due to preferential electroreduction of zwitterion, which isolates Zn anode from electrolytes. Therefore, the symmetric cells with the proposed electrolyte survive long cycling stability over 600 h at 10 mA cm −2 and 10 mAh cm −2 . The merits of zwitterion additive are further demonstrated in the Zn||V 2 O 5 · n H 2 O full cell with a capacity retention of ∼80 % after 1000 cycles.
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ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Ming Yi,Cher Hon Lau,Shu Xiong,Wenjie Wei,Rongzhen Liao,Liang Shen,Ang Lu,Yan Wang
Biofouling can be overcome with zwitterion grafts and antimicrobial, metallic nanoparticles. However, the mechanism underpinning this effective approach remains unclear. To elucidate the role of each component in this system while maximizing membrane antifouling and antimicrobial properties, here we performed a comparative study to investigate the impact of zwitterion type and their interactions with Ag of various states. Two different zwitterions (SO3–-based and COO–-based) were employed to modify polyamide (PA) thin film composite (TFC) membranes, and the metallized and mineralized membranes were developed via in situ formation of silver (Ag) nanoparticles and deposition of silver chloride (AgCl) particles on the zwitterion-modified TFC membranes. The presence of zwitterions was key to enhance Ag content, resulting in significantly improved antimicrobial and antifouling properties without compromising the nanofiltration separation performance. COO–-based zwitterions were found more favorable toward Ag metallization and mineralization compared to SO3–-based zwitterions. The underlying mechanisms underpinning this discovery were further revealed using density functional theory (DFT) to reveal Gibbs free energy of the binding between zwitterions and Ag+ ions. This fundamental knowledge is crucial for designing next-generation antibiofouling strategies.
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高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 26
·5245-5254
·
IF 6.331
Huiyuan Bai,Quanhao Sun,Fei Kong,Haijiao Dong,Ming Ma,Fangzhou Liu,Chen Wang,Haiyan Xu,Ning Gu,Yu Zhang
Multifunctional drug delivery systems combining two or more therapies have a wide-range of potential for high efficacy tumor treatment. Herein, we designed a novel hollow mesoporous Prussian blue nanoparticles (HMPBs)-based platform for targeted and synergetic chemo-photothermal treatment of acute myeloid leukemia (AML). The HMPBs were first loaded with the anticancer drugs daunorubicin (DNR) and cytarabine (AraC), and were subsequently coated with polyethylenimine (PEI) through electrostatic adsorption. Then, zwitterionic sulfobetaine (ZS) and CXCR4 antagonist peptide E5 were modified onto the surface of the nanoparticles via covalent bonding to fabricate a nanoplatform (denoted as HMPBs(DNR + AraC)@PEI-ZS-E5). The nanoplatform showed excellent photothermal effects, superior photothermal stability, reduced nonspecific protein adsorption, efficient targeting capability, a constant hydrodynamic diameter and good biocompatibility. Additionally, a laser-responsive drug release pattern was observed. In vitro results indicated that the nanoplatform could achieve active targeting and remarkable chemo-photothermal synergetic therapeutic effects, showcasing its great potential in AML treatment.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Luyan Li,Hao Li,Mingzhang Lin,Ning Wang,Sheng Hu,Jun Wen
Developing efficient uranium adsorbent remains a considerable challenge owing to the complexity of seawater and wastewater systems. Herein, a novel graphene oxide (GO)/chitosan (CS)/2-methacryloyloxyethyl phosphorylcholine (MPC) (GCM) aerogel, similar to a turbine with multiple ‘blades’ in appearance, was prepared for separating and extracting uranium. The highly vertically aligned lamellar structure with microchannels provides sufficient movement space for uranium, and the introduction of GO and MPC endows GCM aerogel with excellent photothermal conversion performance, strong uranium adsorption selectivity and biofouling resistance activity. GCM aerogel possessed an adhesion resistance rate of up to 99 % against marine bacteria, and its saturation adsorption capacity of uranium reached 1912 mg/g. It also exhibited good uranium selective adsorption capacity in natural seawater owing to its high adsorption capacity, remarkable selectivity, and outstanding biofouling resistance activity. Additionally, the one-piece GCM aerogel column served as an effective column separation material to maximize the photothermal conversion characteristics. The adsorption capacity and adsorption rate of GCM aerogel column for uranium were significantly enhanced and the recovery rate of uranium from simulated uranium-containing wastewater reached 95.3 % under simulated sunlight irradiation. This study offers a novel strategy for separating and extracting uranium from seawater and wastewater.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Qiying Zhang,Jingbo Xie,Yingyu Pan,Liyong Tian,Yancheng Wu,Ningbo Yi,Chunping Ma,Yangfan Zhang,Gaoyi Xie,Yingpeng Wu
An AmPAM based electrospun separator is first proposed for an ultra-stable Zn metal anode through molecular engineering. • Numerous zwitterion migration channels are formed through electrostatic attraction for highly efficient ion transport. • The Zn|Zn cells using the AmPAM separators achieve unprecedented ultra-low polarization voltage and exceptional lifespans. Rechargeable aqueous zinc-based batteries hold great potential for next-generation energy storage devices, but face three interdependent challenges of dendrite, HER, and corrosion in the Zn metal anode toward practical application. To simultaneously address all three challenges, an amphoteric polyacrylamide (AmPAM) based electrospun separator is first proposed for an ultra-stable Zn metal anode through molecular engineering. The well-designed AmPAM chains with side-chain sulfonate and quaternary ammonium groups in appropriate density form numerous zwitterion migration channels through electrostatic attraction for highly efficient ion transport, thereby leading to negligible Zn 2+ concentration gradient and thus homogenized Zn 2+ flux. The Zn 2+ ion also undergoes rapid desolvation due to a synergistic effect between the hydrogen-bond interaction of amide groups and the electrostatic interaction of sulfonate groups, resulting in inhibited water reactivity and suppressed H 2 O-induced side reactions. Significantly, the Zn|Zn cells using the AmPAM separators achieve unprecedented ultra-low polarization voltage of ∼5.0 mV, exceptional lifespans up to 3000 h at 1 mA cm −2 /1 mAh cm −2 and even over 500 h at 10 mA cm −2 /10 mAh cm −2 , accompanied by reduced corrosion current density (0.15 mA cm −2 ), negligibly small HER current density (−0.0002 mA cm −2 ) and dendrite-free Zn deposition, which are superior to those of the conventional GF separator. Furthermore, the Zn|MnO 2 full battery delivers satisfactory rate performance and long-term cycling stability with capacity retention of 91% after 1000 cycles. This work offers a fresh insight into corrosion-resistant, HER-inhibiting and dendrite-free zinc metal anode from separator molecular engineering. An amphoteric polyacrylamide based electrospun separator with zwitterion migration channels is first proposed to simultaneously address all three challenges of dendrite, HER, and corrosion for an ultra-stable Zn anode through molecular engineering. Download: Download high-res image (253KB) Download: Download full-size image
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高影响因子
LANGMUIR
·
2020
·
IF 3.557
Jun Ma,Weifeng Lin,Liangbo Xu,Sihang Liu,Weili Xue,Shengfu Chen
Long-term resistance of biomaterials to the bacterial biofilm formation without antibiotic or biocide is highly demanded for biomedical applications. In this work, a novel biodegradable biomaterial with excellent capability to prevent long-term bacterial biofilm formation is prepared by the following two steps. Ethylcarboxybetaine ester analogue methacrylate (ECBEMA), poly(ethylene glycol) monomethacrylate (PEGMA), and 3-methacryloxypropyletris(trimethylsiloxy)silane (TRIS) were copolymerized to obtain p(ECBEMA-PEGMA-TRIS) (PEPT). Then, PEPT was cross-linked by isocyanate-terminated polylactic acid (IPDI-PLA-IPDI) to obtain the final PEPTx-PLAy (x and y are the number-average molecular weights (Mn) of PEPT and PLA, respectively) with optimal mechanical strength and adjustable surface regeneration rate. Static contact angle measurement, protein adsorption measurement, and attenuated total reflectance infrared (ATR-IR) results show that the PEPT19800-PLA800 film surface can generate a zwitterionic layer to resist nonspecific protein adsorption after surface hydrolysis. Quartz crystal microbalance with dissipation (QCM-D) results indicates that the PEPT19800-PLA800 film can undergo gradual degradation of the surface layer at the lowest swelling rate. Particularly, this material can efficiently resist the bacterial biofilm formation of both Gram-positive bacteria and Gram-negative bacteria over 14 and 6 days, respectively. Moreover, the material also shows an ideal self-healing feature to adapt to harsh conditions. Thus, this nonfouling material shows great potential in biomedical applications and marine antifouling coatings without antibiotic or biocide.
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TALANTA
·
2019
·
IF 4.916
Xiaoyu Jia,Junyi Zhao,Hongyun Ren,Jiani Wang,Zixiao Hong,Xian Zhang
Zwitterion-functionalized polymer microspheres (ZPMs) have been designed and used as the core adsorbent for the selective and rapid enrichment of mercury species in environmental waters by an on-line solid-phase extraction (SPE). Zwitterionic S-ZPMs and N-ZPMs having an anionic sulfonic group, but differing in cationic S + and N + moieties were prepared from Merrifield resin by treating with 1,2-ethanedithiol and imidazole , followed by modification with 1,3-propanesultone. Without any additional reagents, inorganic mercury (In-Hg), methylmercury (MeHg) and ethylmercury (EtHg) were quantitatively adsorbed on the home-made mini-column packed with ZPMs. Following extraction with 60 mM ammonium acetate and 0.15% L -cysteine ( L -Cys) solution within seconds, separation and speciation of mercury were successfully achieved by the HPLC–ICP-MS technique. Under the optimized experimental conditions, the enrichment factors (EFs) are up to 105 and 98 for inorganic and organic mercury only with 40 mL sample solution, respectively. The low detection limits of 0.78 ng L −1 , 0.63 ng L −1 , and 0.49 ng L −1 were reached for In-Hg, MeHg and EtHg, respectively, with the relative standard deviations (RSDs) below 4.1%. The feasibility and accuracy of the on-line SPE–HPLC–ICP-MS method were successfully applied for mercury speciation in surface water, seawater as well as certified reference material (CRM). The results here demonstrate a facile, sensitive and selective method for speciation of mercury at trace levels.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2019
·Vol. 29
·期 23
·1901026
·
IF 15.621
Weiran Zhou,Dan Li,Zhengguo Xiao,Zhilin Wen,Mengmeng Zhang,Wanpei Hu,Xiaojun Wu,Mingtai Wang,Wen-Hua Zhang,Yalin Lu,Shihe Yang,Shangfeng Yang
The organic–inorganic halide CH 3 NH 3 PbI 3 (MAPbI 3 ) has been the most commonly used light absorber layer of perovskite solar cells (PSCs); however, solution-processed MAPbI 3 films usually suffer from random crystal orientation and high trap density, resulting in inferior power conversion efficiency (PCE) with open circuit voltage ( V oc ) being typically below 1.2 V for PSC devices. Herein, for the first time an imidazole sulfonate zwitterion, 4-(1H-imidazol-3-ium-3-yl)butane-1-sulfonate (IMS), is applied as a bifunctional additive in regular-structure planar heterojunction PSC devices to regulate the crystal orientation, yielding highly ordered MAPbI 3 film and passivating the trap states of the film. Such a dual effect of IMS is fulfilled via coordination interactions between the sulfonate moiety of IMS with the Pb2 + ion and the electrostatic interaction between the imidazole of IMS with the I – ion of MAPbI 3 . As a result, under a optimized IMS doping ratio of 0.5 wt%, the PSC device exhibits a significant increase in PCE from 18.77% to 20.84%, with suppressed current–voltage hysteresis and promoted ambient stability. Moreover, a high V oc of 1.208 V is achieved under a higher IMS doping ratio of 1.2 wt%, which is the highest V oc for regular-structure MAPbI 3 planar PSC devices based on TiO 2 electron transport layer.
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危险品化学品经营许可证（带存储）