Biomedical Materials
·
2024
·
IF 3.9
Jingrong Yu,Zhengkun Gao,Qingyue Han,Zi Wang,Wenjie Zhang,Jie Zhao,Shan Qiao,Xinxin Zou,Fengjie Huang
At present, wound dressings in clinical applications are primarily used for superficial skin wounds.However these dressings have significant limitations, including poor biocompatibility and limited ability to promote wound healing. To address this issue, t this study used aldehyde polyethylene glycol as the cross-linking agent to design a carboxymethyl chitosan-methacrylic acid gelatin hydrogel with enhanced biocompatibility, which can promote wound healing and angiogenesis.The CSDG hydrogel exhibites acid sensitivity, with a swelling ratio of up to 300%. Additionally, it exhibited excellent resistance to external stress, withstanding pressures of up to 160 kPa and self-deformation of 80%. Compared to commercially available chitosan wound gels, the CSDG hydrogel demonstrates excellent biocompatibility, antibacterial properties, and hemostatic ability. Both in vitro and in vivo results showed that the CSDG hydrogel accelerated blood vessel regeneration by upregulating the expression of CD31, IL-6, FGF, and VEGF, thereby promoting rapid healing of wounds. In conclusion, this study successfully prepared the CSDG hydrogel wound dressings, providing a new approach and method for the development of hydrogel dressings based on natural macromolecules.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomass Conversion and Biorefinery
·
2024
·
IF 3.5
Ma Yuanjie,Qiao Cong
A magnetized functional biochar (MCBC) with excellent adsorption properties for Cd 2+ removal from aqueous solutions was prepared using apple tree branches as feedstock and chitosan as the surface modifier. Batch adsorption experiment was carried out to examine adsorption performance of biochar before and after modification. Characterization techniques were employed to analyze physicochemical differences of biochar and to investigate Cd²⁺ adsorption mechanisms. The results showed that after chitosan modification and iron oxide loading, the surface of MCBC possessed abundant oxygen-containing groups and amino groups, which served as available active sites for Cd²⁺ removal. At a solution pH of 5.0, Cd²⁺ concentrations ranging from 5 to 300 mg/L, and a temperature of 298 K, the saturation adsorption capacity of MCBC (166.42 mg/g) was significantly higher than that of chitosan-modified biochar (132.28 mg/g) and original biochar (50.58 mg/g). The remova l processes were effectively characterized by Pseudo-second-order model and Langmuir model. The primary mechanisms of Cd²⁺ adsorption included coordination, precipitation, and cation-π interactions. The removal processes were spontaneous, endothermic, and primarily driven by chemical interactions. After five regenerations, the removal amounts of MCBC for Cd²⁺ remained above 90%. The study suggested that magnetic chitosan-modified biochar was effectively applied for remediating cadmium-contaminated water.
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Ye He,Xingxian Wu,Guanglin Zhang,Xingwen Huang,Wenrui Zhang,Mei Tu,Rong Zeng
A zwitterionic phosphoryldiserine (PDS)- chitosan conjugate was synthesized via Atherton-Todd reaction, and its degree of substitution of PDS and structure were characterized by 1 H and 31 P NMR spectra, ICP, FTIR and XRD. Thermal analysis confirmed that there existed the freezing bound water surrounding PDS-chitosan due to the introduction of zwitterionic PDS groups onto chitosan backbone. In vitro cytotoxicity and hemolysis assay demonstrated that PDS-chitosan had excellent cell compatibility. UV adsorption and fluorescence spectra revealed that the model protein, bovine serum albumin (BSA) tended to keep its native conformation and showed better thermal stability in aqueous media in the presence of PDS-chitosan. We also found that the esterase-like activity of BSA could be enhanced by low concentration of PDS-chitosan (C BSA = 0.33 mg/mL, C PDS-chitosan = 0.0625 and 0.125 mg/mL, pH = 7.4, T = 25 °C). The results indicated that zwitterionic PDS-chitosan showed great potential for maintaining protein function in biomedical applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·
IF 2.7
Xiaofei Yan,Zhaoyang Gao,Yehua Shao,Dongming Qi,Bei Wu,Shirong Guo
The frequent occurrence of respiratory infectious diseases has made it difficult for traditional antibacterial materials to meet practical needs in recent years. There was an urgent need to develop new antimicrobial materials with stronger antimicrobial effects and biosafety. In this paper, the carboxymethyl chitosan (CMCTS)/silk fibroin (SF) composite microspheres were synthesized through self-assembly, and the Ag + /CMCTS/SF composite microspheres were prepared by loading the Ag + onto their surface. It investigated the effect of CMCTS contents, SF on the size and secondary structure of CMCTS/SF composite microspheres, and the antibacterial activity and mechanism of Ag + /CMCTS/SF composite microspheres. The results showed that the average particle size distribution size of CMCTS/SF composite microspheres was ranged from approximately 593–1115 nm. When CMCTS was added at 50 wt%, the content of β -sheet structures in silk fibroin microspheres was the largest at 38.6%. And the CMCTS/SF composite microspheres loaded with Ag + enhanced the bactericidal rate against Escherichia coli and Staphylococcus aureus by 27.51% and 36.39%, respectively. In addition, the Ag + /CMCTS/SF composite microspheres have high biological safety, providing a new method for designing an efficient, green, and safe composite antibacterial agent.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL PHYSICS LETTERS
·
2025
·
IF 3.1
Guozheng Zhao
In this study, a sandwich-type immunoassay was employed for the simultaneous detection of four glucocorticoids (cortisone, clobetasol 17-propionate, triamcinolone, and dexamethasone) using graphene (GNP)-chitosan (CHI)\nanogold\glucocorticoid receptor (GR) bioimmunosensor. A novel strategy was developed, which involved the integration of surface modification technology, electrochemical detection technology, and immunoassay technology. The electrochemical characteristics of the modified bioimmunosensor were investigated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) methods. The GR concentration and incubation time were optimized to achieve the best detection effect. The differential pulse voltammetry (DPV) response sequence based on the identical concentration level was found to be cortisone > clobetasol 17-propionate > triamcinolone > dexamethasone. The bioimmunosensor demonstrated excellent performance characteristics with a wider linear range of 0.5–7000 ng⋅mL −1 , lower detection limit of 0.071–0.106 ng⋅mL −1 , better stability and repeatability. Cortisone and clobetasol 17-propionate were detected in skincare samples and achieved satisfactory test results.
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2024
·
IF 6.6
Kui Zhang,Yan Liu,Zhenrui Zhao,Xuewen Shi,Ruihao Zhang,Yixiang He,Huaibin Zhang,Wenji Wang
Background Polyvinyl alcohol/Chitosan hydrogel is often employed as a carrier because it is non-toxic, biodegradable, and has a three-dimensional network structure. Meanwhile, Magnesium-doped nano-hydroxyapatite(Mg-nHA) demonstrated high characterization to promote the osteogenic differentiation of bone marrow derived mesenchymal stem cell(BMSCs). Therefore, in order to develop a porous hydrogel scaffold for the application of bone tissue engineering, an appropriate-type Mg-nHA hydrogel scaffold was developed and evaluated.Methods A composite hydrogel containing magnesium-doped nano-hydroxyapatite (Mg-nHA/PVA/CS) was developed using a magnetic stirring-ion exchange method and cyclic freeze-thaw method design, with polyvinyl alcohol and chitosan as the main components. Fourier transform infrared spectra (FTIR), electron energy dispersive spectroscopy (EDS), X-ray photoelectron spectrometer (XPS) and scanning electron microscopy (SEM) were employed to analyze the chemical structure, porosity, and elemental composition of each hydrogels. The equilibrium swelling degree, moisture content, pH change, potential for biomineralization, biocompatibility, the osteogenic potential and magnesium ion release rate of the composite hydrogel were also evaluated.Results SEM analysis revealed a well-defined 3D spatial structure of micropores in the synthesised hydrogel. FTIR analysis showed that doping nanoparticles had little effect on the hydrogel’s structure and both the 5% Mg-nHA/PVA/CS and 10% Mg-nHA/PVA/CS groups promoted amide bond formation. EDS observation indicated that the new material exhibited favourable biomineralization ability, with optimal performance seen in the 5% Mg-nHA/PVA/CS group. The composite hydrogel not only displayed favourable water content, enhanced biocompatibility, and porosity (similar to human cancellous bone), but also maintained an equilibrium swelling degree and released magnesium ions that created an alkaline environment around it. Additionally, it facilitated the proliferation of bone marrow mesenchymal stem cells and their osteogenic differentiation.Conclusion The Mg-nHA/PVA/CS hydrogel demonstrates significant potential for application in the field of bone repair, making it an excellent composite material for bone tissue engineering.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Bingjie Zhang,Weiqing Lan,Zhicheng Wang,Zhe Shao,Jing Xie
This study synthesized five phenolic acid-chitosan copolymers utilizing the carbodiimide-mediated chemical crosslinking reaction. Comprehensive evaluations were conducted on their structural attributes, physicochemical properties, and biological activities. Fourier transform infrared confirmed successful grafting of phenolic acids onto chitosan via amide linkages. Additionally, ultraviolet–visible absorption spectroscopy and proton nuclear magnetic resonance analyses revealed novel absorption peaks between 200 and 400 nm and 6.0–8.0 ppm, respectively, attributable to the incorporated phenolic acids. Notably, the chitosan-gentisate acid copolymer exhibited significantly enhanced biological activity ( p < 0.05 ) compared to pure chitosan and the other four conjugates, attributed to its highest grafting degree of approximately 295.93 mg/g. These modified chitosan derivatives effectively preserved the quality of sea bass ( Lateolabrax japonicus ) during refrigerated storage, extending its shelf-life by up to 9 days, 7 days, and 4 days relative to control, chitosan, and gentisate acid groups.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Ruoying Wang,Shixin Xu,Miaomiao Zhang,Wei Feng,Chengwei Wang,Xuefeng Qiu,Jierui Li,Wen Zhao
Hemostasis, infection, oxidative stress, and inflammation still severely impede the wound repair process. It is significant to develop multifunctional wound dressings that can function as needed in various stages of wound healing. In this study, iridium nanoparticles (IrNPs) with multi-enzyme mimetic activity were complexed with chitosan (CS) and fucoidan (FD) for the first time to make a multifunctional CS/FD/IrNPs hydrogel with excellent antioxidant effect. The hydrogel has excellent physicochemical properties. In particular, the incorporation of IrNPs imparts excellent antioxidant properties to the hydrogel, which could scavenge reactive oxygen species (ROS). In addition, the hydrogel shows excellent hemostatic and antibacterial properties. The CS/FD/IrNPs hydrogel performs fast and efficient hemostasis in 21 s. Moreover, the blood loss of the CS/FD/IrNPs hydrogel group was approximately 10% of that in the control group and the antibacterial rate of CS/FD/IrNPs hydrogel against E. coli and S. aureus was up to 95 %. In vivo results demonstrate that CS/FD/IrNPs hydrogel promotes wound healing by attenuating ROS levels, reducing oxidative damage, mitigating inflammation, and accelerating angiogenesis. To summarize, the CS/FD/IrNPs hydrogel system, with hemostatic, antibacterial, antioxidant, anti-inflammatory and pro-healing activities, can be a promising and effective strategy for the treatment of clinically difficult-to-heal wounds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xinying Liao,Xiaoyi Feng,Ziyi Xiao,Gareth R. Williams,Xiaozhi Huang,Yunyun Shi,Hui Qin,Yang Liu
Hydrogels prepared from natural polysaccharide, such as chitosan, have attracted much attention owing to their advantageous physicochemical properties and functions. Therefore, it is of great significance to develop novel crosslinking and preparation methods for hydrogels. Here, a class of multifunctional chitosan-based (CBT) hydrogels were prepared from 3-carboxy-5-nitrophenylboronic acid (PBA) modified carboxymethyl chitosan (CMCS) and tannic acid (TA) by double crosslinking of borate ester and hydrogen bonds. They could rapidly gel within 1 min through physical blending under physiological conditions. They had good physicochemical properties such as injectability, plasticity, self-healing, swelling and biodegradability. They also exhibited the inherent viscoelastic behavior of hydrogels and had a maximum compressive strength of up to 0.31 Mpa. Moreover, they had excellent biocompatibility, hemostatic ability and antioxidant ability. Their maximum antibacterial rate against S. aureus and E.coli were up to 85.22 ± 2.73 % and 48.50 ± 1.04 %, respectively. They could be loaded with the model drug curcumin through borate ester bond and achieve glucose-sensitive controlled release. Preliminary in vivo experiments also showed good biosafety and degradability. Therefore, the multifunctional hydrogels provided a new approach for the design of polysaccharide-based hydrogels, and could potentially be applied in wound repair, drug delivery and other biomedical fields.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2024
·
IF 10
Qiuting Xu,Wei Su,Cuilan Huang,Haiyi Zhong,Lini Huo,Jinyun Cai,Peiyuan Li
As the misuse of antibiotics increases bacterial resistance, the treatment of infected wounds caused by bacteria encounters significant challenges. Conventional antimicrobial dressings often fall short in their ability to inhibit bacterial infections while simultaneously promoting wound healing. To address this issue, a polysaccharide self-healing hydrogel (CPP@PDA/Que3) wound dressing is successfully developed by incorporating quercetin and polydopamine nanoparticles into a carboxymethyl chitosan matrix. The dressing can be easily injected locally to create a protective barrier over the wound, effectively stopping bleeding and rapidly inhibiting inflammation. Furthermore, the CPP@PDA/Que3 hydrogel exhibits remarkable antioxidant and antibacterial properties, stemming from the combination of quercetin and near-infrared (NIR) photothermal therapy. It demonstrates the ability to eliminate 99.52% of Staphylococcus aureus and 99.39% of Escherichia coli in in vitro antibacterial experiments. Additionally, the in vivo wound healing experiment shows a healing rate of ≈97%. The experimental results indicate that under NIR laser (808 nm) irradiation, the polysaccharide-based hydrogel dressing significantly inhibits bacterial growth, reduces oxidative stress, expedites angiogenesis, and thereby accelerates the transition from inflammation to wound healing. In summary, the CPP@PDA/Que3 hydrogel exhibits significant potential as a wound dressing, providing a novel approach for clinically advancing the treatment of bacterial wounds.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2024
·Vol. 16
·期 16
·2368
·
IF 4.7
Bukatuka Futila Clemence,Lin Xiao,Guang Yang
In this study, a novel oral formulation of berberine hydrochloride (BBH) hydrogel was successfully synthesized through physical cross-linking using chitosan (CS) and carboxymethyl-β-cyclodextrin (CMCD). The characterization results confirmed the successful synthesis of the CS/CMCD hydrogel and the subsequent loading of BBH into this composite (CS/CMCD/BBH) was effectively accomplished. The BBH was used as a model drug and the resulting hydrogel demonstrated a sustained drug release profile. In addition to its improved solubility and sustained release characteristics, the hydrogel exhibited excellent antibacterial activity against common pathogens such asEscherichia coli(E. coli),Staphylococcus aureus(S. aureus), andCandida albicans(C. albicans). Additionally, in vitro studies indicated that the hydrogel was not cytotoxic to NIH3T3 and HaCaT cells, suggesting its safety for biomedical applications. This lack of cytotoxic effects, combined with the mechanical strength, solubility improvements, and antibacterial properties of the hydrogel, positions the CS/CMCD/BBH hydrogel as a promising candidate for the effective oral delivery of BBH. By addressing the solubility and delivery challenges of BBH, this hydrogel offers a viable solution for the oral administration of BBH, with potential applications in various biomedical fields.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2024
·
IF 2.2
Zhou Kui,Hu Rugang,Li Hanjing,Chen Hongwei
In this study, chitosan/hydroxyapatite nanowire composite scaffolds were prepared by the cryogenic 3D printing method. Their properties were investigated for bone regeneration. Synthesized hydroxyapatite nanowire and strontium doped hydroxyapatite nanowire were studied by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and thermogravimetry. The synthesized nanowires have good biocompatibility. Then, chitosan/hydroxyapatite nanowire composite scaffolds were prepared by cryogenic 3D printing. The morphologies, composition, biocompatibility, and osseogenesis in vivo of scaffolds were observed. Results indicated that scaffolds prepared by cryogenic 3D printing exhibited desirable 3D interconnected macro/microporous structures and good biocompatibility. Meanwhile, in vivo cranial defect implantation results confirmed that chitosan and strontium-doped hydroxyapatite nanowire composite scaffolds have the best ability of in vivo bone regeneration. The present composite scaffold has promising characteristics for bone regeneration.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）