ANALYTICA CHIMICA ACTA
·
2025
·
IF 6
Jiabin Yang,Min Wang
Background Abnormal expression of microRNA (miRNA) is closely associated with the occurrence and development of cancer and various other diseases. Therefore, obtaining quantitative information on miRNA expression, especially detecting miRNA expression levels in living cells, is of great significance for studying related physiological and pathological processes as well as diagnosing diseases. RNA-cleaving DNAzyme (RCD)-based DNA walkers have shown great potential in the detection of miRNA. However, their application is hindered by low intracellular delivery efficiency, limited catalytic efficiency, and the requirement for additional supply of cofactors. Results In this study, we developed a novel self-feedback dual-walker (SFDW) nanosystem, loaded onto urchin-like nano-MnO 2 (UNM), for intracellular trace-level miR-21 imaging. The SFDW nanosystem incorporates a hairpin-structured capture probe and two mutually activating DNA walkers. During the detection process, the capture probe recognizes and binds to miR-21 in the matrix, opens the hairpin structure, and subsequently activates the DNA walkers. The cleavage product of each DNA walker in the nanosystem serves as the activator for the other, thereby establishing a biocircuit (self-feedback circuit) with cyclic amplification effect between the two. This mechanism significantly enhances the signal amplification capability. The UNM carrier not only promotes cellular uptake for the SFDW nanosystem, but supplies endogenous Mn 2+ cofactors via intracellular glutathione-triggered degradation as well. The SFDW nanosystem achieved a low detection limit of 2.8 pM, and successfully enabled miRNA visualization in living cells. Significance The self-feedback circuit improved detection sensitivity and reduced the detection limit, while the introduction of UNM enhanced delivery efficiency and provided the necessary cofactors. This proposed strategy can address the limitations of RCD-based DNA walkers in intracellular miRNA detection and holds great potential for clinical diagnosis and early-stage disease screening.
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2021
·
IF 7.46
Mengna Huang,Yanping Fan,Xiang Yuan,Lin Wei
Malathion is widely applied in agriculture as one of organophosphorus pesticides (OPs) and easily causes a number of health and environmental problems. Traditional methods for analyzing malathion residues have failed to meet the current requirements of detection. To address this challenge, we designed a colorimetric-based single particle detection (SPD) method to quantify malathion using MnO 2 -coated gold nanoparticles (GNP@MnO 2 NPs) as the probe. In the existence of alkaline phosphatase (ALP), p-aminophenyl phosphate (p-APP) can be hydrolyzed to p-aminophenol (p-AP), which employs as a reductant to induce MnO 2 to Mn 2+ and make the gold core exposure. With the dark field optical microscopy (DFM), the color change of the probe can be readily observed at the single particle level. However, malathion is able to inhibit the activity of ALP and makes the color of the probe remain. Thus, the content of malathion can be accurately quantified by monitoring the changes in color and scattering intensity of the probe. The linear range of this assay is 0.001–0.1 ng/mL and the limit of detection (LOD) is as low as 0.82 pg/mL. In addition, degradation of malathion can be achieved due to the interaction between malathion and ALP. Therefore, this strategy offers new insights on the design of an ultrasensitive assay for OPs detection and degradation in the future.
研究领域:
环境科学
·
分析化学
·
生物医学工程
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Small Methods
·
2022
·Vol. 7
·期 1
·2201266
·
IF 15.367
Mingjun Nan,Min Wu,Yuqin Liu,Lin Qiao,Huamin Zhang,Xiangkun Ma
Aqueous manganese-based flow batteries (AMFBs) have attracted great attention due to the advantages of low cost and environmental friendliness. Extending the cycle life of AMFBs has long been a challenging theme. The titanium-manganese single-flow batteries (TMSFB) are promising due to their special structure and electrolyte composition. However, TMSFB with high areal capacity faces capacity decay for unknown reasons. In this work, the capacity decay mechanism (accumulation and growth of MnO 2 ) is clarified by a homemade in situ microscope system. Given that, a redox mediator of Fe 2+ /Fe 3+ is specially designed to boost the areal capacity of TMSFB without side reaction. The directional promoting principle of the Fe 2+ /Fe 3+ is elaborated in detail. Fe 2+ chemically reacts with the residual MnO 2 to form Fe 3+ , which is reduced to Fe 2+ by the electrochemical reaction. And then Fe 2+ continues reacting with MnO 2 until MnO 2 is consumed completely. As a result, the TMSFB with the areal capacity of ≈55 mA h cm −2 can stably operate at a current density of 40 mA cm −2 , which is the highest areal capacity reported in aqueous manganese-based batteries. This work provides a new strategy for boosting the capacity of manganese-based batteries, shedding light on the improvement of other deposition-type batteries.
研究领域:
电化学
·
能源材料科学
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Journal of Energy Storage
·
2024
·
IF 8.9
Yan Xiong,Haibang Zhang,Yan Qian,Yinzuo Wu,Ziyue Fu,Pingchun Guo,Hedong Jiang,Jiake Li,Yan-xiang Wang,Shijin Yu,Hua Zhu
Silicon (Si) exhibits significant potential as a high-capacity anode material for lithium-ion batteries. However, its commercial viability is hindered by challenges such as volumetric expansion during charge and discharge cycles, inadequate electrical conductivity, and a limited cycle life. To address these issues, the combination of Si with transition metal oxides and carbon coatings has proven to be an effective strategy for enhancing cycling performance. This paper presents a straightforward and cost-effective one-pot method for synthesizing Si@AMOA (Silicon composite carbon-coated amorphous manganese oxides) composites. The pores between the cross-linked nanorods can provide a large volume expansion space, and the embedded nanorods have strong Si C bonding, which can buffer the volume change of the Si active material, while the use of phenolic resin to form an amorphous carbon layer encapsulated with Si-composite amorphous MnO 2 improves electrical conductivity and stability, and the Si@AMOA anode material is loose and porous, with a large specific surface area, which is conducive to the ionic and electronic transport. The absence of the MnO 2 lattice leads to the presence of oxygen vacancies thus enabling the electrode material to have a better wettability with the electrolyte, which reduces the polarisation and improves the material's electrical conductivity, thus enabling the lithium to be rapidly intercalated/decalcified through the thin wall, thus improving its cycling stability performance. The Si@AMOA anode demonstrates a specific discharge capacity of 972.6 mAh g −1 after more than 600 cycles at a current density of 0.5 A g −1 , while exhibiting excellent electrochemical stability across varying current densities.
研究领域:
材料科学
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能源科学
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高影响因子
JOURNAL OF POWER SOURCES
·
2024
·
IF 8.1
Ying Wu,Bei Yan,Yiran Liu,Jingyi Kong,Xiang Lin,Min Gong,Liang Zhang,Dongrui Wang
Enhancing the energy density of aqueous rechargeable zinc-based batteries is critical for boosting their application in a variety of practical scenarios. Herein we demonstrate a strategy to improve specific energies of Zn//MnO 2 batteries in mild electrolyte via utilizing three-dimensional (3D) current collectors for both the anode and cathode. By electrodepositing limited amounts of Zn on surface-alloyed Ag mesh and coupling it with MnO 2 cathode electrodeposited on carbon cloth with no binder, the resultant batteries exhibit specific energy up to 253 and 196 Wh/kg (based on total mass of active materials) at negative-to-positive electrode capacity (N/P) ratios of 1:1 and 2:1. By elevating the working temperature to 35 °C, the specific energy and life span of the battery with N/P = 2 can be further increased to 216 Wh/kg and >225 cycles, respectively. The key to achieving a high specific energy relies primarily on the great reversibility of the Zn anode, which is conferred by the 3D Ag mesh.
研究领域:
材料科学
·
电化学
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Qiang Ma,Fan Li,Xianglong Zhang,Bowen Yang,Yingjie Zhang,Qingyuan Wang,Qihong Wu,Jin Huang,Jiming Hao
With the rapid development of ore refining, coal power plants, and mining, aqueous thallium pollution in natural waters has been reported over the past few decades. However, few thallium control technologies have been put into practice. In this study, a modified MOF adsorbent, MnO 2 @HKUST-1(MOH), was fabricated. Its chemical component shift, thermal stability, and microstructure changes during thallium adsorption were analyzed using TGA, XRD, XPS, and TEM-EDS techniques. The results showed a promising Tl + removal rate of over 90 %, and an adsorption capacity of 178.8 mg/g was obtained at a pH of 5 and a temperature of 293 K. The dynamic behavior of Tl + adsorption on MOH was simulated using power rate law expression (PRL), pseudo-first-order model (PFO), and pseudo-second-order model (PSO), which revealed a superior selection of Tl + among other competing heavy metal ions (Cr 3+ , Fe 3+ , Ca 2+ , Zn 2+ , and Cu 2+ ). The Tl + removal mechanism was further studied, which was mainly forced by surface adsorption/desorption. Based on its efficient Tl + removal rate, high adsorption capacity, promising regeneration property, and economical price, the MOH adsorbent has the potential to be a feasible option for smelting, ore refining, packaging, and testing wastewater treatment.
研究领域:
环境科学
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材料科学
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RSC Advances
·
2024
·Vol. 14
·期 50
·37512-37520
·
IF 3.9
Wenlong Xiong,Qiyuan Xie,Haoran Zhang,Md. Asraful Alam,Chenjie Zhu,Lele Wang,Jingliang Xu
Hydrogel electrolytes have received tremendous research interest in designing flexible zinc-ion secondary batteries, making them highly promising for flexible energy storage and wearable electronic devices. Herein, we report a composite hydrogel electrolyte (CHE) prepared using a fumed silica-doped gelatin hydrogel. This electrolyte is specifically designed for use in rechargeable aqueous Zn/MnO2 batteries (ReAZMBs). Experimental results showed that after fumed silica was added, the porosity and ionic conductivity of the gelatin hydrogel electrolyte increased. Meanwhile, adding fumed silica to the hydrogel electrolyte contributed to reducing self-corrosion and promoting rapid and uniform deposition of zinc ions. When the addition of fumed silica to gelatin was 10 wt%, ReAZMBs with this CHE exhibited a superior rate and cycling performance. More specifically, ReAZMBs with this CHE achieved an initial specific capacity of 150 mA h g−1 at a current density of 1.5 A g−1 and a capacity retention rate of 67% after 1000 cycles, which was much higher than that of the battery with the pure gelatin hydrogel electrolyte (33%). This was because of the improved interface stability between the zinc anode and electrolyte and the reduced formation of by-products (3Zn(OH)2·ZnSO4·3H2O and 3Zn(OH)2·ZnSO4·5H2O), according to the results of the charge–discharge test of Zn//Zn symmetric batteries and SEM and XRD characterizations of post-run zinc anodes. In addition, the ReAZMBs with the CHE demonstrated good flexibility and could supply power reliably even when bent.
研究领域:
材料科学
·
能源存储
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APPLIED SURFACE SCIENCE
·
2020
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IF 6.182
Mengwei Gao,Yuanbo Song,Yidan Liu,Wentao Jiang,Jianchao Peng,Liyi Shi,Rongrong Jia,Yaseen Muhammad,Lei Huang
In this work, we proposed a new approach for the fabrication of Au@MnO 2 core/shell assembled nanosheets using localized surface plasmon resonance ( LSPR) effect of gold nanoparticles (Au NPs). When KMnO 4 and Au NPs mixed solution were irradiated by 520 nm light, LSPR effect driven the reduction of KMnO 4 to MnO 2 on Au NPs, and gradually assembled into thin sheeted morphology. The influences of irradiation conditions and surface functional groups were systematically studied. Both 520 nm light and citrate group were proved significant for the formation of stable Au@MnO 2 core-shell assembled nanosheets. This approach is controllable, green and facile, and can be extended to synthesize other complex nanomaterials for a variety of applications.
研究领域:
材料科学
·
纳米技术
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高影响因子
ACS Biomaterials Science & Engineering
·
2024
·
IF 5.4
Mengqin Zhou,Xueying An,Zongguang Liu,Jianmei Chen
Surgical bleeding and cumulative oxidative stress are significant factors in the development of postoperative adhesions, which are always associated with adverse patient outcomes. However, effective strategies for adhesion prevention are currently lacking in clinical practice. In this study, we propose a solution using polydopamine-decorated manganese dioxide nanoparticles (MnO2@PDA) with rapid hemostasis and remarkable antioxidant properties to prevent postsurgical adhesion. The PDA modification provides MnO2@PDA with enhanced tissue adhesiveness and hemocompatibility with negligible hemolysis. Furthermore, MnO2@PDA exhibits impressive antioxidant and free radical scavenging properties, protecting cells from the negative effects of oxidative stress. The hemostatic activity of MnO2@PDA is evaluated in a mouse truncated tail model and a liver injury model, with results demonstrating reduced bleeding time and volume. The in vivo test on a mouse cecal abrasion model shows that MnO2@PDA exhibits excellent antiadhesion properties coupled with alleviated inflammation around the damaged tissue. Therefore, MnO2@PDA, which exhibits high biosafety, rapid hemostasis, and beneficial antioxidant capacity, displays exceptional antiadhesion performance, holding great potential for clinical applications to prevent postoperative adhesion.
研究领域:
纳米技术
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生物医学工程
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外科手术
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材料科学
·
药学
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高影响因子
ACS Nano
·
2026
·
IF 17.3
Ouyang Qin,Xiang Shiqi,Guo Yupeng,Yuan Jun,Chen Pan,Tang Qishun,Hu Chunhui,Zhou Wenhu,Huang Shu
Pyrolusite,
a traditional mineral medicine rich in manganese, has
long been used to promote fracture healing; however, its complex composition,
limited bioavailability, and poorly defined mechanisms have hindered
its modernization and clinical translation. Here, we present a nanotechnology-enabled
strategy to modernize pyrolusite by constructing a pyrolusite-derived
MnO 2 nanoplatform for osteo-angio-immunomodulatory bone
repair. Pyrolusite nanosuspensions were prepared via a top-down high-energy
ball-milling approach and incorporated into an injectable chitosan/β-glycerophosphate
thermosensitive hydrogel, thereby enabling precise local delivery
and sustained release. By directly comparing natural pyrolusite with
its monomeric component MnO 2 , we elucidated the pharmacological
substance basis of pyrolusite-mediated bone repair. Comprehensive in vitro and in vivo studies demonstrated
that both materials promote osteogenic differentiation, suppress osteoclastogenesis,
enhance angiogenesis, and induce reparative M2 macrophage polarization,
thereby reshaping the bone-regeneration microenvironment. Transcriptomic
analysis combined with protein–protein interaction mapping
and phosphorylation validation identified the PI3K–Akt signaling
pathway as a central regulatory hub orchestrating these effects, with
MnO 2 exhibiting consistently stronger biological activity
and pathway activation than natural pyrolusite. In a mouse femoral
defect model, MnO 2 -loaded hydrogels significantly accelerated
bone regeneration, improved bone microarchitecture and vascularization,
modulated immune responses, and exhibited excellent in vivo biosafety. Collectively, this work establishes a translatable paradigm
for upgrading traditional mineral medicine into a mechanism-driven
nanotherapeutic platform and highlights the potential of mineral-derived
nanomedicine for high-quality bone regeneration.
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DESALINATION
·
2026
·
IF 9.9
Tielin Du,Yuxiao Ran,Lang Liu
Monolithic MnO 2 /GO-cellulose sponge couples solar evaporation with photocatalytic antibiotic degradation. • Evaporation rate of 1.40 kg m −2 h −1 and 85% tetracycline degradation achieved under one sun. • 78% degradation efficiency maintained in 10 wt% NaCl with zero surface salt crystallization. • “Mesopore-concentration and macropore-reflux” mechanism enables robust salt resistance. Simultaneous antibiotic removal and salt resistance remain a promising yet challenging frontier in solar-driven interfacial evaporation. Herein, we fabricated a three-dimensional super-hydrophilic cellulose sponge integrated with a MnO 2 /GO composite (MGCS) via polydopamine-assisted deposition, successfully coupling photothermal steam generation with photocatalysis. This composite architecture enables efficient broadband solar harvesting and suppresses photogenerated electron–hole recombination, thereby enhancing both photothermal evaporation and photocatalytic degradation. Under one sun irradiation, MGCS delivers an evaporation rate of 1.40 kg m −2 h −1 and degrades 85% of tetracycline (15 mg L −1 , 150 min). Crucially, in a 10 wt% NaCl matrix, the system maintains a 78% degradation efficiency with zero surface salt crystallization over 24 h of continuous operation. This exceptional salt tolerance originates from a synergistic anti-fouling mechanism driven by the negatively charged, super-hydrophilic surface and a dynamic “mesopore-concentration and macropore-reflux” structural architecture. Ultimately, this monolithic platform provides a robust material framework for purifying complex, hypersaline wastewaters. Download: Download high-res image (186KB) Download: Download full-size image
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iScience
·
2026
·Vol. 29
·期 4
·
IF 4.5
Chuanchuan He,Shuaizhi Kong,Jie Zhang,Lihua Chen,Guoqing Zhang,Limin Jin,Xiaojuan Zhang,Baoyue Ding
Efficient completion of the CAPIR (circulation, accumulation, penetration, internalization, and release) cascade is essential for nanosystems to achieve satisfactory therapeutic efficacy and prognosis. Herein, we fabricated a manganese dioxide (MnO 2 )-coated cationic liposomal nanocarrier (MnO 2 @CLDOX) for enhanced doxorubicin (DOX) delivery via a multistage strategy. The anionic MnO 2 shell conferred negative zeta potential, enabling prolonged blood circulation and reduced systemic toxicity. In the tumor microenvironment, MnO 2 selectively decomposed under acidic pH and high hydrogen peroxide, exposing cationic CLDOX and generating O 2 . Cationic CLDOX facilitated cellular uptake via electrostatic interactions with tumor cell membranes. Meanwhile, O 2 alleviated tumor hypoxia, downregulated hypoxia-inducible factor-1 α , decreased collagen deposition, and improved extracellular matrix permeability, thus boosting drug penetration. Collectively, MnO 2 @CLDOX enhanced DOX delivery efficiency through synergistic mechanisms, achieving superior therapeutic efficacy against breast cancer.
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