Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 30
·5011-5020
·
IF 4.776
Jinyu Li,Yue Yang,Yibin Yu,Qi Li,Guoxin Tan,Yuanyuan Wang,Wei Liu,Weisan Pan
The synthetic clay material, LAPONITE® (LAP), having a nanodisk structure together with a negatively charged surface, has been used for effective drug encapsulation by virtue of its interlayer space. In this research effort, the LAP nanodisk was used for the first time to encapsulate the antifolic methotrexate (MTX); the MTX-loaded LAP nanodisks (LAP/MTX) demonstrated a high drug loading efficiency of 80.39%. An efficient and reliable tumor-targeting device that rests on the synthesized oligomeric hyaluronic acid-L-histidine (oHA–His) was then encapsulated in the MTX-loaded LAP disks (forming LAP/MTX/oHA–His nanohybrids). The drug released from the LAP/MTX/oHA–His nanohybrids was pH-dependent and matched the first-order kinetics that describes the diffusion mechanism. In vitro biological evaluation manifested that the MTX-loaded LAP nanocarriers, particularly the LAP/MTX/oHA–His nanohybrids that have targetability and lysosomal antineoplastic activity, can be effectively internalized by the MCF-7 cell line, and can exhibit a more prominent anticancer cytotoxicity than free MTX. In vivo studies with mice indicated that the LAP/MTX/oHA–His nanohybrids demonstrated much higher antitumor efficiency compared to the LAP/MTX nanohybrids and pure MTX. Taken together, the LAP/oHA–His, CD44 receptor targeting and pH-sensitive multifunctional nanohybrids conferred the MTX with excellent cytocompatibility, dispersion stability, sustained pH-responsive release properties, and improved anticancer activity, and may be further developed as a potential active nanoplatform for various anticancer drugs.
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Materials Today Bio
·
2024
·
IF 8.7
Linquan Zhou,Chengcheng Zhang,Tengbin Shi,Dingwei Wu,Huina Chen,Jiaxin Han,Dehui Chen,Jinxin Lin,Wenge Liu
The migration and differentiation of bone marrow mesenchymal stem cells (BMSCs) play crucial roles in bone repair processes. However, conventional scaffolds often lack of effectively inducing and recruiting BMSCs. In our study, we present a novel approach by introducing a 3D-bioprinted scaffold composed of hydrogels, with the addition of laponite to the GelMA solution, aimed at enhancing scaffold performance. Both in vivo and in vitro experiments have confirmed the outstanding biocompatibility of the scaffold. Furthermore, for the first time, Apt19s has been chemically modified onto the surface of the hydrogel scaffold, resulting in a remarkable enhancement in the migration and adhesion of BMSCs. Moreover, the scaffold has demonstrated robust osteogenic differentiation capability in both in vivo and in vitro environments. Additionally, the hydrogel scaffold has shown the ability to induce the polarization of macrophages from M1 to M2, thereby facilitating the osteogenic differentiation of BMSCs via the bone immune pathway. Through RNA-seq analysis, it has been revealed that macrophages regulate the osteogenic differentiation of BMSCs through the AMPK/mTOR signaling pathway. In summary, the functionalized GelMA/Laponite scaffold offers a cost-effective approach for tailored in situ bone regeneration.
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CRYSTENGCOMM
·
2020
·Vol. 22
·期 37
·6182-6188
·
IF 3.117
Xueshuai Chen,Rongli Jiang,Huilin Hou,Zihan Zhou,Xingwen Wang
ZSM-5/SAPO-34 zeolite composites were successfully synthesized by adding ZSM-5 into SAPO-34 synthetic gel under hydrothermal synthesis conditions, and SAPO-34 as a part of the composite zeolite was synthesized from LAPONITE® as the Si source. The presence of ZSM-5 in the synthetic gel affects the nucleation and crystal growth rate, and core–shell structured zeolite composites can be formed by adding an appropriate amount of ZSM-5. LAPONITE® itself contains Li and Mg atoms which were subsequently introduced into the framework of the SAPO-34 part in the composites via depolymerization–reorganization during the process of crystallization. Furthermore, the depolymerized LAPONITE® can be converted in situ into zeolitic precursors and act as crystalline seeds under hydrothermal conditions. Compared with the ZSM-5/SAPO-34 zeolite composites synthesized from tetraethylorthosilicate (TEOS) instead of LAPONITE® as the Si source, the ZSM-5/SAPO-34 composites synthesized from LAPONITE® exhibited higher selectivity to light olefins and longer lifetime in the MTO reaction. This work provides a convenient route to the synthesis of ZSM-5/SAPO-34 zeolite composites with excellent MTO performance.
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Petroleum Science
·
2025
·
IF 6.1
Li-Yao Dai,Jin-Sheng Sun,Kai-He Lv,Ying-Rui Bai,Bo Liao,Dong-Qing Yang,Chao-Zheng Liu,Mei-Chun Li
Fractures in geological formations, which are commonly encountered during oil and gas exploration, pose significant challenges by facilitating fluid loss and reducing wellbore stability. Polymer gels hold significant promise as lost circulation materials due to their excellent deformability under pressure and self-adaptability. However, conventional gels face certain limitations, such as poor retention of gel-forming suspensions in fractures, low structural strength, and instability at high temperatures. These issues result in low pressure-bearing capacity and, consequently, reduced effectiveness in sealing formation fractures. This study presents the synthesis of a supramolecular polymer gel (SPG) composed of acrylamide (AM), 2-acrylamide-2-methylpropanesulfonic acid (AMPS), divinylbenzene (DVB), polyvinyl alcohol (PVA), TEMPO-oxidized cellulose nanofibers (CNFs), and laponite via in situ radical polymerization. Due to the synergistic effects of hydrogen bonding and electrostatic interactions, the supramolecular polymer gel-forming suspension exhibits high retention capacity in fractures. The as-synthesized gels demonstrate remarkable temperature resistance and high mechanical strength, attributed to covalent bonding, multiple hydrogen bonding, and electrostatic interactions, along with the high aspect ratio and modulus of CNFs and laponite. This study broadens the application scope of CNFs, laponite, and SPGs, offering a novel approach for the efficient development of unconventional oil and gas resources.
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Journal of Environmental Chemical Engineering
·
2025
·Vol. 14
·期 1
·120823
·
IF 7.2
Nan Dai,Chuan Jing,Dong Liu,Yuxin Zhang
A novel multidimensional mineral composite catalyst, FeOOH@Laponite@Diatomite (FeOOH@La@D), was synthesized by loading FeOOH onto Laponite@diatomite (La@D). The sea-urchin-like structure of FeOOH@La@D provides a large specific surface area and numerous active sites. It has a good adsorption performance for methylene blue (MB) and congo red (CR), with adsorption capacities of 630.3 mg/g and 257.1 mg/g, respectively. The synergistic effect of FeOOH and Laponite enhanced peroxymonosulfate (PMS) activation performance, achieving 99 % methyl orange (MO) removal within 20 min. Quenching experiments and EPR spectra indicate that SO 4 ●- and 1 O 2 are the dominant active species. Electrochemical and XPS results support electron transfer and Fe 2+ /Fe 3+ cycling. Combining response surface methodology with random forest models, pH value and dosage are identified as key factors. This work provides candidate materials and a theoretical basis for designing environmentally friendly non-homogeneous catalysts for wastewater treatment.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2021
·
IF 3.764
Xianqiang Peng,Tingting Zhang,Jie Zheng,Xingbin Lv,Hualian Zhang,Jia-Qi Hu,Wen Tian,Shuai Tan,Junyi Ji
Development of graphene-based membrane electrodes with high electron and charge transfer capability can meet the increasing requirement for high-rate energy storage devices. Herein, we demonstrate a novel spin regularization strategy to prepare regularized graphene oxide (GO) membranes with uniform interlayer spacing for high-performance electrodes. The outer stretching forces on the radial direction together with the inner electrostatic interaction can form smoother GO flakes and 2D interlayer channels. The positively/negatively charged laponites embedded between the interlayer or at the edges of the GO flakes can enhance the stability of the channel structure, thus further promoting the mass transfer efficiency. Moreover, the membranes with ordered and stable laminar structures reveal high mechanical strength and water stability. Therefore, the as-prepared 2L@GO-10 membrane with regular interlayer channels exhibits a high gravimetric capacitance (406.5 F g–1 at 0.5 A g–1) and rate capability (53% capacitance retention from 0.5 to 100 A g–1) as well as robust cyclic stability (95% retention after 20,000 cycles). Additionally, the multiple membrane stacked electrode also exhibits high energy storage capacity.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Yongxu Xie,Susu Xing,Xiaohua Li,Rongyao Chen,Miaomiao Hu,Jintang Guo
Under ultra-high temperature conditions in cementing engineering, sharp slurry viscosity drop, polymer additive decomposition and accelerated solid particle thermal motion collectively trigger severe instability, leading to marked density inhomogeneities and mechanical strength loss in set cement and threatening cementing operational safety. To address this problem, a novel ultra-high-temperature suspension stabilizer, PADNV-L hybrid, was fabricated via a one-pot reaction in this study. Specifically, laponite was incorporated into the long-chain thermothickening copolymer through covalent bonding interactions, and the organic-inorganic hybrid synergistic effect was harnessed to enhance the ultra-high temperature performance of the suspension stabilizer. The ¹H NMR, FTIR, XPS, and TGA characterizations confirmed the successful synthesis of the co-polymer (AMPS-DEAA-NVP) (namely PADN) and the Organic-inorganic hybrid polymeric material p(AMPS-DEAA-NVP-laponite) (namely PADNV-L hybrid).Comprehensive evaluations revealed that the cement slurry containing 0.5% PADNV-L polymer possesses superior stability at 200℃ compared to that containing 0.5% PADN polymer. Furthermore, the PADN-L modified slurry exhibited superior rheological and compressive properties compared to systems incorporating other polymer additives or lacking a suspension stabilizer. Through the combination of Zeta potential analysis on cement slurry supernatants and microstructural characterization of the cement, the suspension stabilization mechanism governing the PADNV-L hybrid in oil well cement (OWC) slurries was systematically revealed. The PADNV-L hybrid forms an adsorption layer on the surface of the cement particles upon addition. Furthermore, the organic-inorganic hybrid forms a three-dimensional spatial network structure in solution, enabling effective particle adsorption and support. The nucleation effect of nanoparticles promotes cement hydration, refines the pore structure of the cement stone, and consequently enhances its mechanical properties.
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RSC Advances
·
2021
·Vol. 11
·期 4
·1952-1959
·
IF 3.361
Yi Zhao,Fangfang Peng,Yangchuan Ke
The application of nanotechnology in the oil and gas industry has attracted widespread attention in recent years. This study aims to develop a nanoemulsion (NE) for use in enhanced oil recovery (EOR). The NE stabilized by anion amphiphilic copolymer, nonionic surfactant (Brij30) and modified LAPONITE® RD was prepared by the phase inversion composition (PIC) method. The appearance of the emulsion is translucent and the average particle size is less than 60 nm. The micromorphology and interfacial tension (IFT) are examined using transmission electron microscopy (TEM) and a spinning drop IFT meter, respectively. The NE possesses good stability evaluated by conductivity and particle size tests. The absolute value of the zeta potential of NE increases when modified LAPONITE® RD is added. In a core flooding experiment with an artificial sandstone core, the NE flooding increased oil recovery by 23.53% compared to water flooding.
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AAPS PHARMSCITECH
·
2019
·Vol. 21
·期 1
·1-10
·
IF 2.608
Yang Yue,Li Jinyu,Chen Fen,Qiao Sen,Li Yunjian,Pan Weisan
As a synthetic clay material, laponite RDS (LR) was investigated as an effective drug carrier as a result of the special nanodisk structure together with the negative-charged surface to achieve enhanced cellular uptake and targeted delivery. In this research work, the synthesized oligomeric hyaluronic acid-aminophenylboronic acid (oHA-APBA) was entangled onto LR nanodisks to fabricate a valid targeted platform for breast cancer therapy. Briefly, through the formation of amide bonds, 3-APBA was connected to the chain of oHA with a substituted ratio of 4.0 ± 0.2% to synthesize oHA-APBA copolymer. Thereafter, doxorubicin (DOX) was inserted into the interlayer space of LR by the way of the ion exchange process, followed by an assembly with oHA-APBA as a targeted protection layer. The satisfactory drug encapsulation efficiency (> 80%) and narrow size distribution were achieved. The in vitro drug release study demonstrated the release of DOX from DOX@LR/oHA-APBA was sustained and acid dependent. In addition, after fitting the drug cumulative release of DOX@LR/oHA-APBA under different pH conditions with several kinetic models, it was identified that drug release from DOX@LR/oHA-APBA nanohybrids at pH 5.0 was mainly dependent on both diffusion and ion exchange effects. However, under the condition of pH 7.4, the drug was most efficiently released by diffusion effect. Importantly, DOX@LR/oHA-APBA showed remarkable cellular uptake and intracellular drug distribution in MCF-7 cells, which were consistent with inhibitory ability against MCF-7 cells. Hence, the high DOX loading capacity and enhanced cellular tracking can enlighten LR/oHA-APBA as an effective drug delivery carrier for breast cancer therapy.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xiancai Jiang,Siqi Wei,Jinquan Wang
Hydrogel electrolytes are ideal for flexible wearable electronic devices because of their high ionic conductivity, flexibility, and biocompatibility. However, some problems, such as poor mechanical properties, low conductivity, and lack of adhesivity, are encountered in the process of hydrogel preparation and application, which restrict the further development of hydrogel electrolytes. In this study, PVA was used as the first network, and P(AM-co-AMPS) as the second network to prepare a double-network hydrogel electrolyte. Laponite and Na2SO4 were introduced into the hydrogel during hydrogel formation as the nanofiller and salt with the salting-out effect to enhance its mechanical properties. The hydrogel electrolyte with high toughness (1663 kJ·m–3), adhesivity (77 kPa), and ionic conductivity (1.7 S·m–1) was obtained. In addition, the hydrogel electrolyte also has excellent antifatigue performance. In the 10 consecutive tensile cycles, the tensile strength does not decay. Due to the high adhesivity of the hydrogel electrolyte, a symmetrical all-solid-state supercapacitor was assembled with a tight interface between the hydrogel electrolyte and the AC/CNT composite electrode. The supercapacitor has a high specific capacitance of 186.1 mF·cm–2 at the current density of 1 mA·cm–2. In addition, the capacitor has good flexibility and can withstand bending at various angles. The hydrogel electrolyte also has excellent strain sensing performance, with an ultrafast tensile response time (0.17 s) and high sensitivity factor (GF = 10.01). Finally, the self-powered sensor system composed of a supercapacitor as the power supply device and hydrogel electrolyte as the sensing part was obtained and applied to human motion monitoring, which provides a potential application in the integrated flexible electronic system.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Jiahui Li,Boxuan Peng,Siyuan Yu,Fangzheng Zhao,Qiqi Han,Shuaibing Huang,Fengmin Jin,Jinfeng Xing
With the rapid development of industry, water pollution has become one of the important problems that harm the ecological environment and human health. The extensive use and random discharge of dyes have caused serious damage to water resources. Hydrogel bead is a promising material for dye adsorption due to its advantages of rich functional groups and high specific surface area. Here, acrylic acid sodium salt (AAS) and 2-acrylamide-2-methylpropanesulfonic acid (AMPS) as monomers, N,N’-Methylene-bis-acrylamide (MBA) as crosslinking agent, sodium alginate (SA) as semi-interpenetrating network component, laponite as nano-clay additive, and single 2′,4′,5′,7′ −tetrabromofluorescein disodium salt (EY)/ Triethanolamine (TEOA)/ diphenyl iodonium hexafluorophosphate (DPI) as green light polymerization initiating system were combined to prepare composite hydrogel beads within 10 s under green LED irradiation. The composite hydrogels were characterized by infrared spectroscopy (FTIR), thermogravimetric analyzer (TG), scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). The addition of sodium alginate and laponite can improve the mechanical properties of hydrogel beads. In the adsorption study of malachite green, the influence of time, temperature, dye concentration, pH, ionic strength, and other factors on the adsorption effect were investigated. The adsorption process was consistent with the second-order kinetic process and Langmuir adsorption. At room temperature, the highest adsorption capacity of the hydrogel beads for malachite green reached 829.63 mg/g. The PAAS-SL hydrogel beads maintained a high adsorption effect in the pH range (3–10), and the capacity reached 575.0 mg /g at pH 3, which had a good ability to resist low pH. In the adsorption–desorption experiments, the removal rate of PAAS-SL hydrogel beads for MG is still more than 80 % after 5 cycles. Our research provides a promising strategy for the efficient and rapid preparation of hydrogel beads with excellent properties.
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ANALYTICAL CHEMISTRY
·
2023
·
IF 7.4
Rihui Su,Gongke Li,Xiaohua Xiao
In this work, Ag nanoparticles (AgNPs) were embedded into a poly(N-isopropylacrylamide)-laponite (Ag/PNIP-LAP) hydrogel membrane for highly sensitive surface-enhancement Raman scattering (SERS) detection. In situ polymerization was initiated by UV light to encapsulate AgNPs in a PNIP-LAP hydrogel to prepare a highly active SERS membrane with a three-dimensional structure. Due to the surface plasmon resonance and high swelling/shrinkage ratio of the Ag/PNIP-LAP hydrogel SERS membrane, its network structure has a “sieving” effect, which makes it easier for hydrophilic small-molecule targets to enter the sterically confined hydrogel, and the AgNPs are close to each other to form a Raman “hot spot” through the shrinkage of the hydrogel, at the same time, the analyte is enriched in the confined space and close to the AgNPs to form a stronger SERS signal. The characterization of the SERS activity of the Ag/PNIP-LAP hydrogel showed that the prepared three-dimensional membrane had high detection sensitivity for urotropine, 2,5-dimethylpyrazine, pyrazinamide, and pyrazine; the detection limits (S/N = 3) were 17.4, 31.0, 53.1, and 1.11 μg/L, and the analytical time was 35 min. Due to the hydrophilicity of the Ag/PNIP-LAP hydrogel membrane, the small molecules can easily enter the SERS membrane, and the hydrophobic macromolecules are blocked outside the SERS membrane. The SERS method has good selectivity, stability, and reproducibility. The SERS method was applied to the detection of urotropine in dried bean curd sticks, 2,5-dimethylpyrazine in nuts and potato chips, and pyrazinamide in human plasma with recoveries of 81.8–116.8% and the relative standard deviation within 4.9–9.9%. The results matched well with that found by the corresponding chromatographic methods. The proposed method has the advantages of simple sample pretreatment, speediness, high sensitivity, and good selectivity to hydrophilic compounds and has potential application in the rapid on-site detection.
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