MINERALS ENGINEERING
·
2025
·
IF 5
Yunzhen Hu,Kangjing Wu,Shuai Wang,Zhanfang Cao,Xin Ma,Hong Zhong
The flotation separation of chalcopyrite (CuFeS 2 ) and molybdenite (MoS 2 ) is hindered by similar surface properties, typically requiring environmentally detrimental high-alkalinity conditions (pH > 10.0). Herein, we introduce 3,4,5-Trihydroxy-N,N-bis(2-hydroxyethyl)benzamide (TBHB), a gallic acid-derived surfactant, as an efficient selective depressant for chalcopyrite under near-neutral conditions (pH 6.0–8.0). Notably, chalcopyrite recovery is reactivatable via pH adjustment (pH > 9.0). Micro-flotation tests demonstrated TBHB's high selectivity, achieving 91.81% molybdenite recovery while suppressing chalcopyrite recovery to 12.61% at pH 8.0, outperforming conventional depressants (e.g., sodium thioglycolate). Artificial mixed minerals flotation further confirmed TBHB's efficacy, with a dosage of 75 mg/L achieving Mo recovery exceeding 80%, Cu recovery below 20%. Mechanistic investigations revealed TBHB chemisorbs on the chalcopyrite surface via phenolic hydroxyl-Fe coordination, supported by high adsorption capacity (> 1.6 mg/m 2 ), reduced hydrophobicity, and FTIR/XPS analyses, which showed Fe–O bond formation and red-shifted C=O/benzene ring vibrations. Zeta potential measurements affirmed pH-dependent adsorption/desorption. DFT calculations confirmed spontaneous adsorption ( ΔE = −1.8206 eV) and short O–Fe bond (1.99 Å), verifying Fe-site affinity. Conversely, TBHB showed negligible adsorption on the molybdenite surface, with values below 0.4 mg/m 2 and a contact angle of approximately 70°, preserving its floatability. This work establishes TBHB as a sustainable alternative for Cu-Mo separation, eliminating high-alkalinity requirements while advancing green reagent design through integrated experimental and computational insights.
研究领域:
矿物加工工程
·
表面化学
·
环境友好技术
·
计算化学
·
资源回收
✓ 已验证
产品关联
DOI
高影响因子
Nanoscale
·
2018
·Vol. 10
·期 26
·12788-12796
·
IF 7.233
Shuang E,Quan-Xing Mao,Xiao-Li Yuan,Xiao-Lei Kong,Xu-Wei Chen,Jian-Hua Wang
Organelles play crucial roles in cellular activities and the functions of organelles are related greatly to the pH values, therefore, the bio-imaging of targeted organelles and their related pH sensing is of great importance in biological assays. Herein we report the fluorescence imaging of specific organelles, i.e., lysosomes and endoplasmic reticulum, and their pH sensing with surface regulated carbon dots (CDs). Carbon dots functionalized with amine groups (ACDs) are first prepared by hydrothermal treatment of citric acid and urea, and then laurylamine functionalized CDs (LCDs) are obtained via the conjugation of laurylamine with ACDs. The as-prepared ACDs and LCDs provide clear and bright imaging results for the lysosome and endoplasmic reticulum, respectively. The subcellular targeting features of the two CDs are attributed to their surface chemistries and cellular uptake pathways. Moreover, both the CDs are pH responsive within a certain pH range, i.e., 4.0–5.4 for ACDs and 6.2–7.2 for LCDs. The ACDs and LCDs are thus successfully applied to visualize the pH fluctuations of the lysosome and endoplasmic reticulum in MCF-7 cells.
研究领域:
细胞生物学
·
生物医学工程
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 10
·1-9
·
IF 5.705
Wang Lude,Chen Yang
A colorimetric and fluorescent pH probe was designed by doping carbon dots (C-dots) with Eu(III), Tb(III) and 2,6-pyridinedicarboxylic acid (DPA). The resulting nanoparticles were applied as fluorescent indicators for pH values (best detected at excitation/emission wavelengths of 272/545, 614 nm). The pH induced optical effects are due to pH induced variations in energy transfer. The fluorescence of the probe shows a continuous color variation, and a linear change with pH values in the range from 3.0 to 10.0 can be established by using a Commission Internationale de L’Eclairage (CIE) chromaticity diagram. This new kind of pH nanoprobe is more accurate than previously reported pH indicator probes because the pH value can be calculated by using chromaticity coordinates that only depend on the chromaticity. The pH nanoprobe was applied to visualize pH values in human breast adenocarcinoma cells (MCF-7).
Carbon dots modified with Eu(III) and Tb(III) complexes of 2,6-pyridinedicarboxylic acid (DPA) were prepared. The doped carbon dots were used as a pH-sensitive nanosensor. The fluorescence chromaticity of the nanoparticles changes with the variation of pH value.
研究领域:
生物化学
·
材料科学
·
医学检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Deyan Gong,Lu Liu,Ziwen Xiao,Zhuonan Yang,Yaoyu Hu,Taikui Sheng,Yajing Liu,Zhaohua Miao,Zhengbao Zha
Nanozymes have made great achievements in the research of tumor therapy. However, due to the complex tumor microenvironment, the catalytic activity and biosafety of nanozymes are limited. High catalytic efficiency is a relentless pursuit for the preparation of high-performance nanozymes. Dimensional reduction from 3D nanoscale metal–organic frameworks (nMOFs) to 2D nanoscale metal–organic layers (nMOLs) increases the encounters frequency of nanozymes and substrate, which facilitates the diffusion of reactive oxygen species (ROS) from nMOLs, thus significantly improving the effectiveness of chemodynamic therapy. In this study, He@Ce-BTC nMOF and He@Ce-BTB nMOL based on Ce 6 SBUs were synthesized by solvothermal reaction. Compared with the 3D nMOFs, the 2D nanozymes He@Ce-BTB nMOL possessed enhanced ROS catalytic efficiency, were able to be activated by the tumor acidic microenvironment with the polymerase mimetic activities (CAT, POD, GSH-OXD) that enhances the lipid peroxidation process and accelerates the process of ferroptosis thereby killing tumor cells. In addition, He@Ce-BTB does not affect normal tissue cells, thus avoiding diffusion-induced side effects. He@Ce-BTB has shown excellent therapeutic effects in vitro and in vivo , which indicates its potential for clinical application, and is expected to become a new generation of drugs for the treatment of tumors.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2021
·
IF 2.646
Qiang Li,Dongsheng Fu,Jie Zhang,Tianyang Li,Huifang Wang,Wenjuan Hou,Baolong Niu,Ruijie Guo,Yiming Liu
Encapsulation of therapeutic molecules into nanocarrier is an extensively explored strategy to treat cancer more effectively. In this study, pH-responsive targeting dual-agent delivery nanoparticles were prepared, into which hydrophilic doxorubicin hydrochloride (DOX) and hydrophobic curcumin (CUR) were entrapped. Tyrosine (Tyr) was grafted onto poly(aspartic acid) (PASP) to produce PASP-Tyr, the following reaction between hyaluronic acid (HA) and ethylenediamine (EDA) modified PASP-Tyr formed the nanocarrier HA-EDA-PASP-Tyr (HEPT), and the loading capacity was up to 50.9 ± 4.3% for CUR and 26.0 ± 1.9% for DOX. The spherical HEPT with the mean particle size of 142.9 ± 11.4 nm expanded and deformed into petaloid pattern with an increased size of about 2 µm when triggered by the acidic microenvironment. In vitro anticancer activity evaluation revealed that the co-loaded (DOX+CUR)@HEPT nanoparticles presented higher cytotoxicity against HCT-116 cells compared with that of the free combination of (DOX+CUR). Confocal laser scanning microscopy observation indicated that HEPT carrier promoted cellular uptake of drugs by means of active targeting capacity of HA ligand. With high loading capacity and tailored carrier structure, the nanoparticles formulations may offer a new strategy for cancer treatment.
研究领域:
药剂学
·
肿瘤学
·
生物材料
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Yanling Feng,Yufei Liu,Chen Su,Xinghu Ji,Zhike He
Silicon nanodots (SiNDs) are currently appealing to extensive studies due to their low toxicity and unique optical and electrical properties. In this work, we obtained label-free SiNDs via a facile hydrothermal method. The approach offers advantages in terms of cheap reactants, easy operation and a short time. The quantum yield (QY) of the SiNDs is up to 32.8%, and the as-prepared nanoparticles exhibit strong fluorescence (FL), higher photostability and obviously longer FL lifetime. More importantly, these label-free SiNDs can be used as a highly sensitive pH sensor, which FL respond rapidly to pH fluctuations and reveal a good linear relationship. Also, a superior pH-reversibility was demonstrated. Different salt ions show a little influence on the pH-responsive behavior. The pH of real water samples were tested on the basis of the proposed SiNDs sensor and the results are satisfactory. Further, traditional SiNDs with Si H or Si C surfaces make them less water-soluble or sensitive to the pH. Whereas, our SiNDs feature amino-terminated surface and these amino groups are conducive to the pH sensitivity. In a word, this new, cheap, low-toxic, and effective fluorescent pH sensor based on label-free SiNDs would be a promising candidate in biological field.
研究领域:
生物化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2023
·
IF 17.1
Yiyang Guo,Yubin Ma,Xin Chen,Min Li,Xuehu Ma,Gang Cheng,Changying Xue,Yi Y. Zuo,Bingbing Sun
The penetration behavior of nanoparticles in mucous depends on physicochemical properties of the nanoparticles and the mucus microenvironment, due to particle–mucin interactions and the presence of the mucin mesh space filtration effect. To date, it is still unclear how the surface properties of nanoparticles influence their mucus penetration behaviors in various physiological and pathophysiological conditions. In this study, we have prepared a comprehensive library of amine-, carboxyl-, and PEG-modified silica nanoparticles (SNPs) with controlled surface ligand densities. Using multiple particle tracking, we have studied the mechanism responsible for the mucus penetration behaviors of these SNPs. It was found that PEG- and amine-modified SNPs exhibited pH-independent immobilization under iso-density conditions, while carboxyl-modified SNPs exhibited enhanced movement only in weakly alkaline mucus. Biophysical characterizations demonstrated that amine- and carboxyl-modified SNPs were trapped in mucus due to electrostatic interactions and hydrogen bonding with mucin. In contrast, high-density PEGylated surface formed a brush conformation that shields particle–mucin interactions. We have further investigated the surface property-dependent mucus penetration behavior using a murine airway distribution model. This study provides insights for designing efficient transmucosal nanocarriers for prevention and treatment of pulmonary diseases.
研究领域:
生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2020
·
IF 4.872
Teng Xu,Feng Nan,Xiaofeng Jiang,Yuling Tang,Yunhang Zeng,Wenhua Zhang,Bi Shi
This work was conducted to study the effect of soil pH (4.0, 6.0, and 8.0) on the transport, fractionation, and oxidation of trivalent chromium [Cr(III)]. Variation in pH altered soil chemical and mineralogical properties such as zeta potential, cation exchange capacity and redox potential of natural soil. Breakthrough curves and batch sorption experiments coupled with fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) analyses demonstrated that the easy mobility of Cr(III) in pH 4.0 soil was dominated by the limited coordination effect. The high retention of Cr(III) in pH 8.0 soil was mainly ascribed to the hydrolysis. Incubation experiments indicated that the proportions of Cr in exchangeable fraction decreased with increasing of soil pH and incubation time, and kinetics analysis revealed that the time dependent transformation was controlled by mass transfer and chemical processes (e.g., hydrolysis, ion association). The XPS confirmed the oxidation of Cr(III) in pH 8.0 soil during the incubation period. Furthermore, the content of toxic hexavalent chromium [Cr(VI)] was positively associated with time and initial concentration of Cr(III) released. These results revealed the hazardousness of Cr(III) in soil contaminated simultaneously by inorganic acid and alkali.
研究领域:
环境科学
·
土壤化学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2020
·
IF 4.845
Yuman Dong,Peng Liu
Efficient approach was established to improve the drug delivery performance of the pH-triggered prodrug nanoparticles by introducing a polycation block as a pH-sensitive gatekeeper. With the help of the poly(2-(diisopropylamino)ethyl methacrylate) (PDPA) block as a pH-sensitive shell gatekeeper, the proposed core-shell-corona PEG 43 - b -PDPA 65 - b -PFPMA 36 -DOX nanoparticles possessed a higher drug release rate in the simulated acidic tumor intracellular micro-environment while a lower premature drug leakage in the simulated weak basic normal physiological medium, compared with the core-shell PEG 43 - b -PFPMA 36 -DOX nanoparticles. The proposed strategy is expected to design high-performance drug delivery systems (DDSs) for tumor treatment, with improved anticancer efficacy but minimized toxic side effects.
研究领域:
药物递送
·
生物材料
·
肿瘤治疗
✓ 已验证
DOI
高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2023
·Vol. 308
·期 11
·2300141
·
IF 3.9
Seojin Jung,Seokhee Chang,Na-Eun Kim,Yoon-Jae Song,Jooyoun Kim
A wound evolves with variable pHs depending on the healing stage, and the maintenance of mild acidic condition can help healing by deterring the formation of a biofilm. Herein, a dual-layer wound dressing with an acid-responsive zeolitic imidazolate framework–8 (ZIF-8) layer and an acid-modulating layer is designed to control the acid-dependent release of therapeutic agents for the improved healing process. The outer dressing layer is coated with curcumin-incorporated ZIF-8, where curcumin and zinc ions are released upon dissociation of ZIF-8 in an acidic condition. The inner layer, a pH modulator, is fabricated by electrospinning polyvinylpyrrolidone with addition of acetic acid. In vitro release test shows that the outer layer dressing attains a considerably higher release of curcumin and Zn 2+ under an acidic condition. Combined with the inner acidic layer, the dual layer dressing exhibits facilitated release of effective agents regardless of environmental pHs, attributed to the proper pH modulation to about 6.5. The anti-oxidant activity of curcumin and antibacterial activity of Zn 2+ are confirmed. The study highlights the novel proof-of-concept design of active wound dressing demonstrating the dual functions of pH regulation and the stimulus-responsive drug delivery.
研究领域:
材料科学
·
生物医学工程
·
药理学
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2016
·
IF 5.583
Xubo Zhao,Xu Jia,Lei Liu,Jin Zeng,Kun Tian,Tingting Zhou,Peng Liu
A versatile folate-receptor-mediated targeting tumor theranostics has been designed for pH/reduction dual-responsive controlled anticancer drug release and pH-modulated fluorescent tumor imaging via facile ionic (pH sensitive) and covalent (reduction responsive) double-cross-linking (DCL) of the folic acid (FA) and Rhodamine 6G modified hyaluronic acid (HA) (FA-HA-Rh 6G). After optimizing the morphology and diameter of the resultant nanoparticles (DCL FA-HA-Rh 6G NPs) via modulating the concentration of the ionic and covalent cross-linking agents, the one with Ca and S contents of 1.70 and 2.84 wt % and an average hydrodynamic diameter of 154 nm was chosen as the desired drug delivery system (DDS) for DOX. They not only had high drug loading capacity and drug encapsulation efficiency (716 ± 34 mg/g and 71.6 ± 3.4%) but also possessed perfect triggered release and strong fluorescence intensity in the stimulated tumor microenvironment. The MTT assay and CLSM analysis revealed that the proposed double-cross-linked HA-based DDS had favorable cytocompatibility and folate-receptor-mediated targeting functionality to the HeLa cells and could obviously enhance the anticancer efficiency of DOX. The integration of the pH and reduction dual-responsiveness, folate-receptor-mediated targeting functionality, and pH-dependent fluorescence intensity into the biodegradable and biocompatible HA nanoparticles make the DCL FA-HA-Rh 6G NPs significant potential for future visualized chemotherapy of cancers.
研究领域:
生物材料
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Yingna Bi,Huixia Di,Erzao Zeng,Qiang Li,Wenshuai Li,Jie Yang,Dingbin Liu
Intracellular pH is an important parameter that is highly associated with diverse physiological processes. The reliable measurement of pH values inside cells remains a formidable challenge because of the complexity of cytoplasm. Herein, we report a robust Prussian blue (PB)-caged pH-responsive surface-enhanced Raman scattering (SERS) probe for precisely mapping the dynamic pH values in live cells. The PB shell has a subnanoscale porous structure that allows only very small biospecies such as H+ or OH– to pass freely through the shell and react with the encased pH-responsive SERS probe, while physically resisting the entry of large biomolecules. This probe achieved unmatched detection linearity (R2 > 0.999) for pH measurements in diverse complex biological samples. Moreover, the nitrile (C≡N) in PB shows a sharp band in the cellular Raman-silent region, which serves as a background-free internal standard for accurate profiling of the probe distribution inside the cells. We applied the proposed probe to monitor the dynamic pH changes during cellular autophagy induced by different stimuli and thereby demonstrated that the PB-caged probe can reliably quantify subtle intracellular pH variations, providing an effective tool for revealing the relationship between abnormal intracellular pH and cellular functions.
研究领域:
生物医学工程
·
分析化学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）