Toxics
·
2022
·Vol. 11
·期 1
·24
·
IF 4.472
Siqi Liang,Kangkang Wang,Kefu Wang,Yuli Kou,Tao Wang,Changyan Guo,Wei Wang,Jide Wang
Microplastics (MPs) are novel pollutants, which can carry toxic contaminants and are released in biota and accumulate. The adsorption behavior of MPs and aged MPs has attracted extensive attention. In this paper, the aging process of polystyrene (PS) and poly (butyleneadipate-co-terephthalate) (PBAT) plastics under ultraviolet (UV) irradiation at a high temperature and their adsorption properties for the contaminant diclofenac sodium (DCF) before and after aging was investigated. There are many factors affecting the adsorption capacity of MPs. In this experiment, three aspects of MPs, organic pollutants, and environmental factors are explored. The Freundlich model as well as the pseudosecondary kinetic model is more applicable to the process of DCF adsorption by MPs. The main effects of adsorption of organic pollutants by MPs are electrostatic interactions, hydrogen-halogen bonds, and hydrophobic interactions. The adsorption capacity of the UV-aged MPs on DCF is significantly enhanced, and the order of adsorption capacity is Q(A-PBAT)(27.65 mg/g) > Q(A-PS)(23.91 mg/g) > Q(PBAT)(9.30 mg/g) > Q(PS)(9.21 mg/g). The results show that more active sites are generated on the surface of MPs after aging, which can enhance their adsorption capacity for organic pollutants. This adsorption mechanism will increase their role as contaminant carriers in the aquatic food chain.Keywords:ultraviolet radiation;diclofenac sodium;aged microplastics;adsorption mechanisms
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PubMed
高影响因子
COLLOID AND POLYMER SCIENCE
·
2018
·Vol. 296
·期 3
·471-481
·
IF 1.967
Han Lidong,Yang Rong,Yuan Shengxiao,Ding Shuang,Wu Ziheng,Wu Zhenghong,Qi Xiaole
Multiple emulsions are potential transdermal drug carriers for their remarkable ability to enhance skin permeability, but their intrinsic thermodynamically instability always limits further application. Here, we developed freeze-thawing water-in-oil-in-water multiple emulsion transdermal drug delivery system, which could accomplish solid-liquid transition in freeze-thawing cycles and keep stable under hypothermic storage (4 °C). In this study, freeze-thawing multiple emulsions were prepared by a two-step emulsification method with isopropyl palmitate as the oil phase, which could freeze at 4 °C to gain solid multiple emulsions and regain intact liquid emulsions at a shell temperature (32 °C) upon application on the skin. In vitro skin permeation studies on excised mice skin showed that the cumulative permeation percentages of diclofenac sodium from freeze-thawing multiple emulsions, multiple emulsions, and cream (Dakangfen®) were 41.22 ± 4.27, 36.63 ± 4.71, and 23.96 ± 3.49% separately. Moreover, pharmacokinetic experiments in rabbits indicated that the AUC 0 − t (area under the curve) of freeze-thawing multiple emulsions (30.872 ± 3.989 μg/mL h) and multiple emulsions (27.337 ± 2.804 μg/mL h) were significantly higher than those of the controlled cream (14.981 ± 1.331 μg/mL h) ( p < 0.05). These results suggested that freeze-thawing multiple emulsions could be a promising substitute of traditional multiple emulsions for transdermal drug delivery.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2018
·Vol. 25
·期 23
·22998-23008
·
IF 2.8
Zhao Junfeng,Wang Qun,Fu Yongsheng,Peng Bo,Zhou Gaofeng
In this study, the effect of Fe 3+ , Fe 2+ , and Mn 2+ dose, solution pH, reaction temperature, background water matrix (i.e., inorganic anions, cations, and natural organic matters (NOM)), and the kinetics and mechanism for the reaction system of Fe(VI)/Fe 3+ , Fe(VI)/Fe 2+ , and Fe(VI)/Mn 2+ were investigated systematically. Traces of Fe 3+ , Fe 2+ , and Mn 2+ promoted the DCF removal by Fe(VI) significantly. The pseudo-first-order rate constant ( k obs ) of DCF increased with decreasing pH (9–6) and increasing temperature (10–30 °C) due to the gradually reduced stability and enhanced reactivity of Fe(VI). Cu 2+ and Zn 2+ ions evidently improved the DCF removal, while CO 3 2− restrained it. Besides, SO 4 2− , Cl − , NO 3 − , Mg 2+ , and Ca 2+ almost had no influence on the degradation of DCF by Fe(VI)/Fe 3+ , Fe(VI)/Fe 2+ , and Fe(VI)/Mn 2+ within the tested concentration. The addition of 5 or 20 mg L −1 NOM decreased the removal efficiency of DCF. Moreover, Fe 2 O 3 and Fe(OH) 3 , the by-products of Fe(VI), slightly inhibited the DCF removal, while α-FeOOH, another by-product of Fe(VI), showed no influence at pH 7. In addition, MnO 2 and MnO 4 − , the by-products of Mn 2+ , enhanced the DCF degradation due to catalysis and superposition of oxidation capacity, respectively. This study indicates that Fe 3+ and Fe 2+ promoted the DCF removal mainly via the self-catalysis for Fe(VI), and meanwhile, the catalysis of Mn 2+ and the effect of its by-products (i.e., MnO 2 and MnO 4 − ) contributed synchronously for DCF degradation.
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高影响因子
RSC Advances
·
2017
·Vol. 7
·期 61
·38279-38286
·
IF 3.108
Tao Liu,Zhihai Xie,Yu Zhang,Jin Fan,Qing Liu
New cationic polymeric nanoparticles (PNPs) were synthesized by precipitation polymerization using [2-(methacryloyloxy)ethyl] trimethylammonium chloride and ethylene glycol dimethacrylate for adsorption of diclofenac sodium. The PNPs were characterized using FTIR, SEM, TEM, and their specific surface areas and thermal stabilities were measured. The adsorption capacity of PNPs was studied by static adsorption experiments. The adsorption equilibrium was achieved within only 7 min, and quantitative desorption required 3 min using 0.1 mol L−1 NaOH/methanol (1 : 1, v/v) as eluent. The maximum adsorption capacity of the PNPs for diclofenac sodium was 334.2 mg g−1. The specific surface area for the PNPs was 192.5 m2 g−1. The isothermal adsorption model and the kinetic model were well fitted with the Langmuir adsorption model and a pseudo-second order kinetic model, and the adsorption mechanism was also discussed in detail. The PNPs could be used repeatedly for 6 cycles without a significant decrease in adsorption capacity. The prepared PNPs can be considered to be a promising sorbent for the adsorption of diclofenac sodium from water samples.
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ENVIRONMENTAL POLLUTION
·
2021
·
IF 8.071
Yan Feng,Zichen Li,Yingying Long,Ning Suo,Zhongwei Wang,Lipin Qiu
Electric and magnetic fields characterized by high efficiency, low consumption and environment-friendly performance have recently generated interest as a possible measure to enhance the performance of the biological treatment process used to remove refractory organics. Few studies have been carried out to-date regarding the simultaneous application of electric and magnetic fields on biofilm process to degrade diclofenac. In this study, 3DEM-BAF was designed to evaluate the electrio-magnetic superposition effect on diclofenac removal performance, kinetics, community structure and synergistic mechanism. The results show that 3DEM-BAF could significantly increase the average removal rate of diclofenac by 65.30 %, 57.46 %, 9.48 % as compared with that of BAF, 3DM-BAF, 3DE-BAF, respectively. The diclofenac degradation kinetic constants and dehydrogenase activity of 3DEM-BAF were almost 6.72 and 2.53 times higher than those of BAF. Microorganisms of 3DEM-BAF in the Methylophilus and Methyloversatilis genera were distinctively enriched, which was attributed to the screening function of electric field and propagation effect of magnetic field. Moreover, three processes were found to contribute to diclofenac degradation, namely electro-magnetic-adsorption, electro-chemical oxidation and electro-magnetic-biodegradation. Thus, the simultaneous application of electric and magnetic fields on biofilm process was demonstrated to be a promising technique as well as a viable alternative in diclofenac degradation enhancement.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2016
·
IF 3.782
Yalei Zhang,Zengfu Yin,Chaomeng Dai,Xuefei Zhou,Wen Chen
Flower-like MoS 2 with numerous wrinkled nanosheets was prepared via a facile hydrothermal method . The surface morphology and microstructure of the obtained materials were characterized using X-ray diffraction data (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Additionally, the compositions of the flower-like MoS 2 were further revealed by an energy dispersion spectrometer (EDX) and X-ray photoelectron spectrometry (XPS). The obtained MoS 2 was used as an adsorbent to remove diclofenac (DCF, C 14 H 10 Cl 2 NO 2 Na) from aqueous solutions and presented excellent performance for removing DCF. The sorption kinetics, isotherms and effect of solution pH on the sorption were evaluated in batch sorption experiments. The sorption characteristics of the interactions between DCF and MoS 2 in water were analyzed using a pseudo-second-order model, an intraparticle diffusion model and Boyd model to determine the sorption rate-determining steps. It was concluded that the sorption of DCF on MoS 2 was fitted better by the pseudo-second-order model and that external diffusion governed the sorption process of DCF onto the MoS 2 . The interfacial interaction free energies between DCF and MoS 2 in the sorption process can be calculated based on the extended Derjaguin–Landau–Verwey–Overbeek (XDLVO). The flower-like MoS 2 presenting excellent performance for removing DCF, could be a better choice of treating DCF-containing wastewaters.
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高影响因子
DRUG DELIVERY
·
2014
·
IF 2.202
Chunyu Yang,Yan Shen,Jue Wang,Ammar Ouahab,Tao Zhang,Jiasheng Tu
The objective of the present study was to develop a topical preparation with enhanced skin permeation, high safety and self-preserving ability. Microemulsion (ME) and cationic polymer based micro-emulgel (CPBM) were investigated for the transdermal delivery of diclofenac sodium (DS). Medium-chain triglyceride was selected as the oil phase of ME due to its good solubilization of DS and high safety. Orthogonal test was applied to optimize the formula of ME based on the cumulative skin permeation amount in vitro after preliminary formula test. Chitosan (CS) or polylysine was employed as the cationic polymer in the formula of CPBM. The transdermal delivery of DS was evaluated through in vitro skin permeation test. The results showed that the skin permeation rate of DS from the optimized CPBM (126.17 ± 15.82 μg/cm2/h) were 1.86-folds and 5.76-folds higher than that of DS commercial Emulgel and DS control hydrogel, respectively. MEs and the cationic polymer were found to have skin penetration co-enhancing effect when they were combined in the CPBM system. Furthermore, the CPBM showed a good growth inhibition of E. coli and S. aureus. The stability test revealed that the CPBM was stable at room temperature and 4 °C for a period of three months.
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高影响因子
CHEMOSPHERE
·
2018
·
IF 4.427
Xiang Li,Minghua Zhou,Yuwei Pan
Diclofenac sodium (DCF) is frequently detected as a non-steroidal pharmaceutical in the aquatic environment. In this study, the degradation of DCF in two heterogeneous systems, pre-magnetization Fe 0 /H 2 O 2 (Pre-Fe 0 /H 2 O 2 ) and Fe 0 /H 2 O 2 system, was comparably studied. Our findings proved that Pre-Fe 0 could significantly improve the degradation and dechlorination of DCF due to the change of Fe 0 characteristics after pre-magnetization. Compared with Fe 0 /H 2 O 2 process, Pre-Fe 0 /H 2 O 2 process has 2.1–7.0 times higher rate constant for DCF degradation at different H 2 O 2 dosages (0.25–2.0 mM), initial pH (3.0–6.0) and Fe 0 dosages (0.25–1.5 mM). The characterizations by X-ray Photoelectron Spectroscopy and Electron Paramagnetic Resonance confirmed that the enhancement attributed to the increase of Fe 0 corrosion and fast generation of OH . In addition, preliminary degradation mechanism was elucidated by major products identification using UPLC-MS, through which the degradation intermediates, such as 4-hydroxy-diclofenac or 5-hydroxydiclofenac, 2,6-dichloroaniline, phenylacetic acid, 1,3-dichlorobenzene and 2-aminophenylacetic acid were identified. Hydroxylation, decarboxylation , C N bond cleavage and ring-opening involving the attack of OH or other substances, were the main degradation mechanism. Therefore, Pre-Fe 0 /H 2 O 2 process, which does not need extra energy and costly reagents, is an efficient and environmental-friendly process to degrade DCF.
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高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2017
·
IF 3.743
Xian Lu,Yisheng Shao,Naiyun Gao,Juxiang Chen,Yansen Zhang,Huiming Xiang,Youluo Guo
Diclofenac (DCF) is the frequently detected non-steroidal pharmaceuticals in the aquatic environment. In this study, the degradation of DCF was evaluated by UV-254 nm activated persulfate (UV/PS). The degradation of DCF followed the pseudo first-order kinetics pattern. The degradation rate constant (k obs ) was accelerated by UV/PS compared to UV alone and PS alone. Increasing the initial PS dosage or solution pH significantly enhanced the degradation efficiency. Presence of various natural water constituents had different effects on DCF degradation, with an enhancement or inhibition in the presence of inorganic anions (HCO 3 − or Cl − ) and a significant inhibition in the presence of NOM. In addition, preliminary degradation mechanisms and major products were elucidated using LC-MS/MS. Hydroxylation, decarbonylation, ring-opening and cyclation reaction involving the attack of SO 4 • − or other substances, were the main degradation mechanism. TOC analyzer and Microtox bioassay were employed to evaluate the mineralization and cytotoxicity of solutions treated by UV/PS at different times, respectively. Limited elimination of TOC (32%) was observed during the mineralization of DCF. More toxic degradation products and their related intermediate species were formed, and the UV/PS process was suitable for removing the toxicity. Of note, longer degradation time may be considered for the final toxicity removal.
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高影响因子
SEPARATION SCIENCE AND TECHNOLOGY
·
2026
·
IF 2.3
Haiming Guo,Guorong Ma,Yingqi Huang,Shuxi Shi,Dong Ding,Yan Wang
In this work, an in-situ polymerization of pyrrole was performed to coat Fe3O4 nanoparticles with a polypyrrole (PPy) layer, yielding magnetically separable Fe3O4@PPy composites. The composite was employed to activate peroxymonosulfate (PMS), facilitating the rapid degradation of sodium diclofenac (DCFS). In this work, PPy encapsulates the metal oxides in a shell layer, effectively reducing the leaching of metal ions. Moreover, the PPy encapsulation promoted the formation of oxygen vacancies (Ovac). PPy and Ovac play a crucial role in promoting electron transfer, with Fe2+, PPy and Ovac being able to synergistically activate the PMS to yield abundant reactive oxygen species (ROS). These ROS contributed to the efficient degradation of DCFS. The degradation efficiency of DCFS (50 mg/L) reached 91.0% within just 2 minutes. Among the influential parameters, the initial pH value emerged as the most significant factor. The quenching experiments demonstrated that both the radical and non-radical pathways contributed synergistically to the DCFS degradation, with 1O2 being the dominant ROS. Finally, Fe3O4@PPy exhibited excellent stability and reusability, maintaining high catalytic performance over six consecutive cycles. This work provided a novel and efficient strategy for the removal of pollutants from wastewater, leveraging the synergistic effect of PPy-coated magnetic catalyst for pollutant removal.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Hao-Ze Li,Ru-Meng Liu,Jia-Si Zhang,Chen-Yan Zheng,Jin-E Wu,Chao Chang,Zhi-Yong Gong,Yong-Ning Wu,Kai Zhang,Xin Liu
The persistent environmental threat posed by diclofenac sodium (DCF), a low-biodegradability pharmaceutical contaminant in aquatic systems, necessitates advanced adsorbents capable of overcoming the capacity, kinetics, and recyclability limitations of conventional materials. To address this, we synthesized a novel cationic covalent organic framework/chitosan (iCOF/CS) aerogel. This was achieved first through the Schiff base condensation of 1,2,3-triaminoguanidinium chloride (TG Cl ) and 6-dihydroxynaphthalene-1,5-dicarbaldehyde (DHNDA) to form the iCOF. Subsequently, the iCOF was integrated into a chitosan matrix that was cross-linked with 1,3,5-triformylphloroglucinol (Tp), resulting in a hierarchical pore structure. The composite demonstrated exceptional DCF adsorption performance with ultrafast equilibrium within 10 min (98 % removal in 2 min) and a record capacity of 557.1 mg·g −1 , surpassing pure iCOF (473.1 mg·g −1 ) and CS aerogel (381.6 mg·g −1 ), attributed to synergistic ion exchange (Cl − /DCF − ), electrostatic attraction, π-π stacking, and hydrogen bonding, as validated by spectroscopy and theoretical calculation. The pioneering cationic COF/CS aerogel was engineered to overcome inherent recyclability limitations of powdered iCOF. The iCOF/CS aerogel gave above 97 % DCF removal in real aqueous matrices (tap, river and lake water) and over 91 % adsorption capacity after four regeneration cycles, thereby establishing a scalable remediation platform for pharmaceutical contaminants via engineered iCOF composites.
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高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2022
·Vol. 31
·期 3
·1129-1143
·
IF 4.705
Tang Qi,Qiu Chongpeng,Zhang You,Zhang Xuefeng,Yuan Zihui,Tan Hailu,Wang Lei,de Hoop Cornelis F.,Qi Jinqiu,Huang Xingyan
In this work, a novel nanocellulose/alum/chitosan/polyethyleneimine biohybrid aerogel (NACPBA) beads adsorbent was successfully prepared to remove diclofenac sodium (DS) from wastewater. The NACPBA beads adsorbent was characterized using Fourier transform infrared spectroscopy, scanning electron microscopy, X-ray photoelectron spectroscopy, X-ray diffractometer, and Brunauer–Emmett–Teller. A possible adsorption mechanism was also discussed. The experimental results showed that the adsorption process was followed by a pseudo-second-order kinetic model and Sips isotherm model with the calculated maximum adsorption capacity of 321.3 mg/g on DS. It was much higher than most of the previously reported works. The adsorption capacity of NACPBA beads on DS was increased rapidly within 120 min, especially in the first 60 min. Furthermore, after five regeneration cycles, NACPBA still retained a good adsorption capacity of 103.7 mg/g with a removal efficiency of 50%. Moreover, 95.4% of DS was removed from river water (simulated 5 mg/L DS-contaminated wastewater). The possible adsorption mechanism was primarily governed by electrostatic attractions and hydrogen bond interactions.
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高影响因子
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