INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Shuai Dong,Shu-Min Hu,Si-Jia Yu,Shaobo Zhou,Tao Zhou
Rutin is a flavonoid polyphenol with excellent biological activity, but due to its instability and poor water solubility, the utilization rate is reduced in vivo . Preparation of rutin microcapsules from soybean protein isolate (SPI) and chitosan hydrochloride (CHC) by composite coacervation can improve this restriction. The optimal preparation conditions were as follows: the volume ratio of CHC/SPI 1:8, pH 6, and total concentration of CHC and SPI 2 %. The rutin encapsulation rate and loading capacity of the microcapsules were 90.34 % and 0.51 % under optimal conditions. The SPI-CHC-rutin (SCR) microcapsules had a gel mesh structure and good thermal stability , and the system was stable and homogeneous after 12 d storage. During in vitro digestion, the release rates of SCR microcapsules in simulated gastric and intestinal fluids were 16.97 % and 76.53 %, respectively, achieving a targeted release of rutin in intestinal fluids; and the digested products were found to exhibit superior antioxidant activity to that of free rutin digests, indicating a good protection of microencapsulation on the bioactivity of rutin. Overall, SCR microcapsules developed in this study effectively enhanced the bioavailability of rutin. The present work provides a promising delivery system for natural compounds with low bioavailability and stability.
研究领域:
食品科学
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生物化学
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
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2023
·Vol. 58
·期 46
·17711-17725
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IF 4.5
Jia Tianshuo,Kuang Dajiang,Qi Zhenzhen,Tan Guohongfang,Yang Xiaojing,Kundu Subhas C.,Lu Shenzhou
Silk fibroin is a widely used biocompatible medical material with tunable mechanical, degradability and environmental non-toxicity. This paper prepared the silk fibroin/chitosan hydrogel microneedle with pH sensitivity by blending silk fibroin with chitosan to induce graft cross-linking. The cross-linked silk fibroin/chitosan microneedles network is expanded by hydrogen ions and water molecules, forming a more significant swelling. In vitro, the transdermal drug release showed that insulin loaded in microneedles exhibited pH-sensitive drug release behavior and was released faster under acidic conditions than under neutral conditions. By changing the pH of the solution, microneedles can achieve a stimulating response to the environment, thereby intelligently regulating the transdermal release of insulin.
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高影响因子
Vietnam Journal of Chemistry
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2024
·
IF 1.3
Nguyen Binh Duong,Quan Thi Thu Trang,Phan Thi Ngoc Bich,Pham Van Lam
In this article, new interpenetrating polymer network (IPN) hydrogel as an efficient adsorbent for ammonium was prepared by a two-step process. First, semi-IPN hydrogel of chitosan-g-poly(acrylic acid)/bentonite (CAB) and chitosan (CTS) was synthesized by grafting polymerization in the presence of exfoliated bentonite as both cross-linking agent and nanoscale inorganic filler. Second, cross-linking polymer network of chitosan-glutaraldehyde (CGA) was formed by reaction of CTS with glutaraldehyde (GA). The obtained IPN hydrogel (CAB/CGA) was characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy and its swelling degree and PZC value were also measured. These results demonstrate that copolymerized graft reaction was occurred between CTS, AA and bentonite forming CAB, and CGA presented as a cross-linker in CAB/CGA polymer network. CAB/CGA has a moderate swelling degree of 7.8. CAB/CGA exhibits high adsorption capacity and fast adsorption rate for ammonium. Adsorption process reaches equilibrium in 30 min and fits well to Langmuir adsorption model with a fairly high maximum adsorption capacity of 41.06 mg g −1 . The material has a good regeneration ability. After five times of adsorption–desorption, there was almost no decrease in ammonium adsorption capacity. Moreover, the low swelling degree leads to an improvement in material strength and a reduction of equipment cost.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Yuanzhu Long,Xingxing Liu,Fengxiang Huang,Lu Peng,Yingqian Duan,Guohui Bai,Zhaoqiong Zhu,Diansan Su
Liquid dressings are essential in wound care due to their excellent conformability and spontaneous film-forming properties. However, their application is hindered by two key challenges: strict biocompatibility requirements and the need for water-resistant film formation upon drying. Additionally, incorporating active repair functions is extremely difficult. Chitosan, a natural biopolymer with proven wound-healing properties, could address these limitations. However, conventional solubilization methods using acetic acid compromise biocompatibility and impede water-resistant film formation. Herein, we report the first normal-pressure synthesis of purified chitosan carbonate liquid dressing using an ammonium bicarbonate-mediated acetate replacement strategy. This solution spontaneously forms a water-resistant film of pure chitosan upon drying (water contact angle: 99.4°). In full-thickness wound models, it demonstrated remarkable reparative efficacy, including hair follicle regeneration within 10 days, a feature absent in commercial benchmarks like 3 M Cavilon. Importantly, this chitosan carbonate liquid dressing not only overcomes the limitations of conventional chitosan-based solutions in direct biomedical applications but also provides a new repair-facilitating option for the limited pool of liquid dressings. Its unique transformation into a pure chitosan film upon drying resolves long-standing processing limitations of chitosan, unlocking broader applications in biomedical fields such as drug delivery and tissue engineering.
研究领域:
生物医学
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材料科学
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伤口护理
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DOI
PubMed
高影响因子
Food Bioscience
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2025
·
IF 5.9
Jingyi He,Sai Zhang,Hetong Chen,Yaping Wang,Kewei Feng,Junfeng Yao,Yahong Yuan,Tianli Yue,Qinglin Sheng
New antibacterial materials play an important role in preventing food safety caused by pathogen contamination. In this study, a pH-responsive nanoparticle was developed by incorporating hypericin (HY) into a chitosan/carboxymethyl chitosan carrier (CS/CMC@HY). CS/CMC@HY had excellent pH-responsive release performance (85.3%), photodynamic performance and surface charge. Depending on the antibacterial properties of polysaccharides and the photodynamic therapy (PDT) activity of HY, CS/CMC@HY showed excellent synergistic antibacterial effect on Staphylococcus aureus ( S. aureus ) and Escherichia coli ( E. coli ), and its performance was proportional to the material concentration and light time. The minimum inhibitory concentration of Staphylococcus aureus was 100 mg/mL. Then, the actual sample test showed that CS/CMC@HY could effectively prevent the bacterial infection of green grapes, and the weight loss rate decreased to 6.04% and 9.03% within 10 days, indicating that the material had excellent application prospects in the field of food antibacterial and preservation.
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高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Lan Cui,Wentao Liu,Hao Liu,Qian Qin,Shuangxia Wu,Suqin He,Xinchang Pang,Chengshen Zhu,Peihong Shen
Surface modification of mesoporous silica nanoparticles (MSNs) is a promising way to enhance therapeutic efficacy and minimize side effects of anticancer drugs. In this work, MSNs with reduced particle size and optimum pore diameter were obtained and catalyzed by ammonia/triethanolamine. In view of the negatively charged carboxymethyl chitosan (CMC) and positively charged chitosan oligosaccharide (CS), the pH-triggered charge-reversal CS/CMC bilayer was designed as a stimuli-responsive switch for MSNs via the protonation and deprotonation effect. The results showed that MSNs-CS/CMC were core–shell and mesoporous in structure. Surface charge conversion and pH dependence were clearly observed in the doxorubicin hydrochloride (DOX) delivery. The intracellular uptake indicated that DOX@MSNs-CS/CMC could be distributed in the cytoplasm of MCF-7 cells and exhibited lower toxicity, which would improve the stability and prolong the retention time compared to free DOX and unmodified DOX@MSNs at pH 7.4. Moreover, the cellular uptake and internalization of DOX@MSNs-CS/CMC were enhanced to promote drug delivery into the cell nucleus at pH 6.5. The biocompatible and surface-charge-reversible MSNs-CS/CMC have the potential to prolong the retention time in the bloodstream, facilitate the endosome escape, and enrich the targeted antitumor strategy, providing an alternative platform for efficient drug delivery in breast cancer therapy.
研究领域:
纳米医学
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药物递送系统
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肿瘤治疗
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DOI
PubMed
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Meng Zhang,Yuqi Zheng,Yang Jin,Dong Wang,Guohui Wang,Xin Zhang,Yanxin Li,Shaoxiang Lee
Developing novel bilayer food packing film having the ability to prevent bacterial infections and capable of inhibiting oxidation is utmost important, since bacterial infections and oxidation can cause food spoilage. Ag-Metal−organic framework loaded p-coumaric acid modified chitosan (P-CS/Ag@MOF) or chitosan nanoparticles (P-CSNPs/Ag@MOF) and polyvinyl alcohol/starch (PVA/ST) were used as the upper film and lower layer film to successfully prepare a bilayer composite film. The microscopic morphology, water resistance, oil resistance, oxidation resistance, optical properties, cytotoxicity and antibacterial properties of the composite films were compared. The results showed that the surface of P-CS/Ag@MOF bilayer was relatively smooth and its tensile strength (TS) was higher (27.67 MPa). Among them, P-CS/Ag@MOF bilayer films had better oil resistance and oxidation resistance activity. In addition, the P-CS/Ag@MOF bilayer film had good UV-blocking properties and transparency. P-CSNPs/Ag@MOF bilayer film had higher antibacterial activity and cytotoxicity.
研究领域:
食品科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Shaoxiang Lee,Meng Zhang,Guohui Wang,Wenqiao Meng,Xin Zhang,Dong Wang,Yue Zhou,Zhonghua Wang
In this paper, polyvinyl alcohol/starch composite films with p-coumaric acid modified chitosan (P-CS) and chitosan nanoparticles (P-CSNPs) at different concentrations were successfully prepared. The films were compared for their mechanical, thermal, physical, antioxidant, antibacterial, cytotoxicity and optical barrier properties. The results suggested that P-CS could significantly increase the tensile strength (TS) of the film from 15.67 MPa to a maximum of 24.32 MPa. The compact structure of P-CSNPs film prevented water diffusion, reducing the water amount within. Both films showed a reduction in water solubility, the extent of swelling, and water vapor transmittance. Specifically, P-CSNPs films showed better thermal stability while P-CS films revealed higher antioxidant activity. Besides, the P-CS films exhibited excellent transparency and good ultraviolet-barrier at 200−280 nm. P-CSNPs films demonstrated higher antibacterial activity on both Gram-negative and Gram-positive bacteria. Additionally, P-CS films were less cytotoxic compared to P-CSNPs films.
研究领域:
材料科学
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高分子科学
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生物技术
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食品科学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Lin Wang,Meihua Xin,Mingchun Li,Wenfeng Liu,Yangfan Mao
N -(4- N′, N′, N′ -trimethylphosphonium chloride) benzoyl chitosan (TMPCS), N -(4- N′, N′, N′ -triphenylphosphonium chloride) benzoyl chitosan (TPPCS), and N- (4- N′, N′, N′ -trimethylmethanaminium chloride) benzoyl chitosan (TMACS) were synthesized. The structures of the products were characterized by Fourier transform infrared spectroscopy, Nuclear magnetic resonance spectroscopy and ultraviolet-visible spectroscopy. Their antibacterial activities against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) were investigated in vitro using the antibacterial rate, minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), the antibiofilm activity was investigated by crystal violet assay. The antibacterial assessment revealed that the chitosan quaternary phosphonium salts of similar structure had superior antibacterial activity than chitosan quaternary ammonium salt. The antibacterial rate of CS, TMPCS, TPPCS and TMACS against E. coli at 0.5 mg/mL was 10.4 %, 42.0 %, 58.5 % and 21.6 % respectively. At the same concentration, the antibacterial rate of TMPCS, TPPCS and TMACS against S.aureus was all up to 100 %. The biofilm inhibition rate of CS, TMPCS, TPPCS and TMACS at a half of MIC against E.coli was 28.4 %, 33.9 %, 56.6 % and 57.6 % respectively, and against S.aureus was 30.8 %, 53.8 %, 62.2 % and 58.5 % respectively. The biofilm removal rate of CS, TMPCS, TPPCS, TMACS against E.coli at 2.5 mg/mL was 20.6 %, 46.4 %, 48.9 % and 41.6 % respectively, and against S.aureus at 2.5 mg/mL was 41.5 %, 60.4 %, 69.9 % and 59.01 % respectively.
研究领域:
材料科学
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生物技术
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微生物学
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DOI
PubMed
高影响因子
MOLECULES
·
2021
·Vol. 26
·期 2
·452
·
IF 4.412
Wei-Yan Quan,Song-Zhi Kong,Si-Dong Li,Hua-Zhong Liu,Qian-Qian Ouyang,Yong-Mei Huang,Hui Luo
Chitosan is the only cationic polysaccharide found in nature. It has broad application prospects in biomaterials, but its application is limited due to its poor solubility in water. A novel chitosan derivative was synthesized by amidation of chitosan with 18β-glycyrrhetinic acid and sialic acid. The chitosan derivatives were characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, and measurement of the zeta potential. We also investigated the solubility, cytotoxicity, and blood compatibility of chitosan derivatives. 18β-glycyrrhetinic acid and sialic acid could be grafted onto chitosan molecular chains. The thermal stability of the synthesized chitosan derivatives was decreased and the surface was positively charged in water and phosphate-buffered saline. After chitosan had been modified by 18 β-glycyrrhetinic acid and sialic acid, the solubility of chitosan was improved greatly in water and phosphate-buffered saline, and percent hemolysis was <5%. Novel amphiphilic chitosan derivatives could be suitable polymers for biomedical purposes.Keywords:chitosan;chitosan derivatives;18β-glycyrrhetinic acid;sialic acid;cytotoxicity
研究领域:
生物材料学
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医学化学
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DOI
PubMed
高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Fengyang Liu,Wenjie Zou,Wei Zhao
Chitosan-based flocculants represent a highly promising alternative to industrial synthetic organic flocculants, offering exceptional environmental friendliness and efficiency. The carboxymethyl chitosan- graft -poly (acrylamide-dimethyl diallyl ammonium chloride) (CMCPD) and chitosan- graft -poly (acrylamide-dimethyl diallyl ammonium chloride) (CPD) were successful synthesized using UV-induced graft polymerization. The flocculation behavior and mechanism of these two chitosan-graft-copolymers on kaolinite suspension were investigated employing settling test and density functional theory calculation of the structural units of CMCPD and CPD on the kaolinite (00–1) surface. Experimental results indicated that the CMCPD had a greater settling rate of 19.47 m/h at the dosage of 80 g/t than CPD (12.96 m/h). The simulation results revealed distinct adsorption conformations of CMCPD and CPD units on the kaolinite (00–1) surface, characterized by an inclined posture and a horizontal posture, respectively. The stable adsorption of CPD can be attributed to the electrostatic attraction, which is evidenced by its higher adsorption energy (−4.74 eV) on the kaolinite (00–1) surface compared to CMCPD (−3.63 eV). It should be noted that both the adsorption energy and conformation play crucial roles in determining the flocculation efficiency of a flocculant. The inclined adsorption of CMCPD not only displayed electrostatic attraction but also enhanced its bridging ability, leading to a rapid increase in floc size and settling rate. The settling performance was significantly influenced by the bridging effect exerted by flocculants. This study holds great significance for the advancement of novel and efficient flocculant development.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2017
·
IF 5.951
Peng Yu,Han-Qing Wang,Rui-Ying Bao,Zhengying Liu,Wei Yang,Bang-Hu Xie,Ming-Bo Yang
Sponge-like chitosan (CS)/reduced graphene oxide (rGO)/montmorillonite (MT) porous composite hydrogels were synthesized with a facile strategy of in situ reduction of graphene oxide (GO) without cross-linking of CS. Integral pore structure can be formed in the hydrogels when proper amount of MT was introduced. The composite hydrogel can restore to the original shape and dimension after compressive deformation like a sponge and show good stability in acid condition. Batch equilibrium measurements on the composite porous hydrogel were carried out to optimize the parameters for the removal of hexavalent chromium ions (Cr(VI)). The results reveal that the Cr(VI) ion sorption of the composite hydrogels is highly pH dependent and is the most effective at pH = 2. The sorption capacity increases with increasing temperature and the maximum Cr(VI) uptake of the composite hydrogel is 87.03 mg/g at 288 K. The sorption follows pseudo-second-order kinetic model and Langmuir isotherm. The composite porous hydrogels can be repeatedly used as adsorbent and a high sorption capacity after repeated usage can be maintained. Such an in situ GO reduction strategy can also be used to fabricate a variety of porous 3D polymer/rGO-based nanocomposites for biomaterials, energy storage materials, and adsorbent materials.
研究领域:
环境科学
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材料科学
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水处理
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纳米复合材料
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吸附技术
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DOI
高影响因子
危险品化学品经营许可证（带存储）