Polymer Chemistry
·
2019
·Vol. 10
·期 44
·6021-6030
·
IF 4.76
Linfan Shi,Wenyi Wang,Xiong Fu,Yang Yuan,Bin Zhang,Qiang Huang
Ethylene was introduced into cucurbit[n]urils (CB[n]s, n = 5–7) by molecular encapsulation, for comparison with V-type crystalline starch (V-starch) and α-cyclodextrin (α-CD). The encapsulation capacity of inclusion complexes (ICs) followed the order of CB[5] > V-starch > CB[6] > CB[7] > α-CD. X-ray diffractometry, and 13C solid-state nuclear magnetic resonance and Fourier transform infrared spectroscopy confirmed the presence of ethylene gas in the solid matrices. The controlled release kinetics of the ICs were further studied under different storage temperature (4 and 25 °C) and relative humidity (52.9 and 75.5%) conditions. The Avrami equation was adapted to analyze the controlled release kinetics of ethylene gas, showing a diffusion limited mechanism for CB[n]-ICs under all the storage conditions. The ethylene release rate from CB[n]-ICs was accelerated by increasing ambient temperature, but was not sensitive to relative humidity. CB[5] showed the slowest ethylene release rate among the five solid matrices, up to 700 h under 4 °C storage conditions. Molecular simulation suggested two stable molecular conformations for ethylene molecules within the matrices, i.e., type I, two ethylene molecules in the cavity; and type II, one ethylene molecule in the cavity and the other one outside the cavity. CB[5] and CB[6] had a stable type II molecular conformation of ethylene, whereas CB[7] showed similar stability to type I and type II molecular conformations. For the first time, we demonstrated that CB[n]s (particularly CB[5]) are desirable gas storage and release systems for ethylene. This technology can enable precisely controlled and targeted applications of ethylene for food processing and agricultural applications.
研究领域:
食品科学
·
农业科学
·
材料化学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Shiyu Chen,Xiaoe Chen,Gaofeng Yuan
Biocompatible and degradable hydrogels are extensively utilized for the delivery and controlled release of bioactive agents. Chitosan/squid ring teeth protein (SRT) hydrogels (CH/SRTs) cross-linked by genipin were fabricated, and their gel properties and structural characteristics were analyzed across varying SRT contents. Additionally, the curcumin-release behavior of curcumin-loaded CH/SRTs (Cur-CH/SRTs) was evaluated. Results indicated that increasing SRT content enhanced the elasticity, viscosity, gel strength, hardness, and thermal stability of CH/SRTs. Specifically, the hardness and gel strength of CH/SRT3 (Chitosan: SRT, 1:1) were 207.8 % and 220.9 % higher, respectively, than those of the pure chitosan hydrogel. Higher SRT content significantly increased the curcumin encapsulation efficiency of Cur-CH/SRTs while substantially reducing curcumin release in simulated gastrointestinal fluid. Compared to the curcumin-loaded pure chitosan hydrogel, the curcumin release rate of Cur-CH/SRT3 decreased by 56.12 % after 480 min of simulated gastrointestinal digestion. These findings were attributed to reduced swelling and improved gel strength of Cur-CH/SRTs with SRT addition. Consequently, CH/SRTs demonstrate potential for applications in the controlled release of drugs and bioactive agents.
研究领域:
生物材料学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2015
·
IF 4.074
Chan Bai,Sufen Zhang,Lei Huang,Haiyan Wang,Wei Wang,Qingfu Ye
Starch , with properties of eco-friendliness and abundance, is one of the most important natural polymers. Starch-based hydrogels were investigated as carriers of carbendazim to combine controlled-release and water absorption (WA). Three carbendazim-loaded hydrogels (CLHs) with different WA capacities were prepared by solution polymerization. The CLHs were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and liquid-chromatography mass-spectrometry (LC–MS/MS). Release kinetics of CLHs was investigated using 14 C-labeling method. The diffusion parameters of CLHs were 0.47, 0.57 and 0.81 in deionized H 2 O (ddH 2 O). WA affected release profile significantly, the release longevity reaching 240 h when WA was 800 g/g in ddH 2 O. Solution pH influenced release profiles and the lowest release rate occurred in the lowest pH. Addition of CLH (1.3 g/kg soil) markedly increased water-holding capacity (WHC) of soil by 8.2%. The study indicated that starch-based CLH was a good controlled-release agent for carbendazim and water absorbent for soil.
研究领域:
农业科学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NANOTECHNOLOGY
·
2022
·Vol. 33
·期 16
·165102
·
IF 3.953
Weilun Sun,Jingjing Xu,Bo Liu,Yuan-Di Zhao,Ling Yu,Wei Chen
Phage is a promising therapeutic agent for treating antibiotic resistant bacteria. However, in the process of treatment, phage may be cleared by the immune system and cleaved by protease, which could affect the efficacy of phage. In order to solve the above problems, phage encapsulation is usually adopted. In this study, we employed metal phenolic network (MPN) for efficient phage encapsulation which could protect phage from the cleavage of protease, and keep cytotoxicity weak. In the model of skin wound infection, the encapsulated phage could be released in response to pH change to achieve good antibacterial effect. Furthermore, the MPN encapsulation could prolong the T4 phage residence time at the wound. Our findings suggest that MPN can be a promising material for phage encapsulation.
研究领域:
药学
·
生物技术
·
微生物学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Yuchen Li,Xiaobang Hou,Yuanfeng Pan,Lidong Wang,Huining Xiao
The redox-responsive hydrogel as a carrier has been extensively explored for the application associated with drug delivery and tissue engineering due to its super capacity holding water and unique structure for controllable release. However, similar systems for adsorption and release of dyes have been seldom reported. In this work, a novel redox-responsive hydrogel with the size around 14.9 μm was synthesized towards the adsorption of organic dyes. Carboxymethyl cellulose nanocrystals was activated first; followed by reacting with l -cysteine to generate the amide bonds. The resulting disulfide cross-linked hydrogel can rapidly response to the external oxidizing or reducing stimuli to control the process of adsorption or release of dye, i.e., methylene blue (MB). As an efficient adsorbent, the maximum adsorption capacity of the hydrogel reached 756 mg g −1 at pH 11. The experimental data were also fitted with various kinetic and isotherm models. The results indicated that the pseudo-second-order kinetic and Freundlich isotherm models fitted the MB adsorption data well; whereas the release mechanism was better described by Fickian diffusion. Overall, the redox-responsive hydrogel developed in this work is promising for adsorption and enrichment of organic dyes; and its applications could be further broadened.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Tingwei Chen,Chuanqing Huang,Chuanzhen Ye,Lu Li,Zeyu Liu,Wenqian Huang,Lin Lin,Changzhu Li,Yong Ye
The controlled release packaging system has been considered as an efficient strategy for drug delivery, but the contradiction of instability and release difficulty after encapsulation of natural active compound is unsolved. In this research, tea saponin was embedded into the cavity of β-cyclodextrin polymer (β-CDP) to form a stable inclusion complex and then successfully constructed the nanofibers by electrospinning. The optimal polymer substrates (polyacrylonitrile, 0.1 g β-CDP, 0.03 g tea saponin , dendritic mesoporous silica nanoparticles (DMSNs) 3.75 wt% of the mass of PAN) were obtained to fabricate the TS/PAN@ β-CDP-DMSNs with a typical nanofiber structure with uniform diameter distribution and high porosity. The nanofiber exhibited a better thermal stability (270 °C), higher moisture resistance (water contact angle 126.4°) and relatively larger specific surface area. Results of the FTIR and XPS characterization indicate chemical interactions of TS/PAN@ β-CDP-DMSNs via van der Waals forces and hydrogen bonds. As a result, the tea saponin release efficiency increased from 69.30% of liposome to 81.16% of nanofiber at 36 h. Simultaneously, the antibacterial rates against Escherichia coli and Staphylococcus aureus were significantly improved compared with tea saponin and PAN@ β-CDP-DMSNs. This research provides a feasible strategy for the application of the drug delivery systems to both solve the stability and release efficiency of natural active compounds.
研究领域:
材料科学
·
药物递送
·
食品科学
·
生物学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2022
·
IF 11.467
Shuai Zhang,Chao Liu,Yilin Song,Jiuheng Ruan,Peng Quan,Liang Fang
Long-acting transdermal drug delivery system (TDDS) requires high drug-loading and drug controlled-release. To simultaneously improve drug-polymer miscibility and realize drug controlled-release, this work aimed to develop a new pressure sensitive adhesive modified with hydroxyphenyl (HP-PSA) by introducing doubly ionic H-bond into drug-PSA interaction. Eight model drugs divided into R 3 N, R 2 NH and no N type were chosen to understand the characteristics of the HP-PSA and inner mechanism. The results showed that the doubly ionic H-bond between R 3 N and R 2 NH type drugs and HP-PSA, differing from the ionic bond and neutral H-bond, was a reversible and relatively strong interaction. It could significantly enhance their drug-loading by 1.5 to 7 times and control drug release rate to its 1/5 to 1/2 without altering its total release properties, outperforming the commercial Duro-Tak® 87–2510 and Duro-Tak® 87–2852 adhesives. According to the pharmacokinetics results, the high drug-loading patches based on HP-PSA achieved a sustainable plasma drug concentration avoiding burst release, and over 2 times area under concentration-time curve ( AUC ) as well as 6 times mean residence time ( MRT ) revealed its potential to realize long-acting drug delivery. Additionally, its safety and mechanical features were satisfied. The mechanism study showed that the repulsion of the ionic drugs in HP-PSA increased drug-loading, and the relatively strong interaction could also control drug release. The incomplete H-bond transfer determined its reversibility, thus making the drug release percentage up to that of non-functional PSA. In conclusion, the high drug-loading efficiency and drug controlled-release capacity of HP-PSA, as well as its unique interaction, would contribute to the development of TDDS. Moreover, the construction of the doubly ionic H-bond would provide further inspiration for various drug delivery systems in the non-polar environment.
研究领域:
药剂学
·
生物材料学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Pharmaceutics
·
2023
·Vol. 15
·期 3
·816
·
IF 5.4
Ajkia Zaman Juthi,Fenfen Li,Bo Wang,Md Mofasserul Alam,Md Eman Talukder,Bensheng Qiu
Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.Keywords:super-porous hybrid hydrogels;gastroretentive;controlled-release drug delivery
研究领域:
药剂学
·
生物材料学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS SCIENCE FORUM
·
2016
·
IF 0
Bing Lin,Cheng Zhang Zheng,Mei He Zhao,Pei Qi Wu,Wen Xiang Gu,Qi Ming Lu
The blend film is a favorable coating material for controlled-release fertilizer.The biodegradable PVA-boric acid controlled-release film and PVA-borax controlled-release film were prepared by the solution casting method.The water permeability and water absorbency were systematically investigated. The mechanical properties of these materials were determined with a strength-testing machine.The composite structure was determined by Fourier transform infrared (FTIR) spectroscopy and the scanning electron microscopy (SEM).The good controlled-release properties,lower water permeability and better tensile strength implied that the boron controlled-release film may be a potential coating material for the application in the controlled-release fertilizer.
研究领域:
材料科学
·
农业科学
✓ 已验证
DOI
ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Ting Wang,GuangPing Sun,MingDong Wang,BaoJing Zhou,JiaJun Fu
The major challenges of current drug delivery systems for combination chemotherapy focus on how to efficiently transport drugs to target sites and release multiple drugs in a programmed manner. Herein, we report a novel multidrug delivery system, MSNPs 1, based on mechanized silica nanoparticles, which were constructed through functionalization of mesoporous silica nanoparticles with the acid-cleavable intermediate linkages and the monoferrocene functionalized β-cyclodextrin (Fc-β-CD) as supramolecular nanovalves. MSNPs 1 achieved zero premature release in the physiological pH solution and realized two different release modalities. In modality 1, MSNPs 1 released the encapsulated drugs gemcitabine (GEM) and doxorubicin (DOX) in sequence when they were successively applied to voltage and acid stimuli. The release time and dosage of GEM were precisely controlled via external voltage. The subsequent acid-triggered release of DOX was attributed to breakage of the intermediate linkages containing ketal groups. Modality 2 is the concurrent release of these two drugs directly upon acid exposure. Furthermore, the cell viability experiments demonstrated that MSNPs 1 had an improved cytotoxicity to MCF7 cells in comparison with single DOX- or GEM-loaded mechanized silica nanoparticles. We envisage that MSNPs 1 will play an important role in research and development for a new generation of controlled-release drug delivery system.
研究领域:
药学
·
纳米技术
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
LANGMUIR
·
2013
·
IF 4.187
Wei Guo,Chunyu Yang,Liru Cui,Huiming Lin,Fengyu Qu
A simple and green method to fabricate an ingenious enzyme-responsive drug controlled release system was presented. Mesoporous silica material (mSiO2) 100 nm in size was used as the host, and Konjac oligosaccharide (KOGC) was employed to seal the nanopores of mSiO2 to inhibit the drug release. Rhodamine B was used as the model cargo to reveal the release behavior of the system. The KOGC-modified mSiO2 (mSiO2@KOGC) retains the drug until it reaches the colonic environment where bacteria secrete enzymes (β-mannanase) can degrade KOGC and make drug release. The amount of KOGC and enzyme can be used to adjust the release performance. And all the release behaviors fit the two-step Higuchi model, which predominate by KOGC degradation and mesoporous structure, respectively. With well bioactivity and selectivity, the system has potential application as an oral medicine carrier for treating intestinal disease.
研究领域:
材料科学
·
药剂学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Li Lei,Ran Yan,Shougang Chen,Xiangping Hao,Wenwen Dou,Hu Liu,Zhanhu Guo,Dan Kilula,Ilwoo Seok
An intelligent narrow pH-triggered multilayer film was prepared on magnesium alloys, aiming to solve the implant infections during the implantation period and improve the corrosion resistance of magnesium alloys. The encapsulation of ibuprofen by chitosan (IBU@CS) makes the release of IBU sensitive to narrow pH (pH 6.8–7.4). Positive charged IBU@CS was assembled with heparin (Hep) to fabricate (Hep/IBU@CS) 10 film on AZ31 alloys using layer-by-layer method. The microstructure, composition and anticorrosion properties of the film were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and electrochemical experiments. Cellular activity was studied by MTT cell viability assay. The results showed that the Hep/IBU@CS multilayer films improved the corrosion resistance of magnesium alloys. The in vitro test demonstrated that the release of IBU in the film presented narrow pH sensitivity. The films showed no obvious signs of cytotoxicity conformed by the MTT assay and presented antibacterial properties. These preliminary results demonstrate the potential use of the Hep/IBU@CS multilayer films on magnesium-based implants.
研究领域:
材料科学
·
生物医学工程
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）