Nanomaterials
·
2018
·Vol. 8
·期 9
·706
·
IF 3.504
Yuefang Niu,Guo Ling,Li Wang,Shanyue Guan,Zheng Xie,Eran A. Barnoy,Shuyun Zhou,Dror Fixler
Emphasis using phototheranostics has been placed on the construction of multifunctional nanoplatforms for simultaneous tumor diagnosis and therapy. Herein, we put forth a novel nanosized luminescent material using the incorporation of red emissive carbon dots on gold nanorods through polyethylene glycol as a covalent linkage for dual-modal imaging and photothermal therapy. The novel nanohybrids, not only retain the optical properties of the gold nanorod and carbon dots, but also possess superior imaging performance in both confocal laser scanning microscopy and fluorescence lifetime imaging microscopy. The nanohybrids also exhibit excellent photothermal performance as phototheranostic nanohybrid probes for in vitro assays. This study promises a new multifunctional nanoplatform for cancer diagnostics and therapeutics.Keywords:gold nanorod;carbon dots;nanohybrids;bioimaging;photothermal therapy
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PubMed
高影响因子
JOURNAL OF NANOPARTICLE RESEARCH
·
2026
·Vol. 28
·期 9
·221
·
IF 3.5
Li Rongye,Zhu Congying,Song Xiaoping,Zhang Xiaodong,Hamdi Marwa,Chen Jiahong
Recent advances in polymeric nanocarriers have highlighted the potential of amphiphilic block copolymers for the simultaneous delivery of chemotherapeutic agents with different physicochemical properties. In this study, asymmetric poly(ethylene glycol)-b-polylactide-b-poly(ethylene glycol) (PEG- b -PLA- b -PEG) triblock copolymers were synthesized via ring-opening polymerization, end-group functionalization, and click coupling, and subsequently evaluated as biodegradable nanocarriers for the co-delivery of paclitaxel (PTX) and cisplatin (CDDP). The copolymers were characterized by 1 H nuclear magnetic resonance (NMR) spectroscopy and gel permeation chromatography (GPC). Self-assembly in aqueous media yielded spherical micelles with uniform size distributions, as confirmed by transmission electron microscopy (TEM) and dynamic light scattering (DLS). The micelles exhibited efficient encapsulation of PTX and CDDP with high drug-loading capacities and encapsulation efficiencies. Hydrolytic degradation studies conducted at 37 °C for 45 days revealed progressive cleavage of the ester bond, reduction in molecular weight, and gradual disintegration of the micellar structure. In vitro release studies of single- and dual-drug-loaded micelles demonstrated sustained release of both drugs over time. Analysis of the release data using the Korsmeyer–Peppas model provided insight into the release behavior and suggested contributions from both diffusion and polymer degradation processes. The biocompatibility of the unloaded triblock copolymer micelles was assessed through cytocompatibility, hemocompatibility, and zebrafish embryo assays, which indicated low intrinsic toxicity and minimal hemolytic activity. Collectively, these results demonstrate that PEG- b -PLA- b -PEG triblock copolymer micelles can be recognized as biodegradable carriers capable of dual-drug encapsulation and sustained release, providing a useful platform for further investigation of combination drug delivery systems. Graphical abstract Asymmetric PEG- b -PLA- b -PEG triblock copolymers were synthesized and self-assembled into uniform micelles capable of co-encapsulating Paclitaxel and Cisplatin. The micellar architecture provided controlled degradation and synchronized dual-drug release over 45 days. The combination of tunable structure, sustained release, and excellent biocompatibility highlights these triblock copolymer micelles as efficient nanocarriers for combinational cancer therapy
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ChemElectroChem
·
2020
·Vol. 7
·期 15
·3353-3360
·
IF 4.154
Ran Zhang,Zhaoyang Wei,Weiwei Lei,Tao Jiang,Qunchao Zhang,Dean Shi
Graphical Take cover : The shielding effects of ether oxygen atoms in Poly(ethylene glycol) (PEG) molecular chains on the B atoms can be alleviated by introducing siloxane oxygens in between them (B-Si x -PEGs). The deshielding effects of siloxane spacing groups on B atoms increase along with the increase of x in the B-Si x -PEGs polymer electrolytes. Doping boron (B) atoms into poly(ethylene glycol) (PEG)-based solid polymer electrolytes (B-PEG) is believed to be an attractive method to increase the lithium-ion transference number ( ) because of the interaction between the electropositive B atoms and the anions of lithium salts. However, this effect can be largely impeded by the interaction between B and the electronegative ether oxygen atoms in the attached PEG molecular chains, which is referred to as a shielding effect. Enlarging the distance between the center B atoms and the electronegative ether oxygens is believed to be an effective way to reduce such shielding effect. In this work, different number of siloxane spacing groups (Si x ) are introduced in between the B atom and ether oxygen in the B-PEG macromolecules (B-Si x -PEGs x =0,1,3,5). As the siloxane oxygen has less electronegativity to ether oxygen, the shielding effects should be weakened and the ability of B atoms to trap the anions of lithium salt will increase. As the introduction of siloxane groups into the B-Si x -PEGs polymer electrolytes will also reduce the neat contents of both B and PEG, which has the opposite effect on the whole ionic conductivities and values, both the ionic conductivities and values of B-Si x -PEGs electrolytes first increase then decrease along with x increases from 0 to 5 when the [Li + ]:[EO] mole ratio is fixed at 1 : 10. The peak value exists at x =1. Meanwhile, both the mobilities of Li + ions (confirmed via 7 Li nuclear magnetic resonance (NMR) results) and bis(trifluoromethane) sulfonimide (TFSI − ) anions (confirmed from Raman spectra analysis) get their maximum values when x =1. However, if both the concentrations of TFSI − and B atoms in B-Si x -PEGs electrolytes are taken into consideration, the normalized diffusion coefficient of TFSI − anions obtained by molecular dynamic (MD) simulation decrease monotonically when x increases from 0 to 5. As the diffusion coefficient of TFSI − anions is determined by the interaction probability and strength of TFSI − and B atoms; these results confirm that the interaction between the B atoms and TFSI − anions increase with x . Namely, the deshielding effects of siloxane spacing groups on B atoms increase along with the increase of x in the B-Si x -PEGs polymer electrolytes, while it levels off when x exceeds 3.
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ACTA PHYSICO-CHIMICA SINICA
·
2013
·Vol. 29
·期 7
·1524-1533
·
IF 0.869
XIA Juan,SONG Le-Xin,DANG Zheng,SHAO Zhi-Cheng
Fe3O4 nanoparticles with a highly symmetric octadecahedral nanobox structure were fabricated using β-cyclodextrin as a protection agent. A series of composites (CM-1-CM-4) of polyethylene glycol (PEG) and Fe3O4 nanoparticles with
different initial mass ratios were prepared using a colloid process. We found that the shape of the composites depended on the amount of Fe3O4 nanoparticles. In particular, the melting process of PEG was not only influenced by the presence of Fe3O4
nanoparticles, but also by their amount. We also noticed that the crystallinity of PEG lowered upon compositing with Fe3O4 nanoparticles, and decreased as the amount of Fe3O4 nanoparticles increased with the exception of CM-4. Interestingly, the
degradation of PEG was affected by the Fe3O4 nanoparticles, leading to the appearance of different degradation products. Like the initial Fe3O4 nanoparticles, the Fe3O4 components in the composites exhibited typical soft ferromagnetism
but possessed much lower saturation magnetizations. X-ray photoelectron spectroscopy (XPS) experiments revealed that electronic shift occurred from iron to oxygen. The resulting decrease in the electronic density of iron explained the observed decrease in saturation magnetizations of the composites.
The composites induced strong surface-enhanced Raman scattering of organic dyes that depended on the amount of Fe3O4 nanoparticles in the composite. This study contributes to the development of composite materials combining polymers with inorganic nanoparticles.
研究领域:
材料科学
·
纳米技术
·
物理化学
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高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2014
·
IF 4.908
Xi Quan Cheng,Lu Shao,Cher Hon Lau
A hydrophilic thin-film-composite (TFC) nanofiltration (NF) membrane has been developed through the interfacial polymerization (IP) of amino-functional polyethylene glycol (PEG) and trimesoyl chloride. The selective layer is formed on a polyethersulfone (PES) support that is characterized using FTIR, XPS and SEM, and is dependent on monomer immersion duration, and the concentration of monomers and additives. The higher hydrophilicity alongside the larger pore size of the PEG-based selective layer is the key to a high water flux of 66.0 L m −2 h −1 at 5.0 bar. With mean pore radius of 0.42 nm and narrow pore size distribution , the MgSO 4 rejections of the PEG based PA TFC NF membranes can reach up to 80.2%. The rejection rates for different salts of the novel membranes are in the order of R (MgCl 2 )> R (MgSO 4 )> R (NaCl)> R (Na 2 SO 4 ); indicating a membrane with positive surface charges. The pore sizes and water permeability of these membranes are tailored by varying the molecular weight and molecular architecture of amino-functional PEG. These newly developed TFC NF membranes show great potential for water softening, wastewater treatment and separation and purification of active, pharmaceutical molecules.
研究领域:
环境科学
·
材料科学
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高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Yuming Chen,Jiayi Gu,Jian Liu,Ling Tong,Fuxin Shi,Xiaoqin Wang,Xueling Wang,Dehong Yu,Hao Wu
Background: Cisplatin is an extensively used anti-neoplastic agent for the treatment of various solid tumors. However, a high incidence of severe ototoxicity is accompanied by its use in the clinic. Currently, no drugs or therapeutic strategies have been approved for the treatment of cisplatin-induced ototoxicity by the FDA.Purpose: The purpose of this study was to investigate the otoprotective effects of dexamethasone (DEX)-loaded silk-polyethylene hydrogel (DEX-SILK) following round window membrane administration in the cisplatin-induced ototoxicity mouse model.Methods: The morphology, gelation kinetics, viscosity and secondary structure of the DEX-SILK hydrogel were analyzed. DEX concentration in the perilymph was tested at different time points following hydrogel injection on the RWM niche. Cultured cells (HEI-OC1), organ of Corti explants (C57/BL6, P0-2), and cisplatin-induced hearing loss mice model (C57/BL6) were used as in vitro and in vivo models for investigating the otoprotective effects of DEX-SILK hydrogel against cisplatin.Results: Encapsulation of DEX with a loading of 8% (w/v) did not significantly change the silk gelation time, and DEX was evenly distributed in the Silk-PEG hydrogel as visualized by scanning electron microscopy (SEM). The concentration of Silk majorly influenced DEX distribution, morphological characteristics, viscosity, and gelation time. The optimized DEX-SILK hydrogel (8% w/v loading, 15% silk concentration, 10 μl) was administered directly onto the RWM of the guinea pigs. The DEX concentration in the perilymph was maintained above 1 μg/ml for at least 21 days for the DEX-SILK, while it was maintained for less than 6 h in the control sample of free DEX. DEX-SILK (5-60 ng/ml) exhibited significant protective effects against cisplatin-induced cellular ototoxicity and notably reduced the production of reactive oxygen species (ROS). Eventually, pretreatment with DEX-SILK effectively preserved outer hair cells in the cultured organ of Corti explants and demonstrated significant hearing protection at 4, 8, and 16 kHz in the cisplatin-induced hearing loss mice as compared to the effects noted following pretreatment with DEX.Conclusion: These results demonstrated the clinical value of DEX-SILK for the therapy of cisplatin-induced ototoxicity.
研究领域:
药理学
·
耳鼻喉科学
·
材料科学
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高影响因子
AICHE JOURNAL
·
2014
·Vol. 60
·期 6
·2254-2262
·
IF 2.581
Jifeng Pang,Mingyuan Zheng,Aiqin Wang,Ruiyan Sun,Hua Wang,Yu Jiang,Tao Zhang
Miscanthus, a promising energy crop, was used for ethylene glycol (EG) production through one-pot catalytic conversion. With a binary catalyst composed of commercial tungstic acid and Raney Ni, the miscanthus with 1 % concentration was transformed into EG with a yield of 35.5%. However, the yield dropped to 13.6% as the miscanthus concentration was increased to 10 %. The underlying reason for the yield decrease was disclosed through analysis of the liquid products, investigation of pretreatments, and characterization of the catalysts. It was found that the protectors on the surface of miscanthus and the lignin component underwent decomposition under reaction conditions, resulting in the formation of some organic acids and unsaturated compounds that preferentially poisoned the Raney Ni catalyst and consequently decreased the EG yield. When the inhibitors were effectively removed by base solvent pretreatment, the EG yield was successfully improved to 39.0% even under 10% concentration of feedstock. © 2014 American Institute of Chemical Engineers AIChE J , 60: 2254–2262, 2014
研究领域:
生物能源
·
催化化学
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高影响因子
POLYMER SCIENCE SERIES B
·
2025
·Vol. 67
·期 2
·15
·
IF 1
Zhijun Li,Huang Zhengyong,Xing Ruiguang
In this study, the preparation of diphenylsilylene diol (DP)-modified double-A epoxy resin (E51) with resveratrol-functionalized graphene (Res/rGO) composites and their performance characterization were investigated. Firstly, the double-A epoxy resin (EP) was modified with DP to improve its mechanical properties and thermal stability. Then, Res/rGO was introduced into the modified epoxy resin (DP/E51), and a series of modified epoxy resin/resveratrol functionalized graphene (Res/rGO-DP/E51) composites were prepared. The effects of different graphene contents on the mechanical properties of the materials were analyzed by conducting tensile property tests on the composites. The results showed that the DP-modified epoxy resin exhibited a significant improvement in tensile strength, especially after the introduction of an appropriate amount of Res/rGO, the tensile properties of the composites were further optimized. Resveratrol, as a natural antioxidant substance, significantly improved the interfacial bonding and dispersion of the composites after functionalization on the graphene surface, thus enhancing the overall performance of the composites. In addition, the Res/rGO-DP/E51 composites exhibited excellent thermal stability, which has a good application prospect.
研究领域:
材料科学
·
聚合物复合材料
·
纳米材料
·
表面改性
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高影响因子
LANGMUIR
·
2017
·
IF 3.833
Zhen Wang,Jiaqi Song,Shiming Zhang,Xiao-Qi Xu,Yapei Wang
One-step double emulsions via only one-step emulsification are leading to an attractive branch of emulsion research studies owing to the ease of preparation and reduced surfactant numbers. In addition to controlling the oil/water ratio, exploiting emulsifiers with desirable amphiphilicity that can stabilize both the inner and outer water/oil interfaces is crucial to the formation of one-step double emulsions. In particular, new emulsifiers with saving laborious efforts are highly preferred in consideration of low cost and practical applications. In this work, a commonly used homopolymer, polyethylene glycol (PEG), was attempted as emulsifiers to prepare emulsions via one-step emulsification. PEG is generally considered as a hydrophilic polymer and always anchored with a hydrophobic polymer to make the copolymer amphiphilic. In the water–chloroform binary system, PEG itself exhibits amphiphilic performance and tailors the formation of single emulsions or double W/O/W emulsions on the dependence of the oil/water ratio and the PEG concentration. A possible mechanism as explained by dissipative particle dynamics simulation was proposed to demonstrate the amphiphilic feature and emulsification capability of PEG. The amphiphilicity of PEG was further tuned by interacting with iodine as a result of the formation of a supramolecular complex, which, in turn, led to the conversion from single emulsions to O/W/O double emulsions. It is believed that this line of research provides inspiration for the preparation of controllable emulsions through supramolecular routes.
研究领域:
胶体与界面科学
·
高分子科学
·
超分子化学
·
乳液技术
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高影响因子
FLOW TURBULENCE AND COMBUSTION
·
2023
·Vol. 111
·期 2
·697-715
·
IF 2.4
Luo Junxiao,Shi Weidong,Chen Liang,Fang Guofeng,Zhang Liang
Nanofluids have become more and more attractive to the modern industry due to their high performance in heat transfer and combustion. As one of the key influencing factors, the atomization mechanism of nanofluids induced by airflow is more complex than that of pure liquids, which has attracted great attention recently. In this study, the spray characteristics of TiO 2 –propylene glycol nanofluids were investigated by focusing on the effects of nano-TiO 2 additives on atomization. On the basis of high-speed shadow imaging, the spray morphology of the base fluid injected from an air atomizing nozzle under different pressures was analyzed first. Then a laser particle size analyzer was used to obtain the droplet size distribution of the nanofluids. The air pressure at the inlet of the atomizer was found to have more contribution to the atomization of nanofluids. And when the air pressure exceeded 0.35 MPa, the Sauter mean diameter (D 32 ) of the base fluid droplets was insensitive to the change of air pressure. Subsequently, the contribution of nanoparticles to atomization was discussed. An empirical correlation was proposed between the Sauter mean diameter (D 32 ) and the dimensionless parameters such as the gas Weber number (We g ), liquid–gas momentum ratio (q), and the volume fraction of nano-TiO 2 , etc. Results indicated that adding nanoparticles enhanced the jet stability by increasing the viscosity at a low jet velocity, while the jet instability was increased due to the nanoparticles promoting the cavitation at a high jet velocity.
研究领域:
热能工程
·
机械工程
·
流体力学
·
材料科学
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高影响因子
WATER AIR AND SOIL POLLUTION
·
2026
·Vol. 237
·期 21
·1248
·
IF 3.5
Zhang Liping,Mu Ran,Liu Siying,Li Huitong,Cui Yujing,Yan Zhao,Sun Runchao
Polyethylene glycol-400 (PEG-400), a critical lubricant in photovoltaic silicon wafer slicing, is highly recalcitrant to biodegradation and environmentally persistent. Direct discharge of PEG-400 not only induces water eutrophication and disrupts aquatic ecosystems but also poses chronic health risks to humans through long-term environmental accumulation and water contamination. However, conventional wastewater treatment technologies exhibit limited efficiency in removing PEG-400. In this study, the degradation of PEG-400 was systematically investigated using an O 3 + H 2 O 2 + Mn-Cu/γ-Al 2 O 3 catalytic oxidation process. Single-factor experiments combined with response surface methodology were employed to optimize the catalyst preparation and reaction parameters. Finally, the degradation mechanism and pathway are revealed. The results showed that the Mn-Cu/γ-Al 2 O 3 catalyst prepared under the conditions of 0.1 mol/L impregnation concentration, 500℃ calcination temperature, and 2 h calcination time achieved the optimal catalytic activity. Under the optimal conditions of O 3 concentration of 60 mg/L, H 2 O 2 dosage of 1.8 mmol/L, catalyst dosage of 4 g/L, gas flow rate of 400 mL/min, and reaction time of 90 min, the removal rate of PEG-400 reached 100%, with COD and TOC removal rates of 76.3% and 53.76%, respectively. Radical quenching experiments confirmed that ·OH, ·O 2 − and 1 O 2 were the dominant reactive oxygen species. FTIR and GC–MS analysis revealed that PEG-400 degraded via ether bond cleavage into intermediate products (e.g., aldehydes, carboxylic acids), which verified non-toxicity by T.E.S.T software, and ultimately mineralized into CO 2 and H 2 O.
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高影响因子
Case Studies in Construction Materials
·
2025
·
IF 6.6
Miaomiao Ma,Jingyao Ma
To address the issue of insufficient mechanical properties in conventional hydrogels that limit their marine antifouling applications, we innovatively proposed a construction strategy of titanium dioxide (TiO 2 ) nanoparticles reinforced polyethylene glycol (PEG) hydrogels. The TiO 2 -PEG hydrogel with uniformly dispersed nanoparticles were successfully prepared by in-situ polymerization, and the material showed excellent mechanical properties. When the content of TiO 2 is 0.5 wt%, the tensile strength of the TiO 2 -PEG hydrogel can reach 0.97 MPa, which is 68.5 % higher than that of the PEG hydrogel. CLSM analysis shows that TiO 2 nanoparticles effectively enhance the mechanical properties of hydrogels by inducing crack deflection and energy dissipation mechanism. Notably, TiO 2 -PEG hydrogel also has a broad-spectrum antifouling performance, which can effectively resist protein adsorption and adhesion of Escherichia coli, Staphylococcus aureus and diatoms. The structure-property relationship demonstrated that TiO 2 enhanced the TiO 2 -PEG mechanical properties, which inhibited its detachment from the substrate and thereby significantly improved the antifouling durability. This study not only provides new ideas for the design of high-performance marine anti fouling materials, but also provides theoretical basis and practical support for achieving synergistic enhancement of anti fouling performance and mechanical performance.
研究领域:
材料科学
·
海洋技术
·
高分子科学
·
纳米技术
·
表面工程
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高影响因子
危险品化学品经营许可证（带存储）