JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 9
·379
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IF 3.5
Li Hao,Ma Xinyi,Chen Jian,Li Xiaohong,Vishneuski Kanstantsin,Wang Shun,Wu Yadong,Jin Huile
This study synthesizes dendritic mesoporous silica nanoparticles (DMSN) via an anion-assisted templating method, utilizing sheet-like micelles formed from anion-cation complexes to direct silica condensation, followed by calcination. The obtained high-surface-area DMSN were incorporated as a filler into fluororubber (FKM) to fabricate FKM/DMSN composites. The extensive interface and mesoporous structure of DMSN provide sufficient areas for polymer chain adsorption, enhancing mechanical interlocking with the FKM matrix, significantly improving the composite’s properties. At an optimal loading of 10 phr, the composite demonstrates a tensile strength of 15.7 MPa, elongation at break of 300%, modulus at 100% strain of 3.8 MPa, and Shore A hardness of 68, representing increases of 292%, 36%, 217%, and 28%, respectively, over pure FKM. Additionally, the composite exhibits enhanced thermal stability with an initial decomposition temperature of 440 ℃, improved accelerated thermal transport, and retained electrical insulation alongside stable vulcanization characteristics. These superior mechanical and thermal properties make the DMSN-reinforced FKM composite a promising material for advanced sealing applications in aerospace, automotive, and energy sectors.
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ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
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2026
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IF 3.1
Ho Thanh Gia-Thien,Nguyen Phung Anh,Tran-Pham Phuong Khanh,Phan Hong Phuong,Pham-Nguyen Ai Vi,Nguyen Thi Thu Thuy,Do Ba Long,Nguyen Duc Quy,Le Thanh Quang,Pham Thi Thuy Phuong,Van Nguyen Thi Thuy,Nguyen Tri
Developing fully sustainable and recyclable catalysts from agricultural waste remains a major challenge for advanced wastewater treatment. Herein, we report an integrated, zero-waste strategy to fabricate a hierarchically structured Ag/ceria-cellulose porous catalyst derived exclusively from purple Passiflora edulis peel waste. Phytochemical-rich peel extracts were employed as green reducing and stabilizing agents for the in situ synthesis of Ag nanoparticles, while the residual cellulose-rich biomass was converted into a three-dimensional porous aerogel via microwave-assisted extraction and freeze-drying. Incorporation of ceria nanorods endowed the aerogel with abundant oxygen vacancies and strong metal–support interactions, effectively suppressing Ag nanoparticle agglomeration and promoting interfacial electron transfer. The optimized Ag/ceria-cellulose aerogel exhibited uniformly dispersed Ag nanoparticles with an average size of 7.84 nm. Under mild conditions (0.5 wt% Ag loading, catalyst dosage of 0.5 g L −1 , and MO/NaBH 4 molar ratio of 1/200), over 95% of methyl orange was reduced within 30 min, following pseudo-first-order kinetics with an apparent rate constant of 0.14 min −1 . Owing to its monolithic and mechanically robust architecture, the aerogel catalyst could be readily recovered by simple filtration and retained more than 75% of its initial activity after five consecutive cycles. The superior catalytic performance and durability originate from the synergistic interplay between Ag nanoparticles, oxygen vacancy-rich ceria nanorods, and the interconnected cellulose aerogel matrix, which collectively enhance active-site accessibility, charge transfer efficiency, and structural stability. This work demonstrates a scalable and circular pathway for transforming passion fruit peel waste into high-value, reusable catalysts for wastewater remediation.
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NEUROCHEMICAL RESEARCH
·
2026
·Vol. 51
·期 5
·257
·
IF 4.5
Cao Zhi,Yin Linting,Zhang Xinyong,Hong Enhui,Du Jiansheng,Liang Rui,Tang Youjia,Zhang Guofeng
Spontaneous cerebral hemorrhage (sICH) is one of the cerebrovascular diseases with the highest mortality rate. MicroRNAs (miRNAs) are implicated in the regulation of various pathological processes, however, the specific function of miR-642b-3p in sICH remains unclear. Serum miR-642b-3p levels of sICH patients was determined. A thrombin-induced human brain microvascular endothelial cell (hBMECs) injury model was established. Cell viability, apoptosis, inflammatory factors, and related protein expression were assessed using CCK-8 assay, flow cytometry, ELISA, and Western blot. The targeting relationship between miR-642b-3p and CCNA2 was validated via a dual-luciferase reporter assay. MiR-642b-3p in the serum of ICH patients was significantly increased. Following thrombin induction, miR-642b-3p was upregulated in hBMECs, accompanied by decreased cell viability, increased apoptosis, elevated production of inflammatory factors, upregulated expression of pro-apoptotic proteins (Bax and cleaved caspase-3), and downregulated expression of anti-apoptotic protein (Bcl-2). Additionally, the protein levels of tight junction markers ZO-1 and occludin were markedly decreased. Notably, inhibition of miR-642b-3p significantly reversed these thrombin-induced changes and alleviated cell damage. Mechanistically, CCNA2was confirmed as a direct downstream target gene of miR-642b-3p. MiR-642b-3p is upregulated in sICH and mediates thrombin-induced endothelial cell injury, at least in part, by targeting CCNA2. These findings suggest that the miR-642b-3p/CCNA2 axis may represent a potential mechanistic pathway involved in ICH-induced blood-brain barrier disruption.
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JOM
·
2026
·
IF 2.3
Xiang Zhe,Xu Chengjin,Yu Haiyin,Wang Zhimei,Sun Guoxin,Cui Yu,Peng Xiujing
Titanium white waste acid contains economically recoverable concentrations of scandium (25 mg/L); however, the high acid content and presence of multiple impurity ions present significant challenges for scandium separation. In this study, a novel monoalkyl phosphate extractant, PC68, consisting of 1-hexadecyl phosphate and 1-octadecyl phosphate, was synthesized. The effects of extraction time, sulfuric acid concentration, and temperature on scandium extraction were systematically investigated using a simulated titanium white waste acid solution. The results demonstrated that equilibrium was reached within 50 min at 298 K, and that the extraction efficiency of scandium with 0.1 mol/L PC68 was 99%. Analytical techniques, including the Equimolar Series Method, FT-IR, and XPS, confirmed that PC68 extracts scandium through coordination with P-O − and P=O groups. The separation performance of scandium from titanium white waste acid was evaluated, yielding high separation factors of 1093 for Sc/Fe and 733 for Sc/Mn, which demonstrates excellent separation efficiency. The addition of 1% H 2 O 2 followed by three-stage countercurrent extraction enabled effective separation of scandium and titanium. These results provide new insights and practical approaches for scandium separation from titanium white waste acid.
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CELL BIOLOGY AND TOXICOLOGY
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2026
·
IF 5.7
Zhao Bingbing,Zhang Zhengwei,Li Xiaoxue,Dong Shiyun,Zhong Xin,Li Zhitao,Jin Ye,Bai Yun,Wei Can
Liver fibrosis represents a major unmet clinical challenge, and induction of hepatic stellate cell (HSCs) senescence has emerged as a promising therapeutic strategy to halt or reverse fibrotic progression. PPARγ is a key regulator of HSCs quiescence; however, the downstream molecular mechanisms mediating its pro-senescence effects remain poorly defined. Here, we demonstrate that PPARγ expression is markedly reduced in a CCl₄-induced mouse liver fibrosis model and that its restoration drives HSC inactivation and senescence. Through integrated bioinformatics analysis and functional validation in PPARγ-overexpressing HSC-T6 cells, we identified leukemia inhibitory factor receptor (LIFR) as a direct transcriptional target of PPARγ. Mechanistically, PPARγ upregulates LIFR to suppress STAT3 phosphorylation, thereby downregulating fibrosis markers CO Ⅰ and α-SMA, elevating P21 and γ-H2A.X, and reducing CCND1. Crucially, LIFR knockdown abolished all PPARγ-mediated effects, confirming its indispensable role in this axis. Furthermore, combined treatment with the STAT3 inhibitor WP1066 synergistically enhanced PPARγ-driven HSC senescence in a LIFR-dependent manner. These findings establish a PPARγ-LIFR-STAT3 signaling cascade as a critical regulator of HSCs fate, and suggest that pharmacological activation of this axis represents a tractable approach for fibrosis resolution.
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PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
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2026
·
IF 3.5
Wu Xingjie,Zhu Guihua,Guo Qianqian,Chen Ying,Wang Yu-E,Yang Naijia,Mei Ju,Shen Xiangchun,Tao Ling
Lipopolysaccharide (LPS) contamination in biopharmaceuticals poses severe clinical risks, yet its detection and removal remain enduring challenges. Conventional detection methods are frequently hindered by low endotoxin recovery. Established clearance techniques often compromise the integrity of sensitive biologics or introduce secondary contaminants. To overcome these constraints, we developed an integrated platform for simultaneous LPS detection and removal. This system employs aptamer-conjugated micelles that encapsulate an aggregation-induced emission photosensitizer with high reactive oxygen species quantum yield. The surface aptamers facilitate specific LPS capture, followed by efficient light-triggered oxidative degradation. The capture-first design concentrates LPS near the photosensitizer-loaded core to maximize degradation efficiency. When validated in endotoxin-contaminated insulin solutions, the platform markedly reduced the ELISA-detectable LPS signal under the tested conditions, without measurably impairing insulin-induced glucose uptake in 3T3-L1 adipocytes in this preliminary assay. This biocompatible strategy bridges the gap between LPS monitoring and safe decontamination.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
·
IF 4.1
Zhang Bing Ying,Liu A. Fang,Zhou Cong,Kang Tian Tai,Xu Yu Fang,Guo Yao Hao,Wang Li,Wan Fu
An environmentally friendly ultrasound-assisted liquid-liquid microextraction method based on the in situ formation of a hydrophobic deep eutectic solvent (DES) was developed for monitoring seven polychlorinated biphenyl (PCB) congeners as residues in and migrants from food contact paper. The extraction phase was generated in situ from tetrapropylammonium chloride and 1-octanol (molar ratio 1:3), followed by analyte quantification using high-performance liquid chromatography with diode-array detection (HPLC-DAD). Optimization of the parameters affecting extraction efficiency was performed. Under optimal conditions, the method exhibited good linearity and sensitivity. For residual PCB analysis, the limit of quantification (LOQ) was 0.093–0.11 mg/kg; relative recoveries ranged between 89 and 108%; and relative standard deviations were 4–8%. For migration studies, the LOQ was in the range of 0.47–0.53 μg/L, relative recoveries ranged between 90 and 110%, and relative standard deviations were under 9%. The developed method’s intra-day and inter-day relative standard deviations were 1.9–2.7% and 2.4–3.6%, respectively. The developed approach offers high extraction efficiency, operational simplicity, and environmental compatibility, demonstrating considerable promise for routine monitoring of PCBs in food contact paper materials. Graphical abstract
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Nature Communications
·
2026
·
IF 18.1
Ma Yiyuan,Yin Zhuoyu,Chang Yide,Meng Qi,Qi Qi,Hua Yingkai,Yu Jingya,Zhan Zhen,Deng Canbin,Zhang Zeyu,Wu Mengcheng,Cheung Chi Fai,Huang Jiaqiang,Wang Yanming,Kim Yoonseob,Aurbach Doron,Xu Zheng-Long
Rechargeable calcium batteries are promising for next-generation energy storage devices due to the high crustal abundance of calcium (Ca) and the high-capacity and dendrite-free nature of Ca metal. However, their implementation is hindered by the lack of high-power and high-capacity positive electrodes, largely due to sluggish Ca 2+ diffusion in inorganic hosts and limited active-site utilization in organic electrodes. Here we design a series of covalent organic frameworks incorporating different quinone units to construct carbonyl-staggered channels that accelerate Ca 2+ hopping, enhance accessibility of deep-layer active sites even at high rates, and facilitate electronic charge transport through in situ conjugation reconstruction at ortho-carbonyl sites during repeated Ca 2+ insertion. These combined effects contribute to fast charge-transfer kinetics, endowing the optimized heterogeneous framework with high-rate capability (56.4% capacity retention from 0.05 A g −1 to 2 A g −1 ) and long cyclability (71.7% capacity retention after 5,000 cycles at 2 A g −1 ), with further validation in Ca-metal pouch cells. This work highlights carbonyl staggering as a molecular design strategy for regulating Ca-ion transport and improving active-site utilization in calcium-organic batteries.
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MOLECULAR DIVERSITY
·
2026
·
IF 4.3
Yang Yangyang,Sun Dezhong,Jia Qingyun,Zhu Bing,Lv Huaiqing,Che Fengyuan
Excitotoxicity is a core pathological mechanism underlying various neurological disorders, including depression. It is primarily driven by the overactivation of NMDA receptors and disruption of calcium homeostasis. However, effective therapeutic interventions targeting this process remain limited. In this study, aloe-emodin was shown to reverse NMDA-induced reduction in cell viability, apoptosis, and calcium overload in a dose-dependent manner, while also attenuating NMDA-induced autophosphorylation of CaMKII. In a chronic unpredictable mild stress (CUMS) model, aloe-emodin significantly ameliorated depression-like behaviors, suppressed inflammatory responses and oxidative stress, and downregulated the expression of cleaved-PARP. By conducting biotin pull-down coupled with liquid chromatography-tandem mass spectrometry (LC–MS/MS) analysis, cellular thermal shift assay (CETSA), drug affinity responsive target stability (DARTS) analysis, and surface plasmon resonance (SPR) analysis, RANBP9 was identified as a direct molecular target of aloe-emodin, with a binding affinity (KD) of 716 nM. Molecular docking and molecular dynamics simulations revealed that aloe-emodin selectively binds to the His332 residue of RANBP9. Aloe-emodin promoted the degradation of RANBP9 via the ubiquitin–proteasome pathway by facilitating the interaction between RANBP9 and the E3 ligase CHIP. After RANBP9 was knocked down, the protective effects of aloe-emodin on cell viability and apoptosis were significantly weakened, confirming that the anti-excitotoxic activity of aloe-emodin is RANBP9-dependent. These findings collectively demonstrate that aloe-emodin is a novel and potent RANBP9-targeting compound with antidepressant activity and suggest that RANBP9 may serve as a promising target for developing antidepressant drugs. Graphical abstract
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npj Science of Food
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2026
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IF 9.7
Shi Xuening,Zhang Huiqian,Zheng Jingying,Wang Juan,Zhao Chao
Sterilization technologies for microorganisms in food are limited by safety and antibiotic residue concerns and resistance, creating an urgent need for novel sterilization methods. Photothermal conversion nanomaterials can rapidly convert near-infrared light into thermal energy, offering fast, efficient, and environmentally friendly sterilization, leading to their increasing application. Herein, we designed and prepared a composite multilayer photothermal nanomaterial (MCOF@Au@PEI NPs), integrating “capture-photothermal sterilization-separation and recycling” functions and achieving rapid and efficient sterilization. The material maintains high photothermal conversion efficiency even after multiple cycles and exhibits excellent biocompatibility. Using Escherichia coli and Staphylococcus aureus as model bacteria in milk and drinking water, the material achieves a 100% bacterial sterilization rate within 435 seconds under irradiation, equivalent to pasteurization. Moreover, the material exhibits potent destructive effects on bacterial biofilms, showing broad application prospects in developing novel nano-photothermal sterilization methods and antibiotic alternative therapies.
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Cell Death & Disease
·
2026
·Vol. 17
·期 1
·750
·
IF 12.2
Luomeng Qian,Ping Chen,Bo Wang,Qing Zhang,Yuan Guo,Jie Cui,Ran Ding,Hongkai Zhang,Sihe Zhang
Sorafenib is a widely used targeting drug for hepatocellular carcinoma (HCC) patients; however, sorafenib resistance poses a significant clinical challenge. Hypoxia and extracellular vesicles (EVs) induce vasculogenic mimicry (VM) which is linked to sorafenib resistance in HCC. Migrasomes (Migs), the newly discovered large EVs, foster HCC malignant phenotypes by facilitating the intercellular transfer of functional molecules. Despite these advancements, the precise mechanism by which Migs cause sorafenib resistance is still unknown. In this study, we found that hypoxia upregulates the Migs release and CD147 expression on Migs surface, which is related to sorafenib resistance in HCC. Further investigations revealed that hypoxia-induced migrasomes (hypo-Migs) induce VM formation, thereby promoting sorafenib resistance in HCC. Notably, hypo-Migs are internalized into HCC cells through macropinocytosis, which depends on the expression of lysophosphatidic acid receptor 6 (LPAR6). Mechanistically, CD147-positive (CD147 + ) hypo-Migs activate the PI3K/AKT/TWIST1 signaling pathway, subsequently inducing VM formation and promoting sorafenib resistance. Importantly, dual blockade of CD147 + -hypo-Migs macropinocytosis and VM formation enhances the sorafenib-killing efficacy to HCC. Conclusively, our findings uncover a novel sorafenib resistance mechanism induced by CD147 + -hypo-Migs, and highlight dual-targeting of macropinocytosis and VM as a promising strategy to overcome the sorafenib resistance in HCC.
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PubMed
高影响因子
International Journal of Peptide Research and Therapeutics
·
2026
·Vol. 32
·期 5
·80
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IF 2.5
Jiang Xinyi,Li Junxiang,Lu Yi,Ni Fangyuan,Li Sen
Purpose Advanced glycation end products (AGEs) and their downstream inflammatory consequences contribute to skin dysfunction and aging-related deterioration. EQ-9 has been identified as a novel functional peptide with anti-aging and skin repair potential. In this study, we investigated the effects of EQ-9 and its two derivatives (EL-6 and ac EL-6) on Methylglyoxal (MGO)-induced glycation and inflammatory damage. Methods We exposed HaCaT cells to MGO to simulate hyperglycemic conditions. The protective effects of these peptides were assessed through measurements of cell viability, migration, CML levels, inflammatory cytokine secretion, RAGE expression, and NF-κB pathway activation. Additionally, TNF-α/IFN-γ were used to induce inflammatory injury and evaluate the anti-inflammatory effectiveness of the peptides. A murine excision wound model was also established to examine the effects of ac EL-6 on skin inflammation, collagen deposition, angiogenesis, and wound healing. Results All three peptides significantly reduced MGO-induced CML generation, downregulated RAGE, inhibited NF-κB activation, attenuated proinflammatory cytokine secretion, alleviated cell damage, and promoted migration. They also mitigated TNF-α/IFN-γ-evoked inflammatory responses via NF-κB suppression. Topical application of ac EL-6 decreased cytokine levels, increased VEGF expression and collagen deposition, and consequently accelerated wound healing in mice. Conclusion Together, these findings identify ac EL-6 as a stabilized lead candidate derived from EQ-9, which exhibits anti-glycation activity and modulates NF-κB-mediated inflammatory signaling in keratinocytes, and demonstrates initial skin-repair potential in vivo. The data support further development of ac EL-6 for skin-directed applications. Graphical
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