FUEL
·
2026
·
IF 7.8
Miao Ma,Min Yang,Cai-Yue Zhang,Hai-Yi Sun,Rong-Jing Su,Xiao-Rui Yue,Chen-Xi Li,Yong-Ming Chai,Bin Dong
Developing low-cost, high-performance Ru-based hydrogen evolution reaction (HER) catalysts is crucial for advancing anion exchange membrane water electrolysis (AEMWE) technology. In this study, based on the Sabatier principle, a Ru/CoMoO 4 heterojunction catalyst with a ternary “nanorod-macroparticle-microparticle” structure is designed. Benefiting from the strong electronic interactions, a lower d-band center of Ru/CoMoO 4 is observed, resulting in optimal adsorption between Ru species and the key H* intermediates to greatly enhance the hydrogen desorption kinetics. Importantly, this interface engineering effect prevents the Volmer-Tafel step from becoming rate-limiting step, thereby promoting electron and mass transport. As a consequence, Ru/CoMoO 4 outperforms most of the reported HER catalysts at an ultra-low Ru loading of only 0.2 wt%. In alkaline media, it only requires an overpotential of 55 mV to achieve 100 mA cm −2 , with a low Tafel slope of 16 mV dec -1 , and operates stably for over 230 h at an industrial-grade current density of 1000 mA cm -2 . The AEMWE electrolyzer based on the Ru/CoMoO 4 catalyst achieves efficient and stable hydrogen production at 1000 mA cm⁻ 2 @ 1.93 V. This work not only provides a high-performance catalyst, but also elucidates a strategy for precisely controlling d-band center through heterojunction interface engineering to optimize reaction [email protected]
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高影响因子
BIORESOURCE TECHNOLOGY
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2026
·
IF 8.2
Jing Zhang,Liqiang Yan,Huihui Su,Xiaoyang Ou,Tao Xiong,Mingyong Xie,Fei Peng
Enzyme–inorganic hybrid nanoflowers (HNFs) are promising immobilization platforms because of their simple fabrication and often enhanced catalytic performance. Here, a robust and highly efficient hybrid nanoflower (β-Gal-SC@ST-LFAI) for d -tagatose biosynthesis was developed using co-immobilizing β-galactosidase (β-Gal) and l -arabinose isomerase (LFAI) by ST/SC–mediated self-assembly and biomineralization. First, the effects of key immobilization conditions on the fabrication of β-Gal-SC@ST-LFAI were investigated. Under optimal conditions, β-Gal-SC@ST-LFAI exhibited higher catalytic activity and activity recovery than a conventional β-Gal@LFAI. Compared with the free enzyme system, β-Gal-SC@ST-LFAI showed enhanced thermal stability, pH tolerance and organic solvent resistance. The structure of β-Gal-SC@ST-LFAI was further characterized by SEM, CLSM, DLS, FTIR, CD and BET technology. The resulting HNFs displayed a typical flower-like architecture with an average diameter of 1.83 μm and specific surface area of 18.57 m 2 ·g −1 . CD spectroscopy showed a decrease in α-helix content and an increase in β-sheet content in β-Gal-SC@ST-LFAI compared to the free cascade enzymes. In addition, β-Gal-SC@ST-LFAI exhibited a lower K m than the free cascade enzymes, indicating enhanced substrate affinity. The HNFs also demonstrated better storage stability than the free enzymes and excellent operational stability, retaining more than 77.99% of their cascade catalytic activity after seven reuse cycles. Finally, β-Gal-SC@ST-LFAI can catalyze the conversion of d -lactose to d -tagatose with a yield of 37.22%. This study provides a practical strategy for constructing multienzyme HNFs with high catalytic efficiency and process robustness.
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DOI
PubMed
高影响因子
Journal of Nanotechnology
·
2026
·Vol. 2026
·期 1
·7582895
·
IF 3.1
Xiaoxia Tang,Jinbao Chen,Shu Zhang,Jiaqi Huang,Hui Liu,Xiao Wang,Liulin Li,Yangcheng Li,Manli Xie
Background Colorectal cancer (CRC) often metastasizes to the liver, which complicates treatment strategies. This study evaluates MSN–TK@SA, a mesoporous silica nanoparticle (MSN) loaded with saikosaponin D (SA) and reactive oxygen species (ROS)–cleaving thioketal (TK), as a targeted approach for CRC metastasis. Methods MSN–TK@SA nanoparticles were formulated by loading SA onto MSN to create MSN@SA, followed by coating with ROS-responsive methoxy polyethylene glycol-thioketal-N-hydroxysuccinimide (mPEG-TK-NHS) to produce MSN–TK@SA. The nanoparticles were characterized using different analytical techniques, and drug release profiles were evaluated. CRC cells and a liver metastasis model of CRC with liver qi stagnation were treated with the nanoparticles, and various techniques were used to assess the effects of MSN–TK@SA on tumorigenicity, immune response, and liver metastasis. Results The MSN, MSN@SA, and MSN–TK@SA nanoparticles were spherical, monodispersed, and colloidally stable, with a progressive decrease in zeta potential, which demonstrated successful loading with SA and thioketal coating. Fourier-transform infrared spectroscopy (FTIR) confirmed the silanol, amine, and PEG-TK functionalization. MSN–TK@SA had high encapsulation (81%) and loading efficiency (29%), which was consistent with pore entrapment stabilized by hydrogen bonding and dipole interactions. Drug release was based on a sustained/controlled profile, and approximately 80% of the drug was released within 72 h without a burst effect. First-order and Weibull models best described the concentration-dependent, diffusion-controlled release with anomalous transport of the nanoparticles. In vitro, MSN–TK@SA exhibited significant anticancer activity, including decreased viability, invasion, and migration, and amplified apoptosis of CRC cells. MSN–TK@SA markedly reduced tumor burden and metastasis, enhanced antitumor immunity, and inhibited inflammation in a CRC liver metastasis model. Conclusion MSN–TK@SA nanoparticles enable effective drug loading, controlled release, and immune activation, significantly inhibiting CRC liver metastasis. They are a promising platform for drug delivery and immunotherapy, deserving further preclinical and translational research.
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高影响因子
BIOMEDICAL MICRODEVICES
·
2025
·Vol. 27
·期 4
·1-12
·
IF 3.3
Zhang Jingfei,Nan Xuanxu,Yang Li,Cui Yue
The Lateral flow immunoassay (LFIA) has been widely used in environmental monitoring and disease diagnosis due to its advantages of low cost, simple operation, and convenience. However, its accuracy and sensitivity remain major challenges to be addressed. D-dimer is an important biomarker for thrombotic diseases. In this work, we show for the first time a core–shell Au@Ag nanoparticle (NP) labeled colorimetrically enhanced LFIA for D-dimer detection. The superior performance of Au@Ag LFIA stems from the silver shell's enhancement of plasmon resonance, which boosts optical signals to yield brighter scattering and superior visual contrast. Compared with conventional AuNPs, Au@AgNPs significantly improve sensitivity, leading to more accurate results. The detection limit for D-dimer was improved by approximately tenfold, reaching 1 ng/mL, due to the improved cross-coupling efficiency of Au@AgNPs compared with AuNPs. We anticipate that, with further development and validation, this enhanced LFIA could become a valuable tool in a wide range of clinical diagnostic applications.
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PubMed
高影响因子
Engineering
·
2025
·
IF 11.6
Chao Sun,Tianzuo Wang,Ruijie Gao,Xiaoyang Liu,Kang Xue,Chengxiang Shi,Xiangwen Zhang,Lun Pan,Ji-Jun Zou
Understanding the intrinsic features of dehydrogenation reactions of liquid organic hydrogen carriers (LOHCs) is a formidable challenge due to the combined impact of electronic and geometric effects. Herein, we constructed a series of Pt/MO x catalysts (CeO 2 , MgO, ZrO 2 , TiO 2 , Al 2 O 3 , or SiO 2 ) with similar sizes of Pt (∼1.7 nm) to investigate the effects of Pt electron structures (tuned by electronic metal‒support interactions) on the catalytic dehydrogenation of LOHCs. The results revealed a volcano-shaped correlation between Pt d electrons on different supports and the turnover frequency of catalytic dehydrogenation. Importantly, the Pt/MgO catalyst exhibited the highest dehydrogenation activity. With decreasing d electron content, Pt/MgO increases the bonding orbital dominance of Pt‒C bonds and leads to stable adsorption of H6-monobenzyltoluene (MBT), which facilitates subsequent C‒H bond scission. This study offers insight for the strategic development of high-efficiency dehydrogenation catalysts via d electron density modulation of Pt sites.
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高影响因子
Food Bioscience
·
2026
·
IF 6.2
Mengmeng Ji,Jinwei Li,Liuping Fan,Liang Wang,Shengquan Huang
Pseudomonas aeruginosa , a significant opportunistic pathogen, poses a serious threat to food safety due to its antibiotic resistance and strong biofilm-forming ability. In this study, quercetagetin (Que) was identified as a novel quorum sensing (QS) inhibitor. Reporter strain assays, molecular docking, and dynamic simulation indicated that Que acts as an antagonist of the QS receptors. Que attenuated QS-regulated virulence phenotypes in a dose-dependent manner but showed insufficient antibiofilm activity ( p >0.05) at sub-minimum inhibitory concentration (sub-MIC) levels. In contrast, the combination of 0.5 mmol/L Que with 20 mmol/L D-leucine or D-tryptophan exhibited additive effects on planktonic cells, reducing its survival by 2.19–3.97 log compared to the control. For biofilm cells, the combined treatment potentiated the reduction in cell density by 0.48–1.42 log. Notably, these effects were strain-dependent but were equal to or outperformed those of the ε-polylysine (ε-PL) control. Mechanistically, this enhancement was driven by the disruption of biofilm matrix and cell membrane integrity. This was evidenced by the greater suppression of Acyl-homoserine lactones (AHLs) synthesis and virulence phenotypes, alongside substantial reductions in biofilm biomass and roughness and increased in membrane permeability compared to Que. Furthermore, the combination resulted in repression of key enzymes activities (Na + -K + -ATPase and succinate dehydrogenase) by 29%–38%. These changes indicated a promising strategy to control P. aeruginosa and enhance food safety.
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高影响因子
Journal of Molecular and Engineering Materials
·
2021
·
IF 0
Lili Feng,Pengyu Wang,Hansen Yang,Zhuo Chen,Shuhui Bo
A charge transfer dye with the D– π –A structure was synthesized by Pd catalyzed Hartwig–Buchwald coupling and Knoevenagel condensation reaction, using N, N-dihexylbenzo[b]thiophen-6-amine as donor and 2-(3-cyano-4, 5, 5-trimethylfuran-2 (5H)-ylidene)malononitrile (TCF) as acceptor. The solvatochromic and pH switch properties of the as-synthesized dye were investigated through UV-vis absorption and fluorescence emission spectra. A positive solvatochromism of the dye in different polar solvents was observed along with a visible color change of the solution. By adding acid/base into the DMSO solution of the dye, the color as well as the absorption and emission spectra of the solution exhibited outstanding characteristics of pH switch.
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PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
·
2017
·
IF 0.809
Jin Luo,Anlin Zhao,Caihua Zheng,Tao Wang
GRAPHICAL Display full size
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高影响因子
ACS Omega
·
2019
·
IF 2.584
Zifeng Zheng,Zhixiang Cui,Junhui Si,Shengrui Yu,Qianting Wang,Wenzhe Chen,Lih-Sheng Turng
Composite tissue engineering scaffolds show good comprehensive properties, but improving their interfacial binding force is still a challenge. In this study, polydopamine (PDA) was used as a glue-like layer to solve the interface problem in three-dimensional (3-D) porous hydroxyapatite (HA)/thermoplastic polyurethane (TPU) composite scaffolds and to improve their comprehensive properties. The morphology, water absorption, porosity, hydrophilicity, mechanical properties, and cell viability of HA/TPU and PDA/HA/TPU scaffolds were systematically studied. The scanning electron microscopy and X-ray photoelectron spectroscopy results showed that a uniform PDA coating layer successfully formed on the surface of 3-D porous HA/TPU composite scaffolds by dopamine self-polymerization. Moreover, the conjugation effect occurred between the PDA and HA/TPU matrix, resulting in an increase in the interfacial binding force of the 3-D PDA/HA/TPU scaffold. The hydrophilicity of the PDA/HA/TPU scaffolds was significantly higher than those of the TPU scaffolds. Both static and dynamic mechanical property tests revealed that the PDA/HA/TPU scaffold possessed excellent comprehensive mechanical properties, such as high strength, high stiffness, and good flexibility, due to the enhancement of the interfacial binding force. Compared with TPU and HA/TPU scaffolds, the addition of a PDA coating could effectively improve the attachment and viability of mouse embryonic osteoblasts cells (MC3T3-E1) incubated on PDA/HA/TPU scaffolds. These results indicate that the PDA/HA/TPU scaffolds possess great potential to be used as tissue engineering scaffolds, and that the PDA coating could be a simple, practical, effective, and universal approach to modify composite scaffolds.
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高影响因子
Science Bulletin
·
2026
·
IF 21.1
Chunhui Gao,Zhenjing Jiang,Jie Chen,Kaining Zhang,Huijun Yang,Ruwei Chen,Hang Yang,Qingjin Fu,Zheng Li,Nana Xu,Mengran Wang,Bo Hong,Feixiang Wu,Wei Zhang,Yanqing Lai
Aqueous zinc-ion batteries (AZIBs) are promising for energy storage. However, Zn anode instability—caused by dendrite growth, hydrogen evolution reaction (HER), and by-product formation—limits their practical viability. HER, in particular, accelerates Zn consumption, disrupts electrode integrity, and induces local alkalization, exacerbating passivation. Conventional strategies emphasize electrolyte formulation and surface passivation, yet few address the underlying electronic origin of HER on Zn. Here we report a catalysis-inspired strategy that electronically modulates Zn reactivity via d-band center engineering to intrinsically suppress HER. By introducing oxalic acid (OA) as a molecular additive, we achieve a significant downward shift in the Zn d-band center (from –6.896 to –7.062 eV), weakening hydrogen adsorption and fundamentally reducing HER activity. In parallel, OA disrupts the Zn 2+ solvation structure by displacing coordinated SO2– 4 anions, suppressing interfacial by-product formation. These dual effects yield unprecedented performance: Zn||Zn symmetric cells operate stably for over 3500 h; Zn||Cu cells exhibit 99.41% Coulombic efficiency over 1500 cycles; and Zn||I 2 cell retain 92.8% capacity after 10,000 cycles; the 1.3 Ah Zn||I 2 pouch cell presents good cyclability. This work pioneers a surface electronic tuning paradigm in battery design, extending catalytic d-band theory to electrochemical interfaces for HER suppression and interfacial stabilization in aqueous metal batteries.
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PubMed
高影响因子
Science China-Materials
·
2026
·
IF 7.7
Zhang Wen,Zhang Qiong,Zhang Ruixue,Liu Zhihao,Li Hongdong,Wu Zexing,Zhang Yang,Xu Guang-Rui,Wang Lei
The demand for Cl 2 is increasing globally, and the chlorine evolution from seawater is a promising technique in the chlor-alkali field to generate chlorine gas. Here, we constructed a novel hollow porous CoNiSe 2 /NiSe 2 nanosheet array for the electrosynthesis of chlorine in seawater-like solution. The CoNiSe 2 /NiSe 2 heterostructures were generated by ion exchange and calcination, which can improve their stability. Moreover, the formed porous hollow nanostructures show an ultra-high specific surface area due to the unique morphology and crystal structure, which can provide channels for mass transfer between the electrolyte and the surface of catalysts and expose more catalytically active sites for accelerating the reaction process. What is impressive is that the hybrid coupling of the Se 4p orbital and the Co/Ni 3d orbital in the heterointerface further reduces the reaction energy barrier of the chlorine evolution reaction (CER). The hollow porous CoNiSe 2 /NiSe 2 nanosheet arrays only exhibit an overpotential of 108 mV to reach the current density of 100 mA cm −2 in an acidic medium containing 4.0 M NaCl. Furthermore, the hollow porous CoNiSe 2 /NiSe 2 nanosheet arrays showed excellent stability and Cl 2 selectivity. The designed transition metal selenides provide a choice for the further development of non-noble metal-based catalysts in the chlor-alkali industry.
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高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Xiaoqiong Li,Yunruo Xu,Luming Xu,Qilin Li,Yiwei Zhao,Chunyu Wei,Yuyu Li,Lin Wang,Zheng Wang
Surgery is the mainstay of treatment for patients with solid tumors. However, the intricate inflammatory and immunosuppressive tumor microenvironment after surgery is recognized as a primary cause of tumor recurrence and metastasis. Here, we design and construct an in situ injectable therapeutic hydrogel encapsulating 1-methyl-d-tryptophan (1-d-MT), a small-molecule competitive inhibitor of indoleamine 2,3-dioxygenase, and meloxicam, a selective inhibitor of cyclooxygenase-2 (Ge1MT/Mel hydrogel) to prevent postoperative tumor metastasis and relapse. In this hydrogel system, 1-d-MT increases cytotoxic T lymphocytes and decreases regulatory T cells, thereby reversing the tumor immune tolerance microenvironment, while released meloxicam reduces inflammation caused by postoperative trauma via the COX-2/PGE2 pathway. When delivered into the resected tumor cavity, the hydrogel system mimics a “hot” tumor-immunity niche to attack residual tumor cells and significantly suppresses the postoperative recurrence of colorectal cancer. In the model of postoperative breast cancer and colorectal cancer recurrence and metastasis, the Ge1MT/Mel hydrogel substantially reduces the volume of recurrent tumors and demonstrates 85.1% and 66.7% inhibition rates of metastases, respectively. Importantly, the Ge1MT/Mel hydrogel markedly stimulates a potent antitumor immune response in the cancer lesion microenvironment, increasing antitumor immune cells including CD8+ T cells, as well as elevating antitumor cytokines such as interferon-γ. Overall, combination immunotherapy via the Ge1MT/Mel hydrogel after surgery represents a promising strategy to minimize residual tumor burden and reduce recurrence risk following tumor resection.
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PubMed
高影响因子
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