iScience
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2024
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IF 4.6
Ke Yang,Shuaining Chai,Helong Song,Sinan Cao,Fangmiao Gao,Chenxuan Zhou,Linwei Li
Esophageal carcinoma (EC) is one of the most common malignant tumors in the world. ECRG4 has been recently discovered to be downregulated in EC. However, the mechanism leading to reduced expression of ECRG4 in esophageal cancer remains obscure. Here, we found that ECRG4 expression was significantly downregulated in EC tissues and cell lines. ECRG4 overexpression led to a significant decrease in proliferation in vitro and in vivo . Mechanistically, ECRG4 can activate IRF3/IFN-γ pathway. IFN-γ can promote the expression of miR-29b. MiR-29b reduces the expression of DNMT1. DNMT1 may affect the expression of ECRG4 by affecting the methylation of ECRG4 promoter. These results reveal ECRG4/IRF3/IFN-γ/miR-29b/DNMT1 positive feedback loop in esophageal carcinoma cells, which may become a potential therapeutic target for esophageal carcinoma.
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PubMed
高影响因子
ACS Applied Engineering Materials
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2026
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IF 3.5
Huisheng Yao,Xiao-Peng Li,Xiaoshan Yan,Jiayu Zhai,Bo Yuan,Li Li,Heguo Li,Xinbo Wang,Yue Zhao,Xiaofeng Li
The widespread application of nuclear technology in fields such as energy, medicine, and aerospace has driven the rapid development of high-performance X/γ-ray shielding materials. This work utilized radiation shielding simulation tools, WinXCom and Geant4, to simulate the X/γ-ray shielding performance of heavy-metal/rare-earth metal oxides. Based on the principle of complementary absorption edges, Bi2O3 and Sm2O3 were selected as the optimal shielding components. Three-dimensional models of electrospun membranes were established to systematically investigate the influence of different shielding configurations (single, blended, and core–shell structures) on their X/γ-ray shielding performance. Guided by simulation, coaxial electrospinning technology was employed to load Bi2O3 and Sm2O3 nanoparticles into the shell and core layers of polyacrylonitrile (PAN) nanofibers, respectively, fabricating a hierarchical heteromorphic core–shell nanofibrous membrane (C-SNM). Owing to the complementary absorption characteristics and the multistage shielding attenuation mechanism, a 2 mm thick CSm-SBiNM (70 wt % filler loading) achieved an X-ray shielding efficiency of 52.54% at 80 kV, equivalent to 0.25 mm Pb, while its density was 0.492 g cm–3, merely 4.34% of the Pb plate (11.344 g cm–3). Without weight increase, component optimization and configuration design enhanced shielding performance of the CSm-SBiNM by about 4%, compared to a uniaxial nanofibrous membrane (UNM) with a disordered blended structure. Furthermore, the CSm-SBiNM exhibited a water vapor transmission rate of 6.582 kg m–2 d–1 and PM2.5 filtration efficiency exceeding 99.960%. The C-SNM combines efficient, broad-spectrum radiation protection with lightweight and moisture-permeable properties, overcoming the limitations of traditional rubber/plastic-based materials in this regard, and laying a foundation for next-generation radiation protection materials.
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Materials Today Advances
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2026
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IF 8
Jiabao Xiong,Yuan Wang,Lijun Zhu,Zhong Du,Le Guo,Jiayi Ding,Chi Zhang,Siyiti Amuti,Junhua Hu,Chao Wang,Biao Dong,Nuernisha Alifu
Overcoming thermoresistance and achieving precise, efficient tumor therapy remain major challenges. Heat shock protein 70 (HSP70) expression and autophagy activation are two major cellular defense mechanisms associated with thermal resistance. However, strategies that target both mechanisms to improve tumor treatment efficacy remain limited. Herein, this study presents a novel type of near-infrared II (NIR-II)-responsive theranostic nanoplatform (IR-820@γ-PGA/Arg NPs, PIRA NPs) that integrates photothermal therapy (PTT), photodynamic therapy (PDT), nitric oxide (NO)-mediated gas therapy (GT), and dual-pathway inhibition mechanisms to overcome thermal resistance. The theranostic nanoplatform utilizes a γ-polyglutamic acid (γ-PGA) to encapsulate the NIR-II dye IR-820, which forms stable J-aggregates to improve NIR-II fluorescence emission and photothermal conversion efficiency. The nanoplatform adsorbs L-arginine (Arg) and releases NO under 808 nm laser excitation, exhibiting excellent photothermal properties and NIR-II fluorescence emission for precise tumor treatment. PIRA NPs overcome photothermal resistance via two pathways: suppressing HSP70-mediated thermoresistance and disrupting the autophagy-lysosomal degradation pathway (LC3B/p62 axis) through Arg-derived NO generation. This dual-pathway blockade effectively neutralizes tumor defenses, achieving a 92.7% tumor inhibition rate with minimal systemic toxicity. The γ-PGA framework enhances the stability of J-aggregates and their biocompatibility, further improving therapeutic efficacy. This work provides a versatile nanotherapeutic platform based on a promising strategy for reversing thermoresistance and achieving highly efficient cancer therapy.
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ACS Biomaterials Science & Engineering
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2026
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IF 6
Wei Li,Xiangjiang Wang,Liangjun Jiang,Xianzhou Lu,Zhixiang Zhou
Aim: Nanobiotechnology has grown rapidly in recent years and constitutes an integral part of modern disease diagnosis and treatment. The goal of this study was to evaluate the protective effect of synthesized selenium nanoparticles (SeNPs) against ionizing radiation (IR)-induced hematopoietic system injury. Methods: An aqueous extract of Rhodiola (RHO) was used for the synthesis of SeNPs (RHO-SeNPs). The resulting nanoparticles were characterized by ultraviolet–visible spectrophotometry and transmission electron microscopy, followed by biological assessment (antioxidant and cytotoxicity). Experiments with BALB/c mice and mouse hematopoietic stem cells (HSCs) exposed to 60Co γ-rays were used to evaluate the therapeutic efficiency of RHO-SeNPs. Immunohistochemistry, ELISA, JC-1 staining, CCK-8, TUNEL, flow cytometry, and Western blot were employed to investigate the underlying mechanisms. Results: RHO-SeNPs showed excellent antioxidant performance and had no toxicity in the major organs of BALB/c mice when administered at ≤20 mg/kg. RHO-SeNPs dose-dependently improved hematopoietic function and survival rate of IR-exposed BALB/c mice, in addition to suppressing mitochondrial oxidative stress, inflammatory responses, and bone marrow cell apoptosis. In vitro studies revealed that RHO-SeNPs limited Kelch-like ECH-associated protein 1 (KEAP1) expression and induced nuclear translocation of nuclear factor erythroid 2-related factor 2 (NRF2), thereby attenuating oxidative stress and HSC apoptosis. Both in vivo and in vitro experiments demonstrated that the disruption of NRF2 nuclear translocation partly abolished the radioprotection of RHO-SeNPs. Conclusion: These findings identify the mechanisms underlying the radioprotection of RHO-SeNPs and their potential role as a medical countermeasure against IR exposure.
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Frontiers in Nutrition
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2026
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IF 5.5
Ruyue Deng,Zhiqiang Yan,Danqiu Luo,Huihui Tang,Jianqiang Wu,Chaochao Zheng,Shengwei Wang
Fresh rice noodles (FRNs) are widely consumed starch based foods whose quality and shelf life depend strongly on the structural stability of the starch matrix. γ-Irradiation can effectively extend the shelf life of FRNs but induces starch depolymerization, altering starch structure and functionality. This study investigated the effects of hydroxypropyl starch (HPS) incorporation on the molecular characteristics, ordered structure, and thermal and pasting properties of starch in γ-irradiated FRNs. The results showed that 6% HPS incorporation produced the most balanced structural and functional characteristics. Overall, HPS increased molecular size parameters, apparent α-1,6 linkage ratio, short range molecular order, relative crystallinity, and peak viscosity, while decreasing the long B3 chains proportion and gelatinization enthalpy. Correlation analysis showed that A chains were positively correlated with short-range order, relative crystallinity, and swelling power, and negatively correlated with peak viscosity, whereas B3 chains showed the opposite trend, suggesting that the superior pasting behavior at 6% HPS was associated with a more balanced amylopectin chain architecture. HPS incorporation altered the relative amylopectin chain length distribution of the starch system, with 6% addition increasing the proportion of A and B1 chains relative to B2 and B3 chains, thereby favoring granule swelling and paste viscosity development. However, excessive HPS addition over-enriched short chains and weakened paste stability. These findings clarify the structure–function relationships in γ-irradiated starch systems and provide a scientific basis for optimizing the quality of irradiated rice-based products.
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高影响因子
Food Bioscience
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2026
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IF 6.2
Xinran Chen,Ruren Li,Lan Zhang,Di Zhang,Liangyan Rong
D. hansenii D1 nitrogen overflow drives cross-kingdom bacterial growth. • Amino acid dependencies reveal niche differentiation in bacterial partners. • Cross-feeding supplies precursors but substrates limit GABA and ester synthesis. • Co-supplementation of amino acids and α-keto acids enhances metabolite production. • Nitrogen availability and TORC1 signaling regulate fungal overflow and cross-feeding. Microbial interactions are important for the biosynthesis of flavor and functional metabolites in fermented ecosystems, yet how inter-kingdom nitrogen flux is allocated and contributes to these processes remains poorly understood. In this study, a defined microecosystem comprising the core starter yeast Debaryomyces hansenii D1 and two bacteria, Lactiplantibacillus plantarum LP-2 and Staphylococcus xylosus JH-3, was established to investigate this metabolic network using gas chromatography coupled with tandem mass spectrometry and high-performance liquid chromatography. Results revealed distinct metabolic niches: L. plantarum heavily relied on exogenous amino acids, whereas S. xylosus demonstrated autonomous synthesis. The release of diffusible fungal nitrogen metabolites, including cysteine and glutamine, was associated with nitrogen overflow and enhanced bacterial growth. This cross-feeding enhanced γ-aminobutyric acid (GABA) and ethyl ester biosynthesis. Moreover, co-supplementation with amino acids and α-keto acids increased the accumulation of these key metabolites. Fungal amino acid release appeared to involve regulated efflux rather than passive leakage and was associated with inorganic nitrogen assimilation and the Target of Rapamycin Complex 1 (TORC1) signaling pathway. These findings provide insights into cross-kingdom interactions in a defined three-species community and may inform the future development of synthetic microbial starters. Download: Download high-res image (429KB) Download: Download full-size image
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Sustainable Chemistry and Pharmacy
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2026
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IF 6.7
Deyang Zhao,Xinyu Zhao,Qikai Si,Kongde Li,Huawei Yang,Christophe Len
γ-valerolactone (GVL) is a renewable and sustainable platform chemical derived from biomass, with broad applications in chemical synthesis and energy-related fields. Consequently, the development of efficient strategies for GVL production has attracted significant attentions. In this study, the hydrogenation of ethyl levulinate (EL) to GVL was investigated using copper-cobalt basic carbonate, (CoCu) 2 (OH) 2 CO 3 , as a catalyst. The influence of different substrates—including esters and acids such as EL, GVL, ethyl acetate (EA), and levulinate acid (LA)-on catalyst recyclability and performance was systematically evaluated. Among the substrates tested, EL exhibited the most favorable behavior, delivering a GVL yield of up to 96% in the second recycling cycle under optimized conditions. This superior performance is attributed to the synergistic interaction between the basic sites of the catalyst and the ability of metallic Cu to activate hydrogen, as well as the formation of larger metal particle clusters when EL is used as the substrate. Notably, the catalytic activity remained largely preserved even after the third recycling cycle. In contrast, when GVL was sued as the substrate, moderate yields were obtained, accompanied by the formation of surface coatings on the catalyst particles. Furthermore, both EA and LA induced varying degrees of catalyst etching, resulting in a drastic loss of activity, with negligible catalytic performance observed in the second cycle. These findings indicate that catalyst deactivation due to etching has a more pronounced impact on catalytic performance than structural changes associated with bimetallic cluster formation. This observation indirectly highlights the critical role of basic sites in maintaining catalytic activity during the hydrogenation process.
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Surfaces and Interfaces
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2026
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IF 6
Weijie Lin,Hong Deng,Yishun Wang,Jiaxin Lv,Xucun Ye
Typically, the high-temperature calcination of secondary aluminum dross (SAD) following pyrometallurgical or hydrometallurgical treatments yields α -Al 2 O 3 as the primary product. However, the inherent lack of catalytic activity in this material restricts its application as a high-value-added catalyst. Herein, we propose a targeted "waste-to-catalyst" upcycling strategy that achieves the phase transformation of SAD into γ -Al 2 O 3 nanorods for peroxymonosulfate (PMS) activation and ciprofloxacin (CIP) degradation. Aluminum was first extracted via a Na 2 CO 3 -assisted roasting-leaching process, achieving an aluminum recovery efficiency of 85.1% and a final purity exceeding 98.5%, providing a high-quality precursor. The recovered material was subsequently engineered into a specific nanorod morphology through a geometry-controlled hydrothermal treatment followed by low-temperature calcination. The optimized catalyst (B-400) exhibited superior catalytic performance, removing over 98.5% of CIP within 1.5 h. Notably, the reaction rate constant increased to 2.53 h –1 , which is significantly higher than the 1.34 h –1 observed for unmodified alumina. Mechanistic investigations and theoretical calculations revealed that the enhanced activity originates from the combined effect of the unique nanorod structure and low crystallinity, which collectively preserve abundant coordinatively unsaturated Al 3+ sites and oxygen vacancies. These active sites facilitate PMS activation to generate singlet oxygen ( 1 O 2 ) as the dominant reactive species responsible for pollutant degradation. This work establishes a practical pathway not only for mitigating the environmental risk posed by SAD but also for its directional conversion into high-performance, functional catalytic materials, thereby contributing to a circular economy.
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高影响因子
Materials Today Communications
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2025
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IF 4.5
Yisha Ma,Haijun Wang,Qianqian Yu,Yuxin Wang,Jian Hu,Tong Wang
The γ-phase of poly(vinylidene fluoride) (PVDF) exhibits exceptional dielectric polarization and thermal stability but suffers from kinetically hindered crystallization and high-frequency dielectric losses in conventional processing. We develop a diamine-polyethylene glycol (diamine-PEG) covalent crosslinking strategy that simultaneously overcomes both limitations. The sterically confined network enables rapid γ-phase crystallization (92 % purity within 4 h at 155°C) through directed T 3 GT 3 G′ chain alignment, while suppressing parasitic dipole relaxation. This yields breakthrough dielectric performance: frequency-stable permittivity (ε' ≈ 8) with ultralow loss (tan δ = 0.21 at 10 6 Hz, 60 % reduction vs. pristine PVDF) and ferroelectric switching exhibiting 2.5-fold enhancement in polarization (4.5 μC/cm 2 at 2000 kV/cm). Crucially, the films retain exceptional flexibility (307 % elongation at break with 5 wt% crosslinker vs. 90 % for neat PVDF) and solution processability, establishing a multifunctional platform for flexible power electronics requiring concurrent high-frequency stability, thermal resilience, and mechanical durability.
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FOOD CHEMISTRY
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2025
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IF 9.8
Haiyan Li,Xiao Zhang,Hongmei Luo,Jieling Chen,Qilin Huang
The persistent off-odor in aquatic products has impeded the growth of aquatic industry. An innovative strategy was proposed to remove off-odors using edible γ-cyclodextrin metal–organic frameworks (γ-CD-MOFs). The interaction between the γ-CD-MOFs and off-odors of three aldehydes (nonanal, 4-heptenal, and 2,4-decadienal) is analyzed by adsorption kinetics, isotherms, thermodynamics, and density functional theory (DFT) calculations. The γ-CD-MOFs exhibited the highest adsorption rate for 2,4-decadienal (63.9 %), possibly due to electron delocalization caused by large π bond to enhance the reactivity of the molecule. The highest adsorption capacity of γ-CD-MOFs was observed at 40 °C, but the aldehydes underwent a self-aldol condensation reaction at 90 °C, significantly affecting the adsorption capacity. The aldehydes adsorption by γ-CD-MOFs could have occurred via hydrogen bonding and van der Waals interaction. Consequently, γ-CD-MOFs effectively reduce the levels of volatile aldehyde substances, removing off-odors generated by lipid oxidation in surimi. This work offers novel application for MOFs in the food industry.
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高影响因子
EUROPEAN POLYMER JOURNAL
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2026
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IF 6.8
Mingtao Ding,Song Feng,Tongjun Yang,Yuanlong Guo,Lihua Zhang,Haibo Xie
Chitin dissolution is prerequisite to allow its homogeneous processing and develop value-added regenerated/derivative chitin-based materials. In this work, in combination of [EMIM][OAc] ionic liquids, biomass-derived γ -valerolactone (GVL) was delicately screened as a co-solvent to construct benign organic electrolyte solutions (OESs) for chitin dissolution and homogeneous processing. Kamlet-Taft parameters ( α , β , and π*) of [EMIM][OAc]/GVL OESs with varying molar ratios are examined. Introduction of [EMIM][OAc] into GVL can notably increase the polarity, supported by the increased E T (30) values. The NMR studies of N -acetylglucosamine (GlcNAc, the repeating unit of chitin) solvation further indicate that the hydrogen bonding between GlcNAc and both the anions and cations of the ILs. Rheological properties of chitin/[EMIM][OAc]/GVL solutions are studied, and lower viscous activation energy ( E η ) accompanies the increase of GVL content in the OESs, as the addition of GVL reduces the energy barrier for viscous flow and facilitates the mobility of chitin molecular chains. Furthermore, the potential of the chitin solutions for homogeneous processing into films is primarily demonstrated via a conventional solution casting approach using water as the coagulation bath. Regenerated chitin films are systematically characterized by FTIR, NMR, XRD, TGA, UV–vis, SEM and tensile tests. Thus, it seems that the [EMIM][OAc]/GVL OESs present a green platform for fabricating chitin-based materials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Xiaoqing Jia,Xuhui Wang,Peng Fan,Zizhao Wang,Ting Wang,Dawei Yan,Shige Wang,Qian Chen,Lei Du
Infected wounds are often plagued by dual challenges of persistent bacterial colonization and severe pain, which synergistically impede tissue repair. This study designed a novel multifunctional hydrogel film (G3/γ-PGA/GG-A/B) by integrating γ-polyglutamic acid (γ-PGA), third-generation dendrimers (G3), and guar gum (GG), with loading of amoxicillin (AMX) and bupivacaine (BUP). The solubilization effect of G3 and the hydrogel's unique network structure enhance the release rate of hydrophobic BUP, overcoming the poor delivery efficiency of lipophilic anesthetics in traditional hydrogels and enhancing long-term analgesic efficacy. In vitro assays confirmed that the film achieves over 99% bactericidal rates against Escherichia coli and Staphylococcus aureus , with no obvious cytotoxicity, and no significant damage to major organs in vivo . In C57BL/6 mouse models, G3/γ-PGA/GG-A/B treatment achieved a wound healing rate of 99.12 ± 0.44% for infected wounds within 18 days, with intact epidermal regeneration and orderly collagen deposition. In spared nerve injury (SNI) and plantar incision models (PIM), the film significantly prolonged thermal paw withdrawal latency and increased 50% mechanical withdrawal threshold, delivering potent analgesia for up to 5 days. This all-in-one hydrogel dressing integrates anti-infection, long-acting analgesia, and wound repair functions, offering a promising solution to clinical management of complex infected wounds.
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危险品化学品经营许可证（带存储）