INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2021
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IF 3.764
Lianyu Jia,Yang Jin,Jun Li,Zhizhen Wei,Ming Chen,Jun Ma
In this work, a spiral microchannel reactor was used to study the photocatalytic degradation process of oxytetracycline (OTC) in a titanium dioxide (TiO2) slurry system. The influence of parameters such as residence time, TiO2 dosage, OTC concentration, light intensity, and concentration of added ions (NO3–, SO42–, Ca2+, Fe3+) on OTC removal was systematically investigated, and the degradation stability of OTC in the microreactor was evaluated. The results show that under the best experimental conditions, the degradation rate of OTC can reach 99.33%, the initial stage apparent reaction rate constant is 7.7124 min–1, and the space–time yield is 142.79 m3 pollutants/(m3 reactor day). In addition, the results prove the high efficiency and stability of OTC degradation in the microreactor. OTC can be efficiently degraded under high TiO2 dosage, high initial OTC concentration, and low light intensity, which demonstrates the outstanding advantages of spiral microchannels for OTC degradation in slurry systems. This study has a guiding significance for the efficient photocatalytic degradation of tetracycline antibiotics in slurry systems.
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Frontiers in Microbiology
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2022
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IF 6.064
Cao Xiaoxu,Zhao Wei,Zhang He,Lin Jitong,Hu Jingying,Lou Yanhong,Wang Hui,Yang Quangang,Pan Hong,Zhuge Yuping
Introduction: The large-scale development of animal husbandry and industrialization lead to more and more serious co-contamination from heavy metals and antibiotics in soils. Ecotoxic effects of residues from antibiotics and heavy metals are of increasing concern.Materials and Methods: In this study, oxytetracycline (OTC) and cadmium (Cd) were selected as target pollutants to evaluate the individual and combined effects on nitrification process using four different soil types sampled from North to South China through a 56-day incubation experiment.Results and Discussion: The results demonstrated that the contaminations of OTC and Cd, especially combined pollution had significant inhibitory effects on net nitrification rates (NNRs) as well as on AOA and AOB abundance. The toxic effects of contaminants were greatly enhanced with increasing OTC concentration. AOB was more sensitive than AOA to exogenous contaminants. And the interaction effects of OTC and Cd on ammonia oxidizers were mainly antagonistic. Furthermore, Cd contaminant (with or without OTC) had indirect effects on nitrification activity via inhibiting mineral N and AOA/AOB, while OTC alone indirectly inhibited nitrification activity by inhibiting ammonia oxidizers. The results could provide theoretical foundation for exploring the eco-environmental risks of antibiotics and heavy metals, as well as their toxic effects on nitrification processes.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Lixiao Yang,Mingye Zhu,Hongzhu He,Wenjuan Yang,Xiao Wei,Aixia Chen
Waste Shatian pomelo peel was converted into a cellulose aerogel precursor. • An Fe-based MOG/cellulose carbon aerogel was fabricated by in situ growth. • The aerogel enabled efficient oxytetracycline adsorption and magnetic recovery. • The biobased adsorbent showed good recyclability and regeneration stability. Biomass aerogels often face a trade-off between adsorption capacity and recoverability in antibiotic removal. To address this limitation, Shatian pomelo peel, an abundant agricultural byproduct from pomelo processing, was used as a cellulose precursor to fabricate a pomelo peel-derived porous cellulose material (PPCM). An Fe-based metal-organic gel (MOG) was introduced in situ as an Fe-containing precursor, followed by high-temperature carbonization to prepare an Fe-MOG-derived magnetic carbon aerogel (FMCA) containing Fe species, a well-developed porous structure, and magnetic responsiveness. After response surface optimization, the resulting FMCA achieved an adsorption capacity of 836.1 mg g −1 for oxytetracycline (OTC) at an initial concentration of 100 mg L −1 and exhibited a saturation magnetization of 50.28 emu g −1 , enabling rapid magnetic separation under an external magnetic field. After five adsorption-desorption cycles, the material retained approximately 70% of its initial adsorption capacity. The kinetic and isotherm data were best described by the pseudo-second-order and Langmuir models, respectively. Combined pore-structure, zeta-potential, FT-IR, XPS, and batch adsorption results indicated that OTC uptake involved pore filling and multiple interfacial interactions. These results demonstrate that coupling in situ Fe-based MOG incorporation with carbonization is an effective strategy for simultaneously improving adsorption efficiency and recoverability in pomelo peel-derived aerogels, offering a promising route for agricultural byproduct valorization and antibiotic-contaminated water treatment. Download: Download high-res image (293KB) Download: Download full-size image
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ACS Sustainable Chemistry & Engineering
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2017
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IF 5.951
Lili Lian,Jinyi Lv,Dawei Lou
Multifunctional magnetic microspheres (Mag@ZnO–Co3O4) with bimetal oxide shell were synthesized via a facile method. The Mag@ZnO–Co3O4 composite was characterized through a vibrating sample magnetometer, N2 adsorption analysis, Fourier transform infrared spectroscopy, powder X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy analyses. The structural analysis showed that the as-prepared microsphere possessed a mean diameter of 150 nm, a bimetal oxide shell thickness of ∼10.0 nm, and a magnetic core, which endowed it with good dispersibility, strong magnetism, and excellent adsorption property for oxytetracycline (OTC). Several experimental conditions, such as solution pH, adsorption time, OTC concentration, and ionic strength were systematically investigated. The Mag@ZnO–Co3O4 composite exhibited a fast adsorption rate, that is, the equilibrium was reached within 90 min, when the concentration of OTC was between 10 and 30 mg/L. The composite showed favorable performance for the adsorption of OTC in the pH range 5–9. According to the adsorption isotherms and kinetics, the removal of OTC was efficient and obeyed the pseudo-second-order rate equation and Langmuir adsorption model.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Jie Zhao,Dequan Zhou,Qiang He,Jian Zhang,Binghua Yao
Piezoelectric catalysis is a recently developed eco-friendly approach for the treatment of pollutant. In this study, a piezoelectric catalytic system of manganese indium sulphide (MnIn 2 S 4 ) was constructed for eliminating oxytetracycline (OTC) residues. X-ray diffraction and Scanning electron microscopy showed that MnIn 2 S 4 microspheres with a grain size of 3–5 μm could be hydrothermally produced. Brunauer–Emmett–Teller analysis showed that the specific surface area of the MnIn 2 S 4 sample was 26.6 m 2 ·g −1 , and the average pore size was 20.2 nm. The electrochemical performance test showed that the piezoelectric response current of the MnIn 2 S 4 sample was 0.35 × 10 −6 A. Using OTC as a degradation model, the piezoelectric catalytic performance of MnIn 2 S 4 was explored. The results showed that the maximum degradation efficiency of the OTC could reach 82.2 % after 60 min while the piezoelectric power was 455 W, the pH of the reaction system was 4, the OTC concentration was 0.02 mM, and the MnIn 2 S 4 dosage was 1.4 g·L −1 . During the piezoelectric catalytic process, the main active species were identified as h + , 1 O 2 , and •OH. Meanwhile, eight intermediate products of OTC and three possible degradation pathways were found. This study is important for exploring the application of sulfide-based piezoelectric catalytic materials in wastewater treatment.
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FOOD CHEMISTRY
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2025
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IF 9.8
Aying Wen,Kexin Chi,Yuhang Du,Shaofeng Yuan,Hang Yu,Yahui Guo,Weirong Yao
This work systematically investigated the effect of casein on the thermal transformation behavior of oxytetracycline (OTC). Fluorescence quenching and isothermal titration calorimetry experiments confirmed that OTC binds spontaneously to casein via non-covalent interactions. The -N(CH 3 ) 2 group in OTC was identified as the primary binding site. Casein-bound OTC was prepared using a combination of dialysis and ultrafiltration. During thermal treatment, the degradation of free OTC followed zero-order kinetics, whereas casein-bound OTC adhered to first-order kinetics. Seven identical thermal transformation products were identified, but the quantities of these products varied significantly depending on the existing form of OTC molecule. The binding of casein weakened the reactivity of the -N(CH 3 ) 2 group while enhancing the reactivity of degradation sites on the adjacent ring, resulting in decreased production of three lower-toxic products and increased production of four higher-toxicity products. Cytotoxicity assays revealed that heating increased the overall toxicity of OTC, particularly in its bound form.
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Journal of Cleaner Production
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2024
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IF 9.7
Linya Yi,Shuyan Chen,Yuancai Chen
Bio-remediation are low-cost and environmentally friendly, but microbial enzymes tend to lose their activity when treated antibiotic contaminants due to its high toxicity. In this study, Bacillus megaterium Y-4 was demonstrated to in situ synthesize Pd 0 @cells, and detoxify oxytetracycline (OTC) through enhancing electron transport chain via Pd 0 -dependent F O F 1 -ATPase (proton pumps). Toxicity analyses showed that increasing Pd 0 loading significantly reduced acute and chronic bio-toxicity as well as ecological risk of OTC effluent, as evidenced by the promoting cellular response to oxidative stress with increasing enzymes GSH-Px and IDH activities (4.24 and 1.20-fold). Electrochemical (I-t, LSV, DPV and EDC) showed that the incorporated bio-Pd 0 mainly promoted FDH/Hase-based short chain (gradually took precedence over CoQ-based long chain), diverting OTC extracellular degradation to markedly detoxify OTC to cell. Inhibition (DCCD and TBA) assays and structural equation modelling indicated that bio-Pd 0 upregulated ATP and NADH synthesis. It also acted as transmembrane F O F 1 -ATPase proton pump, which enabled the backward of protons out of the restriction of PMF , eventually maximizing the energy utilization. This study sheds new insights into the detoxification of antibiotics by bio-nanoparticles through proton transmembrane transfer/redistribution.
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OPTICAL MATERIALS
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2024
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IF 3.8
Jinghua Liu,Jing Liu,Bining Xue,Runqiang Yu
This study presents a visible light-driven composite photocatalyst based on an improved ZrO 2 for the removal of oxytetracycline (OTC) from mariculture wastewater. The ZP composite photocatalyst was prepared by co-precipitation and characterized in detail using X-ray diffraction, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and ultraviolet–visible diffuse reflectance spectroscopy methods. It was observed that the incorporation of Pr 6 O 11 resulted in a notable increase in the specific surface area of the ZP composite photocatalyst. Furthermore, the enhanced ZP composite photocatalyst exhibited a band gap width of 2.41 eV and a broad spectral utilization range extending up to 685 nm. Meanwhile, 1.0 g/L of ZP 0.3 composite photocatalyst demonstrated a removal rate of up to 83.25 % for 15 mg/L of OTC at pH 8. The illumination time exhibited the most significant impact on the OTC removal rate. The findings of this study indicate that ZP composite photocatalyst exhibits excellent photocatalytic efficacy and holds considerable promise for the remediation of OTC pollution in mariculture wastewater.
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2025
·Vol. 26
·期 16
·7751
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IF 4.9
Jian Feng,Xiaohui Li,Xia Ran,Li Wang,Bo Xiao,Rong Li,Guangwei Feng
Fenton oxidation technology utilizing hydrogen peroxide is recognized as an effective method for producing reactive oxygen species (ROS) to facilitate the degradation of antibiotics. However, the requirement for strongly acidic conditions during this process significantly restricts its broader applicability. In this study, we synthesized black phosphorus (BP) nanosheets by exposing the {010} crystal planes and then constructed a 0D/2D BP/Bi2MoO6(PBMO) heterojunction to function as a Fenton catalyst. The PBMO-75 heterojunction exhibited a remarkable increase in photo-Fenton catalytic activity towards oxytetracycline (OTC) under neutral conditions, achieving catalytic efficiencies that were 20 and 8 times greater than those of BP and Bi2MoO6(BMO), respectively. This can be attributed to its strong absorption of visible light, the establishment of an internal electric field (IEF) at the interface, and the implementation of a Z-scheme catalytic mechanism. Additionally, the photo-Fenton system was further improved in OTC degradation through the continuous conversion of Mo6+/Mo5+under visible light irradiation in conjunction with H2O2. Based on ERS, XPS, and active species trapping experiments, we propose a Z-scheme charge transfer mechanism for PBMO. This research offers compelling evidence that 0D/2D Z-scheme heterojunctions are promising candidates for the photo-Fenton treatment of antibiotic contaminants.
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MICROCHIMICA ACTA
·
2023
·Vol. 190
·期 5
·1-11
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IF 5.7
Shen Yuru,Sun Chenglong,Chen Mingjian,Du Yun,Cheng Jun,Li Yunlong,Xie Qingji
A new BiVO 4 -carboxylated graphene (cG)-WO 3 Z-scheme heterojunction was constructed on a fluorine-doped tin oxide (FTO) substrate electrode by ultrasonic mixing and cast-coating for determination of oxytetracycline (OTC). Since cG can absorb visible light and well match with the energy levels of WO 3 and BiVO 4 to promote the charge separation and transfer, the photocurrent on the BiVO 4 -cG-WO 3 /FTO photoelectrode is 4.4 times that on the control BiVO 4 -WO 3 /FTO photoelectrode. An amino-functionalized OTC aptamer was fixed on the BiVO 4 -cG-WO 3 /FTO photoelectrode by the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide mediated amide reaction, and then hexaammonium ruthenium(III) (Ru(NH 3 ) 6 3+ ) was attached to the OTC aptamer to increase the photocurrent response to the OTC binding. Under the optimized conditions, the photocurrent on the BiVO 4 -cG-WO 3 /FTO photoelectrode at 0 V vs SCE was linear with the common logarithm of OTC concentration from 0.01 nM to 500 nM, with a limit of detection of 3.1 pM ( S / N = 3). Satisfactory recovery results were obtained in the analysis of real water samples. Graphical abstract
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Xun Han,Junkai Pei,Yan Wang,Yongyan Sun,Fei Zheng
Due to excellent antibacterial properties, silver nanoparticles (AgNPs) have been widely used as a potential alternative to antibiotics in livestock farming, agricultural disinfection, and medical materials. Consequently, excess AgNPs are released into the soil, co-occurring with other antibiotics, and forming a combined contamination. However, effects of combined contamination with AgNPs and oxytetracycline (OTC) on microbial communities across different trophic levels within the soil micro-food web remain poorly understood. In this study, we systematically compared the differential responses of soil and nematode gut microbiomes using high-throughput sequencing under single and combined contamination (Control, AgNPs, OTC, and combined AgNPs+OTC). The results revealed systematic trophic-level differentiation between soil and nematode gut bacterial community in terms of diversity, community structure, assembly mechanisms, and functional phenotypes. Both communities were dominated by stochastic processes, but nematode gut bacterial community was more strongly influenced by deterministic processes and exhibited higher stability. Pollutant exposure induced pronounced trophic decoupling: soil bacterial community remained structurally stable, whereas nematode gut community underwent significant compositional reassembly ( p = 0.031) without a change in alpha diversity, indicating a species replacement pattern. AgNPs treatment enriched Escherichia-Shigella , while OTC and co-contamination enriched the potential degrader genera Pontibacter , Sphingomonas , and Sphingobium . Cross-kingdom network analysis showed that co-contamination strengthened network modularity (clustering coefficient 0.84, modularity 53), highlighting the role of shared ASVs as cross-kingdom bridges. This study introduces the concept of pollution-induced trophic decoupling, demonstrating that the impact of co-contamination on adjacent trophic levels is not a simple transmission of effects but rather a systematic decoupling of structure, function, and assembly mechanisms, thereby providing new perspectives for multi-trophic ecological risk assessment of combined pollution.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Huimin Li,Wangjing Zhai,Xueke Liu,Donghui Liu,Peng Wang,Zhiqiang Zhou
The frequent detection of oxytetracycline in agricultural soils may alter the environmental behavior and risks of coexisting pesticides. This study investigated the influence of oxytetracycline on the degradation and phytotoxicity of pendimethalin in a soil–soybean system. Results demonstrated that oxytetracycline at 50 mg/kg prolonged the half-life of pendimethalin in soil from 33.0 days to 40.8 days. Coexposure inhibited the activities of urease, dehydrogenase, and catalase in the soil. While pendimethalin alone showed no adverse effects on soybean growth, coexposure with oxytetracycline induced pronounced growth inhibition and enhanced oxidative stress. Ecological risk assessment confirmed significantly elevated risks to earthworms. Further analysis revealed suppressed CYP450 and GST activities in both soil and soybean plants, with more pronounced reductions observed in the plants. These findings indicate that the coexistence of antibiotic–herbicide can enhance herbicide persistence and increase environmental contamination risks.
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